Annexon, Inc.
ANNX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001528115
In the last 90 days, Annexon, Inc. insiders filed 1 open-market purchase and 0 sales; 216 institutions reported holding it in 13F filings for Q2 2026, worth $1.02B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Annexon, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 168
- +27 vs. Q3 2025
- Shares held
- 136.9M
- +35.9M (+35.5%) vs. Q3 2025
- Total value
- $687.2M
- +$379.0M (+123.0%) vs. Q3 2025
- New holders
- 41
- 72 more added
- Sold out
- 14
- 30 more reduced
3 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ANNX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 216 | $1.02B |
| Q1 2026 | 217 | $863.7M |
| Q4 2025 | 168 | $687.2M |
| Q3 2025 | 144 | $309.2M |
| Q2 2025 | 129 | $238.7M |
| Q1 2025 | 148 | $192.1M |
| Q4 2024 | 153 | $574.6M |
| Q3 2024 | 142 | $651.8M |
| Q2 2024 | 140 | $526.9M |
| Q1 2024 | 127 | $679.4M |
| Q4 2023 | 99 | $365.7M |
| Q3 2023 | 93 | $126.0M |
| Q2 2023 | 95 | $190.0M |
| Q1 2023 | 100 | $207.6M |
| Q4 2022 | 84 | $243.3M |
| Q3 2022 | 72 | $292.3M |
| Q2 2022 | 78 | $144.9M |
| Q1 2022 | 100 | $105.9M |
| Q4 2021 | 97 | $445.7M |
| Q3 2021 | 82 | $708.6M |
| Q2 2021 | 74 | $873.7M |
| Q1 2021 | 72 | $1.04B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Annexon, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 10,222,470 | $51.3M | 0.00% | −858,693−7.7% | Reduced |
| Redmile Group, LLC | 10,050,644 | $50.5M | 3.72% | +3,750,000+59.5% | Added |
| BVF Inc | 9,128,080 | $45.8M | 1.54% | +2,128,080+30.4% | Added |
| BlackRock, Inc. | 8,960,434 | $45.0M | 0.00% | +1,061,426+13.4% | Added |
| Vanguard Group Inc | 7,753,387 | $38.9M | 0.00% | +1,918,275+32.9% | Added |
| Adage Capital Partners GP, L.L.C. | 5,500,000 | $27.6M | 0.04% | +4,000,000+266.7% | Added |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | $26.4M | 2.02% | 00.0% | Unchanged |
| Bellevue Group AG | 5,157,290 | $25.9M | 0.49% | 00.0% | Unchanged |
| State Street Corp | 4,652,185 | $23.4M | 0.00% | +2,601,877+126.9% | Added |
| Ameriprise Financial Inc | 4,348,782 | $21.8M | 0.00% | +2,156,428+98.4% | Added |
| Woodline Partners LP | 4,000,074 | $20.1M | 0.08% | +1,361,799+51.6% | Added |
| Balyasny Asset Management LLC | 3,299,256 | $16.6M | 0.03% | +2,001,996+154.3% | Added |
| Longaeva Partners L.P. | 3,100,000 | $15.6M | 1.85% | +3,100,000 | New |
| Mak Capital One LLC | 2,958,527 | $14.9M | 2.00% | +2,958,527 | New |
| Nuveen, LLC | 2,915,324 | $14.6M | 0.00% | +2,232,766+327.1% | Added |
| Geode Capital Management, LLC | 2,902,896 | $14.6M | 0.00% | +465,952+19.1% | Added |
| Morgan Stanley | 2,856,143 | $14.3M | 0.00% | −173,705−5.7% | Reduced |
| Millennium Management LLC | 2,836,857 | $14.2M | 0.01% | +14,034+0.5% | Added |
| Opaleye Management Inc. | 2,600,000 | $13.1M | 1.72% | 00.0% | Unchanged |
| Palo Alto Investors LP | 2,384,192 | $12.0M | 1.67% | +2,384,192 | New |
| Qube Research & Technologies Ltd | 2,381,479 | $12.0M | 0.02% | +1,808,835+315.9% | Added |
| Polygon Management Ltd. | 2,032,455 | $10.2M | 2.15% | −80,000−3.8% | Reduced |
| Goldman Sachs Group Inc | 1,768,745 | $8.88M | 0.00% | −637,687−26.5% | Reduced |
| Bank of America Corp | 1,605,581 | $8.06M | 0.00% | +311,279+24.0% | Added |
| Sphera Funds Management Ltd. | 1,316,212 | $6.61M | 1.38% | −478,175−26.6% | Reduced |
| Charles Schwab Investment Management Inc | 1,057,060 | $5.31M | 0.00% | +266,810+33.8% | Added |
| D. E. Shaw & Co., Inc. | 1,046,221 | $5.25M | 0.00% | +1,046,221 | New |
| J. Goldman & Co LP | 993,795 | $4.99M | 0.19% | −113,206−10.2% | Reduced |
| Invesco Ltd. | 972,449 | $4.88M | 0.00% | +770,504+381.5% | Added |
| Massachusetts Financial Services Co | 903,439 | $4.54M | 0.00% | −76,846−7.8% | Reduced |
| Acadian Asset Management LLC | 861,245 | $4.32M | 0.01% | +328,882+61.8% | Added |
| Renaissance Technologies LLC | 802,600 | $4.03M | 0.01% | +49,021+6.5% | Added |
| Northern Trust Corp | 792,000 | $3.98M | 0.00% | +4,292+0.5% | Added |
| AQR Capital Management LLC | 776,307 | $3.90M | 0.00% | +202,184+35.2% | Added |
| Ishara Investments LP | 750,000 | $3.77M | 4.38% | +750,000 | New |
| Dimensional Fund Advisors LP | 718,680 | $3.61M | 0.00% | −48,275−6.3% | Reduced |
| Sirios Capital Management L P | 710,256 | $3.57M | 0.44% | −259,944−26.8% | Reduced |
| Jacobs Levy Equity Management, Inc | 683,879 | $3.43M | 0.01% | +661,290+2,927.5% | Added |
| Russell Investments Group, Ltd. | 683,016 | $3.43M | 0.00% | +664,796+3,648.7% | Added |
| Mutual of America Capital Management LLC | 642,038 | $3.22M | 0.03% | −424,894−39.8% | Reduced |
| Kennedy Capital Management, Inc. | 639,902 | $3.21M | 0.07% | −558−0.1% | Reduced |
| Parkman Healthcare Partners LLC | 601,202 | $3.02M | 0.29% | +195,249+48.1% | Added |
| Deerfield Management Company, L.P. (Series C) | 583,913 | $2.93M | 0.04% | 00.0% | Unchanged |
| Wells Fargo & Company | 573,748 | $2.88M | 0.00% | +164,271+40.1% | Added |
| Deutsche Bank AG | 560,744 | $2.81M | 0.00% | −943,605−62.7% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 534,986 | $2.69M | 0.09% | +59,057+12.4% | Added |
| Schonfeld Strategic Advisors LLC | 522,846 | $2.62M | 0.01% | +310,627+146.4% | Added |
| Marshall Wace, LLP | 520,998 | $2.62M | 0.00% | +520,998 | New |
| Jane Street Group, LLC | 513,836 | $2.58M | 0.00% | +294,342+134.1% | Added |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | $2.42M | 0.49% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 445,074 | $2.23M | 0.00% | −39,701−8.2% | Reduced |
| SummitTX Capital, L.P. | 438,497 | $2.20M | 0.07% | +196,506+81.2% | Added |
| Wellington Management Group LLP | 398,077 | $2.00M | 0.00% | +398,077 | New |
| UBS Group AG | 377,104 | $1.89M | 0.00% | +30,965+8.9% | Added |
| Point72 Asset Management, L.P. | 371,190 | $1.86M | 0.00% | +281,141+312.2% | Added |
| Bank of New York Mellon Corp | 361,677 | $1.82M | 0.00% | +53,489+17.4% | Added |
| Cinctive Capital Management LP | 358,986 | $1.80M | 0.10% | +293,520+448.4% | Added |
| Susquehanna Portfolio Strategies, LLC | 356,619 | $1.79M | 0.03% | +2,875+0.8% | Added |
| Diadema Partners LP | 350,000 | $1.76M | 1.05% | +350,000 | New |
| Two Sigma Investments, LP | 332,038 | $1.67M | 0.00% | +52,904+19.0% | Added |
| Barclays PLC | 289,963 | $1.46M | 0.00% | +142,033+96.0% | Added |
| Citadel Advisors LLC | 275,294 | $1.38M | 0.00% | +107,794+64.4% | Added |
| DAFNA Capital Management LLC | 272,812 | $1.37M | 0.32% | +272,812 | New |
| American Century Companies Inc | 251,158 | $1.26M | 0.00% | +14,422+6.1% | Added |
| XTX Topco Ltd | 243,313 | $1.22M | 0.03% | +95,473+64.6% | Added |
| Ikarian Capital, LLC | 230,244 | $1.16M | 0.15% | +230,244 | New |
| Susquehanna International Group, LLP | 185,508 | $931.3K | 0.00% | +34,258+22.6% | Added |
| Ieq Capital, LLC | 182,982 | $918.6K | 0.00% | +32,660+21.7% | Added |
| Advisor Group Holdings, Inc. | 147,375 | $739.8K | 0.00% | 00.0% | Unchanged |
| Rafferty Asset Management, LLC | 141,644 | $711.1K | 0.00% | +141,644 | New |
| Alliancebernstein L.P. | 140,740 | $706.5K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 137,800 | $691.8K | 0.01% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 130,102 | $655.1K | 0.00% | −2,571−1.9% | Reduced |
| Rhumbline Advisers | 126,463 | $634.8K | 0.00% | −6,140−4.6% | Reduced |
| Brevan Howard Capital Management LP | 123,753 | $621.2K | 0.01% | +29,199+30.9% | Added |
| Jump Financial, LLC | 122,858 | $616.7K | 0.01% | +122,858 | New |
| Caption Management, LLC | 119,491 | $599.8K | 0.03% | +119,491 | New |
| DnB Asset Management AS | 118,324 | $594.0K | 0.00% | +33,801+40.0% | Added |
| J. Safra Sarasin Holding AG | 117,768 | $591.2K | 0.01% | −105,453−47.2% | Reduced |
| Persistent Asset Partners Ltd | 93,657 | $470.2K | 0.23% | +93,657 | New |
| Quarry LP | 75,000 | $376.5K | 0.06% | −35,000−31.8% | Reduced |
| Boothbay Fund Management, LLC | 64,069 | $321.6K | 0.01% | +64,069 | New |
| BNP Paribas Arbitrage, SA | 61,572 | $309.1K | 0.00% | +41,833+211.9% | Added |
| SEI Investments Co | 58,259 | $292.5K | 0.00% | +58,259 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 54,763 | $275.1K | 0.00% | +9,784+21.8% | Added |
| JPMorgan Chase & Co | 53,729 | $269.7K | 0.00% | +6,843+14.6% | Added |
| Virtus Investment Advisers, Inc. | 53,527 | $268.7K | 0.07% | +11,540+27.5% | Added |
| Winton Group Ltd | 53,400 | $268.1K | 0.01% | +53,400 | New |
| Profund Advisors LLC | 53,008 | $266.1K | 0.01% | +53,008 | New |
| Quadrature Capital Ltd | 48,573 | $243.8K | 0.00% | +48,573 | New |
| ADAR1 Capital Management, LLC | 48,000 | $241.0K | 0.02% | +48,000 | New |
| TD Asset Management Inc | 46,848 | $235.2K | 0.00% | 00.0% | Unchanged |
| Allegheny Financial Group LTD | 42,900 | $215.4K | 0.03% | 00.0% | Unchanged |
| EntryPoint Capital, LLC | 42,774 | $214.7K | 0.08% | +22,803+114.2% | Added |
| Intech Investment Management LLC | 42,524 | $213.5K | 0.00% | +15,848+59.4% | Added |
| Citizens Financial Group Inc | 40,000 | $200.8K | 0.00% | 00.0% | Unchanged |
| MetLife Investment Management | 39,059 | $196.1K | 0.00% | −5,573−12.5% | Reduced |
| Pale Fire Capital SE | 38,600 | $193.8K | 0.02% | +38,600 | New |
| China Universal Asset Management Co., Ltd. | 36,084 | $181.1K | 0.01% | +823+2.3% | Added |
| Landing Point Financial Group, LLC | 34,900 | $175.2K | 0.09% | +34,900 | New |