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Annexon, Inc.

ANNX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001528115

In the last 90 days, Annexon, Inc. insiders filed 1 open-market purchase and 0 sales; 216 institutions reported holding it in 13F filings for Q2 2026, worth $1.02B in total; no superinvestor holds it.

13F holders, Q3 2025

Institutional positions in Annexon, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
144
+16 vs. Q2 2025
Shares held
101.4M
+1.69M (+1.7%) vs. Q2 2025
Total value
$309.2M
+$70.5M (+29.5%) vs. Q2 2025
New holders
33
51 more added
Sold out
17
36 more reduced

1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting ANNX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 144 institutions
Q1 2021: 72 institutionsQ2 2021: 74 institutionsQ3 2021: 82 institutionsQ4 2021: 97 institutionsQ1 2022: 100 institutionsQ2 2022: 78 institutionsQ3 2022: 72 institutionsQ4 2022: 84 institutionsQ1 2023: 100 institutionsQ2 2023: 95 institutionsQ3 2023: 93 institutionsQ4 2023: 99 institutionsQ1 2024: 127 institutionsQ2 2024: 140 institutionsQ3 2024: 142 institutionsQ4 2024: 153 institutionsQ1 2025: 148 institutionsQ2 2025: 129 institutionsQ3 2025: 144 institutionsQ4 2025: 168 institutionsQ1 2026: 217 institutionsQ2 2026: 216 institutions
Value heldQ3 2025: $309.2M
Q1 2021: $1.04BQ2 2021: $873.7MQ3 2021: $708.6MQ4 2021: $445.7MQ1 2022: $105.9MQ2 2022: $144.9MQ3 2022: $292.3MQ4 2022: $243.3MQ1 2023: $207.6MQ2 2023: $190.0MQ3 2023: $126.0MQ4 2023: $365.7MQ1 2024: $679.4MQ2 2024: $526.9MQ3 2024: $651.8MQ4 2024: $574.6MQ1 2025: $192.1MQ2 2025: $238.7MQ3 2025: $309.2MQ4 2025: $687.2MQ1 2026: $863.7MQ2 2026: $1.02B
Institutions holding ANNX and their total value by quarter
QuarterHoldersValue
Q2 2026216$1.02B
Q1 2026217$863.7M
Q4 2025168$687.2M
Q3 2025144$309.2M
Q2 2025129$238.7M
Q1 2025148$192.1M
Q4 2024153$574.6M
Q3 2024142$651.8M
Q2 2024140$526.9M
Q1 2024127$679.4M
Q4 202399$365.7M
Q3 202393$126.0M
Q2 202395$190.0M
Q1 2023100$207.6M
Q4 202284$243.3M
Q3 202272$292.3M
Q2 202278$144.9M
Q1 2022100$105.9M
Q4 202197$445.7M
Q3 202182$708.6M
Q2 202174$873.7M
Q1 202172$1.04B

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Annexon, Inc.; share changes are against Q2 2025.

Institutions holding ANNX in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
FMR LLC11,081,163$33.8M0.00%−4,614,063−29.4%Reduced
BlackRock, Inc.7,899,008$24.1M0.00%−63,360−0.8%Reduced
BVF Inc7,000,000$21.4M0.87%00.0%Unchanged
Redmile Group, LLC6,300,644$19.2M1.87%00.0%Unchanged
Vanguard Group Inc5,835,112$17.8M0.00%+469,073+8.7%Added
Bain Capital Life Sciences Investors, LLC5,249,069$16.0M1.06%00.0%Unchanged
Bellevue Group AG5,157,290$15.7M0.33%00.0%Unchanged
Morgan Stanley3,029,848$9.24M0.00%+2,197,308+263.9%Added
Millennium Management LLC2,822,823$8.61M0.01%+308,689+12.3%Added
Woodline Partners LP2,638,275$8.05M0.04%+1,584,566+150.4%Added
Opaleye Management Inc.2,600,000$7.93M1.12%+2,600,000New
Candriam Luxembourg S.C.A.2,534,230$7.73M0.04%00.0%Unchanged
Geode Capital Management, LLC2,436,944$7.43M0.00%+152,171+6.7%Added
Goldman Sachs Group Inc2,406,432$7.34M0.00%+775,783+47.6%Added
Ameriprise Financial Inc2,192,354$6.69M0.00%+26,176+1.2%Added
Polygon Management Ltd.2,112,455$6.44M0.94%−697,545−24.8%Reduced
State Street Corp2,050,308$6.25M0.00%+69,324+3.5%Added
Sphera Funds Management Ltd.1,794,387$5.47M1.30%+30,000+1.7%Added
Deutsche Bank AG1,504,349$4.59M0.00%+992,901+194.1%Added
Adage Capital Partners GP, L.L.C.1,500,000$4.58M0.01%+1,500,000New
Balyasny Asset Management LLC1,297,260$3.96M0.01%+1,297,260New
Bank of America Corp1,294,302$3.95M0.00%−158,493−10.9%Reduced
J. Goldman & Co LP1,107,001$3.38M0.13%+1,107,001New
Mutual of America Capital Management LLC1,066,932$3.25M0.03%−12,029−1.1%Reduced
Massachusetts Financial Services Co980,285$2.99M0.00%−7,228−0.7%Reduced
Sirios Capital Management L P970,200$2.96M0.39%−19,377−2.0%Reduced
Rhenman & Partners Asset Management AB823,000$2.51M0.28%+363,000+78.9%Added
Charles Schwab Investment Management Inc790,250$2.41M0.00%+61,861+8.5%Added
Northern Trust Corp787,708$2.40M0.00%+44,484+6.0%Added
Dimensional Fund Advisors LP766,955$2.34M0.00%−122,908−13.8%Reduced
Renaissance Technologies LLC753,579$2.30M0.00%−24,321−3.1%Reduced
Nuveen, LLC682,558$2.08M0.00%+426,640+166.7%Added
Kennedy Capital Management, Inc.640,460$1.95M0.04%−215,113−25.1%Reduced
Deerfield Management Company, L.P. (Series C)583,913$1.78M0.03%00.0%Unchanged
AQR Capital Management LLC574,123$1.75M0.00%+242,092+72.9%Added
Qube Research & Technologies Ltd572,644$1.75M0.00%+147,924+34.8%Added
Acadian Asset Management LLC532,363$1.62M0.00%+63,154+13.5%Added
Price T Rowe Associates Inc484,775$1.48M0.00%−23,328−4.6%Reduced
Board of Trustees of The Leland Stanford Junior University482,550$1.47M0.17%00.0%Unchanged
Hennion & Walsh Asset Management, Inc.475,929$1.45M0.05%−8,704−1.8%Reduced
Wells Fargo & Company409,477$1.25M0.00%+32,503+8.6%Added
Parkman Healthcare Partners LLC405,953$1.24M0.14%+1,759+0.4%Added
Susquehanna Portfolio Strategies, LLC353,744$1.08M0.02%+146,029+70.3%Added
UBS Group AG346,139$1.06M0.00%+21,017+6.5%Added
Bank of New York Mellon Corp308,188$940.0K0.00%+7,140+2.4%Added
Point72 Europe (London) LLP302,861$923.7K0.05%+96,063+46.5%Added
Royal Bank of Canada285,848$871.0K0.00%+40,649+16.6%Added
Two Sigma Investments, LP279,134$851.4K0.00%+77,974+38.8%Added
ExodusPoint Capital Management, LP243,755$743.5K0.01%+182,064+295.1%Added
SummitTX Capital, L.P.241,991$738.1K0.03%+241,991New
American Century Companies Inc236,736$722.0K0.00%+25,541+12.1%Added
J. Safra Sarasin Holding AG223,221$680.8K0.01%−158,220−41.5%Reduced
Jane Street Group, LLC219,494$669.5K0.00%+73,625+50.5%Added
Schonfeld Strategic Advisors LLC212,219$647.3K0.00%−53,831−20.2%Reduced
Invesco Ltd.201,945$615.9K0.00%+51,531+34.3%Added
Citadel Advisors LLC167,500$510.9K0.00%+154,233+1,162.5%Added
Susquehanna International Group, LLP151,250$461.3K0.00%−115,562−43.3%Reduced
Advisor Group Holdings, Inc.147,375$458.8K0.00%+67,000+83.4%Added
Ieq Capital, LLC150,322$458.5K0.00%+14,525+10.7%Added
Barclays PLC147,930$451.2K0.00%−29,698−16.7%Reduced
XTX Topco Ltd147,840$450.9K0.02%+147,840New
Alliancebernstein L.P.140,740$429.3K0.00%00.0%Unchanged
Bridgeway Capital Management, LLC137,800$420.3K0.01%+40,000+40.9%Added
Manufacturers Life Insurance Company, The132,673$404.7K0.00%−1,362−1.0%Reduced
Rhumbline Advisers132,603$404.4K0.00%−4,933−3.6%Reduced
Park Avenue Securities LLC113,068$345.0K0.00%00.0%Unchanged
Quarry LP110,000$335.5K0.08%+66,867+155.0%Added
Brevan Howard Capital Management LP94,554$288.4K0.00%+41,271+77.5%Added
Point72 Asset Management, L.P.90,049$274.6K0.00%+90,049New
DnB Asset Management AS84,523$257.8K0.00%−15,051−15.1%Reduced
HRT Financial LP84,582$257.0K0.00%+84,582New
Cinctive Capital Management LP65,466$199.7K0.01%−70,000−51.7%Reduced
Alps Advisors Inc47,879$146.0K0.00%−11,322−19.1%Reduced
JPMorgan Chase & Co46,886$143.0K0.00%−5,933−11.2%Reduced
TD Asset Management Inc46,848$142.9K0.00%00.0%Unchanged
Mirae Asset Global ETFs Holdings Ltd.44,979$137.2K0.00%−7,426−14.2%Reduced
MetLife Investment Management44,632$136.1K0.00%−14,390−24.4%Reduced
Allegheny Financial Group LTD42,900$130.8K0.02%00.0%Unchanged
Virtus Investment Advisers, Inc.41,987$128.1K0.04%+7,289+21.0%Added
Citizens Financial Group Inc40,000$122.0K0.00%+5,000+14.3%Added
Group One Trading, L.P.35,565$108.5K0.00%+35,565New
China Universal Asset Management Co., Ltd.35,261$107.5K0.01%+13,225+60.0%Added
Lido Advisors, LLC34,952$106.6K0.00%−48−0.1%Reduced
New York State Common Retirement Fund34,479$105.2K0.00%00.0%Unchanged
Comerica Bank32,357$98.7K0.00%+6,750+26.4%Added
Atom Investors LP30,453$92.9K0.01%+30,453New
Police & Firemen's Retirement System of New Jersey28,105$85.7K0.00%+7,518+36.5%Added
Axq Capital, LP27,867$85.0K0.03%+27,867New
Forefront Analytics, LLC27,027$82.4K0.08%−548−2.0%Reduced
Forefront Wealth Partners, LLC27,027$82.4K0.02%+27,027New
Intech Investment Management LLC26,676$81.4K0.00%−26,023−49.4%Reduced
HSBC Holdings PLC25,721$78.1K0.00%−4,134−13.8%Reduced
Two Sigma Advisers, LP23,800$72.6K0.00%+23,800New
CWM, LLC23,488$72.0K0.00%+5,754+32.4%Added
Cubist Systematic Strategies, LLC22,771$69.5K0.00%+22,771New
Jacobs Levy Equity Management, Inc22,589$68.9K0.00%+22,589New
Matauro, LLC20,572$62.7K0.01%+9,488+85.6%Added
ProShare Advisors LLC20,288$61.9K0.00%−3,444−14.5%Reduced
Raymond James Financial Inc20,000$61.0K0.00%+20,000New
EntryPoint Capital, LLC19,971$60.9K0.02%+19,971New