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Xeris Biopharma Holdings, Inc.

XERS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001867096

In the last 90 days, Xeris Biopharma Holdings, Inc. insiders filed 0 open-market purchases and 10 sales; 242 institutions reported holding it in 13F filings for Q2 2026, worth $857.1M in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Xeris Biopharma Holdings, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
201
+3 vs. Q1 2025
Shares held
90.6M
+2.96M (+3.4%) vs. Q1 2025
Total value
$422.9M
−$58.0M (−12.1%) vs. Q1 2025
New holders
26
79 more added
Sold out
23
59 more reduced

1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XERS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 201 institutions
Q1 2021: 103 institutionsQ2 2021: 94 institutionsQ3 2021: 71 institutionsQ4 2021: 92 institutionsQ1 2022: 103 institutionsQ2 2022: 103 institutionsQ3 2022: 101 institutionsQ4 2022: 97 institutionsQ1 2023: 92 institutionsQ2 2023: 105 institutionsQ3 2023: 111 institutionsQ4 2023: 120 institutionsQ1 2024: 142 institutionsQ2 2024: 135 institutionsQ3 2024: 144 institutionsQ4 2024: 162 institutionsQ1 2025: 199 institutionsQ2 2025: 201 institutionsQ3 2025: 231 institutionsQ4 2025: 227 institutionsQ1 2026: 239 institutionsQ2 2026: 242 institutions
Value heldQ2 2025: $422.9M
Q1 2021: $149.7MQ2 2021: $114.9MQ3 2021: $42.9MQ4 2021: $120.2MQ1 2022: $129.2MQ2 2022: $91.3MQ3 2022: $89.3MQ4 2022: $71.6MQ1 2023: $80.6MQ2 2023: $146.7MQ3 2023: $102.3MQ4 2023: $140.8MQ1 2024: $133.7MQ2 2024: $136.6MQ3 2024: $182.2MQ4 2024: $222.2MQ1 2025: $480.9MQ2 2025: $422.9MQ3 2025: $789.3MQ4 2025: $792.0MQ1 2026: $610.3MQ2 2026: $857.1M
Institutions holding XERS and their total value by quarter
QuarterHoldersValue
Q2 2026242$857.1M
Q1 2026239$610.3M
Q4 2025227$792.0M
Q3 2025231$789.3M
Q2 2025201$422.9M
Q1 2025199$480.9M
Q4 2024162$222.2M
Q3 2024144$182.2M
Q2 2024135$136.6M
Q1 2024142$133.7M
Q4 2023120$140.8M
Q3 2023111$102.3M
Q2 2023105$146.7M
Q1 202392$80.6M
Q4 202297$71.6M
Q3 2022101$89.3M
Q2 2022103$91.3M
Q1 2022103$129.2M
Q4 202192$120.2M
Q3 202171$42.9M
Q2 202194$114.9M
Q1 2021103$149.7M

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Xeris Biopharma Holdings, Inc.; share changes are against Q1 2025.

Institutions holding XERS in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Cetera Investment Advisers46,332$216.4K0.00%+1,735+3.9%Added
Quadrature Capital Ltd46,756$218.8K0.00%+15,623+50.2%Added
Weiss Asset Management LP50,001$233.5K0.00%00.0%Unchanged
Chevy Chase Trust Holdings, Inc.51,243$239.3K0.00%00.0%Unchanged
Manufacturers Life Insurance Company, The54,472$254.4K0.00%+3,562+7.0%Added
CWM, LLC55,111$257.0K0.00%−11,861−17.7%Reduced
Gsa Capital Partners LLP62,322$291.0K0.02%−76,413−55.1%Reduced
GPS Wealth Strategies Group, LLC64,925$303.2K0.03%−2,000−3.0%Reduced
STRS Ohio65,500$305.9K0.00%+4,600+7.6%Added
EntryPoint Capital, LLC72,899$340.4K0.17%−2,807−3.7%Reduced
Simplex Trading, LLC76,644$357.0K0.01%+76,644New
Citigroup Inc77,534$362.1K0.00%−40,674−34.4%Reduced
Wells Fargo & Company80,366$375.3K0.00%+10,485+15.0%Added
OrbiMed Advisors LLC80,420$375.6K0.01%00.0%Unchanged
Globeflex Capital L P80,431$375.6K0.03%−44,779−35.8%Reduced
Mirae Asset Global ETFs Holdings Ltd.82,138$383.6K0.00%−1,844−2.2%Reduced
Invesco Ltd.86,194$402.5K0.00%−940,644−91.6%Reduced
MetLife Investment Management87,318$407.8K0.00%+5,549+6.8%Added
Intech Investment Management LLC94,437$441.0K0.00%+44,330+88.5%Added
Franklin Resources Inc103,278$482.3K0.00%−4,658−4.3%Reduced
Ieq Capital, LLC108,495$506.7K0.00%−46,689−30.1%Reduced
Harvest Investment Services, LLC111,970$522.9K0.12%+65,513+141.0%Added
Brown Advisory Inc114,698$535.6K0.00%00.0%Unchanged
SEI Investments Co116,534$544.2K0.00%+19,043+19.5%Added
Creative Planning117,755$549.9K0.00%+11,023+10.3%Added
Roundview Capital LLC120,000$560.4K0.04%00.0%Unchanged
Russell Investments Group, Ltd.123,189$575.3K0.00%−8,498−6.5%Reduced
Graham Capital Management, L.P.125,417$585.7K0.02%−8,251−6.2%Reduced
Man Group plc130,849$611.1K0.00%−44,398−25.3%Reduced
Campbell & CO Investment Adviser LLC132,382$618.2K0.04%+132,382New
Options Solutions, LLC132,994$621.1K0.22%+47,883+56.3%Added
Polen Capital Management LLC132,994$621.1K0.00%+132,994New
Mackenzie Financial Corp138,092$644.9K0.00%−4,012−2.8%Reduced
Alliancebernstein L.P.144,830$676.4K0.00%00.0%Unchanged
Ameriprise Financial Inc149,028$696.0K0.00%−19,074−11.3%Reduced
Alpine Global Management, LLC150,000$700.5K0.16%+50,000+50.0%Added
Price T Rowe Associates Inc153,271$716.0K0.00%−23,122−13.1%Reduced
Principal Financial Group Inc153,937$718.9K0.00%+40,191+35.3%Added
Quarry LP162,500$758.9K0.18%+91,749+129.7%Added
Diversified Trust Co170,235$795.0K0.02%−5,504−3.1%Reduced
Occudo Quantitative Strategies LP179,354$837.6K0.09%+58,930+48.9%Added
Jacobs Levy Equity Management, Inc181,877$849.4K0.00%−73,683−28.8%Reduced
Commonwealth Equity Services, LLC197,743$923.0K0.00%+300+0.2%Added
Brevan Howard Capital Management LP205,024$957.5K0.01%+12,748+6.6%Added
Stonepine Capital Management, LLC205,100$957.8K0.94%+102,835+100.6%Added
Raymond James Financial Inc209,146$976.7K0.00%+28,830+16.0%Added
Rhumbline Advisers215,691$1.01M0.00%+23,410+12.2%Added
Legato Capital Management LLC216,805$1.01M0.12%−513−0.2%Reduced
Tudor Investment Corp Et Al225,186$1.05M0.01%00.0%Unchanged
UBS Group AG227,865$1.06M0.00%−635,911−73.6%Reduced
Walleye Capital LLC243,275$1.14M0.01%−448,444−64.8%Reduced
Healthcare of Ontario Pension Plan Trust Fund252,000$1.18M0.00%00.0%Unchanged
IHT Wealth Management, LLC263,805$1.23M0.03%+1,000+0.4%Added
Thompson Siegel & Walmsley LLC266,387$1.24M0.02%+93,603+54.2%Added
State of Wisconsin Investment Board278,020$1.30M0.00%+257,745+1,271.2%Added
Squarepoint Ops LLC284,567$1.33M0.00%+268,572+1,679.1%Added
Voss Capital, LLC319,800$1.49M0.10%+44,800+16.3%Added
FMR LLC326,420$1.52M0.00%+14,948+4.8%Added
Y-Intercept (Hong Kong) Ltd336,214$1.57M0.04%+291,696+655.2%Added
Bank of New York Mellon Corp377,127$1.76M0.00%+16,803+4.7%Added
Acadian Asset Management LLC383,237$1.79M0.00%+365,641+2,078.0%Added
Schonfeld Strategic Advisors LLC389,066$1.82M0.01%−211,101−35.2%Reduced
Wellington Management Group LLP399,291$1.86M0.00%+7,192+1.8%Added
Susquehanna International Group, LLP406,202$1.90M0.00%−231,580−36.3%Reduced
Barclays PLC424,248$1.98M0.00%+143,613+51.2%Added
Redmile Group, LLC451,099$2.11M0.22%00.0%Unchanged
Norges Bank561,700$2.62M0.00%−262,100−31.8%Reduced
Charles Schwab Investment Management Inc567,538$2.65M0.00%+143,763+33.9%Added
EAM Investors, LLC586,865$2.74M0.42%−347,781−37.2%Reduced
Federated Hermes, Inc.691,381$3.23M0.01%+3,598+0.5%Added
Essex Investment Management Co LLC725,774$3.39M0.62%−4,670−0.6%Reduced
Deutsche Bank AG736,927$3.44M0.00%−19,480−2.6%Reduced
Jump Financial, LLC756,403$3.53M0.04%+332,880+78.6%Added
Kennedy Capital Management, Inc.816,147$3.81M0.09%+81,060+11.0%Added
Cubist Systematic Strategies, LLC880,314$4.11M0.04%+68,707+8.5%Added
Voloridge Investment Management, LLC994,381$4.64M0.02%−356,733−26.4%Reduced
JPMorgan Chase & Co1,032,262$4.82M0.00%−1,082,447−51.2%Reduced
AQR Capital Management LLC1,048,993$4.90M0.00%+102,227+10.8%Added
Two Sigma Advisers, LP1,056,779$4.94M0.01%+131,164+14.2%Added
Knott David M Jr1,060,000$4.95M2.24%−50,000−4.5%Reduced
Two Sigma Investments, LP1,214,699$5.67M0.01%+324,362+36.4%Added
Connor, Clark & Lunn Investment Management Ltd.1,227,959$5.73M0.02%+638,488+108.3%Added
Northern Trust Corp1,293,530$6.04M0.00%+92,330+7.7%Added
Prudential Financial Inc1,556,629$7.27M0.01%+457,784+41.7%Added
CenterBook Partners LP1,594,229$7.45M0.41%+1,122,154+237.7%Added
Bank of America Corp1,663,490$7.77M0.00%−45,919−2.7%Reduced
Legal & General Group Plc1,804,203$8.43M0.00%+392,589+27.8%Added
Renaissance Technologies LLC2,055,340$9.60M0.01%−107,300−5.0%Reduced
Driehaus Capital Management LLC2,071,075$9.67M0.08%+659,535+46.7%Added
Parkman Healthcare Partners LLC2,107,483$9.84M1.14%+327,029+18.4%Added
Rosalind Advisors, Inc.2,155,594$10.1M4.87%−340,392−13.6%Reduced
Goldman Sachs Group Inc2,271,486$10.6M0.00%−518,528−18.6%Reduced
Nuveen, LLC2,600,442$12.1M0.00%+370,935+16.6%Added
Millennium Management LLC2,933,620$13.7M0.01%+615,648+26.6%Added
Qube Research & Technologies Ltd3,089,771$14.4M0.02%+1,245,188+67.5%Added
Morgan Stanley3,642,584$17.0M0.00%−645,697−15.1%Reduced
Geode Capital Management, LLC3,650,688$17.1M0.00%+244,862+7.2%Added
State Street Corp3,783,200$17.7M0.00%+457,945+13.8%Added
D. E. Shaw & Co., Inc.3,835,407$17.9M0.02%+783,035+25.7%Added
Vanguard Group Inc9,816,937$45.8M0.00%+1,707,293+21.1%Added