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Livermore
Livermore
ZHEN

Perceptive Advisors LLC

SEC CIK
0001224962
Latest filing
Aug 14, 2026

Holdings in Q4 2024

Holdings as of Dec 31, 2024, filed Feb 14, 2025. Long positions only; changes compare share counts with Q3 2024.

Institution overview
Positions
97
−5 vs. Q3 2024
Portfolio value
$3.59B
−$1.07B (−23.0%) vs. Q3 2024
Filed
Feb 14, 2025
SEC
Holdings of Perceptive Advisors LLC in Q4 2024
SecurityClassSharesValue% of portfolioShare changeActionHistory
VRNAVerona Pharma plcSPONSORED ADS6,392,106$296.8M8.3%+76,173+1.2%AddedHistory
ACLXArcellx, Inc.COMMON STOCK3,478,888$266.8M7.4%−409,781−10.5%ReducedHistory
FOLDAmicus Therapeutics, Inc.COM24,245,952$228.4M6.4%−3,811,504−13.6%ReducedHistory
RYTMRhythm Pharmaceuticals, Inc.COM3,680,473$206.0M5.7%+120,259+3.4%AddedHistory
NUVLNuvalent, Inc.COM2,619,977$205.1M5.7%−359,258−12.1%ReducedHistory
IOVAIovance Biotherapeutics, Inc.COM22,112,266$163.6M4.6%−4,505,443−16.9%ReducedHistory
PCVXVaxcyte, Inc.COM1,718,417$140.7M3.9%−309,191−15.2%ReducedHistory
ITCIIntra-Cellular Therapies, Inc.COM1,288,328$107.6M3.0%−333,887−20.6%ReducedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS6,349,220$106.3M3.0%+66,930+1.1%AddedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW1,329,735$102.3M2.9%+165,700+14.2%AddedHistory
AORTArtivion, Inc.COM2,793,703$79.9M2.2%00.0%UnchangedHistory
MGTXMeiraGTx Holdings plcCOM12,581,103$76.6M2.1%00.0%UnchangedHistory
EWTXEdgewise Therapeutics, Inc.COM2,685,537$71.7M2.0%+355,243+15.2%AddedHistory
SLNOSoleno Therapeutics IncCOM1,501,040$67.5M1.9%−1,703,936−53.2%ReducedHistory
IMTXImmatics N.V.SHS9,383,456$66.7M1.9%+1,297,297+16.0%AddedHistory
PODDInsulet CorpStock232,269$60.6M1.7%+90,000+63.3%AddedHistory
SYRESpyre Therapeutics, Inc.COM NEW2,574,723$59.9M1.7%−297,824−10.4%ReducedHistory
ATXSAstria Therapeutics, Inc.COM6,485,420$58.0M1.6%00.0%UnchangedHistory
EOLSEvolus, Inc.COM5,145,846$56.8M1.6%−210,776−3.9%ReducedHistory
AXSMAxsome Therapeutics, Inc.COM664,074$56.2M1.6%−118,770−15.2%ReducedHistory
CRGXCARGO Therapeutics, Inc.COM3,683,004$53.1M1.5%00.0%UnchangedHistory
IMVTImmunovant, Inc.COM2,139,199$53.0M1.5%−239,563−10.1%ReducedHistory
PTGXProtagonist Therapeutics, IncCOM1,271,662$49.1M1.4%−102,901−7.5%ReducedHistory
APGEApogee Therapeutics, Inc.COM1,047,232$47.4M1.3%−967,775−48.0%ReducedHistory
ALDXAldeyra Therapeutics, Inc.COM9,275,851$46.3M1.3%00.0%UnchangedHistory
JANXJanux Therapeutics, Inc.COM817,895$43.8M1.2%+817,895NewHistory
ARGXArgenx SESPONSORED ADR67,471$41.5M1.2%−51,368−43.2%ReducedHistory
VKTXViking Therapeutics, Inc.COM995,894$40.1M1.1%−704,093−41.4%ReducedHistory
AKROAkero Therapeutics, Inc.COM1,185,592$33.0M0.9%−529,214−30.9%ReducedHistory
ISRGIntuitive Surgical IncCOM NEW63,119$32.9M0.9%+5,000+8.6%AddedHistory
ACRVAcrivon Therapeutics, Inc.COMMON STOCK5,360,858$32.3M0.9%00.0%UnchangedHistory
ZYMEZymeworks Inc.COM2,130,020$31.2M0.9%−50,000−2.3%ReducedHistory
CELCCelcuity Inc.COM2,362,279$30.9M0.9%00.0%UnchangedHistory
VRDNViridian Therapeutics, Inc.COM1,486,508$28.5M0.8%−1,326,157−47.1%ReducedHistory
SLDBSolid Biosciences Inc.COM NEW6,906,646$27.6M0.8%00.0%UnchangedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM6,774,348$25.6M0.7%+4,648,699+218.7%AddedHistory
PRCTPROCEPT BioRobotics CorpCOM290,659$23.4M0.7%−25,000−7.9%ReducedHistory
NAUTNautilus Biotechnology, Inc.COM12,594,211$21.2M0.6%00.0%UnchangedHistory
CTNMContineum Therapeutics, Inc.CL A1,441,249$21.1M0.6%−75,419−5.0%ReducedHistory
NTRANatera, Inc.COM125,000$19.8M0.6%−95,000−43.2%ReducedHistory
IKTInhibikase Therapeutics, Inc.COM NEW5,925,000$19.3M0.5%+5,925,000NewHistory
OBIOOrchestra BioMed Holdings, Inc.COM4,592,556$18.4M0.5%00.0%UnchangedHistory
PENPenumbra IncCOM73,338$17.4M0.5%+73,338NewHistory
SEPNSepterna, Inc.COM750,000$17.2M0.5%+750,000NewHistory
ORKAOruka Therapeutics, Inc.COM845,567$16.4M0.5%−389,620−31.5%ReducedHistory
INBXInhibrx Biosciences, Inc.COM1,064,026$16.4M0.5%00.0%UnchangedHistory
ADMAAdma Biologics, Inc.COM890,280$15.3M0.4%−169,920−16.0%ReducedHistory
DRUGBright Minds Biosciences Inc.COM NEW403,649$14.5M0.4%+403,649NewHistory
ARVNArvinas, Inc.COM740,749$14.2M0.4%−287,000−27.9%ReducedHistory
NBIXNeurocrine Biosciences IncStock100,050$13.7M0.4%−112,178−52.9%ReducedHistory
DYNDyne Therapeutics, Inc.COM543,277$12.8M0.4%−174,867−24.3%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM325,324$12.8M0.4%−199,606−38.0%ReducedHistory
MRUSMerus N.V.COM300,000$12.6M0.4%00.0%UnchangedHistory
CGONCG Oncology, Inc.COM419,450$12.0M0.3%−314,245−42.8%ReducedHistory
AVRAnteris Technologies Global Corp.COM2,140,000$11.9M0.3%+2,140,000NewHistory
EYPTEyePoint, Inc.COM NEW1,537,274$11.5M0.3%+500,000+48.2%AddedHistory
EWEdwards Lifesciences CorpStock145,000$10.7M0.3%+145,000NewHistory
TARSTarsus Pharmaceuticals, Inc.COM186,662$10.3M0.3%−1,109,754−85.6%ReducedHistory
ADGMAdagio Medical Holdings, Inc.COM9,812,419$10.3M0.3%00.0%UnchangedHistory
INSMINSMED IncCOM PAR $.01144,000$9.94M0.3%−36,000−20.0%ReducedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM184,525$9.43M0.3%−540,173−74.5%ReducedHistory
RAPTRAPT Therapeutics, Inc.COM5,880,000$9.29M0.3%+5,880,000NewHistory
OCULOcular Therapeutix, IncCOM1,078,495$9.21M0.3%−2,245,973−67.6%ReducedHistory
NARIInari Medical, Inc.Stock178,797$9.13M0.3%+178,797NewHistory
OKUROnKure Therapeutics, Inc.COM CL A1,004,439$8.64M0.2%+1,004,439NewHistory
NRIXNurix Therapeutics, Inc.COM330,614$6.23M0.2%+330,614NewHistory
ZBIOZenas BioPharma, Inc.COM744,035$6.09M0.2%−400,000−35.0%ReducedHistory
IRTCiRhythm Holdings, Inc.COM65,153$5.87M0.2%+42,562+188.4%AddedHistory
RAPPRapport Therapeutics, Inc.COM311,551$5.53M0.2%−436,632−58.4%ReducedHistory
BBOTBridgeBio Oncology Therapeutics, Inc.CL A ORD SHS500,000$5.25M0.1%00.0%UnchangedHistory
RCKTRocket Pharmaceuticals, Inc.COM378,584$4.76M0.1%−553,267−59.4%ReducedHistory
CBLLCeribell, Inc.COM180,546$4.67M0.1%+180,546NewHistory
VERUVeru Inc.COM6,483,157$4.22M0.1%−800,000−11.0%ReducedHistory
MREOMereo BioPharma Group plcSPON ADS1,085,512$3.80M0.1%+269,790+33.1%AddedHistory
CATXPerspective Therapeutics, Inc.COM NEW1,190,263$3.80M0.1%+1,190,263NewHistory
LCTXLineage Cell Therapeutics, Inc.COM7,236,843$3.64M0.1%+7,236,843NewHistory
BDSXBiodesix IncCOM2,173,880$3.33M0.1%00.0%UnchangedHistory
LONALeonaBio, Inc.COM5,402,964$3.17M0.1%00.0%UnchangedHistory
PEPGPepGen Inc.COM829,536$3.14M0.1%−580,902−41.2%ReducedHistory
IBRXImmunityBio, Inc.COM1,221,734$3.13M0.1%+1,221,734NewHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS197,108$2.76M0.1%−58,886−23.0%ReducedHistory
LYRALyra Therapeutics, Inc.COM12,757,562$2.63M0.1%00.0%UnchangedHistory
VRCAVerrica Pharmaceuticals Inc.COM3,249,669$2.27M0.1%−3,849,513−54.2%ReducedHistory
FBRXForte Biosciences, Inc.COM NEW95,742$2.17M0.1%00.0%UnchangedHistory
SCPHscPharmaceuticals Inc.COM500,000$1.77M<0.1%+500,000NewHistory
TRIBTrinity Biotech PLCSPONS ADR NEW1,790,000$1.58M<0.1%−10,000−0.6%ReducedHistory
TRAWTraws Pharma, Inc.COM NEW164,157$1.46M<0.1%+164,157NewHistory
FULCFulcrum Therapeutics, Inc.COM238,000$1.12M<0.1%+238,000NewHistory
LXEOLexeo Therapeutics, Inc.COM139,835$920.1K<0.1%00.0%UnchangedHistory
NBTXNanobiotix S.A.SPONSORED ADS266,093$763.7K<0.1%−288,973−52.1%ReducedHistory
APLTApplied Therapeutics, Inc.COM860,000$736.3K<0.1%−7,145,000−89.3%ReducedHistory
ENSCEnsysce Biosciences, Inc.COM NEW86,666$705.5K<0.1%+86,666NewHistory
DCTHDelcath Systems, Inc.COM NEW50,000$602.0K<0.1%+50,000NewHistory
PYXSPyxis Oncology, Inc.COMMON STOCK188,462$294.0K<0.1%−320,000−62.9%ReducedHistory
APYXApyx Medical CorpCOM150,000$237.0K<0.1%+150,000NewHistory
RVMDWRevolution Medicines, Inc.*W EXP 12/17/202250,000$45.0K<0.1%00.0%UnchangedHistory
Surrozen, Inc.86889P117*W EXP 08/01/203166,666$3.57K<0.1%00.0%Unchanged–

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Perceptive Advisors LLC in Q4 2024
SecurityClassPutsCalls
PRAXPraxis Precision Medicines, Inc.COM NEW–$38.5M
NVAXNovavax IncCOM NEW$804.0K–

Sold out since Q3 2024 (26)

Positions held at the end of Q3 2024 that are gone from this filing.

Positions of Perceptive Advisors LLC sold out since Q3 2024
SecurityClassShares in Q3 2024Value in Q3 2024% of portfolio in Q3 2024History
BHVNBiohaven Ltd.COM1,485,232$74.2M1.6%History
TILInstil Bio, Inc.COM NEW345,545$23.3M0.5%History
LIVNLivaNova PLCSHS429,000$22.5M0.5%History
SWTXSpringWorks Therapeutics, Inc.COM692,263$22.2M0.5%History
MDTMedtronic plcStock245,332$22.1M0.5%History
IRONDisc Medicine, Inc.COM387,017$19.0M0.4%History
ICLRIcon PLCCOM44,353$12.7M0.3%History
ARQTArcutis Biotherapeutics, Inc.COM1,358,500$12.6M0.3%History
TYRATyra Biosciences, Inc.COM511,226$12.0M0.3%History
XNCRXencor IncCOM527,671$10.6M0.2%History
ROIVRoivant Sciences Ltd.SHS847,745$9.78M0.2%History
AVBPArriVent BioPharma, Inc.COM415,000$9.75M0.2%History
EXASExact Sciences CorpCOM125,000$8.52M0.2%History
ALLOAllogene Therapeutics, Inc.COM2,725,000$7.63M0.2%History
DTILPrecision Biosciences IncCOM NEW426,293$3.82M0.1%History
ABSIAbsci CorpCOM700,000$2.67M0.1%History
XFORX4 Pharmaceuticals, IncCOM3,545,454$2.37M0.1%History
NVNOenVVeno Medical CorpCOMMON STOCK694,315$2.33M0.1%History
KYMRKymera Therapeutics, Inc.COM46,213$2.19M<0.1%History
GPCRStructure Therapeutics Inc.SPONSORED ADS34,852$1.53M<0.1%History
FATEFate Therapeutics IncCOM345,575$1.21M<0.1%History
OMICSingular Genomics Systems, Inc.COM NEW50,896$797.5K<0.1%History
KYTXKyverna Therapeutics, Inc.COM150,000$733.5K<0.1%History
SYRSSyros Pharmaceuticals, Inc.COM NEW116,754$251.0K<0.1%History
CMAXCareMax, Inc.COMM STK100,000$170.0K<0.1%History
CareMax, Inc.14171W111*W EXP 06/08/20260,000$594<0.1%–