Annexon, Inc.
ANNX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001528115
In the last 90 days, Annexon, Inc. insiders filed 1 open-market purchase and 0 sales; 216 institutions reported holding it in 13F filings for Q2 2026, worth $1.02B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Annexon, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 168
- +27 vs. Q3 2025
- Shares held
- 136.9M
- +35.9M (+35.5%) vs. Q3 2025
- Total value
- $687.2M
- +$379.0M (+123.0%) vs. Q3 2025
- New holders
- 41
- 72 more added
- Sold out
- 14
- 30 more reduced
3 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ANNX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 216 | $1.02B |
| Q1 2026 | 217 | $863.7M |
| Q4 2025 | 168 | $687.2M |
| Q3 2025 | 144 | $309.2M |
| Q2 2025 | 129 | $238.7M |
| Q1 2025 | 148 | $192.1M |
| Q4 2024 | 153 | $574.6M |
| Q3 2024 | 142 | $651.8M |
| Q2 2024 | 140 | $526.9M |
| Q1 2024 | 127 | $679.4M |
| Q4 2023 | 99 | $365.7M |
| Q3 2023 | 93 | $126.0M |
| Q2 2023 | 95 | $190.0M |
| Q1 2023 | 100 | $207.6M |
| Q4 2022 | 84 | $243.3M |
| Q3 2022 | 72 | $292.3M |
| Q2 2022 | 78 | $144.9M |
| Q1 2022 | 100 | $105.9M |
| Q4 2021 | 97 | $445.7M |
| Q3 2021 | 82 | $708.6M |
| Q2 2021 | 74 | $873.7M |
| Q1 2021 | 72 | $1.04B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Annexon, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ieq Capital, LLC | 182,982 | $918.6K | 0.00% | +32,660+21.7% | Added |
| Susquehanna International Group, LLP | 185,508 | $931.3K | 0.00% | +34,258+22.6% | Added |
| Ikarian Capital, LLC | 230,244 | $1.16M | 0.15% | +230,244 | New |
| XTX Topco Ltd | 243,313 | $1.22M | 0.03% | +95,473+64.6% | Added |
| American Century Companies Inc | 251,158 | $1.26M | 0.00% | +14,422+6.1% | Added |
| DAFNA Capital Management LLC | 272,812 | $1.37M | 0.32% | +272,812 | New |
| Citadel Advisors LLC | 275,294 | $1.38M | 0.00% | +107,794+64.4% | Added |
| Barclays PLC | 289,963 | $1.46M | 0.00% | +142,033+96.0% | Added |
| Two Sigma Investments, LP | 332,038 | $1.67M | 0.00% | +52,904+19.0% | Added |
| Diadema Partners LP | 350,000 | $1.76M | 1.05% | +350,000 | New |
| Susquehanna Portfolio Strategies, LLC | 356,619 | $1.79M | 0.03% | +2,875+0.8% | Added |
| Cinctive Capital Management LP | 358,986 | $1.80M | 0.10% | +293,520+448.4% | Added |
| Bank of New York Mellon Corp | 361,677 | $1.82M | 0.00% | +53,489+17.4% | Added |
| Point72 Asset Management, L.P. | 371,190 | $1.86M | 0.00% | +281,141+312.2% | Added |
| UBS Group AG | 377,104 | $1.89M | 0.00% | +30,965+8.9% | Added |
| Wellington Management Group LLP | 398,077 | $2.00M | 0.00% | +398,077 | New |
| SummitTX Capital, L.P. | 438,497 | $2.20M | 0.07% | +196,506+81.2% | Added |
| Price T Rowe Associates Inc | 445,074 | $2.23M | 0.00% | −39,701−8.2% | Reduced |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | $2.42M | 0.49% | 00.0% | Unchanged |
| Jane Street Group, LLC | 513,836 | $2.58M | 0.00% | +294,342+134.1% | Added |
| Marshall Wace, LLP | 520,998 | $2.62M | 0.00% | +520,998 | New |
| Schonfeld Strategic Advisors LLC | 522,846 | $2.62M | 0.01% | +310,627+146.4% | Added |
| Hennion & Walsh Asset Management, Inc. | 534,986 | $2.69M | 0.09% | +59,057+12.4% | Added |
| Deutsche Bank AG | 560,744 | $2.81M | 0.00% | −943,605−62.7% | Reduced |
| Wells Fargo & Company | 573,748 | $2.88M | 0.00% | +164,271+40.1% | Added |
| Deerfield Management Company, L.P. (Series C) | 583,913 | $2.93M | 0.04% | 00.0% | Unchanged |
| Parkman Healthcare Partners LLC | 601,202 | $3.02M | 0.29% | +195,249+48.1% | Added |
| Kennedy Capital Management, Inc. | 639,902 | $3.21M | 0.07% | −558−0.1% | Reduced |
| Mutual of America Capital Management LLC | 642,038 | $3.22M | 0.03% | −424,894−39.8% | Reduced |
| Russell Investments Group, Ltd. | 683,016 | $3.43M | 0.00% | +664,796+3,648.7% | Added |
| Jacobs Levy Equity Management, Inc | 683,879 | $3.43M | 0.01% | +661,290+2,927.5% | Added |
| Sirios Capital Management L P | 710,256 | $3.57M | 0.44% | −259,944−26.8% | Reduced |
| Dimensional Fund Advisors LP | 718,680 | $3.61M | 0.00% | −48,275−6.3% | Reduced |
| Ishara Investments LP | 750,000 | $3.77M | 4.38% | +750,000 | New |
| AQR Capital Management LLC | 776,307 | $3.90M | 0.00% | +202,184+35.2% | Added |
| Northern Trust Corp | 792,000 | $3.98M | 0.00% | +4,292+0.5% | Added |
| Renaissance Technologies LLC | 802,600 | $4.03M | 0.01% | +49,021+6.5% | Added |
| Acadian Asset Management LLC | 861,245 | $4.32M | 0.01% | +328,882+61.8% | Added |
| Massachusetts Financial Services Co | 903,439 | $4.54M | 0.00% | −76,846−7.8% | Reduced |
| Invesco Ltd. | 972,449 | $4.88M | 0.00% | +770,504+381.5% | Added |
| J. Goldman & Co LP | 993,795 | $4.99M | 0.19% | −113,206−10.2% | Reduced |
| D. E. Shaw & Co., Inc. | 1,046,221 | $5.25M | 0.00% | +1,046,221 | New |
| Charles Schwab Investment Management Inc | 1,057,060 | $5.31M | 0.00% | +266,810+33.8% | Added |
| Sphera Funds Management Ltd. | 1,316,212 | $6.61M | 1.38% | −478,175−26.6% | Reduced |
| Bank of America Corp | 1,605,581 | $8.06M | 0.00% | +311,279+24.0% | Added |
| Goldman Sachs Group Inc | 1,768,745 | $8.88M | 0.00% | −637,687−26.5% | Reduced |
| Polygon Management Ltd. | 2,032,455 | $10.2M | 2.15% | −80,000−3.8% | Reduced |
| Qube Research & Technologies Ltd | 2,381,479 | $12.0M | 0.02% | +1,808,835+315.9% | Added |
| Palo Alto Investors LP | 2,384,192 | $12.0M | 1.67% | +2,384,192 | New |
| Opaleye Management Inc. | 2,600,000 | $13.1M | 1.72% | 00.0% | Unchanged |
| Millennium Management LLC | 2,836,857 | $14.2M | 0.01% | +14,034+0.5% | Added |
| Morgan Stanley | 2,856,143 | $14.3M | 0.00% | −173,705−5.7% | Reduced |
| Geode Capital Management, LLC | 2,902,896 | $14.6M | 0.00% | +465,952+19.1% | Added |
| Nuveen, LLC | 2,915,324 | $14.6M | 0.00% | +2,232,766+327.1% | Added |
| Mak Capital One LLC | 2,958,527 | $14.9M | 2.00% | +2,958,527 | New |
| Longaeva Partners L.P. | 3,100,000 | $15.6M | 1.85% | +3,100,000 | New |
| Balyasny Asset Management LLC | 3,299,256 | $16.6M | 0.03% | +2,001,996+154.3% | Added |
| Woodline Partners LP | 4,000,074 | $20.1M | 0.08% | +1,361,799+51.6% | Added |
| Ameriprise Financial Inc | 4,348,782 | $21.8M | 0.00% | +2,156,428+98.4% | Added |
| State Street Corp | 4,652,185 | $23.4M | 0.00% | +2,601,877+126.9% | Added |
| Bellevue Group AG | 5,157,290 | $25.9M | 0.49% | 00.0% | Unchanged |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | $26.4M | 2.02% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 5,500,000 | $27.6M | 0.04% | +4,000,000+266.7% | Added |
| Vanguard Group Inc | 7,753,387 | $38.9M | 0.00% | +1,918,275+32.9% | Added |
| BlackRock, Inc. | 8,960,434 | $45.0M | 0.00% | +1,061,426+13.4% | Added |
| BVF Inc | 9,128,080 | $45.8M | 1.54% | +2,128,080+30.4% | Added |
| Redmile Group, LLC | 10,050,644 | $50.5M | 3.72% | +3,750,000+59.5% | Added |
| FMR LLC | 10,222,470 | $51.3M | 0.00% | −858,693−7.7% | Reduced |
| Candriam Luxembourg S.C.A. | 0 | $0 | 0.00% | −2,534,230−100.0% | Sold out |
| Rhenman & Partners Asset Management AB | 0 | $0 | 0.00% | −823,000−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −243,755−100.0% | Sold out |
| Park Avenue Securities LLC | 0 | $0 | 0.00% | −113,068−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −84,582−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −47,879−100.0% | Sold out |
| Atom Investors LP | 0 | $0 | 0.00% | −30,453−100.0% | Sold out |
| Forefront Wealth Partners, LLC | 0 | $0 | 0.00% | −27,027−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −23,800−100.0% | Sold out |
| Matauro, LLC | 0 | $0 | 0.00% | −20,572−100.0% | Sold out |
| 49 Wealth Management, LLC | 0 | $0 | 0.00% | −12,083−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −11,670−100.0% | Sold out |
| Clearstead Advisors, LLC | 0 | $0 | 0.00% | −355−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −23−100.0% | Sold out |
| Point72 Europe (London) LLP | – | – | – | – | Not filed |
| Cubist Systematic Strategies, LLC | – | – | – | – | Not filed |
| CIBC Bancorp USA Inc. | – | – | – | – | Not filed |