Upstream Bio, Inc.
UPB- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
近 90 天，Upstream Bio, Inc. 內部人申報 0 筆公開市場買進、5 筆賣出；2026 年第 2 季末有 148 家機構在 13F 申報持有，市值合計 $3.50 億；沒有大師持有。
2026 年第 1 季 13F 持有人
Upstream Bio, Inc. 在 2026/3/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 140
- 較 2025 年第 4 季 +10 家
- 持有股數
- 4,489 萬
- 較 2025 年第 4 季 −101.8 萬 (−2.2%)
- 總市值
- $4.04 億
- 較 2025 年第 4 季 −$8.42 億 (−67.5%)
- 新進機構
- 47
- 另有 47 家加碼
- 清倉機構
- 37
- 另有 35 家減碼
另有 3 家機構在 2025 年第 4 季持有、還沒有申報 2026 年第 1 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 UPB 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 148 | $3.50 億 |
| 2026 年第 1 季 | 140 | $4.04 億 |
| 2025 年第 4 季 | 133 | $13.9 億 |
| 2025 年第 3 季 | 95 | $8.36 億 |
| 2025 年第 2 季 | 83 | $5.31 億 |
| 2025 年第 1 季 | 79 | $2.67 億 |
| 2024 年第 4 季 | 70 | $6.90 億 |
| 2024 年第 3 季 | 0 | $0 |
| 2024 年第 2 季 | 0 | $0 |
| 2024 年第 1 季 | 0 | $0 |
| 2023 年第 4 季 | 0 | $0 |
| 2023 年第 3 季 | 0 | $0 |
| 2023 年第 2 季 | 0 | $0 |
| 2023 年第 1 季 | 0 | $0 |
| 2022 年第 4 季 | 0 | $0 |
| 2022 年第 3 季 | 0 | $0 |
| 2022 年第 2 季 | 0 | $0 |
| 2022 年第 1 季 | 0 | $0 |
| 2021 年第 4 季 | 0 | $0 |
| 2021 年第 3 季 | 0 | $0 |
| 2021 年第 2 季 | 0 | $0 |
| 2021 年第 1 季 | 0 | $0 |
2026 年第 1 季持有機構
每家機構持有 Upstream Bio, Inc. 的股數、市值與佔組合比重；股數變化跟 2025 年第 4 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| Deutsche Bank AG | 180,889 | $162.8 萬 | 0.00% | +53,074+41.5% | 加碼 |
| TCG Crossover Management, LLC | 181,063 | $163.0 萬 | 0.05% | −562,823−75.7% | 減碼 |
| Arrowstreet Capital, Limited Partnership | 185,087 | $166.6 萬 | 0.00% | +185,087 | 新進 |
| XTX Topco Ltd | 209,277 | $188.3 萬 | 0.03% | +194,186+1,286.8% | 加碼 |
| Vanguard Fiduciary Trust Co | 224,157 | $201.7 萬 | 0.00% | +224,157 | 新進 |
| UBS Group AG | 231,254 | $208.1 萬 | 0.00% | −1,574,989−87.2% | 減碼 |
| Prosight Management, LP | 241,123 | $217.0 萬 | 0.36% | +241,123 | 新進 |
| Charles Schwab Investment Management Inc | 257,729 | $232.0 萬 | 0.00% | −27,202−9.5% | 減碼 |
| Northern Trust Corp | 260,992 | $234.9 萬 | 0.00% | +24,193+10.2% | 加碼 |
| Alyeska Investment Group, L.P. | 298,329 | $268.5 萬 | 0.01% | 00.0% | 不變 |
| Goldman Sachs Group Inc | 316,587 | $284.9 萬 | 0.00% | −16,894−5.1% | 減碼 |
| Jump Financial, LLC | 319,400 | $287.5 萬 | 0.04% | +319,400 | 新進 |
| Wellington Management Group LLP | 342,353 | $308.1 萬 | 0.00% | −552,380−61.7% | 減碼 |
| Propel Bio Management, LLC | 341,779 | $310.0 萬 | 1.95% | +341,779 | 新進 |
| Sphera Funds Management Ltd. | 358,000 | $322.2 萬 | 0.55% | +358,000 | 新進 |
| Altshuler Shaham Ltd | 380,061 | $342.1 萬 | 0.06% | −961,479−71.7% | 減碼 |
| Nantahala Capital Management, LLC | 400,000 | $360.0 萬 | 0.22% | −94,971−19.2% | 減碼 |
| JPMorgan Chase & Co | 463,001 | $406.5 萬 | 0.00% | +352,721+319.8% | 加碼 |
| Morgan Stanley | 552,609 | $497.3 萬 | 0.00% | +430,541+352.7% | 加碼 |
| Qube Research & Technologies Ltd | 619,321 | $557.4 萬 | 0.01% | +619,321 | 新進 |
| HSBC Holdings PLC | 640,326 | $576.3 萬 | 0.00% | +640,326 | 新進 |
| State Street Corp | 705,350 | $634.8 萬 | 0.00% | −613,876−46.5% | 減碼 |
| Vanguard Portfolio Management LLC | 727,711 | $654.9 萬 | 0.00% | +727,711 | 新進 |
| Pictet Asset Management Holding SA | 733,431 | $660.1 萬 | 0.01% | −39,717−5.1% | 減碼 |
| Samsara BioCapital, LLC | 736,047 | $662.4 萬 | 0.64% | 00.0% | 不變 |
| Parkman Healthcare Partners LLC | 786,783 | $708.1 萬 | 0.73% | −47,776−5.7% | 減碼 |
| D. E. Shaw & Co., Inc. | 820,480 | $738.4 萬 | 0.01% | +793,389+2,928.6% | 加碼 |
| Woodline Partners LP | 831,481 | $748.3 萬 | 0.03% | +71,229+9.4% | 加碼 |
| Bain Capital Life Sciences Investors, LLC | 867,211 | $780.5 萬 | 0.70% | −462,333−34.8% | 減碼 |
| SEB Asset Management AB | 878,473 | $790.6 萬 | 0.03% | +878,473 | 新進 |
| Millennium Management LLC | 937,323 | $843.6 萬 | 0.01% | +420,059+81.2% | 加碼 |
| Geode Capital Management, LLC | 950,617 | $855.7 萬 | 0.00% | +98,709+11.6% | 加碼 |
| Federated Hermes, Inc. | 979,758 | $881.8 萬 | 0.01% | +979,276+203,169.3% | 加碼 |
| Y-Intercept (Hong Kong) Ltd | 1,000,631 | $900.6 萬 | 0.17% | +954,072+2,049.2% | 加碼 |
| Vanguard Capital Management LLC | 1,873,574 | $1,686 萬 | 0.00% | +1,873,574 | 新進 |
| Enavate Sciences GP, LLC | 2,459,703 | $2,214 萬 | 6.30% | 00.0% | 不變 |
| Decheng Capital LLC | 2,724,868 | $2,452 萬 | 3.71% | −418,210−13.3% | 減碼 |
| BlackRock, Inc. | 3,370,689 | $3,034 萬 | 0.00% | +26,185+0.8% | 加碼 |
| OrbiMed Advisors LLC | 5,693,589 | $5,124 萬 | 1.16% | 00.0% | 不變 |
| FMR LLC | 8,101,563 | $7,291 萬 | 0.00% | +583,361+7.8% | 加碼 |
| Janus Henderson Group PLC | 0 | $0 | 0.00% | −1,527,958−100.0% | 清倉 |
| Omega Fund Management, LLC | 0 | $0 | 0.00% | −1,326,293−100.0% | 清倉 |
| VR Adviser, LLC | 0 | $0 | 0.00% | −1,169,298−100.0% | 清倉 |
| Integral Health Asset Management, LLC | 0 | $0 | 0.00% | −750,000−100.0% | 清倉 |
| Vestal Point Capital, LP | 0 | $0 | 0.00% | −720,000−100.0% | 清倉 |
| Siren, L.L.C. | 0 | $0 | 0.00% | −588,450−100.0% | 清倉 |
| Great Point Partners LLC | 0 | $0 | 0.00% | −300,000−100.0% | 清倉 |
| Jennison Associates LLC | 0 | $0 | 0.00% | −288,847−100.0% | 清倉 |
| Squadron Capital Management LLC | 0 | $0 | 0.00% | −230,650−100.0% | 清倉 |
| SummitTX Capital, L.P. | 0 | $0 | 0.00% | −116,724−100.0% | 清倉 |
| Artia Global Partners LP | 0 | $0 | 0.00% | −68,653−100.0% | 清倉 |
| Exome Asset Management LLC | 0 | $0 | 0.00% | −64,845−100.0% | 清倉 |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −56,557−100.0% | 清倉 |
| Seven Grand Managers, LLC | 0 | $0 | 0.00% | −50,000−100.0% | 清倉 |
| Rafferty Asset Management, LLC | 0 | $0 | 0.00% | −38,683−100.0% | 清倉 |
| PSP Research LLC | 0 | $0 | 0.00% | −17,634−100.0% | 清倉 |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −16,560−100.0% | 清倉 |
| Profund Advisors LLC | 0 | $0 | 0.00% | −14,582−100.0% | 清倉 |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −13,712−100.0% | 清倉 |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −13,420−100.0% | 清倉 |
| Virtu Financial LLC | 0 | $0 | 0.00% | −12,246−100.0% | 清倉 |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −12,020−100.0% | 清倉 |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −10,500−100.0% | 清倉 |
| Intech Investment Management LLC | 0 | $0 | 0.00% | −10,396−100.0% | 清倉 |
| VARCOV Co. | 0 | $0 | 0.00% | −9,619−100.0% | 清倉 |
| ProShare Advisors LLC | 0 | $0 | 0.00% | −8,354−100.0% | 清倉 |
| SEI Investments Co | 0 | $0 | 0.00% | −8,087−100.0% | 清倉 |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −5,518−100.0% | 清倉 |
| Amalgamated Bank | 0 | $0 | 0.00% | −1,031−100.0% | 清倉 |
| Royal Bank of Canada | 0 | $0 | 0.00% | −969−100.0% | 清倉 |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −466−100.0% | 清倉 |
| Aster Capital Management (DIFC) Ltd | 0 | $0 | 0.00% | −271−100.0% | 清倉 |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −180−100.0% | 清倉 |
| J.Safra Asset Management Corp | 0 | $0 | 0.00% | −128−100.0% | 清倉 |
| The PNC Financial Services Group, Inc. | 0 | $0 | 0.00% | −106−100.0% | 清倉 |
| SageView Advisory Group, LLC | 0 | $0 | 0.00% | −30−100.0% | 清倉 |
| Sunbelt Securities, Inc. | 0 | $0 | 0.00% | −19−100.0% | 清倉 |
| Norges Bank | – | – | – | – | 本季未申報 |
| Vanguard Group Inc | – | – | – | – | 本季未申報 |
| Global Retirement Partners, LLC | – | – | – | – | 本季未申報 |