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Perceptive Advisors LLC

SEC CIK
0001224962
Latest filing
Aug 14, 2026

Holdings in Q2 2025

Holdings as of Jun 30, 2025, filed Aug 14, 2025. Long positions only; changes compare share counts with Q1 2025.

Institution overview
Positions
82
−4 vs. Q1 2025
Portfolio value
$2.67B
−$154.7M (−5.5%) vs. Q1 2025
Filed
Aug 14, 2025
SEC
Holdings of Perceptive Advisors LLC in Q2 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
VRNAVerona Pharma plcSPONSORED ADS5,507,591$520.9M19.5%−1,055,749−16.1%ReducedHistory
ASNDAscendis Pharma A/SSPONSORED ADR963,886$166.4M6.2%+963,886NewHistory
ACLXArcellx, Inc.COMMON STOCK2,478,000$163.2M6.1%−448,478−15.3%ReducedHistory
RYTMRhythm Pharmaceuticals, Inc.COM2,418,299$152.8M5.7%−130,146−5.1%ReducedHistory
NUVLNuvalent, Inc.COM1,375,180$104.9M3.9%−258,788−15.8%ReducedHistory
AORTArtivion, Inc.COM2,793,703$86.9M3.3%00.0%UnchangedHistory
MGTXMeiraGTx Holdings plcCOM12,626,103$82.2M3.1%+45,000+0.4%AddedHistory
INSMINSMED IncCOM PAR $.01650,252$65.4M2.5%+140,952+27.7%AddedHistory
EWTXEdgewise Therapeutics, Inc.COM4,639,949$60.8M2.3%−1,907,379−29.1%ReducedHistory
PTGXProtagonist Therapeutics, IncCOM1,074,448$59.4M2.2%−16,823−1.5%ReducedHistory
SLDBSolid Biosciences Inc.COM NEW11,906,646$58.0M2.2%00.0%UnchangedHistory
APGEApogee Therapeutics, Inc.COM1,182,148$51.3M1.9%+59,381+5.3%AddedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM7,902,365$50.7M1.9%+28,017+0.4%AddedHistory
IMTXImmatics N.V.SHS9,383,456$50.5M1.9%00.0%UnchangedHistory
AKROAkero Therapeutics, Inc.COM915,887$48.9M1.8%+122,927+15.5%AddedHistory
OMDAOmada Health, Inc.COM2,426,330$44.4M1.7%+2,426,330NewHistory
FOLDAmicus Therapeutics, Inc.COM7,412,830$42.5M1.6%−14,051,697−65.5%ReducedHistory
ROIVRoivant Sciences Ltd.SHS3,331,465$37.5M1.4%+3,331,465NewHistory
MRUSMerus N.V.COM708,176$37.3M1.4%+17,691+2.6%AddedHistory
SLNOSoleno Therapeutics IncCOM430,439$36.1M1.4%−1,076,163−71.4%ReducedHistory
ATXSAstria Therapeutics, Inc.COM6,485,420$34.8M1.3%00.0%UnchangedHistory
IMVTImmunovant, Inc.COM2,137,890$34.2M1.3%−706,182−24.8%ReducedHistory
NBIXNeurocrine Biosciences IncStock255,050$32.1M1.2%+155,000+154.9%AddedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW752,921$31.7M1.2%−227,973−23.2%ReducedHistory
BSXBoston Scientific CorpStock280,000$30.1M1.1%+150,000+115.4%AddedHistory
CAICaris Life Sciences, Inc.COM1,098,163$29.3M1.1%+1,098,163NewHistory
ISRGIntuitive Surgical IncCOM NEW45,119$24.5M0.9%+4,500+11.1%AddedHistory
ADMAAdma Biologics, Inc.COM1,303,468$23.7M0.9%−69,765−5.1%ReducedHistory
BBNXBeta Bionics, Inc.COM1,593,608$23.2M0.9%00.0%UnchangedHistory
SYRESpyre Therapeutics, Inc.COM NEW1,529,445$22.9M0.9%−783,827−33.9%ReducedHistory
EOLSEvolus, Inc.COM2,474,843$22.8M0.9%−1,654,299−40.1%ReducedHistory
CELCCelcuity Inc.COM1,633,208$21.8M0.8%−729,071−30.9%ReducedHistory
DYNDyne Therapeutics, Inc.COM2,247,390$21.4M0.8%−66,013−2.9%ReducedHistory
SIONSionna Therapeutics, Inc.COM1,216,045$21.1M0.8%−35,056−2.8%ReducedHistory
AXSMAxsome Therapeutics, Inc.COM198,534$20.7M0.8%−156,573−44.1%ReducedHistory
RGENRepligen CorpCOM166,000$20.6M0.8%+36,199+27.9%AddedHistory
PODDInsulet CorpStock60,387$19.0M0.7%−11,210−15.7%ReducedHistory
OMOutset Medical, Inc.COM NEW833,333$16.0M0.6%00.0%UnchangedHistory
ZYMEZymeworks Inc.COM1,275,274$16.0M0.6%−589,398−31.6%ReducedHistory
CTMXCytomX Therapeutics, Inc.COM6,993,646$15.9M0.6%+6,993,646NewHistory
ALDXAldeyra Therapeutics, Inc.COM4,051,631$15.5M0.6%−5,224,220−56.3%ReducedHistory
CRLCharles River Laboratories International, Inc.COM100,000$15.2M0.6%+100,000NewHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS1,146,935$15.1M0.6%−1,893,460−62.3%ReducedHistory
INBXInhibrx Biosciences, Inc.COM977,892$14.0M0.5%−86,134−8.1%ReducedHistory
ADGMAdagio Medical Holdings, Inc.COM9,876,576$12.8M0.5%+64,157+0.7%AddedHistory
NRIXNurix Therapeutics, Inc.COM1,096,985$12.5M0.5%+799,432+268.7%AddedHistory
TVTXTravere Therapeutics, Inc.COM834,252$12.3M0.5%+834,252NewHistory
OBIOOrchestra BioMed Holdings, Inc.COM4,592,556$12.3M0.5%00.0%UnchangedHistory
DRUGBright Minds Biosciences Inc.COM NEW420,690$11.0M0.4%−23,959−5.4%ReducedHistory
IKTInhibikase Therapeutics, Inc.COM NEW5,432,293$10.6M0.4%−492,707−8.3%ReducedHistory
VKTXViking Therapeutics, Inc.COM380,700$10.1M0.4%−128,305−25.2%ReducedHistory
RAREUltragenyx Pharmaceutical Inc.COM270,000$9.82M0.4%+270,000NewHistory
KYMRKymera Therapeutics, Inc.COM210,106$9.17M0.3%+210,106NewHistory
NAUTNautilus Biotechnology, Inc.COM12,594,211$9.13M0.3%00.0%UnchangedHistory
PENPenumbra IncCOM32,797$8.42M0.3%+32,797NewHistory
CBIOCrescent Biopharma, Inc.COM453,686$7.32M0.3%+453,686NewHistory
AQSTAquestive Therapeutics, Inc.COM2,190,420$7.25M0.3%−1,536,788−41.2%ReducedHistory
JANXJanux Therapeutics, Inc.COM292,686$6.76M0.3%−677,726−69.8%ReducedHistory
AVRAnteris Technologies Global Corp.COM1,705,130$6.46M0.2%−434,870−20.3%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM200,791$6.28M0.2%−124,533−38.3%ReducedHistory
VRDNViridian Therapeutics, Inc.COM447,507$6.26M0.2%−212,155−32.2%ReducedHistory
CRVSCorvus Pharmaceuticals, Inc.COM1,438,595$5.75M0.2%+1,438,595NewHistory
SEPNSepterna, Inc.COM541,450$5.72M0.2%+541,450NewHistory
GMEDGlobus Medical IncStock88,500$5.22M0.2%+88,500NewHistory
NVNOenVVeno Medical CorpCOMMON STOCK1,284,966$5.13M0.2%+1,284,966NewHistory
BBOTBridgeBio Oncology Therapeutics, Inc.CL A ORD SHS398,000$4.23M0.2%00.0%UnchangedHistory
IRDOpus Genetics, Inc.COM4,325,000$4.07M0.2%00.0%UnchangedHistory
CTNMContineum Therapeutics, Inc.CL A699,486$2.78M0.1%−741,763−51.5%ReducedHistory
LYRALyra Therapeutics, Inc.COM NEW255,150$2.29M0.1%00.0%UnchangedConverted for a 1-for-50 splitHistory
SCPHscPharmaceuticals Inc.COM500,000$1.91M0.1%00.0%UnchangedHistory
LONALeonaBio, Inc.COM5,402,964$1.63M0.1%00.0%UnchangedHistory
RAPTRAPT Therapeutics, Inc.COM NEW183,890$1.47M0.1%+183,890NewHistory
TRIBTrinity Biotech PLCSPONS ADR NEW1,790,000$1.16M<0.1%+1,790,000NewHistory
FBRXForte Biosciences, Inc.COM NEW68,192$881.7K<0.1%+68,192NewHistory
AVTXAvalo Therapeutics, Inc.COM NEW139,667$696.9K<0.1%−380,333−73.1%ReducedHistory
BDSXBiodesix IncCOM2,173,880$613.0K<0.1%00.0%UnchangedHistory
LXEOLexeo Therapeutics, Inc.COM139,835$562.1K<0.1%00.0%UnchangedHistory
APYXApyx Medical CorpCOM150,000$337.5K<0.1%00.0%UnchangedHistory
KALAKALA BIO, Inc.COMM STK55,227$262.9K<0.1%−222,383−80.1%ReducedHistory
ENSCEnsysce Biosciences, Inc.COM NEW86,666$193.3K<0.1%00.0%UnchangedHistory
RVMDWRevolution Medicines, Inc.*W EXP 12/17/202250,000$65.7K<0.1%00.0%UnchangedHistory
Surrozen, Inc.86889P117*W EXP 08/01/203166,666$3.02K<0.1%00.0%Unchanged–

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Perceptive Advisors LLC in Q2 2025
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF$24.9M–
CAPRCapricor Therapeutics, Inc.COM NEW$6.45M$993.0K

Sold out since Q1 2025 (22)

Positions held at the end of Q1 2025 that are gone from this filing.

Positions of Perceptive Advisors LLC sold out since Q1 2025
SecurityClassShares in Q1 2025Value in Q1 2025% of portfolio in Q1 2025History
ITCIIntra-Cellular Therapies, Inc.COM786,358$103.7M3.7%History
IOVAIovance Biotherapeutics, Inc.COM12,711,788$42.3M1.5%History
ARGXArgenx SESPONSORED ADR59,510$35.2M1.2%History
PCVXVaxcyte, Inc.COM706,567$26.7M0.9%History
MDGLMadrigal Pharmaceuticals, Inc.COM46,500$15.4M0.5%History
DXCMDexcom IncCOM178,000$12.2M0.4%History
ACRVAcrivon Therapeutics, Inc.COMMON STOCK5,360,858$10.9M0.4%History
CRGXCARGO Therapeutics, Inc.COM2,431,085$9.89M0.4%History
EYPTEyePoint, Inc.COM NEW1,537,274$8.33M0.3%History
IRONDisc Medicine, Inc.COM150,000$7.45M0.3%History
ADPTAdaptive Biotechnologies CorpCOM930,972$6.92M0.2%History
OCULOcular Therapeutix, IncCOM915,775$6.71M0.2%History
DCTHDelcath Systems, Inc.COM NEW462,422$5.89M0.2%History
RAPTRAPT Therapeutics, Inc.COM4,418,947$5.39M0.2%History
KMTSKestra Medical Technologies, Ltd.SHS200,000$4.98M0.2%History
OKUROnKure Therapeutics, Inc.COM CL A1,004,439$4.32M0.2%History
MREOMereo BioPharma Group plcSPON ADS876,961$1.97M0.1%History
TRAWTraws Pharma, Inc.COM NEW421,781$970.1K<0.1%History
RCKTRocket Pharmaceuticals, Inc.COM140,726$938.6K<0.1%History
CGEMCullinan Therapeutics, Inc.COM80,100$606.4K<0.1%History
APLTApplied Therapeutics, Inc.COM860,000$420.5K<0.1%History
NBTXNanobiotix S.A.SPONSORED ADS105,053$376.1K<0.1%History