| FMR LLC | 18,386,840 | $2,776 萬 | 0.00% | – | – |
| WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 6,424,366 | $970.1 萬 | 0.10% | – | – |
| Raging Capital Management, LLC | 5,543,845 | $837.1 萬 | 16.22% | – | – |
| Whetstone Capital Advisors, LLC | 5,290,861 | $798.9 萬 | 1.70% | – | – |
| Vanguard Group Inc | 4,834,243 | $730.0 萬 | 0.00% | – | – |
| Gagnon Securities LLC | 4,132,008 | $623.9 萬 | 0.95% | – | – |
| Venrock Management VI, LLC | 3,707,442 | $559.8 萬 | 3.11% | – | – |
| BlackRock Inc. | 3,191,093 | $481.8 萬 | 0.00% | – | – |
| Royce & Associates LP | 3,122,552 | $471.5 萬 | 0.03% | – | – |
| Gagnon Advisors, LLC | 2,958,279 | $446.7 萬 | 1.84% | – | – |
| Acadian Asset Management LLC | 2,886,365 | $435.8 萬 | 0.02% | – | – |
| Renaissance Technologies LLC | 2,398,500 | $362.2 萬 | 0.00% | – | – |
| Millennium Management LLC | 2,124,597 | $320.8 萬 | 0.00% | – | – |
| Maverick Capital Ltd大師Maverick 資本 | 1,881,640 | $284.1 萬 | 0.03% | – | – |
| Parian Global Management LP | 1,721,744 | $260.0 萬 | 1.21% | – | – |
| Perkins Capital Management Inc | 1,459,500 | $220.4 萬 | 1.27% | – | – |
| SCW Capital Management, LP | 1,322,366 | $199.7 萬 | 1.25% | – | – |
| Bridgeway Capital Management, LLC | 1,305,652 | $197.2 萬 | 0.04% | – | – |
| Venrock Management V, LLC | 1,133,948 | $171.2 萬 | 0.18% | – | – |
| Price T Rowe Associates Inc | 923,958 | $139.5 萬 | 0.00% | – | – |
| Dimensional Fund Advisors LP | 910,420 | $137.4 萬 | 0.00% | – | – |
| Two Sigma Investments, LP | 869,263 | $131.3 萬 | 0.00% | – | – |
| Two Sigma Advisers, LP | 812,600 | $122.7 萬 | 0.00% | – | – |
| Johnson & Johnson Innovation - JJDC, Inc. | 811,295 | $122.5 萬 | 0.16% | – | – |
| GMT Capital Corp | 693,867 | $104.8 萬 | 0.08% | – | – |
| Jacob Asset Management of New York LLC | 648,000 | $97.8 萬 | 0.38% | – | – |
| Geode Capital Management, LLC | 625,832 | $94.5 萬 | 0.00% | – | – |
| Jacobs Levy Equity Management, Inc | 579,752 | $87.5 萬 | 0.01% | – | – |
| Parkman Healthcare Partners LLC | 500,393 | $75.6 萬 | 0.18% | – | – |
| Arrowstreet Capital, Limited Partnership | 496,821 | $75.0 萬 | 0.00% | – | – |
| Voss Capital, LLC | 459,900 | $69.5 萬 | 0.29% | – | – |
| Charles Schwab Investment Management Inc | 446,921 | $67.5 萬 | 0.00% | – | – |
| Assenagon Asset Management S.A. | 403,956 | $61.0 萬 | 0.00% | – | – |
| HarbourVest Partners LLC | 349,070 | $52.7 萬 | 0.07% | – | – |
| ExodusPoint Capital Management, LP | 337,995 | $51.0 萬 | 0.01% | – | – |
| New York Life Investments Alternatives | 282,592 | $42.7 萬 | 0.30% | – | – |
| Russell Investments Group, Ltd. | 215,331 | $32.4 萬 | 0.00% | – | – |
| Alliancebernstein L.P. | 211,864 | $32.0 萬 | 0.00% | – | – |
| Morgan Stanley | 192,665 | $29.0 萬 | 0.00% | – | – |
| Northern Trust Corp | 184,484 | $27.9 萬 | 0.00% | – | – |
| Bank of America Corp | 183,142 | $27.7 萬 | 0.00% | – | – |
| Goldman Sachs Group Inc | 175,911 | $26.6 萬 | 0.00% | – | – |
| Transcend Wealth Collective, LLC | 155,000 | $23.4 萬 | 0.03% | – | – |
| Squarepoint Ops LLC | 153,183 | $23.1 萬 | 0.00% | – | – |
| Brookside Equity Partners LLC | 127,709 | $19.3 萬 | 0.03% | – | – |
| Creative Planning | 125,858 | $19.0 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 122,135 | $18.4 萬 | 0.00% | – | – |
| Penbrook Management LLC | 113,820 | $17.2 萬 | 0.12% | – | – |
| Rock Creek Group, LP | 109,900 | $16.6 萬 | 0.03% | – | – |
| First Quadrant L P | 107,570 | $16.2 萬 | 0.02% | – | – |
| Invesco Ltd. | 106,870 | $16.1 萬 | 0.00% | – | – |
| California Public Employees Retirement System | 106,400 | $16.1 萬 | 0.00% | – | – |
| Cubist Systematic Strategies, LLC | 70,744 | $10.7 萬 | 0.00% | – | – |
| Kennedy Capital Management, Inc. | 68,384 | $10.3 萬 | 0.00% | – | – |
| State Street Corp | 57,830 | $8.70 萬 | 0.00% | – | – |
| Citigroup Inc | 56,874 | $8.60 萬 | 0.00% | – | – |
| Susquehanna International Group, LLP | 49,276 | $7.40 萬 | 0.00% | – | – |
| Algert Global LLC | 44,629 | $6.70 萬 | 0.02% | – | – |
| Bank of New York Mellon Corp | 44,556 | $6.70 萬 | 0.00% | – | – |
| HRT Financial LP | 41,403 | $6.20 萬 | 0.00% | – | – |
| LMR Partners LLP | 41,370 | $6.20 萬 | 0.00% | – | – |
| Madison Wealth Management | 39,551 | $6.00 萬 | 0.01% | – | – |
| Caxton Associates LP | 38,096 | $5.80 萬 | 0.01% | – | – |
| Must Asset Management Inc. | 37,521 | $5.50 萬 | 0.04% | – | – |
| Jefferies Group LLC | 28,900 | $4.36 萬 | 0.00% | – | – |
| Tower Research Capital LLC (TRC) | 24,726 | $3.70 萬 | 0.00% | – | – |
| Diametric Capital, LP | 23,944 | $3.60 萬 | 0.03% | – | – |
| Qube Research & Technologies Ltd | 22,456 | $3.40 萬 | 0.00% | – | – |
| UBS Group AG | 20,500 | $3.10 萬 | 0.00% | – | – |
| Simplex Trading, LLC | 19,984 | $3.00 萬 | 0.00% | – | – |
| Checchi Capital Advisers, LLC | 10,000 | $3.00 萬 | 0.00% | – | – |
| Barclays PLC | 17,908 | $2.70 萬 | 0.00% | – | – |
| JJJ Advisors Inc. | 18,192 | $2.70 萬 | 0.01% | – | – |
| Sciencast Management LP | 16,600 | $2.70 萬 | 0.01% | – | – |
| Capstone Investment Advisors, LLC | 16,850 | $2.50 萬 | 0.00% | – | – |
| Balyasny Asset Management LLC | 15,660 | $2.40 萬 | 0.00% | – | – |
| Prelude Capital Management, LLC | 15,712 | $2.40 萬 | 0.00% | – | – |
| Susquehanna Fundamental Investments, LLC | 16,100 | $2.40 萬 | 0.00% | – | – |
| Schonfeld Strategic Advisors LLC | 15,034 | $2.30 萬 | 0.00% | – | – |
| Raymond James & Associates | 11,600 | $1.80 萬 | 0.00% | – | – |
| HighTower Advisors, LLC | 11,497 | $1.80 萬 | 0.00% | – | – |
| Redmile Group, LLC | 10,229 | $1.50 萬 | 0.00% | – | – |
| Cowen Prime Services LLC | 3,700 | $6,000 | 0.00% | – | – |
| Public Employees Retirement System of Ohio | 3,539 | $5,000 | 0.00% | – | – |
| BNP Paribas Arbitrage, SA | 3,211 | $4,849 | 0.00% | – | – |
| Ameritas Investment Company, LLC | 2,000 | $3,020 | 0.00% | – | – |
| Federated Hermes, Inc. | 1,340 | $2,000 | 0.00% | – | – |
| Cutler Group LP | 1,530 | $2,000 | 0.00% | – | – |
| Valeo Financial Advisors, LLC | 1,607 | $2,000 | 0.00% | – | – |
| Wells Fargo & Company | 581 | $1,000 | 0.00% | – | – |
| Royal Bank of Canada | 417 | $1,000 | 0.00% | – | – |
| Halpern Financial, Inc. | 500 | $755 | 0.00% | – | – |
| American Portfolios Advisors | 156 | $236 | 0.00% | – | – |
| O'Shaughnessy Asset Management, LLC | 1 | $0 | 0.00% | – | – |
| NEXT Financial Group, Inc | 100 | $0 | 0.00% | – | – |
