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Perceptive Advisors LLC

SEC CIK
0001224962
Latest filing
Aug 14, 2026

Holdings in Q1 2025

Holdings as of Mar 31, 2025, filed Aug 6, 2025. Long positions only; changes compare share counts with Q4 2024.

Institution overview
Positions
86
−11 vs. Q4 2024
Portfolio value
$2.82B
−$769.7M (−21.4%) vs. Q4 2024
Filed
Aug 6, 2025
AmendedSEC
Holdings of Perceptive Advisors LLC in Q1 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
VRNAVerona Pharma plcSPONSORED ADS6,563,340$416.7M14.8%+171,234+2.7%AddedHistory
ACLXArcellx, Inc.COMMON STOCK2,926,478$192.0M6.8%−552,410−15.9%ReducedHistory
FOLDAmicus Therapeutics, Inc.COM21,464,527$175.2M6.2%−2,781,425−11.5%ReducedHistory
EWTXEdgewise Therapeutics, Inc.COM6,547,328$144.0M5.1%+3,861,791+143.8%AddedHistory
RYTMRhythm Pharmaceuticals, Inc.COM2,548,445$135.0M4.8%−1,132,028−30.8%ReducedHistory
NUVLNuvalent, Inc.COM1,633,968$115.9M4.1%−986,009−37.6%ReducedHistory
SLNOSoleno Therapeutics IncCOM1,506,602$107.6M3.8%+5,562+0.4%AddedHistory
ITCIIntra-Cellular Therapies, Inc.COM786,358$103.7M3.7%−501,970−39.0%ReducedHistory
MGTXMeiraGTx Holdings plcCOM12,581,103$85.3M3.0%00.0%UnchangedHistory
AORTArtivion, Inc.COM2,793,703$68.7M2.4%00.0%UnchangedHistory
ALDXAldeyra Therapeutics, Inc.COM9,275,851$53.3M1.9%00.0%UnchangedHistory
PTGXProtagonist Therapeutics, IncCOM1,091,271$52.8M1.9%−180,391−14.2%ReducedHistory
EOLSEvolus, Inc.COM4,129,142$49.7M1.8%−1,016,704−19.8%ReducedHistory
IMVTImmunovant, Inc.COM2,844,072$48.6M1.7%+704,873+33.0%AddedHistory
SLDBSolid Biosciences Inc.COM NEW11,906,646$44.1M1.6%+5,000,000+72.4%AddedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS3,040,395$43.7M1.6%−3,308,825−52.1%ReducedHistory
IOVAIovance Biotherapeutics, Inc.COM12,711,788$42.3M1.5%−9,400,478−42.5%ReducedHistory
IMTXImmatics N.V.SHS9,383,456$42.3M1.5%00.0%UnchangedHistory
APGEApogee Therapeutics, Inc.COM1,122,767$41.9M1.5%+75,535+7.2%AddedHistory
AXSMAxsome Therapeutics, Inc.COM355,107$41.4M1.5%−308,967−46.5%ReducedHistory
INSMINSMED IncCOM PAR $.01509,300$38.9M1.4%+365,300+253.7%AddedHistory
SYRESpyre Therapeutics, Inc.COM NEW2,313,272$37.3M1.3%−261,451−10.2%ReducedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW980,894$37.1M1.3%−348,841−26.2%ReducedHistory
ARGXArgenx SESPONSORED ADR59,510$35.2M1.2%−7,961−11.8%ReducedHistory
ATXSAstria Therapeutics, Inc.COM6,485,420$34.6M1.2%00.0%UnchangedHistory
AKROAkero Therapeutics, Inc.COM792,960$32.1M1.1%−392,632−33.1%ReducedHistory
MRUSMerus N.V.COM690,485$29.1M1.0%+390,485+130.2%AddedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM7,874,348$27.9M1.0%+1,100,000+16.2%AddedHistory
ADMAAdma Biologics, Inc.COM1,373,233$27.2M1.0%+482,953+54.2%AddedHistory
PCVXVaxcyte, Inc.COM706,567$26.7M0.9%−1,011,850−58.9%ReducedHistory
JANXJanux Therapeutics, Inc.COM970,412$26.2M0.9%+152,517+18.6%AddedHistory
DYNDyne Therapeutics, Inc.COM2,313,403$24.2M0.9%+1,770,126+325.8%AddedHistory
CELCCelcuity Inc.COM2,362,279$23.9M0.8%00.0%UnchangedHistory
ZYMEZymeworks Inc.COM1,864,672$22.2M0.8%−265,348−12.5%ReducedHistory
ISRGIntuitive Surgical IncCOM NEW40,619$20.1M0.7%−22,500−35.6%ReducedHistory
OBIOOrchestra BioMed Holdings, Inc.COM4,592,556$19.7M0.7%00.0%UnchangedHistory
BBNXBeta Bionics, Inc.COM1,593,608$19.5M0.7%+1,593,608NewHistory
PODDInsulet CorpStock71,597$18.8M0.7%−160,672−69.2%ReducedHistory
RGENRepligen CorpCOM129,801$16.5M0.6%+129,801NewHistory
DRUGBright Minds Biosciences Inc.COM NEW444,649$16.0M0.6%+41,000+10.2%AddedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM46,500$15.4M0.5%+46,500NewHistory
INBXInhibrx Biosciences, Inc.COM1,064,026$14.9M0.5%00.0%UnchangedHistory
BSXBoston Scientific CorpStock130,000$13.1M0.5%+130,000NewHistory
SIONSionna Therapeutics, Inc.COM1,251,101$13.1M0.5%+1,251,101NewHistory
IKTInhibikase Therapeutics, Inc.COM NEW5,925,000$13.0M0.5%00.0%UnchangedHistory
VKTXViking Therapeutics, Inc.COM509,005$12.3M0.4%−486,889−48.9%ReducedHistory
DXCMDexcom IncCOM178,000$12.2M0.4%+178,000NewHistory
NBIXNeurocrine Biosciences IncStock100,050$11.1M0.4%00.0%UnchangedHistory
XENEXenon Pharmaceuticals Inc.COM325,324$10.9M0.4%00.0%UnchangedHistory
ACRVAcrivon Therapeutics, Inc.COMMON STOCK5,360,858$10.9M0.4%00.0%UnchangedHistory
NAUTNautilus Biotechnology, Inc.COM12,594,211$10.8M0.4%00.0%UnchangedHistory
AQSTAquestive Therapeutics, Inc.COM3,727,208$10.8M0.4%+3,727,208NewHistory
CTNMContineum Therapeutics, Inc.CL A1,441,249$10.1M0.4%00.0%UnchangedHistory
CRGXCARGO Therapeutics, Inc.COM2,431,085$9.89M0.4%−1,251,919−34.0%ReducedHistory
OMOutset Medical, Inc.COM NEW833,333$9.22M0.3%+833,333NewHistory
VRDNViridian Therapeutics, Inc.COM659,662$8.89M0.3%−826,846−55.6%ReducedHistory
EYPTEyePoint, Inc.COM NEW1,537,274$8.33M0.3%00.0%UnchangedHistory
ADGMAdagio Medical Holdings, Inc.COM9,812,419$7.90M0.3%00.0%UnchangedHistory
AVRAnteris Technologies Global Corp.COM2,140,000$7.79M0.3%00.0%UnchangedHistory
IRONDisc Medicine, Inc.COM150,000$7.45M0.3%+150,000NewHistory
ADPTAdaptive Biotechnologies CorpCOM930,972$6.92M0.2%+930,972NewHistory
OCULOcular Therapeutix, IncCOM915,775$6.71M0.2%−162,720−15.1%ReducedHistory
DCTHDelcath Systems, Inc.COM NEW462,422$5.89M0.2%+412,422+824.8%AddedHistory
RAPTRAPT Therapeutics, Inc.COM4,418,947$5.39M0.2%−1,461,053−24.8%ReducedHistory
KMTSKestra Medical Technologies, Ltd.SHS200,000$4.98M0.2%+200,000NewHistory
BBOTBridgeBio Oncology Therapeutics, Inc.CL A ORD SHS398,000$4.50M0.2%−102,000−20.4%ReducedHistory
OKUROnKure Therapeutics, Inc.COM CL A1,004,439$4.32M0.2%00.0%UnchangedHistory
IRDOpus Genetics, Inc.COM4,325,000$4.25M0.2%+4,325,000NewHistory
AVTXAvalo Therapeutics, Inc.COM NEW520,000$4.17M0.1%+520,000NewHistory
NRIXNurix Therapeutics, Inc.COM297,553$3.53M0.1%−33,061−10.0%ReducedHistory
MREOMereo BioPharma Group plcSPON ADS876,961$1.97M0.1%−208,551−19.2%ReducedHistory
LYRALyra Therapeutics, Inc.COM12,757,562$1.61M0.1%00.0%UnchangedHistory
KALAKALA BIO, Inc.COMM STK277,610$1.59M0.1%+277,610NewHistory
LONALeonaBio, Inc.COM5,402,964$1.54M0.1%00.0%UnchangedHistory
BDSXBiodesix IncCOM2,173,880$1.36M<0.1%00.0%UnchangedHistory
SCPHscPharmaceuticals Inc.COM500,000$1.31M<0.1%00.0%UnchangedHistory
TRAWTraws Pharma, Inc.COM NEW421,781$970.1K<0.1%+257,624+156.9%AddedHistory
RCKTRocket Pharmaceuticals, Inc.COM140,726$938.6K<0.1%−237,858−62.8%ReducedHistory
CGEMCullinan Therapeutics, Inc.COM80,100$606.4K<0.1%+80,100NewHistory
LXEOLexeo Therapeutics, Inc.COM139,835$485.2K<0.1%00.0%UnchangedHistory
APLTApplied Therapeutics, Inc.COM860,000$420.5K<0.1%00.0%UnchangedHistory
NBTXNanobiotix S.A.SPONSORED ADS105,053$376.1K<0.1%−161,040−60.5%ReducedHistory
ENSCEnsysce Biosciences, Inc.COM NEW86,666$221.9K<0.1%00.0%UnchangedHistory
APYXApyx Medical CorpCOM150,000$205.5K<0.1%00.0%UnchangedHistory
RVMDWRevolution Medicines, Inc.*W EXP 12/17/202250,000$9.50K<0.1%00.0%UnchangedHistory
Surrozen, Inc.86889P117*W EXP 08/01/203166,666$5.00K<0.1%00.0%Unchanged–

Options (1)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Perceptive Advisors LLC in Q1 2025
SecurityClassPutsCalls
EWTXEdgewise Therapeutics, Inc.COM–$11.0M

Sold out since Q4 2024 (26)

Positions held at the end of Q4 2024 that are gone from this filing.

Positions of Perceptive Advisors LLC sold out since Q4 2024
SecurityClassShares in Q4 2024Value in Q4 2024% of portfolio in Q4 2024History
PRCTPROCEPT BioRobotics CorpCOM290,659$23.4M0.7%History
NTRANatera, Inc.COM125,000$19.8M0.6%History
PENPenumbra IncCOM73,338$17.4M0.5%History
SEPNSepterna, Inc.COM750,000$17.2M0.5%History
ORKAOruka Therapeutics, Inc.COM845,567$16.4M0.5%History
ARVNArvinas, Inc.COM740,749$14.2M0.4%History
CGONCG Oncology, Inc.COM419,450$12.0M0.3%History
EWEdwards Lifesciences CorpStock145,000$10.7M0.3%History
TARSTarsus Pharmaceuticals, Inc.COM186,662$10.3M0.3%History
CRNXCrinetics Pharmaceuticals, Inc.COM184,525$9.43M0.3%History
NARIInari Medical, Inc.Stock178,797$9.13M0.3%History
ZBIOZenas BioPharma, Inc.COM744,035$6.09M0.2%History
IRTCiRhythm Holdings, Inc.COM65,153$5.87M0.2%History
RAPPRapport Therapeutics, Inc.COM311,551$5.53M0.2%History
CBLLCeribell, Inc.COM180,546$4.67M0.1%History
VERUVeru Inc.COM6,483,157$4.22M0.1%History
CATXPerspective Therapeutics, Inc.COM NEW1,190,263$3.80M0.1%History
LCTXLineage Cell Therapeutics, Inc.COM7,236,843$3.64M0.1%History
PEPGPepGen Inc.COM829,536$3.14M0.1%History
IBRXImmunityBio, Inc.COM1,221,734$3.13M0.1%History
BCYCBicycle Therapeutics PLCSPONSORED ADS197,108$2.76M0.1%History
VRCAVerrica Pharmaceuticals Inc.COM3,249,669$2.27M0.1%History
FBRXForte Biosciences, Inc.COM NEW95,742$2.17M0.1%History
TRIBTrinity Biotech PLCSPONS ADR NEW1,790,000$1.58M<0.1%History
FULCFulcrum Therapeutics, Inc.COM238,000$1.12M<0.1%History
PYXSPyxis Oncology, Inc.COMMON STOCK188,462$294.0K<0.1%History