Xeris Biopharma Holdings, Inc.
XERS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001867096
In the last 90 days, Xeris Biopharma Holdings, Inc. insiders filed 0 open-market purchases and 8 sales; 242 institutions reported holding it in 13F filings for Q2 2026, worth $857.1M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Xeris Biopharma Holdings, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 227
- −3 vs. Q3 2025
- Shares held
- 100.9M
- +3.95M (+4.1%) vs. Q3 2025
- Total value
- $792.0M
- +$2.83M (+0.4%) vs. Q3 2025
- New holders
- 35
- 79 more added
- Sold out
- 38
- 78 more reduced
1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XERS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 242 | $857.1M |
| Q1 2026 | 239 | $610.3M |
| Q4 2025 | 227 | $792.0M |
| Q3 2025 | 231 | $789.3M |
| Q2 2025 | 201 | $422.9M |
| Q1 2025 | 199 | $480.9M |
| Q4 2024 | 162 | $222.2M |
| Q3 2024 | 144 | $182.2M |
| Q2 2024 | 135 | $136.6M |
| Q1 2024 | 142 | $133.7M |
| Q4 2023 | 120 | $140.8M |
| Q3 2023 | 111 | $102.3M |
| Q2 2023 | 105 | $146.7M |
| Q1 2023 | 92 | $80.6M |
| Q4 2022 | 97 | $71.6M |
| Q3 2022 | 101 | $89.3M |
| Q2 2022 | 103 | $91.3M |
| Q1 2022 | 103 | $129.2M |
| Q4 2021 | 92 | $120.2M |
| Q3 2021 | 71 | $42.9M |
| Q2 2021 | 94 | $114.9M |
| Q1 2021 | 103 | $149.7M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Xeris Biopharma Holdings, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Millennium Management LLC | 859,051 | $6.74M | 0.00% | +334,302+63.7% | Added |
| JPMorgan Chase & Co | 895,059 | $7.03M | 0.00% | −10,017−1.1% | Reduced |
| Deutsche Bank AG | 940,592 | $7.38M | 0.00% | −627,053−40.0% | Reduced |
| AQR Capital Management LLC | 957,579 | $7.52M | 0.00% | −26,021−2.6% | Reduced |
| Knott David M Jr | 970,000 | $7.61M | 3.53% | −45,000−4.4% | Reduced |
| Acadian Asset Management LLC | 971,598 | $7.62M | 0.01% | +50,495+5.5% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 1,058,692 | $8.31M | 0.02% | −640,065−37.7% | Reduced |
| Kennedy Capital Management, Inc. | 1,213,969 | $9.53M | 0.20% | +2,386+0.2% | Added |
| Granahan Investment Management Inc | 1,223,404 | $9.60M | 0.41% | +873,236+249.4% | Added |
| Northern Trust Corp | 1,386,829 | $10.9M | 0.00% | +23,700+1.7% | Added |
| CenterBook Partners LP | 1,391,590 | $10.9M | 0.53% | +693,386+99.3% | Added |
| Legal & General Group Plc | 1,396,265 | $11.0M | 0.00% | +38,838+2.9% | Added |
| Charles Schwab Investment Management Inc | 1,403,824 | $11.0M | 0.00% | −42,795−3.0% | Reduced |
| Goldman Sachs Group Inc | 1,568,421 | $12.3M | 0.00% | −227,034−12.6% | Reduced |
| Parkman Healthcare Partners LLC | 1,691,585 | $13.3M | 1.26% | −100,089−5.6% | Reduced |
| Two Sigma Investments, LP | 1,732,667 | $13.6M | 0.02% | +118,088+7.3% | Added |
| Rosalind Advisors, Inc. | 2,111,700 | $16.6M | 6.35% | +315,934+17.6% | Added |
| Wellington Management Group LLP | 2,286,598 | $17.9M | 0.00% | +1,705,636+293.6% | Added |
| Morgan Stanley | 2,707,783 | $21.3M | 0.00% | −511,918−15.9% | Reduced |
| Nuveen, LLC | 2,806,806 | $22.0M | 0.01% | −21,068−0.7% | Reduced |
| Driehaus Capital Management LLC | 2,980,567 | $23.4M | 0.16% | +361,438+13.8% | Added |
| Qube Research & Technologies Ltd | 3,498,197 | $27.5M | 0.04% | +223,363+6.8% | Added |
| State Street Corp | 4,116,924 | $32.3M | 0.00% | +378,595+10.1% | Added |
| Geode Capital Management, LLC | 4,275,989 | $33.6M | 0.00% | +135,815+3.3% | Added |
| D. E. Shaw & Co., Inc. | 7,574,850 | $59.5M | 0.05% | +1,734,964+29.7% | Added |
| Vanguard Group Inc | 11,186,677 | $87.8M | 0.00% | +1,358,760+13.8% | Added |
| BlackRock, Inc. | 12,639,318 | $99.2M | 0.00% | +711,619+6.0% | Added |
| Walleye Capital LLC | 0 | $0 | 0.00% | −623,962−100.0% | Sold out |
| Redmile Group, LLC | 0 | $0 | 0.00% | −451,099−100.0% | Sold out |
| Divisadero Street Capital Management, LP | 0 | $0 | 0.00% | −406,334−100.0% | Sold out |
| Mackenzie Financial Corp | 0 | $0 | 0.00% | −152,161−100.0% | Sold out |
| CWM Advisors, LLC | 0 | $0 | 0.00% | −128,494−100.0% | Sold out |
| Roundview Capital LLC | 0 | $0 | 0.00% | −120,000−100.0% | Sold out |
| Fred Alger Management, LLC | 0 | $0 | 0.00% | −108,936−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −86,920−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −83,000−100.0% | Sold out |
| OrbiMed Advisors LLC | 0 | $0 | 0.00% | −80,420−100.0% | Sold out |
| Bayesian Capital Management, LP | 0 | $0 | 0.00% | −70,800−100.0% | Sold out |
| GPS Wealth Strategies Group, LLC | 0 | $0 | 0.00% | −65,089−100.0% | Sold out |
| Occudo Quantitative Strategies LP | 0 | $0 | 0.00% | −47,674−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −45,931−100.0% | Sold out |
| Semanteon Capital Management, LP | 0 | $0 | 0.00% | −32,925−100.0% | Sold out |
| Baader Bank INC | 0 | $0 | 0.00% | −28,312−100.0% | Sold out |
| Skandinaviska Enskilda Banken AB (publ) | 0 | $0 | 0.00% | −25,000−100.0% | Sold out |
| Omers Administration Corp | 0 | $0 | 0.00% | −24,600−100.0% | Sold out |
| Petrus Trust Company, LTA | 0 | $0 | 0.00% | −24,351−100.0% | Sold out |
| Sunpointe, LLC | 0 | $0 | 0.00% | −21,000−100.0% | Sold out |
| Verdence Capital Advisors LLC | 0 | $0 | 0.00% | −17,549−100.0% | Sold out |
| Toroso Investments, LLC | 0 | $0 | 0.00% | −19,485−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −17,289−100.0% | Sold out |
| Capstone Investment Advisors, LLC | 0 | $0 | 0.00% | −17,130−100.0% | Sold out |
| Susquehanna Fundamental Investments, LLC | 0 | $0 | 0.00% | −17,087−100.0% | Sold out |
| JustInvest LLC | 0 | $0 | 0.00% | −15,561−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −15,500−100.0% | Sold out |
| Atom Investors LP | 0 | $0 | 0.00% | −14,968−100.0% | Sold out |
| Avenue 1 Advisors, LLC | 0 | $0 | 0.00% | −14,163−100.0% | Sold out |
| R Squared Ltd | 0 | $0 | 0.00% | −12,709−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −12,229−100.0% | Sold out |
| Mercer Global Advisors Inc | 0 | $0 | 0.00% | −10,466−100.0% | Sold out |
| Mariner, LLC | 0 | $0 | 0.00% | −10,404−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Larson Financial Group LLC | 0 | $0 | 0.00% | −400−100.0% | Sold out |
| Wealthspire Advisors, LLC | 0 | $0 | 0.00% | −354−100.0% | Sold out |
| Optiver Holding B.V. | 0 | $0 | 0.00% | −336−100.0% | Sold out |
| Comerica Bank | 0 | $0 | 0.00% | −308−100.0% | Sold out |
| CIBC Bancorp USA Inc. | – | – | – | – | Not filed |