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Perceptive Advisors LLC

SEC CIK
0001224962
Latest filing
Aug 14, 2026

Holdings in Q3 2025

Holdings as of Sep 30, 2025, filed Nov 14, 2025. Long positions only; changes compare share counts with Q2 2025.

Institution overview
Positions
91
+9 vs. Q2 2025
Portfolio value
$3.46B
+$796.1M (+29.9%) vs. Q2 2025
Filed
Nov 14, 2025
SEC
Holdings of Perceptive Advisors LLC in Q3 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
RYTMRhythm Pharmaceuticals, Inc.COM2,438,969$288.4M8.3%+20,670+0.9%AddedHistory
ASNDAscendis Pharma A/SSPONSORED ADR1,088,501$216.4M6.3%+124,615+12.9%AddedHistory
ACLXArcellx, Inc.COMMON STOCK2,468,353$202.7M5.9%−9,647−0.4%ReducedHistory
CELCCelcuity Inc.COM2,956,319$146.0M4.2%+1,323,111+81.0%AddedHistory
NUVLNuvalent, Inc.COM1,562,336$135.1M3.9%+187,156+13.6%AddedHistory
MRUSMerus N.V.COM1,353,093$127.4M3.7%+644,917+91.1%AddedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM8,952,365$121.7M3.5%+1,050,000+13.3%AddedHistory
ROIVRoivant Sciences Ltd.SHS7,368,461$111.5M3.2%+4,036,996+121.2%AddedHistory
MGTXMeiraGTx Holdings plcCOM12,626,103$103.8M3.0%00.0%UnchangedHistory
INSMINSMED IncCOM PAR $.01702,130$101.1M2.9%+51,878+8.0%AddedHistory
TVTXTravere Therapeutics, Inc.COM3,794,615$90.7M2.6%+2,960,363+354.9%AddedHistory
AORTArtivion, Inc.COM2,020,000$85.5M2.5%−773,703−27.7%ReducedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW1,564,554$82.9M2.4%+811,633+107.8%AddedHistory
IMTXImmatics N.V.SHS9,383,456$79.9M2.3%00.0%UnchangedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS3,100,902$75.2M2.2%+1,953,967+170.4%AddedHistory
SLDBSolid Biosciences Inc.COM NEW11,833,539$73.0M2.1%−73,107−0.6%ReducedHistory
PTGXProtagonist Therapeutics, IncCOM1,030,134$68.4M2.0%−44,314−4.1%ReducedHistory
NBIXNeurocrine Biosciences IncStock450,050$63.2M1.8%+195,000+76.5%AddedHistory
EWTXEdgewise Therapeutics, Inc.COM3,795,894$61.6M1.8%−844,055−18.2%ReducedHistory
VRNAVerona Pharma plcSPONSORED ADS524,088$55.9M1.6%−4,983,503−90.5%ReducedHistory
PENPenumbra IncCOM220,547$55.9M1.6%+187,750+572.5%AddedHistory
AKROAkero Therapeutics, Inc.COM1,135,766$53.9M1.6%+219,879+24.0%AddedHistory
APGEApogee Therapeutics, Inc.COM1,351,989$53.7M1.6%+169,841+14.4%AddedHistory
OMDAOmada Health, Inc.COM2,396,330$53.0M1.5%−30,000−1.2%ReducedHistory
FOLDAmicus Therapeutics, Inc.COM6,370,851$50.2M1.5%−1,041,979−14.1%ReducedHistory
ATXSAstria Therapeutics, Inc.COM6,485,420$47.2M1.4%00.0%UnchangedHistory
INBXInhibrx Biosciences, Inc.COM1,327,707$44.7M1.3%+349,815+35.8%AddedHistory
RGENRepligen CorpCOM270,428$36.1M1.0%+104,428+62.9%AddedHistory
ZYMEZymeworks Inc.COM2,090,663$35.7M1.0%+815,389+63.9%AddedHistory
SIONSionna Therapeutics, Inc.COM1,179,098$34.7M1.0%−36,947−3.0%ReducedHistory
CAICaris Life Sciences, Inc.COM1,098,163$33.2M1.0%00.0%UnchangedHistory
ABVXAbivax S.A.SPONSORED ADS388,608$33.0M1.0%+388,608NewHistory
VRDNViridian Therapeutics, Inc.COM1,462,400$31.6M0.9%+1,014,893+226.8%AddedHistory
CTMXCytomX Therapeutics, Inc.COM9,680,185$30.9M0.9%+2,686,539+38.4%AddedHistory
BSXBoston Scientific CorpStock310,000$30.3M0.9%+30,000+10.7%AddedHistory
ALDXAldeyra Therapeutics, Inc.COM5,222,311$27.3M0.8%+1,170,680+28.9%AddedHistory
DRUGBright Minds Biosciences Inc.COM NEW449,290$27.3M0.8%+28,600+6.8%AddedHistory
IMVTImmunovant, Inc.COM1,587,890$25.6M0.7%−550,000−25.7%ReducedHistory
EXASExact Sciences CorpCOM465,487$25.5M0.7%+465,487NewHistory
PVLAPalvella Therapeutics, Inc.COM395,093$24.8M0.7%+395,093NewHistory
ORKAOruka Therapeutics, Inc.COM1,268,021$24.4M0.7%+1,268,021NewHistory
ISRGIntuitive Surgical IncCOM NEW52,119$23.3M0.7%+7,000+15.5%AddedHistory
IRTCiRhythm Holdings, Inc.COM123,000$21.2M0.6%+123,000NewHistory
AQSTAquestive Therapeutics, Inc.COM3,760,099$21.0M0.6%+1,569,679+71.7%AddedHistory
SYRESpyre Therapeutics, Inc.COM NEW1,229,445$20.6M0.6%−300,000−19.6%ReducedHistory
ADGMAdagio Medical Holdings, Inc.COM9,876,576$19.2M0.6%00.0%UnchangedHistory
AXSMAxsome Therapeutics, Inc.COM148,900$18.1M0.5%−49,634−25.0%ReducedHistory
ADMAAdma Biologics, Inc.COM1,153,468$16.9M0.5%−150,000−11.5%ReducedHistory
ENGNenGene Therapeutics Inc.COM2,097,236$14.3M0.4%+2,097,236NewHistory
OBIOOrchestra BioMed Holdings, Inc.COM5,292,556$13.1M0.4%+700,000+15.2%AddedHistory
NRIXNurix Therapeutics, Inc.COM1,416,149$13.1M0.4%+319,164+29.1%AddedHistory
RAPPRapport Therapeutics, Inc.COM403,923$12.0M0.3%+403,923NewHistory
OMOutset Medical, Inc.COM NEW833,333$11.8M0.3%00.0%UnchangedHistory
NAUTNautilus Biotechnology, Inc.COM12,594,211$10.6M0.3%00.0%UnchangedHistory
CRVSCorvus Pharmaceuticals, Inc.COM1,438,595$10.6M0.3%00.0%UnchangedHistory
KODKodiak Sciences Inc.COM634,577$10.4M0.3%+634,577NewHistory
SEPNSepterna, Inc.COM541,450$10.2M0.3%00.0%UnchangedHistory
GOSSGossamer Bio, Inc.COM3,812,797$10.0M0.3%+3,812,797NewHistory
KYMRKymera Therapeutics, Inc.COM169,796$9.61M0.3%−40,310−19.2%ReducedHistory
IKTInhibikase Therapeutics, Inc.COM NEW5,421,568$8.78M0.3%−10,725−0.2%ReducedHistory
Celcuity Inc.15102KAA8NOTE 2.750% 8/0–$8.72M0.3%–New–
CTNMContineum Therapeutics, Inc.CL A714,592$8.40M0.2%+15,106+2.2%AddedHistory
XENEXenon Pharmaceuticals Inc.COM200,791$8.06M0.2%00.0%UnchangedHistory
AVRAnteris Technologies Global Corp.COM1,705,130$7.67M0.2%00.0%UnchangedHistory
JANXJanux Therapeutics, Inc.COM292,686$7.15M0.2%00.0%UnchangedHistory
IRDOpus Genetics, Inc.COM4,325,000$7.14M0.2%00.0%UnchangedHistory
TEMTempus AI, Inc.CL A85,000$6.86M0.2%+85,000NewHistory
DYNDyne Therapeutics, Inc.COM540,444$6.84M0.2%−1,706,946−76.0%ReducedHistory
KRYSKrystal Biotech, Inc.COM35,000$6.18M0.2%+35,000NewHistory
BBNXBeta Bionics, Inc.COM277,944$5.52M0.2%−1,315,664−82.6%ReducedHistory
CBIOCrescent Biopharma, Inc.COM453,686$5.39M0.2%00.0%UnchangedHistory
HTFLHeartflow, Inc.COM150,000$5.05M0.1%+150,000NewHistory
RAPTRAPT Therapeutics, Inc.COM NEW183,890$4.74M0.1%00.0%UnchangedHistory
PEPGPepGen Inc.COM829,870$3.83M0.1%+829,870NewHistory
BLTEBelite Bio, IncSPONSORED ADS49,788$3.68M0.1%+49,788NewHistory
SCPHscPharmaceuticals Inc.COM583,142$3.31M0.1%+83,142+16.6%AddedHistory
VKTXViking Therapeutics, Inc.COM105,597$2.78M0.1%−275,103−72.3%ReducedHistory
PYXSPyxis Oncology, Inc.COMMON STOCK1,178,307$2.62M0.1%+1,178,307NewHistory
LONALeonaBio, Inc.COM540,296$2.24M0.1%00.0%UnchangedConverted for a 1-for-10 splitHistory
TRIBTrinity Biotech PLCSPONS ADR NEW1,790,000$1.86M0.1%00.0%UnchangedHistory
AVTXAvalo Therapeutics, Inc.COM NEW139,667$1.78M0.1%00.0%UnchangedHistory
NVNOenVVeno Medical CorpCOMMON STOCK1,759,035$1.59M<0.1%+474,069+36.9%AddedHistory
LYRALyra Therapeutics, Inc.COM NEW229,382$1.50M<0.1%−25,768−10.1%ReducedHistory
QUREuniQure N.V.SHS20,000$1.17M<0.1%+20,000NewHistory
LXEOLexeo Therapeutics, Inc.COM139,835$928.5K<0.1%00.0%UnchangedHistory
BDSXBiodesix IncCOM108,694$820.6K<0.1%00.0%UnchangedConverted for a 1-for-20 splitHistory
ANROAlto Neuroscience, Inc.COM SHS155,366$624.6K<0.1%+155,366NewHistory
APYXApyx Medical CorpCOM150,000$321.0K<0.1%00.0%UnchangedHistory
ENSCEnsysce Biosciences, Inc.COM NEW86,666$205.4K<0.1%00.0%UnchangedHistory
RVMDWRevolution Medicines, Inc.*W EXP 12/17/202250,000$75.0K<0.1%00.0%UnchangedHistory
Surrozen, Inc.86889P117*W EXP 08/01/203166,666$2.97K<0.1%00.0%Unchanged–

Options (1)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Perceptive Advisors LLC in Q3 2025
SecurityClassPutsCalls
SPRYARS Pharmaceuticals, Inc.COM$2.01M–

Sold out since Q2 2025 (9)

Positions held at the end of Q2 2025 that are gone from this filing.

Positions of Perceptive Advisors LLC sold out since Q2 2025
SecurityClassShares in Q2 2025Value in Q2 2025% of portfolio in Q2 2025History
SLNOSoleno Therapeutics IncCOM430,439$36.1M1.4%History
EOLSEvolus, Inc.COM2,474,843$22.8M0.9%History
PODDInsulet CorpStock60,387$19.0M0.7%History
CRLCharles River Laboratories International, Inc.COM100,000$15.2M0.6%History
RAREUltragenyx Pharmaceutical Inc.COM270,000$9.82M0.4%History
GMEDGlobus Medical IncStock88,500$5.22M0.2%History
BBOTBridgeBio Oncology Therapeutics, Inc.CL A ORD SHS398,000$4.23M0.2%History
FBRXForte Biosciences, Inc.COM NEW68,192$881.7K<0.1%History
KALAKALA BIO, Inc.COMM STK55,227$262.9K<0.1%History