| Jun 22, 2022 (view filing) | Jun 17 | 5 days | Himes Vaughn BChief Technical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.13K | $160.00 | −$181.4K | −0.9%119.5K after | |
| Jun 30, 2022 (view filing) | Jun 28 | 2 days | Dansey Roger DChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −34.6K | $180.00 | −$6.23M | −35.8%62.1K after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average. |
| Jul 7, 2022 (view filing) | Jul 5 | 2 days | Romp Charles REVP, Commercial | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −712 | $179.46 | −$127.8K | −1.4%48.8K after | |
| Aug 17, 2022 (view filing) | Aug 16 | 1 day | Dansey Roger DInterim CEO & CMO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −4.25K | $170.22 | −$724.1K | −4.0%102.6K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 17, 2022 (view filing) | Aug 16 | 1 day | Himes Vaughn BChief Technical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.53K | $170.22 | −$259.9K | −2.1%70.8K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 17, 2022 (view filing) | Aug 16 | 1 day | Liu Jean IChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.64K | $170.22 | −$279.0K | −1.8%88.0K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 17, 2022 (view filing) | Aug 16 | 1 day | Romp Charles REVP, Commercial | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.76K | $170.22 | −$300.4K | −2.8%60.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 17, 2022 (view filing) | Aug 16 | 1 day | Simpson Todd EChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.97K | $170.22 | −$334.8K | −1.4%141.4K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 1, 2022 (view filing) | Aug 31 | 1 day | Liu Jean IChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.65K | $154.41 | −$563.3K | −4.1%84.4K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 1, 2022 (view filing) | Aug 31 | 1 day | Dansey Roger DInterim CEO & CMO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.02K | $154.41 | −$775.0K | −4.9%97.5K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 1, 2022 (view filing) | Aug 31 | 1 day | Romp Charles REVP, Commercial | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.13K | $154.41 | −$174.9K | −1.9%59.6K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 1, 2022 (view filing) | Aug 31 | 1 day | Himes Vaughn BChief Technical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.58K | $154.41 | −$553.4K | −5.1%67.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 1, 2022 (view filing) | Aug 31 | 1 day | Simpson Todd EChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −4.19K | $154.41 | −$646.4K | −3.0%137.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Oct 19, 2022 (view filing) | Oct 17 | 2 days | Dansey Roger DInterim CEO & CMO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $135.00 | −$1.35M | −9.3%97.5K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 15, 2022 (view filing) | Nov 11 | 4 days | Gryska David WDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.50K | $129.10 | −$968.3K | −15.7%40.3K after | |
| Nov 18, 2022 (view filing) | Nov 17 | 1 day | Liu Jean IChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.33K | $131.05 | −$1.09M | −8.9%85.7K after | |
| Dec 16, 2022 (view filing) | Dec 14 | 2 days | Dansey Roger DPresident, Research and Develo | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $135.00 | −$1.35M | −9.3%97.5K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 21, 2022 (view filing) | Dec 20 | 1 day | Romp Charles REVP, Commercial U.S. | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.13K | $127.63 | −$144.1K | −1.9%58.5K after | |
| Jan 6, 2023 (view filing) | Jan 4-5 | 2 days | Liu Jean IChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $135.00 | −$675.0K | −5.5%85.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 6, 2023 (view filing) | Jan 4-5 | 2 days | Dansey Roger DPresident R&D & CMO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $135.00 | −$1.35M | −9.3%97.5K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 19, 2023 (view filing) | Jan 17 | 2 days | Liu Jean IChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −578 | $130.71 | −$75.6K | −0.7%85.1K after | |
| Jan 26, 2023 (view filing) | Jan 24 | 2 days | Liu Jean IChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $135.03 | −$675.1K | −5.5%85.1K after | |
| Jan 26, 2023 (view filing) | Jan 24 | 2 days | Dansey Roger DPresident, R&D & CMO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $135.00 | −$1.35M | −9.3%97.5K after | |
| Feb 3, 2023 (view filing) | Feb 2 | 1 day | Dansey Roger DPresident, R&D & CMO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −783 | $138.52 | −$108.5K | −0.8%96.9K after | |
| Feb 17, 2023 (view filing) | Feb 15 | 2 days | Dansey Roger DPresident, R&D & CMO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $140.64 | −$1.41M | −9.4%96.9K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 21, 2023 (view filing) | Feb 16 | 5 days | Liu Jean IChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $155.00 | −$775.0K | −5.5%85.1K after | |
| Feb 21, 2023 (view filing) | Feb 16 | 5 days | Simpson Todd EChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −39.9K | $160.00 | −$6.39M | −22.6%137.2K after | |
| Feb 28, 2023 (view filing) | Feb 27 | 1 day | Simpson Todd EChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.0K | $182.53 | −$3.65M | −14.6%117.2K after | |
| Mar 3, 2023 (view filing) | Mar 2 | 1 day | Himes Vaughn BChief Technical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −16.2K | $177.21 | −$2.87M | −19.4%67.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 10, 2023 (view filing) | Mar 9 | 1 day | Simpson Todd EChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −42.8K | $176.61 | −$7.56M | −26.7%117.2K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 16, 2023 (view filing) | Mar 13-14 | 3 daysLateFiled more than 2 business days after the trade (the Form 4 deadline). A few cases, such as trades a broker makes under a 10b5-1 plan, have a longer deadline, so this flag comes from the dates alone and does not mean a rule was broken. | Welch Daniel GDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −17.9K | $200.35 | −$3.59M | −71.3%7.22K after | 9 lotsThis row combines 9 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 16, 2023 (view filing) | Mar 13-14 | 3 daysLateFiled more than 2 business days after the trade (the Form 4 deadline). A few cases, such as trades a broker makes under a 10b5-1 plan, have a longer deadline, so this flag comes from the dates alone and does not mean a rule was broken. | Welch Daniel GDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −9.48K | $200.35 | −$1.90M | −28.1%24.3K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 17, 2023 (view filing) | Mar 15 | 2 days | Dansey Roger DPresident, R&D & CMO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $199.81 | −$2.00M | −9.4%96.9K after | |
| Mar 17, 2023 (view filing) | Mar 15 | 2 days | Welch Daniel GDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.36K | $200.05 | −$471.5K | −25.5%6.90K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 17, 2023 (view filing) | Mar 15 | 2 days | Welch Daniel GDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.25K | $200.05 | −$249.3K | −5.1%23.1K after | |
| Mar 17, 2023 (view filing) | Mar 16 | 1 day | Liu Jean IChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $199.90 | −$999.5K | −5.5%85.1K after | |
| Apr 5, 2023 (view filing) | Apr 3 | 2 days | Welch Daniel GDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.3K | $201.61 | −$4.09M | −83.0%4.15K after | From originalReported on the original filing 0000899243-23-010823. A later amendment (Form 4/A) restated only part of that filing, so this trade still stands and is listed under the amendment. The filing date shown is the original's.9 lotsThis row combines 9 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 5, 2023 (view filing) | Apr 3 | 2 days | Welch Daniel GDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.7K | $201.61 | −$2.16M | −46.5%12.3K after | From originalReported on the original filing 0000899243-23-010823. A later amendment (Form 4/A) restated only part of that filing, so this trade still stands and is listed under the amendment. The filing date shown is the original's.3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 7, 2023 (view filing) | Apr 6 | 1 day | Simpson Todd EChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −243 | $205.86 | −$50.0K | −0.2%118.9K after | From originalReported on the original filing 0001203311-23-000038. A later amendment (Form 4/A) restated only part of that filing, so this trade still stands and is listed under the amendment. The filing date shown is the original's.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 7, 2023 (view filing) | Apr 6 | 1 day | Himes Vaughn BChief Technical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −243 | $205.86 | −$50.0K | −0.4%68.8K after | From originalReported on the original filing 0001203311-23-000035. A later amendment (Form 4/A) restated only part of that filing, so this trade still stands and is listed under the amendment. The filing date shown is the original's.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 7, 2023 (view filing) | Apr 6 | 1 day | Romp Charles REVP, Commercial U.S. | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −133 | $205.86 | −$27.4K | −0.2%60.1K after | From originalReported on the original filing 0001203311-23-000037. A later amendment (Form 4/A) restated only part of that filing, so this trade still stands and is listed under the amendment. The filing date shown is the original's.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 7, 2023 (view filing) | Apr 6 | 1 day | Liu Jean IChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −174 | $205.86 | −$35.8K | −0.2%86.8K after | From originalReported on the original filing 0001203311-23-000036. A later amendment (Form 4/A) restated only part of that filing, so this trade still stands and is listed under the amendment. The filing date shown is the original's.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 7, 2023 (view filing) | Apr 6 | 1 day | Dansey Roger DPresident, R&D & CMO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −333 | $205.86 | −$68.6K | −0.3%99.4K after | From originalReported on the original filing 0001203311-23-000034. A later amendment (Form 4/A) restated only part of that filing, so this trade still stands and is listed under the amendment. The filing date shown is the original's.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 12, 2023 (view filing) | Apr 10 | 2 days | Simpson Todd EChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −55.3K | $204.58 | −$11.3M | −31.8%118.9K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 19, 2023 (view filing) | Apr 17 | 2 days | Dansey Roger DPresident, R&D & CMO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $205.95 | −$2.06M | −9.1%99.4K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 19, 2023 (view filing) | Apr 17 | 2 days | Liu Jean IChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $205.86 | −$1.03M | −5.4%86.8K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 3, 2023 (view filing) | May 1-2 | 2 days | Welch Daniel GDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −16.3K | $200.07 | −$3.26M | −72.3%6.25K after | 7 lotsThis row combines 7 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 3, 2023 (view filing) | May 1-2 | 2 days | Welch Daniel GDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.7K | $200.07 | −$2.15M | −46.5%12.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 16, 2023 (view filing) | May 15 | 1 day | Welch Daniel GDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.86K | $200.02 | −$372.8K | −23.0%6.25K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 18, 2023 (view filing) | May 16 | 2 days | Romp Charles REVP, Commercial U.S. | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −349 | $189.86 | −$66.3K | −0.6%59.8K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
