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Caris Life Sciences, Inc.

CAI
Exchange
Nasdaq
Industry
Services-Medical Laboratories
SEC CIK
0002019410

In the last 90 days, Caris Life Sciences, Inc. insiders filed 1 open-market purchase and 3 sales; 247 institutions reported holding it in 13F filings for Q2 2026, worth $2.75B in total; superinvestors Coatue Management and Duquesne Family Office hold it.

13F holders, Q3 2025

Institutional positions in Caris Life Sciences, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
138
+23 vs. Q2 2025
Shares held
113.4M
+4.45M (+4.1%) vs. Q2 2025
Total value
$3.41B
+$495.5M (+17.0%) vs. Q2 2025
New holders
53
45 more added
Sold out
30
19 more reduced

1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting CAI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 138 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 0 institutionsQ2 2022: 0 institutionsQ3 2022: 0 institutionsQ4 2022: 0 institutionsQ1 2023: 0 institutionsQ2 2023: 0 institutionsQ3 2023: 0 institutionsQ4 2023: 0 institutionsQ1 2024: 0 institutionsQ2 2024: 0 institutionsQ3 2024: 0 institutionsQ4 2024: 0 institutionsQ1 2025: 0 institutionsQ2 2025: 116 institutionsQ3 2025: 138 institutionsQ4 2025: 186 institutionsQ1 2026: 202 institutionsQ2 2026: 247 institutions
Value heldQ3 2025: $3.41B
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $0Q2 2022: $0Q3 2022: $0Q4 2022: $0Q1 2023: $0Q2 2023: $0Q3 2023: $0Q4 2023: $0Q1 2024: $0Q2 2024: $0Q3 2024: $0Q4 2024: $0Q1 2025: $0Q2 2025: $2.92BQ3 2025: $3.41BQ4 2025: $3.92BQ1 2026: $2.80BQ2 2026: $2.75B
Institutions holding CAI and their total value by quarter
QuarterHoldersValue
Q2 2026247$2.75B
Q1 2026202$2.80B
Q4 2025186$3.92B
Q3 2025138$3.41B
Q2 2025116$2.92B
Q1 20250$0
Q4 20240$0
Q3 20240$0
Q2 20240$0
Q1 20240$0
Q4 20230$0
Q3 20230$0
Q2 20230$0
Q1 20230$0
Q4 20220$0
Q3 20220$0
Q2 20220$0
Q1 20220$0
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Caris Life Sciences, Inc.; share changes are against Q2 2025.

Institutions holding CAI in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Tortoise Investment Management, LLC1$300.00%+1New
Global Retirement Partners, LLC1$300.00%+1New
Cedar Mountain Advisors, LLC5$1510.00%00.0%Unchanged
Massmutual Trust Co FSB5$1510.00%+5New
J.Safra Asset Management Corp21$6350.00%+21New
Tower Research Capital LLC (TRC)23$6960.00%−2,085−98.9%Reduced
Financial Management Professionals, Inc.71$2.15K0.00%+51+255.0%Added
Jones Financial Companies LLLP140$4.09K0.00%+140New
GWM Advisors LLC200$6.05K0.00%00.0%Unchanged
ORG Wealth Partners, LLC200$6.05K0.00%00.0%Unchanged
Caitong International Asset Management Co., Ltd208$6.29K0.00%+208New
SRS Capital Advisors, Inc.217$6.57K0.00%+198+1,042.1%Added
Brown Brothers Harriman & Co344$10.4K0.00%+344New
STRS Ohio536$16.2K0.00%+536New
Advisor Group Holdings, Inc.450$16.9K0.00%−550−55.0%Reduced
Nomura Asset Management Co Ltd562$17.0K0.00%00.0%Unchanged
Comerica Bank662$20.0K0.00%+662New
Sterling Capital Management LLC714$21.6K0.00%+714New
CWM, LLC778$24.0K0.00%+628+418.7%Added
The PNC Financial Services Group, Inc.855$25.9K0.00%+655+327.5%Added
MetLife Investment Management899$27.2K0.00%+899New
Bokf, NA1,131$34.2K0.00%+1,131New
BNP Paribas Arbitrage, SA1,200$36.3K0.00%+1,200New
SBI Securities Co., Ltd.1,226$37.1K0.00%+1,068+675.9%Added
California State Teachers Retirement System1,306$39.5K0.00%+1,306New
Amalgamated Bank1,463$44.0K0.00%+1,463New
Wells Fargo & Company1,770$53.5K0.00%+470+36.2%Added
Russell Investments Group, Ltd.1,995$60.3K0.00%+1,995New
Legal & General Group Plc2,297$69.4K0.00%+1,297+129.7%Added
Barclays PLC3,177$96.1K0.00%−6,823−68.2%Reduced
Simplex Trading, LLC3,983$120.0K0.00%+3,151+378.7%Added
Royal Bank of Canada4,291$130.0K0.00%+3,470+422.7%Added
Picton Mahoney Asset Management6,210$188.0K0.00%+6,210New
Wealthcare Advisory Partners LLC6,666$201.6K0.00%+6,666New
SummitTX Capital, L.P.6,736$203.8K0.01%+6,736New
American Century Companies Inc6,865$207.7K0.00%+6,865New
Balyasny Asset Management LLC6,917$209.2K0.00%−43,453−86.3%Reduced
Public Employees Retirement System of Ohio6,997$211.7K0.00%+6,997New
Edmond de Rothschild Holding S.A.7,500$226.9K0.00%+7,500New
Omers Administration Corp8,200$248.1K0.00%+8,200New
Davy Global Fund Management Ltd8,326$251.9K0.02%+8,326New
Sandia Investment Management LP8,600$260.1K0.78%−1,400−14.0%Reduced
Bellevue Group AG9,605$290.6K0.01%−395−4.0%Reduced
Treasurer of the State of North Carolina10,073$305.0K0.00%+10,073New
Worldquant Millennium Advisors LLC10,092$305.3K0.00%+10,092New
Police & Firemen's Retirement System of New Jersey10,372$313.8K0.00%+10,372New
CastleKnight Management LP10,436$315.7K0.02%−102,994−90.8%Reduced
Perbak Capital Partners LLP10,703$323.8K0.06%+10,703New
Triton Wealth Management, PLLC10,505$327.2K0.12%00.0%Unchanged
Americana Partners, LLC12,433$376.1K0.01%+12,433New
US Bancorp12,722$384.8K0.00%+854+7.2%Added
Jane Street Group, LLC14,595$441.5K0.00%+14,595New
Harbor Investment Advisory, LLC15,650$473.4K0.04%+15,650New
LPL Financial LLC15,991$483.7K0.00%+6,799+74.0%Added
Man Group plc16,078$486.4K0.00%+16,078New
Ieq Capital, LLC17,141$518.5K0.00%+17,141New
MSA Advisors, LLC19,200$580.8K0.15%00.0%Unchanged
Park Avenue Securities LLC20,730$627.0K0.00%+20,730New
Rhumbline Advisers21,497$650.3K0.00%+21,497New
Engineers Gate Manager LP22,028$666.3K0.01%+22,028New
Nuveen, LLC22,413$678.0K0.00%+22,413New
WPWealth LLP23,036$696.8K0.11%+23,036New
Bank of New York Mellon Corp24,869$752.3K0.00%+24,869New
Atika Capital Management LLC25,000$756.3K0.06%00.0%Unchanged
Deutsche Bank AG25,290$765.0K0.00%00.0%Unchanged
XTX Topco Ltd28,081$849.5K0.04%+28,081New
Renaissance Capital LLC28,460$860.9K0.48%+28,460New
Susquehanna International Group, LLP28,988$876.9K0.00%+28,988New
Verition Fund Management LLC30,910$935.0K0.01%+30,910New
Dark Forest Capital Management LP31,657$957.6K0.04%+31,657New
Qube Research & Technologies Ltd32,752$990.7K0.00%+24,998+322.4%Added
Gotham Asset Management, LLC33,203$1.00M0.00%+33,203New
Northern Trust Corp45,595$1.38M0.00%+45,595New
Nikko Asset Management Americas, Inc.47,371$1.43M0.01%+47,371New
Citigroup Inc48,445$1.47M0.00%+48,433+403,608.3%Added
D. E. Shaw & Co., Inc.49,785$1.51M0.00%+42,285+563.8%Added
SRS Investment Management, LLC50,000$1.51M0.02%00.0%Unchanged
Soros Fund Management LLCSuperinvestorSoros Fund Management55,650$1.68M0.03%+5,650+11.3%Added
Sumitomo Mitsui Trust Holdings, Inc.59,552$1.80M0.00%+47,371+388.9%Added
Cubist Systematic Strategies, LLC70,731$2.14M0.03%+68,731+3,436.5%Added
Quantinno Capital Management LP72,223$2.18M0.01%+72,223New
Burkehill Global Management, LP75,000$2.27M0.13%00.0%Unchanged
Marshall Wace, LLP82,975$2.51M0.00%+45,102+119.1%Added
Jennison Associates LLC84,459$2.55M0.00%−202,165−70.5%Reduced
Pura Vida Investments, LLC89,940$2.72M17.65%+44,940+99.9%Added
Raymond James Financial Inc94,888$2.87M0.00%+92,043+3,235.3%Added
Seven Grand Managers, LLC100,000$3.02M0.25%+50,000+100.0%Added
Manufacturers Life Insurance Company, The110,084$3.33M0.00%+87,525+388.0%Added
State of Wisconsin Investment Board150,000$4.54M0.01%00.0%Unchanged
State Street Corp155,340$4.70M0.00%+155,340New
Holocene Advisors, LP171,127$5.18M0.01%−1,816−1.1%Reduced
Vanguard Group Inc175,544$5.31M0.00%+25,544+17.0%Added
Franklin Resources Inc216,964$6.56M0.00%−310,075−58.8%Reduced
TD Asset Management Inc222,336$6.73M0.01%+22,512+11.3%Added
Renaissance Technologies LLC225,100$6.81M0.01%+225,100New
FIL Ltd225,920$6.83M0.01%−70,051−23.7%Reduced
UBS Group AG235,873$7.14M0.00%+235,873New
ARK Investment Management LLCSuperinvestorARK Invest245,350$7.42M0.04%+198,300+421.5%Added
Point72 Asset Management, L.P.246,624$7.46M0.02%−211,852−46.2%Reduced
Freestone Grove Partners LP251,389$7.60M0.06%+201,389+402.8%Added