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Castle Biosciences Inc

CSTL
Exchange
Nasdaq
Industry
Services-Medical Laboratories
SEC CIK
0001447362

In the last 90 days, Castle Biosciences Inc insiders filed 0 open-market purchases and 20 sales; 176 institutions reported holding it in 13F filings for Q2 2026, worth $653.8M in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Castle Biosciences Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
195
+26 vs. Q3 2025
Shares held
27.3M
+724.4K (+2.7%) vs. Q3 2025
Total value
$1.06B
+$455.1M (+75.0%) vs. Q3 2025
New holders
43
64 more added
Sold out
17
69 more reduced

4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting CSTL on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 195 institutions
Q1 2021: 175 institutionsQ2 2021: 182 institutionsQ3 2021: 188 institutionsQ4 2021: 159 institutionsQ1 2022: 160 institutionsQ2 2022: 146 institutionsQ3 2022: 157 institutionsQ4 2022: 153 institutionsQ1 2023: 148 institutionsQ2 2023: 130 institutionsQ3 2023: 135 institutionsQ4 2023: 153 institutionsQ1 2024: 151 institutionsQ2 2024: 159 institutionsQ3 2024: 185 institutionsQ4 2024: 197 institutionsQ1 2025: 180 institutionsQ2 2025: 152 institutionsQ3 2025: 173 institutionsQ4 2025: 195 institutionsQ1 2026: 186 institutionsQ2 2026: 176 institutions
Value heldQ4 2025: $1.06B
Q1 2021: $1.46BQ2 2021: $1.52BQ3 2021: $1.42BQ4 2021: $918.6MQ1 2022: $1.02BQ2 2022: $495.0MQ3 2022: $569.8MQ4 2022: $522.0MQ1 2023: $501.9MQ2 2023: $316.6MQ3 2023: $391.0MQ4 2023: $515.4MQ1 2024: $553.2MQ2 2024: $549.4MQ3 2024: $736.9MQ4 2024: $706.4MQ1 2025: $516.3MQ2 2025: $541.8MQ3 2025: $608.3MQ4 2025: $1.06BQ1 2026: $677.8MQ2 2026: $653.8M
Institutions holding CSTL and their total value by quarter
QuarterHoldersValue
Q2 2026176$653.8M
Q1 2026186$677.8M
Q4 2025195$1.06B
Q3 2025173$608.3M
Q2 2025152$541.8M
Q1 2025180$516.3M
Q4 2024197$706.4M
Q3 2024185$736.9M
Q2 2024159$549.4M
Q1 2024151$553.2M
Q4 2023153$515.4M
Q3 2023135$391.0M
Q2 2023130$316.6M
Q1 2023148$501.9M
Q4 2022153$522.0M
Q3 2022157$569.8M
Q2 2022146$495.0M
Q1 2022160$1.02B
Q4 2021159$918.6M
Q3 2021188$1.42B
Q2 2021182$1.52B
Q1 2021175$1.46B

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Castle Biosciences Inc; share changes are against Q3 2025.

Institutions holding CSTL in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Larson Financial Group LLC1$390.00%00.0%Unchanged
Sunbelt Securities, Inc.1$390.00%+1New
True Wealth Design, LLC5$1950.00%+4+400.0%Added
Signature Equity Partners, LLC16$6220.00%+16New
Missouri Trust & Investment Co19$7390.00%00.0%Unchanged
Torren Management, LLC21$8170.00%+21New
Parkside Financial Bank & Trust25$9730.00%+25New
EverSource Wealth Advisors, LLC28$1.09K0.00%+8+40.0%Added
Northwestern Mutual Wealth Management Co28$1.09K0.00%+28New
Allworth Financial LP30$1.17K0.00%+11+57.9%Added
SRS Capital Advisors, Inc.37$1.44K0.00%−537−93.6%Reduced
Signaturefd, LLC45$1.75K0.00%00.0%Unchanged
Quantbot Technologies LP47$1.83K0.00%+47New
US Bancorp48$1.87K0.00%+22+84.6%Added
Spire Wealth Management50$1.95K0.00%00.0%Unchanged
SBI Securities Co., Ltd.52$2.02K0.00%−1−1.9%Reduced
IFP Advisors, Inc52$2.02K0.00%00.0%Unchanged
GAMMA Investing LLC52$2.02K0.00%00.0%Unchanged
Rothschild Investment LLC53$2.06K0.00%−2−3.6%Reduced
Daiwa Securities Group Inc.86$3.00K0.00%00.0%Unchanged
Rockefeller Capital Management L.P.87$3.38K0.00%+87New
BFSG, LLC90$3.50K0.00%00.0%Unchanged
Essential Partners LLC134$5.21K0.00%+11+8.9%Added
Huntington National Bank139$5.41K0.00%00.0%Unchanged
Aster Capital Management (DIFC) Ltd151$5.87K0.00%+151New
Versant Capital Management, Inc181$7.04K0.00%00.0%Unchanged
Nisa Investment Advisors, LLC281$10.9K0.00%−83−22.8%Reduced
Quadrant Capital Group LLC336$13.1K0.00%00.0%Unchanged
Rossby Financial, LCC429$16.7K0.01%+47+12.3%Added
Hughes Financial Services, LLC436$17.0K0.00%+1+0.2%Added
Jones Financial Companies LLLP515$20.0K0.00%+490+1,960.0%Added
The PNC Financial Services Group, Inc.546$21.2K0.00%+431+374.8%Added
GF Fund Management Co. Ltd.573$22.3K0.00%−51−8.2%Reduced
Federated Hermes, Inc.660$25.7K0.00%+660New
First Horizon Corp678$26.4K0.00%+231+51.7%Added
Royal Bank of Canada865$33.0K0.00%−32−3.6%Reduced
Kemnay Advisory Services Inc.889$34.6K0.01%+889New
Amalgamated Bank892$35.0K0.00%−1−0.1%Reduced
Covestor Ltd998$39.0K0.02%−1,071−51.8%Reduced
Global Retirement Partners, LLC1,100$42.8K0.00%00.0%Unchanged
Mirae Asset Global Investments Co., Ltd.1,418$55.2K0.00%+297+26.5%Added
State of Alaska, Department of Revenue1,553$60.0K0.00%00.0%Unchanged
Sterling Capital Management LLC1,637$63.7K0.00%−323−16.5%Reduced
BNP PARIBAS ASSET MANAGEMENT Holding S.A.1,839$72.0K0.00%+1,378+298.9%Added
Tower Research Capital LLC (TRC)2,013$78.3K0.00%−1,653−45.1%Reduced
Caitong International Asset Management Co., Ltd2,099$81.7K0.02%+1,371+188.3%Added
CWM, LLC2,302$90.0K0.00%+391+20.5%Added
Ameritas Investment Partners, Inc.2,373$92.3K0.00%00.0%Unchanged
Persistent Asset Partners Ltd2,463$95.8K0.05%+2,463New
Russell Investments Group, Ltd.2,488$96.8K0.00%−20−0.8%Reduced
State of Wyoming3,014$117.2K0.01%+3,014New
Harbour Investments, Inc.3,137$122.0K0.00%00.0%Unchanged
Great West Life Assurance Co3,244$126.0K0.00%−7,469−69.7%Reduced
Farther Finance Advisors, LLC3,337$129.8K0.00%+1,945+139.7%Added
Globeflex Capital L P3,759$146.2K0.02%+3,759New
China Universal Asset Management Co., Ltd.4,756$185.0K0.01%−329−6.5%Reduced
Raymond James Financial Inc5,238$203.8K0.00%+5,238New
Voya Investment Management LLC5,246$204.1K0.00%+5,246New
Assetmark, Inc5,287$205.7K0.00%−418−7.3%Reduced
Jump Financial, LLC5,500$213.9K0.00%+5,500New
Lido Advisors, LLC10,036$228.5K0.00%00.0%Unchanged
Pictet Asset Management Holding SA5,899$229.5K0.00%+5,899New
Portside Wealth Group, LLC5,942$231.1K0.03%+5,942New
Cornerstone Investment Partners, LLC6,078$236.4K0.01%+6,078New
KLP Kapitalforvaltning AS6,200$241.2K0.00%−2,700−30.3%Reduced
Canada Pension Plan Investment Board6,300$245.1K0.00%+3,900+162.5%Added
Capstone Capital Management Ltd6,446$250.7K0.24%+6,446New
Blueshift Asset Management, LLC6,458$251.2K0.07%+6,458New
ProShare Advisors LLC6,478$252.0K0.00%+6,478New
Commonwealth Equity Services, LLC6,591$256.4K0.00%+6,591New
Arrowstreet Capital, Limited Partnership7,029$273.4K0.00%+7,029New
Verdad Advisers, LP7,085$275.6K0.32%+7,085New
State Board of Administration of Florida Retirement System7,154$278.3K0.00%+7,154New
Intrust Bank NA7,378$287.0K0.02%+7,378New
Police & Firemen's Retirement System of New Jersey7,829$304.5K0.00%00.0%Unchanged
Arizona State Retirement System8,071$314.0K0.00%+8,071New
Glenmede Trust Co NA8,190$318.6K0.00%+8,190New
Manufacturers Life Insurance Company, The8,487$330.1K0.00%−1,052−11.0%Reduced
Simon Quick Advisors, LLC8,561$333.0K0.01%−5,001−36.9%Reduced
Cetera Investment Advisers8,935$347.6K0.00%+8,935New
Quantinno Capital Management LP9,332$363.0K0.00%+9,332New
Green Alpha Advisors, LLC10,236$398.2K0.36%+698+7.3%Added
Aquatic Capital Management LLC10,570$411.2K0.01%+8,235+352.7%Added
TritonPoint Partners, LLC10,777$419.2K0.22%+10,777New
LPL Financial LLC10,877$423.1K0.00%+1,480+15.7%Added
Graham Capital Management, L.P.10,928$425.1K0.01%−10,205−48.3%Reduced
Stephens Inc11,122$432.6K0.01%00.0%Unchanged
Jackson Creek Investment Advisors LLC11,235$437.0K0.13%+11,235New
Man Group plc11,585$450.7K0.00%+11,585New
Intech Investment Management LLC11,718$455.8K0.00%−674−5.4%Reduced
Diversify Wealth Management, LLC11,588$459.3K0.02%−159−1.4%Reduced
Zurcher Kantonalbank (Zurich Cantonalbank)11,810$459.4K0.00%−397−3.3%Reduced
CWM Advisors, LLC12,011$467.2K0.04%−7,876−39.6%Reduced
Summit Global Investments12,365$481.0K0.03%+13+0.1%Added
STRS Ohio12,600$490.1K0.00%+2,800+28.6%Added
Counterpoint Mutual Funds LLC12,952$503.8K0.04%+12,952New
Mirae Asset Global ETFs Holdings Ltd.13,223$514.4K0.00%−50−0.4%Reduced
Y-Intercept (Hong Kong) Ltd13,246$515.3K0.01%+13,246New
Harbor Capital Advisors, Inc.13,432$523.0K0.04%+261+2.0%Added
Oak Harvest Investment Services13,485$524.6K0.06%−3,398−20.1%Reduced