| Jun 4, 2026 | Jun 2, 2026 | Doyle Janeen NoelChief Corp. & Bus. Dev. Ofcr | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −4.06K | $14.03 | −$56.95K | 75.94K | −5.1% | SEC↗ |
| May 13, 2026 | May 11, 2026 | Dobek MariaVice President, Accounting | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −2.04K | $14.17 | −$28.88K | 32.27K | −5.9% | SEC↗ |
| Jan 2, 2026 | Jan 2, 2026 | McIver ZachariahChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −2.71K | $13.73 | −$37.26K | 23.29K | −10.4% | SEC↗ |
| Jan 2, 2026 | Jan 2, 2026 | Dobek MariaVice President, Accounting | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −1.46K | $13.73 | −$20.07K | 15.37K | −8.7% | SEC↗ |
| Jan 2, 2026 | Jan 2, 2026 | DiRaimondo ThomasChief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −2.51K | $13.73 | −$34.39K | 124.43K | −2.0% | SEC↗ |
| Jan 2, 2026 | Jan 2, 2026 | Winter Charles M.Chief Technical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −2.4K | $13.73 | −$32.97K | 77.72K | −3.0% | SEC↗ |
| Jan 2, 2026 | Jan 2, 2026 | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −1.88K | $13.73 | −$25.8K | 83.1K | −2.2% | SEC↗ |
| Jan 2, 2026 | Jan 2, 2026 | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −8.07K | $13.73 | −$110.83K | 284.98K | −2.8% | SEC↗ |
| Dec 3, 2025 | Dec 1, 2025 | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −3.33K | $32.9772 | −$109.91K | 84.97K | −3.8% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 14, 2025 | Nov 14, 2025 | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −3.33K | $30.00 | −$99.99K | 84.97K | −3.8% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 30, 2025 | Oct 28, 2025 | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −16.67K | $30.06 | −$500.95K | 82.14K | −16.9% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 2, 2025 | May 1, 2025 | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −3.33K | $32.028 | −$106.75K | 82.14K | −3.9% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 23, 2025 | Apr 21, 2025 | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −3.33K | $30.00 | −$100.02K | 82.14K | −3.9% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 7, 20256:05 PM ET | Mar 5 – Mar 7, 2025 | RA Capital Healthcare Fund LP and 4 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Stock | +824.04K | $30.7545 | +$25.34M | 10.14M | +8.8% | SEC↗ |
| Mar 5, 2025 | Mar 3, 2025 | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −3.33K | $32.1421 | −$107.16K | 82.14K | −3.9% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 5, 2025 | Feb 3, 2025 | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −3.33K | $42.2945 | −$141.01K | 82.14K | −3.9% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 8, 2025 | Jan 7, 2025 | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −5K | $60.00 | −$300K | 293.05K | −1.7% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 3, 2025 | Jan 2, 2025 | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −13.33K | $54.8816 | −$731.79K | 82.14K | −14.0% | SEC↗ |
| Dec 27, 2024 | Dec 24, 2024 | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −25K | $56.19 | −$1.4M | 217.05K | −10.3% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 3, 2024 | Dec 3, 2024 | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −15K | $67.00 | −$1.01M | 242.05K | −5.8% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 27, 2024 | Nov 25, 2024 | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −25K | $51.5939 | −$1.29M | 257.05K | −8.9% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 30, 2024 | Oct 28, 2024 | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −25K | $53.5398 | −$1.34M | 282.05K | −8.1% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 24, 2024 | Sep 13, 2024 | Lichter Jay10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −3.82K | $46.68 | −$178.08K | 7K | −35.3% | SEC↗ |
| Oct 22, 20244:20 PM ET | Oct 18, 2024 | RA Capital Healthcare Fund LP and 4 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Stock | +1.2M | $44.75 | +$53.7M | 9.32M | +14.8% | SEC↗ |
| Oct 18, 20246:51 PM ET | Oct 16 – Oct 18, 2024 | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −762.47K | $46.3443 | −$35.34M | 2.07M | −26.9% | SEC↗ |
| Oct 18, 20246:51 PM ET | Oct 16 – Oct 18, 2024 | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −910.66K | $46.2701 | −$42.14M | 2.12M | −30.1% | SEC↗ |
| Sep 30, 20248:49 PM ET | Sep 26 – Sep 30, 2024 | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −140.49K | $46.9489 | −$6.6M | 6.89K | −95.3% | SEC↗ |
| Sep 30, 20248:49 PM ET | Sep 26 – Sep 27, 2024 | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −167.29K | $46.9639 | −$7.86M | 2.88M | −5.5% | SEC↗ |
| Sep 27, 2024 | Sep 27, 2024 | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −50K | $45.96 | −$2.3M | 67.59K | −42.5% | SEC↗ |
| Sep 27, 2024 | Sep 27, 2024 | DiRaimondo ThomasChief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −5K | $46.3464 | −$231.73K | 97.94K | −4.9% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 27, 2024 | Sep 27, 2024 | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −25K | $46.3073 | −$1.16M | 307.05K | −7.5% | SEC↗10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 12, 20248:42 PM ET | Sep 10 – Sep 12, 2024 | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −203.68K | $46.8943 | −$9.55M | 2.96M | −6.4% | SEC↗ |
| Sep 12, 20248:42 PM ET | Sep 10 – Sep 12, 2024 | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −247.42K | $46.8944 | −$11.6M | 3.02M | −7.6% | SEC↗ |
| Sep 10, 20245:02 PM ET | Sep 6 – Sep 9, 2024 | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −110.55K | $42.0065 | −$4.64M | 7K | −94.0% | SEC↗ |
| Sep 10, 20245:02 PM ET | Sep 6, 2024 | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −131.64K | $42.00 | −$5.53M | 3.23M | −3.9% | SEC↗ |
| Jun 5, 20247:19 PM ET | Jun 3, 2024 | Avalon Ventures XI, L.P. and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −677.28K | $54.75 | −$37.08M | 3.27M | −17.2% | SEC↗ |
| Jun 5, 20247:19 PM ET | Jun 3, 2024 | Avalon Ventures XI, L.P. and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −822.72K | $54.75 | −$45.04M | 3.34M | −19.8% | SEC↗ |
| Jun 5, 2024 | Jun 3, 2024 | Lichter JayDirector, 10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −1.5M | $54.75 | −$82.13M | 3.34M | −31.0% | SEC↗ |
| Jun 5, 2024 | Jun 3, 2024 | Reardon TigheActing Chief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −822.72K | $54.75 | −$45.04M | 3.34M | −19.8% | SEC↗ |
| Mar 6, 20244:15 PM ET | Mar 4, 2024 | RA Capital Healthcare Fund LP and 4 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Stock · Derivative | +1.4M | $46.499 | +$65M | 1.4M | – | SEC↗ |
| Nov 15, 2023 | Nov 13, 2023 | Reardon TigheActing Chief Financial Officer | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Stock | +849.85K | $5.87 | +$4.99M | 849.85K | New position | SEC↗ |
| Nov 15, 2023 | Nov 13, 2023 | Lichter JayDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Stock | +849.85K | $5.87 | +$4.99M | 849.85K | New position | SEC↗ |
| Nov 13, 20237:11 PM ET | Nov 13, 2023 | Avalon Ventures XI, L.P. and 2 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Stock | +849.85K | $5.87 | +$4.99M | 849.85K | New position | SEC↗ |
| Jul 21, 20234:31 PM ET | Jul 19, 2023 | RA Capital Healthcare Fund LP and 4 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Stock | +495.01K | $12.46 | +$6.17M | 8.12M | +6.5% | SEC↗ |
| Jul 21, 20234:31 PM ET | Jul 19, 2023 | RA Capital Healthcare Fund LP and 4 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Stock · Derivative | +503.23K | $12.459 | +$6.27M | 503.23K | – | SEC↗ |
| Dec 30, 20219:00 PM ET | Dec 29, 2021 | ORBIMED ADVISORS LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −40.4K | $20.30 | −$820.12K | 231.1K | −14.9% | SEC↗ |
| Dec 30, 2021 | Dec 29, 2021 | Thompson Peter A.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −40.4K | $20.30 | −$820.12K | 231.1K | −14.9% | SEC↗ |
| Dec 23, 20214:13 PM ET | Dec 21, 2021 | ORBIMED ADVISORS LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −119.4K | $19.00 | −$2.27M | 234.8K | −33.7% | SEC↗ |
| Dec 23, 2021 | Dec 21, 2021 | Thompson Peter A.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −119.4K | $19.00 | −$2.27M | 234.8K | −33.7% | SEC↗ |
| Dec 17, 20215:13 PM ET | Dec 16, 2021 | ORBIMED ADVISORS LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock | −393.3K | $19.07 | −$7.5M | 245.9K | −61.5% | SEC↗ |
