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Maze Therapeutics, Inc.

MAZE
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001842295

In the last 90 days, Maze Therapeutics, Inc. insiders filed 0 open-market purchases and 13 sales; 161 institutions reported holding it in 13F filings for Q2 2026, worth $1.75B in total; HHLR Advisors (Hillhouse) is the only superinvestor holding it.

13F holders, Q4 2025

Institutional positions in Maze Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
143
+49 vs. Q3 2025
Shares held
48.4M
+5.40M (+12.6%) vs. Q3 2025
Total value
$2.00B
+$889.5M (+79.8%) vs. Q3 2025
New holders
57
46 more added
Sold out
8
20 more reduced

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting MAZE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 143 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 0 institutionsQ2 2022: 0 institutionsQ3 2022: 0 institutionsQ4 2022: 0 institutionsQ1 2023: 0 institutionsQ2 2023: 0 institutionsQ3 2023: 0 institutionsQ4 2023: 0 institutionsQ1 2024: 0 institutionsQ2 2024: 0 institutionsQ3 2024: 0 institutionsQ4 2024: 0 institutionsQ1 2025: 68 institutionsQ2 2025: 75 institutionsQ3 2025: 94 institutionsQ4 2025: 143 institutionsQ1 2026: 165 institutionsQ2 2026: 161 institutions
Value heldQ4 2025: $2.00B
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $0Q2 2022: $0Q3 2022: $0Q4 2022: $0Q1 2023: $0Q2 2023: $0Q3 2023: $0Q4 2023: $0Q1 2024: $0Q2 2024: $0Q3 2024: $0Q4 2024: $0Q1 2025: $441.4MQ2 2025: $476.7MQ3 2025: $1.11BQ4 2025: $2.00BQ1 2026: $1.54BQ2 2026: $1.75B
Institutions holding MAZE and their total value by quarter
QuarterHoldersValue
Q2 2026161$1.75B
Q1 2026165$1.54B
Q4 2025143$2.00B
Q3 202594$1.11B
Q2 202575$476.7M
Q1 202568$441.4M
Q4 20240$0
Q3 20240$0
Q2 20240$0
Q1 20240$0
Q4 20230$0
Q3 20230$0
Q2 20230$0
Q1 20230$0
Q4 20220$0
Q3 20220$0
Q2 20220$0
Q1 20220$0
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Maze Therapeutics, Inc.; share changes are against Q3 2025.

Institutions holding MAZE in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
True Wealth Design, LLC5$2080.00%00.0%Unchanged
Allworth Financial LP5$2080.00%+5New
Rachor Investment Advisory Services, LLC6$2490.00%+6New
Essential Partners LLC7$2900.00%00.0%Unchanged
Rothschild Investment LLC10$4140.00%00.0%Unchanged
Sunbelt Securities, Inc.12$4970.00%00.0%Unchanged
Signaturefd, LLC14$5800.00%+14New
Cornerstone Financial Management LLC28$1.16K0.00%+28New
US Bancorp41$1.70K0.00%+41New
SageView Advisory Group, LLC54$2.24K0.00%+54New
The PNC Financial Services Group, Inc.58$2.40K0.00%−35−37.6%Reduced
SBI Securities Co., Ltd.67$2.78K0.00%+6+9.8%Added
Jones Financial Companies LLLP90$3.73K0.00%+90New
UBS Asset Management Americas Inc99$4.10K0.00%+99New
Torren Management, LLC112$4.64K0.00%+112New
EverSource Wealth Advisors, LLC149$6.17K0.00%00.0%Unchanged
Daiwa Securities Group Inc.160$7.00K0.00%+160New
GAMMA Investing LLC172$7.13K0.00%+13+8.2%Added
Nisa Investment Advisors, LLC204$8.45K0.00%+178+684.6%Added
Farther Finance Advisors, LLC359$14.9K0.00%−24−6.3%Reduced
Royal Bank of Canada646$27.0K0.00%+363+128.3%Added
Amalgamated Bank674$28.0K0.00%+369+121.0%Added
GF Fund Management Co. Ltd.944$39.1K0.00%+944New
Sterling Capital Management LLC1,161$48.1K0.00%−99−7.9%Reduced
California State Teachers Retirement System1,321$54.7K0.00%+766+138.0%Added
Tower Research Capital LLC (TRC)1,349$55.9K0.00%−663−33.0%Reduced
Ameritas Investment Partners, Inc.1,632$67.6K0.00%00.0%Unchanged
CWM, LLC2,229$92.0K0.00%+91+4.3%Added
Mirae Asset Global Investments Co., Ltd.2,338$96.9K0.00%+2,338New
Caitong International Asset Management Co., Ltd3,501$145.0K0.04%+3,501New
IFP Advisors, Inc3,514$145.6K0.00%+3,514New
Brevan Howard Capital Management LP5,042$208.9K0.00%+5,042New
WestHill Financial Advisors, Inc.5,186$214.9K0.04%+5,186New
Quantbot Technologies LP5,221$216.3K0.01%+5,221New
Rafferty Asset Management, LLC5,244$217.3K0.00%+5,244New
Legal & General Group Plc5,379$222.9K0.00%+160+3.1%Added
CIBC Private Wealth Group, LLC5,400$223.7K0.00%+5,400New
BNP Paribas Arbitrage, SA5,473$226.7K0.00%−6,545−54.5%Reduced
SEI Investments Co5,668$234.8K0.00%+5,668New
Police & Firemen's Retirement System of New Jersey5,961$247.0K0.00%+931+18.5%Added
Profund Advisors LLC6,016$249.2K0.01%+6,016New
ProShare Advisors LLC6,047$250.5K0.00%+6,047New
Landscape Capital Management, L.L.C.6,050$250.7K0.02%+6,050New
Intech Investment Management LLC6,443$266.9K0.00%+6,443New
Persistent Asset Partners Ltd6,605$273.6K0.13%+6,605New
New York State Common Retirement Fund6,700$277.6K0.00%00.0%Unchanged
Virtus Investment Advisers, Inc.6,846$283.6K0.08%−1,551−18.5%Reduced
Manufacturers Life Insurance Company, The6,897$285.7K0.00%+6,897New
Two Sigma Investments, LP7,245$300.2K0.00%−3,905−35.0%Reduced
SG Americas Securities, LLC8,493$352.0K0.00%+3,478+69.4%Added
Falcon Wealth Planning10,030$415.5K0.03%+10,030New
STRS Ohio11,200$464.0K0.00%−6,700−37.4%Reduced
Citigroup Inc11,252$466.2K0.00%+10,983+4,082.9%Added
China Universal Asset Management Co., Ltd.11,441$474.0K0.04%+9,441+472.1%Added
MetLife Investment Management11,801$488.9K0.00%00.0%Unchanged
PSP Research LLC12,672$525.0K0.46%+12,672New
Two Sigma Advisers, LP14,800$613.2K0.00%+14,800New
Los Angeles Capital Management LLC19,100$634.5K0.00%+19,100New
Deutsche Bank AG15,522$643.1K0.00%+6,637+74.7%Added
Bank of America Corp18,381$761.5K0.00%+8,807+92.0%Added
Acuta Capital Partners, LLC20,000$828.6K0.56%+20,000New
JPMorgan Chase & Co20,007$828.9K0.00%+12,117+153.6%Added
American Century Companies Inc21,509$891.1K0.00%+21,509New
Verition Fund Management LLC22,512$932.7K0.01%+22,512New
Russell Investments Group, Ltd.22,545$934.0K0.00%+20,638+1,082.2%Added
Gilder Gagnon Howe & Co LLC23,282$964.6K0.01%+23,282New
Rhumbline Advisers23,731$983.2K0.00%+2,761+13.2%Added
Wells Fargo & Company24,008$994.7K0.00%+9,229+62.4%Added
Tudor Investment Corp Et Al24,059$996.8K0.01%+24,059New
Renaissance Technologies LLC27,100$1.12M0.00%−59,000−68.5%Reduced
AQR Capital Management LLC27,439$1.14M0.00%−176−0.6%Reduced
UBS Group AG28,698$1.19M0.00%+905+3.3%Added
Cinctive Capital Management LP29,134$1.21M0.07%+29,134New
Mirae Asset Global ETFs Holdings Ltd.31,295$1.30M0.00%+22,217+244.7%Added
XTX Topco Ltd33,021$1.37M0.04%+6,154+22.9%Added
Alliancebernstein L.P.33,220$1.38M0.00%−26,880−44.7%Reduced
D. E. Shaw & Co., Inc.33,694$1.40M0.00%+33,694New
Barclays PLC39,508$1.64M0.00%+11,992+43.6%Added
Schonfeld Strategic Advisors LLC48,200$2.00M0.01%−65,849−57.7%Reduced
Seven Grand Managers, LLC50,000$2.07M0.16%+50,000New
Trexquant Investment LP52,459$2.17M0.02%+52,459New
Franklin Resources Inc55,229$2.29M0.00%+37,031+203.5%Added
Nuveen, LLC57,258$2.37M0.00%+26,954+88.9%Added
Advisor Group Holdings, Inc.59,762$2.48M0.00%+29,237+95.8%Added
Bank of New York Mellon Corp60,436$2.50M0.00%+15,196+33.6%Added
Wellington Management Group LLP61,205$2.54M0.00%+61,205New
Raymond James Financial Inc67,718$2.81M0.00%+67,718New
SummitTX Capital, L.P.69,560$2.88M0.09%+69,560New
Sphera Funds Management Ltd.71,843$2.98M0.62%−82,500−53.5%Reduced
MPM Oncology Impact Management LP81,145$3.36M0.38%+81,145New
Foresite Capital Management V, LLC86,291$3.58M2.17%00.0%Unchanged
Ameriprise Financial Inc96,688$4.01M0.00%+96,688New
Integral Health Asset Management, LLC100,000$4.14M0.21%+100,000New
Goldman Sachs Group Inc114,455$4.74M0.00%+114,455New
Price T Rowe Associates Inc115,711$4.79M0.00%+105,237+1,004.7%Added
Freestone Grove Partners LP118,876$4.93M0.04%+118,876New
StemPoint Capital LP125,877$5.22M0.89%+125,877New
Invesco Ltd.134,033$5.55M0.00%+1,971+1.5%Added
Millennium Management LLC154,470$6.40M0.00%+154,470New
HighVista Strategies LLC170,353$7.06M1.82%+170,353New