| Dec 17, 2021 (view filing) | Dec 16 | 1 day | Thompson Peter A.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −393.3K | $19.07 | −$7.50M | −61.5%245.9K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 17, 2021 (view filing)5:13 PM ET | Dec 16 | 1 day | OrbiMed Advisors LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −393.3K | $19.07 | −$7.50M | −61.5%245.9K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Dec 23, 2021 (view filing) | Dec 21 | 2 days | Thompson Peter A.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −119.4K | $19.00 | −$2.27M | −33.7%234.8K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 23, 2021 (view filing)4:13 PM ET | Dec 21 | 2 days | OrbiMed Advisors LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −119.4K | $19.00 | −$2.27M | −33.7%234.8K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Dec 30, 2021 (view filing) | Dec 29 | 1 day | Thompson Peter A.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −40.4K | $20.30 | −$820.1K | −14.9%231.1K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 30, 2021 (view filing)9:00 PM ET | Dec 29 | 1 day | OrbiMed Advisors LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −40.4K | $20.30 | −$820.1K | −14.9%231.1K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Jul 21, 2023 (view filing)4:31 PM ET | Jul 19 | 2 days | RA Capital Healthcare Fund LP and 4 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +495.0K | $12.46 | +$6.17M | +6.5%8.12M after | |
| Jul 21, 2023 (view filing)4:31 PM ET | Jul 19 | 2 days | RA Capital Healthcare Fund LP and 4 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +503.2K | $12.46 | +$6.27M | –503.2K after | DerivativeA trade in a derivative security (option, warrant, restricted stock unit and so on). The value is the derivative's own price times the quantity. |
| Nov 13, 2023 (view filing)7:11 PM ET | Nov 13 | Same day | Avalon Ventures XI, L.P. and 2 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +849.9K | $5.87 | +$4.99M | New position849.9K after | |
| Nov 15, 2023 (view filing) | Nov 13 | 2 days | Lichter JayDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +849.9K | $5.87 | +$4.99M | New position849.9K after | Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Nov 15, 2023 (view filing) | Nov 13 | 2 days | Reardon TigheActing Chief Financial Officer | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +849.9K | $5.87 | +$4.99M | New position849.9K after | Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Mar 6, 2024 (view filing)4:15 PM ET | Mar 4 | 2 days | RA Capital Healthcare Fund LP and 4 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.40M | $46.50 | +$65.0M | –1.40M after | DerivativeA trade in a derivative security (option, warrant, restricted stock unit and so on). The value is the derivative's own price times the quantity. |
| Jun 5, 2024 (view filing) | Jun 3 | 2 days | Reardon TigheActing Chief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −822.7K | $54.75 | −$45.0M | −19.8%3.34M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 5, 2024 (view filing) | Jun 3 | 2 days | Lichter JayDirector, 10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.50M | $54.75 | −$82.1M | −31.0%3.34M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 5, 2024 (view filing)7:19 PM ET | Jun 3 | 2 days | Avalon Ventures XI, L.P. and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −677.3K | $54.75 | −$37.1M | −17.2%3.27M after | |
| Jun 5, 2024 (view filing)7:19 PM ET | Jun 3 | 2 days | Avalon Ventures XI, L.P. and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −822.7K | $54.75 | −$45.0M | −19.8%3.34M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Sep 10, 2024 (view filing)5:02 PM ET | Sep 6-9 | 4 days | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −110.5K | $42.01 | −$4.64M | −94.0%7.00K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 10, 2024 (view filing)5:02 PM ET | Sep 6 | 4 days | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −131.6K | $42.00 | −$5.53M | −3.9%3.23M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 12, 2024 (view filing)8:42 PM ET | Sep 10-12 | 2 days | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −203.7K | $46.89 | −$9.55M | −6.4%2.96M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 12, 2024 (view filing)8:42 PM ET | Sep 10-12 | 2 days | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −247.4K | $46.89 | −$11.6M | −7.6%3.02M after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 27, 2024 (view filing) | Sep 27 | Same day | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $46.31 | −$1.16M | −7.5%307.1K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 27, 2024 (view filing) | Sep 27 | Same day | DiRaimondo ThomasChief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $46.35 | −$231.7K | −4.9%97.9K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 27, 2024 (view filing) | Sep 27 | Same day | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −50.0K | $45.96 | −$2.30M | −42.5%67.6K after | |
| Sep 30, 2024 (view filing)8:49 PM ET | Sep 26-30 | 4 days | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −140.5K | $46.95 | −$6.60M | −95.3%6.89K after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 30, 2024 (view filing)8:49 PM ET | Sep 26-27 | 4 days | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −167.3K | $46.96 | −$7.86M | −5.5%2.88M after | 8 lotsThis row combines 8 trades of the same kind from one filing. The price is the value-weighted average. |
| Oct 18, 2024 (view filing)6:51 PM ET | Oct 16-18 | 2 days | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −762.5K | $46.34 | −$35.3M | −26.9%2.07M after | 7 lotsThis row combines 7 trades of the same kind from one filing. The price is the value-weighted average. |
| Oct 18, 2024 (view filing)6:51 PM ET | Oct 16-18 | 2 days | Lichter Jay and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −910.7K | $46.27 | −$42.1M | −30.1%2.12M after | 10 lotsThis row combines 10 trades of the same kind from one filing. The price is the value-weighted average. |
| Oct 22, 2024 (view filing)4:20 PM ET | Oct 18 | 4 days | RA Capital Healthcare Fund LP and 4 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.20M | $44.75 | +$53.7M | +14.8%9.32M after | |
| Oct 24, 2024 (view filing) | Sep 13 | 41 daysLateFiled more than 2 business days after the trade (the Form 4 deadline). A few cases, such as trades a broker makes under a 10b5-1 plan, have a longer deadline, so this flag comes from the dates alone and does not mean a rule was broken. | Lichter Jay10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.81K | $46.68 | −$178.1K | −35.3%7.00K after | |
| Oct 30, 2024 (view filing) | Oct 28 | 2 days | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $53.54 | −$1.34M | −8.1%282.1K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 27, 2024 (view filing) | Nov 25 | 2 days | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $51.59 | −$1.29M | −8.9%257.1K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 3, 2024 (view filing) | Dec 3 | Same day | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −15.0K | $67.00 | −$1.00M | −5.8%242.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 27, 2024 (view filing) | Dec 24 | 3 days | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $56.19 | −$1.40M | −10.3%217.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 3, 2025 (view filing) | Jan 2 | 1 day | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −13.3K | $54.88 | −$731.8K | −14.0%82.1K after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 8, 2025 (view filing) | Jan 7 | 1 day | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $60.00 | −$300.0K | −1.7%293.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 5, 2025 (view filing) | Feb 3 | 2 days | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.33K | $42.29 | −$141.0K | −3.9%82.1K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 5, 2025 (view filing) | Mar 3 | 2 days | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.33K | $32.14 | −$107.2K | −3.9%82.1K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 7, 2025 (view filing)6:05 PM ET | Mar 5-7 | 2 days | RA Capital Healthcare Fund LP and 4 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +824.0K | $30.75 | +$25.3M | +8.8%10.1M after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Apr 23, 2025 (view filing) | Apr 21 | 2 days | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.33K | $30.00 | −$100.0K | −3.9%82.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 2, 2025 (view filing) | May 1 | 1 day | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.33K | $32.03 | −$106.7K | −3.9%82.1K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 30, 2025 (view filing) | Oct 28 | 2 days | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −16.7K | $30.06 | −$500.9K | −16.9%82.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 14, 2025 (view filing) | Nov 14 | Same day | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.33K | $30.00 | −$100.0K | −3.8%85.0K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 3, 2025 (view filing) | Dec 1 | 2 days | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.33K | $32.98 | −$109.9K | −3.8%85.0K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 2, 2026 (view filing) | Jan 2 | Same day | Campbell David AlanPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.07K | $13.73 | −$110.8K | −2.8%285.0K after | |
| Jan 2, 2026 (view filing) | Jan 2 | Same day | Meyer Andrew HollmanChief Business Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.88K | $13.73 | −$25.8K | −2.2%83.1K after | |
| Jan 2, 2026 (view filing) | Jan 2 | Same day | Winter Charles M.Chief Technical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.40K | $13.73 | −$33.0K | −3.0%77.7K after | |
| Jan 2, 2026 (view filing) | Jan 2 | Same day | DiRaimondo ThomasChief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.50K | $13.73 | −$34.4K | −2.0%124.4K after | |
| Jan 2, 2026 (view filing) | Jan 2 | Same day | Dobek MariaVice President, Accounting | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.46K | $13.73 | −$20.1K | −8.7%15.4K after | |
| Jan 2, 2026 (view filing) | Jan 2 | Same day | McIver ZachariahChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.71K | $13.73 | −$37.3K | −10.4%23.3K after | |
| May 13, 2026 (view filing) | May 11 | 2 days | Dobek MariaVice President, Accounting | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.04K | $14.17 | −$28.9K | −5.9%32.3K after | |
