Agios Pharmaceuticals, Inc.
AGIO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001439222
In the last 90 days, Agios Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 2 sales; 238 institutions reported holding it in 13F filings for Q2 2026, worth $2.45B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Agios Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 238
- +21 vs. Q3 2025
- Shares held
- 61.3M
- −2.05M (−3.2%) vs. Q3 2025
- Total value
- $1.67B
- −$870.9M (−34.3%) vs. Q3 2025
- New holders
- 65
- 79 more added
- Sold out
- 44
- 70 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AGIO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 238 | $2.45B |
| Q1 2026 | 234 | $2.12B |
| Q4 2025 | 238 | $1.67B |
| Q3 2025 | 221 | $2.55B |
| Q2 2025 | 216 | $2.05B |
| Q1 2025 | 221 | $1.76B |
| Q4 2024 | 225 | $1.97B |
| Q3 2024 | 208 | $2.58B |
| Q2 2024 | 206 | $2.51B |
| Q1 2024 | 187 | $1.81B |
| Q4 2023 | 170 | $1.33B |
| Q3 2023 | 146 | $1.46B |
| Q2 2023 | 153 | $1.68B |
| Q1 2023 | 165 | $1.36B |
| Q4 2022 | 160 | $1.67B |
| Q3 2022 | 168 | $1.64B |
| Q2 2022 | 157 | $1.31B |
| Q1 2022 | 161 | $1.74B |
| Q4 2021 | 161 | $1.95B |
| Q3 2021 | 165 | $2.81B |
| Q2 2021 | 186 | $3.63B |
| Q1 2021 | 175 | $3.37B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Agios Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| State Board of Administration of Florida Retirement System | 15,847 | $431.4K | 0.00% | 00.0% | Unchanged |
| Winton Group Ltd | 16,751 | $456.0K | 0.02% | +351+2.1% | Added |
| CWM Advisors, LLC | 17,115 | $465.9K | 0.04% | +5,720+50.2% | Added |
| Knott David M Jr | 18,000 | $490.0K | 0.23% | +18,000 | New |
| Canada Pension Plan Investment Board | 18,200 | $495.4K | 0.00% | +18,200 | New |
| VARCOV Co. | 19,104 | $520.0K | 0.21% | +19,104 | New |
| Entropy Technologies, LP | 19,163 | $521.6K | 0.03% | +19,163 | New |
| Handelsbanken Fonder AB | 19,323 | $526.0K | 0.00% | 00.0% | Unchanged |
| Brevan Howard Capital Management LP | 19,336 | $526.3K | 0.01% | +7,265+60.2% | Added |
| Oak Ridge Investments LLC | 20,004 | $544.5K | 0.03% | −5,381−21.2% | Reduced |
| Rockefeller Capital Management L.P. | 21,071 | $573.6K | 0.00% | +5,033+31.4% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 23,620 | $642.9K | 0.00% | +3,144+15.4% | Added |
| Janus Henderson Group PLC | 23,797 | $648.2K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 24,334 | $662.4K | 0.00% | +3,622+17.5% | Added |
| Russell Investments Group, Ltd. | 24,679 | $671.8K | 0.00% | +17,823+260.0% | Added |
| Federated Hermes, Inc. | 25,055 | $682.0K | 0.00% | +25,002+47,173.6% | Added |
| Virtus Investment Advisers, Inc. | 25,060 | $682.1K | 0.19% | +12,179+94.6% | Added |
| Aigen Investment Management, LP | 25,915 | $705.4K | 0.16% | +25,915 | New |
| Quantinno Capital Management LP | 26,855 | $731.0K | 0.00% | +26,855 | New |
| Victory Capital Management Inc | 27,697 | $753.9K | 0.00% | −2,535−8.4% | Reduced |
| AQR Capital Management LLC | 27,926 | $754.0K | 0.00% | −63,709−69.5% | Reduced |
| Intech Investment Management LLC | 27,827 | $757.5K | 0.01% | +4,249+18.0% | Added |
| Ishara Investments LP | 30,000 | $816.6K | 0.95% | +30,000 | New |
| Seven Fleet Capital Management LP | 31,738 | $863.9K | 0.58% | +31,738 | New |
| MetLife Investment Management | 32,217 | $876.9K | 0.00% | −1,815−5.3% | Reduced |
| Jump Financial, LLC | 33,052 | $899.7K | 0.01% | −54,848−62.4% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 33,470 | $911.1K | 0.03% | +7,969+31.2% | Added |
| Prelude Capital Management, LLC | 33,685 | $916.9K | 0.07% | +33,685 | New |
| State of Wisconsin Investment Board | 34,637 | $942.8K | 0.00% | −936−2.6% | Reduced |
| Edgewood Management LLC | 35,000 | $952.7K | 0.00% | 00.0% | Unchanged |
| Capital Fund Management S.A. | 35,788 | $974.1K | 0.01% | +35,788 | New |
| Quadrature Capital Ltd | 35,857 | $976.0K | 0.01% | +35,857 | New |
| Aquatic Capital Management LLC | 36,006 | $980.1K | 0.03% | +36,006 | New |
| Harbor Capital Advisors, Inc. | 37,228 | $1.01M | 0.08% | +2,393+6.9% | Added |
| Boothbay Fund Management, LLC | 37,291 | $1.02M | 0.03% | −458,050−92.5% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 39,455 | $1.07M | 0.00% | +2,863+7.8% | Added |
| Profund Advisors LLC | 39,850 | $1.08M | 0.03% | +24,741+163.8% | Added |
| Freestone Grove Partners LP | 40,841 | $1.11M | 0.01% | +25,417+164.8% | Added |
| Virginia Retirement Systems Et Al | 41,361 | $1.13M | 0.01% | +300+0.7% | Added |
| XTX Topco Ltd | 46,039 | $1.25M | 0.03% | +46,039 | New |
| Schroder Investment Management Group | 46,242 | $1.26M | 0.00% | +46,242 | New |
| SG Americas Securities, LLC | 46,451 | $1.26M | 0.00% | +18,801+68.0% | Added |
| DekaBank Deutsche Girozentrale | 40,000 | $1.27M | 0.00% | 00.0% | Unchanged |
| State of New Jersey Common Pension Fund D | 47,414 | $1.29M | 0.00% | +47,414 | New |
| Alps Advisors Inc | 47,881 | $1.30M | 0.01% | +20,327+73.8% | Added |
| Engineers Gate Manager LP | 49,128 | $1.34M | 0.02% | +49,128 | New |
| New York State Common Retirement Fund | 51,707 | $1.41M | 0.00% | +1,917+3.9% | Added |
| Headlands Technologies LLC | 52,739 | $1.44M | 0.12% | +52,739 | New |
| California State Teachers Retirement System | 53,239 | $1.45M | 0.00% | −8,057−13.1% | Reduced |
| TD Asset Management Inc | 57,292 | $1.56M | 0.00% | −71,002−55.3% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 60,560 | $1.65M | 0.00% | −10,653−15.0% | Reduced |
| Tudor Investment Corp Et Al | 61,345 | $1.67M | 0.01% | +61,345 | New |
| Alliancebernstein L.P. | 61,494 | $1.67M | 0.00% | −90.0% | Reduced |
| Wells Fargo & Company | 64,772 | $1.76M | 0.00% | +20,018+44.7% | Added |
| Kennedy Capital Management, Inc. | 65,655 | $1.79M | 0.04% | +41,014+166.4% | Added |
| Manufacturers Life Insurance Company, The | 70,256 | $1.92M | 0.00% | −25,756−26.8% | Reduced |
| ExodusPoint Capital Management, LP | 71,146 | $1.94M | 0.02% | +71,146 | New |
| Rhumbline Advisers | 74,153 | $2.02M | 0.00% | −13,549−15.4% | Reduced |
| Woodline Partners LP | 74,423 | $2.03M | 0.01% | +427+0.6% | Added |
| First Trust Advisors LP | 78,656 | $2.14M | 0.00% | +4,227+5.7% | Added |
| Lynx1 Capital Management LP | 79,624 | $2.17M | 0.44% | +79,624 | New |
| Y-Intercept (Hong Kong) Ltd | 79,831 | $2.17M | 0.05% | +71,899+906.4% | Added |
| Panagora Asset Management Inc | 79,840 | $2.17M | 0.01% | +79,840 | New |
| Prudential Financial Inc | 81,055 | $2.21M | 0.00% | −17,184−17.5% | Reduced |
| Two Sigma Advisers, LP | 85,200 | $2.32M | 0.00% | +71,600+526.5% | Added |
| Citigroup Inc | 88,238 | $2.40M | 0.00% | +44,618+102.3% | Added |
| Caption Management, LLC | 93,486 | $2.54M | 0.11% | +75,992+434.4% | Added |
| Parkman Healthcare Partners LLC | 99,604 | $2.71M | 0.26% | −776−0.8% | Reduced |
| Hudson Bay Capital Management LP | 100,000 | $2.72M | 0.02% | −22,500−18.4% | Reduced |
| UBS Asset Management Americas Inc | 106,996 | $2.91M | 0.00% | +121+0.1% | Added |
| Rafferty Asset Management, LLC | 107,490 | $2.93M | 0.01% | +39,270+57.6% | Added |
| Swiss National Bank | 108,860 | $2.96M | 0.00% | +2,200+2.1% | Added |
| Assenagon Asset Management S.A. | 110,440 | $3.01M | 0.00% | +43,287+64.5% | Added |
| Jacobs Levy Equity Management, Inc | 111,150 | $3.03M | 0.01% | +111,150 | New |
| Ikarian Capital, LLC | 115,489 | $3.14M | 0.41% | −11,490−9.0% | Reduced |
| Squarepoint Ops LLC | 121,763 | $3.31M | 0.01% | +121,763 | New |
| Deutsche Bank AG | 122,875 | $3.34M | 0.00% | −803,859−86.7% | Reduced |
| UBS Group AG | 126,665 | $3.45M | 0.00% | −116,148−47.8% | Reduced |
| Exome Asset Management LLC | 136,942 | $3.73M | 1.84% | +136,942 | New |
| Invesco Ltd. | 142,580 | $3.88M | 0.00% | +15,604+12.3% | Added |
| HRT Financial LP | 146,469 | $3.99M | 0.01% | +146,469 | New |
| HighVista Strategies LLC | 147,662 | $4.02M | 1.04% | −47,636−24.4% | Reduced |
| Allianz Asset Management GmbH | 147,950 | $4.03M | 0.00% | +1,307+0.9% | Added |
| Moore Capital Management, LP | 150,000 | $4.08M | 0.08% | +95,000+172.7% | Added |
| American Century Companies Inc | 151,486 | $4.12M | 0.00% | +6,365+4.4% | Added |
| Polygon Management Ltd. | 162,018 | $4.41M | 0.93% | +162,018 | New |
| Group One Trading, L.P. | 166,614 | $4.54M | 0.13% | +166,614 | New |
| Edgestream Partners, L.P. | 167,998 | $4.57M | 0.13% | +167,998 | New |
| ADAR1 Capital Management, LLC | 188,000 | $5.12M | 0.38% | +151,000+408.1% | Added |
| Bank of New York Mellon Corp | 196,893 | $5.36M | 0.00% | −73,203−27.1% | Reduced |
| Point72 Asset Management, L.P. | 200,000 | $5.44M | 0.01% | +193,493+2,973.6% | Added |
| Pictet Asset Management Holding SA | 205,019 | $5.57M | 0.01% | −67,142−24.7% | Reduced |
| Palo Alto Investors LP | 212,499 | $5.78M | 0.81% | −52,998−20.0% | Reduced |
| Trexquant Investment LP | 226,600 | $6.17M | 0.05% | +226,600 | New |
| BNP Paribas Arbitrage, SA | 242,670 | $6.61M | 0.00% | +227,972+1,551.0% | Added |
| JPMorgan Chase & Co | 251,777 | $6.85M | 0.00% | +68,677+37.5% | Added |
| Nuveen, LLC | 297,908 | $8.11M | 0.00% | +178,328+149.1% | Added |
| Two Sigma Investments, LP | 300,156 | $8.17M | 0.01% | +240,527+403.4% | Added |
| Barclays PLC | 320,352 | $8.72M | 0.00% | +104,312+48.3% | Added |
| Vestal Point Capital, LP | 325,000 | $8.85M | 0.32% | +198,000+155.9% | Added |