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Livermore
Livermore
ZHEN

Perceptive Advisors LLC

SEC CIK
0001224962
Latest filing
Aug 14, 2026

Holdings in Q4 2024

Holdings as of Dec 31, 2024, filed Feb 14, 2025. Long positions only; changes compare share counts with Q3 2024.

Institution overview
Positions
97
−5 vs. Q3 2024
Portfolio value
$3.59B
−$1.07B (−23.0%) vs. Q3 2024
Filed
Feb 14, 2025
SEC
Holdings of Perceptive Advisors LLC in Q4 2024
SecurityClassSharesValue% of portfolioShare changeActionHistory
Surrozen, Inc.86889P117*W EXP 08/01/203166,666$3.57K<0.1%00.0%Unchanged–
RVMDWRevolution Medicines, Inc.*W EXP 12/17/202250,000$45.0K<0.1%00.0%UnchangedHistory
APYXApyx Medical CorpCOM150,000$237.0K<0.1%+150,000NewHistory
PYXSPyxis Oncology, Inc.COMMON STOCK188,462$294.0K<0.1%−320,000−62.9%ReducedHistory
DCTHDelcath Systems, Inc.COM NEW50,000$602.0K<0.1%+50,000NewHistory
ENSCEnsysce Biosciences, Inc.COM NEW86,666$705.5K<0.1%+86,666NewHistory
APLTApplied Therapeutics, Inc.COM860,000$736.3K<0.1%−7,145,000−89.3%ReducedHistory
NBTXNanobiotix S.A.SPONSORED ADS266,093$763.7K<0.1%−288,973−52.1%ReducedHistory
LXEOLexeo Therapeutics, Inc.COM139,835$920.1K<0.1%00.0%UnchangedHistory
FULCFulcrum Therapeutics, Inc.COM238,000$1.12M<0.1%+238,000NewHistory
TRAWTraws Pharma, Inc.COM NEW164,157$1.46M<0.1%+164,157NewHistory
TRIBTrinity Biotech PLCSPONS ADR NEW1,790,000$1.58M<0.1%−10,000−0.6%ReducedHistory
SCPHscPharmaceuticals Inc.COM500,000$1.77M<0.1%+500,000NewHistory
FBRXForte Biosciences, Inc.COM NEW95,742$2.17M0.1%00.0%UnchangedHistory
VRCAVerrica Pharmaceuticals Inc.COM3,249,669$2.27M0.1%−3,849,513−54.2%ReducedHistory
LYRALyra Therapeutics, Inc.COM12,757,562$2.63M0.1%00.0%UnchangedHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS197,108$2.76M0.1%−58,886−23.0%ReducedHistory
IBRXImmunityBio, Inc.COM1,221,734$3.13M0.1%+1,221,734NewHistory
PEPGPepGen Inc.COM829,536$3.14M0.1%−580,902−41.2%ReducedHistory
LONALeonaBio, Inc.COM5,402,964$3.17M0.1%00.0%UnchangedHistory
BDSXBiodesix IncCOM2,173,880$3.33M0.1%00.0%UnchangedHistory
LCTXLineage Cell Therapeutics, Inc.COM7,236,843$3.64M0.1%+7,236,843NewHistory
CATXPerspective Therapeutics, Inc.COM NEW1,190,263$3.80M0.1%+1,190,263NewHistory
MREOMereo BioPharma Group plcSPON ADS1,085,512$3.80M0.1%+269,790+33.1%AddedHistory
VERUVeru Inc.COM6,483,157$4.22M0.1%−800,000−11.0%ReducedHistory
CBLLCeribell, Inc.COM180,546$4.67M0.1%+180,546NewHistory
RCKTRocket Pharmaceuticals, Inc.COM378,584$4.76M0.1%−553,267−59.4%ReducedHistory
BBOTBridgeBio Oncology Therapeutics, Inc.CL A ORD SHS500,000$5.25M0.1%00.0%UnchangedHistory
RAPPRapport Therapeutics, Inc.COM311,551$5.53M0.2%−436,632−58.4%ReducedHistory
IRTCiRhythm Holdings, Inc.COM65,153$5.87M0.2%+42,562+188.4%AddedHistory
ZBIOZenas BioPharma, Inc.COM744,035$6.09M0.2%−400,000−35.0%ReducedHistory
NRIXNurix Therapeutics, Inc.COM330,614$6.23M0.2%+330,614NewHistory
OKUROnKure Therapeutics, Inc.COM CL A1,004,439$8.64M0.2%+1,004,439NewHistory
NARIInari Medical, Inc.Stock178,797$9.13M0.3%+178,797NewHistory
OCULOcular Therapeutix, IncCOM1,078,495$9.21M0.3%−2,245,973−67.6%ReducedHistory
RAPTRAPT Therapeutics, Inc.COM5,880,000$9.29M0.3%+5,880,000NewHistory
CRNXCrinetics Pharmaceuticals, Inc.COM184,525$9.43M0.3%−540,173−74.5%ReducedHistory
INSMINSMED IncCOM PAR $.01144,000$9.94M0.3%−36,000−20.0%ReducedHistory
ADGMAdagio Medical Holdings, Inc.COM9,812,419$10.3M0.3%00.0%UnchangedHistory
TARSTarsus Pharmaceuticals, Inc.COM186,662$10.3M0.3%−1,109,754−85.6%ReducedHistory
EWEdwards Lifesciences CorpStock145,000$10.7M0.3%+145,000NewHistory
EYPTEyePoint, Inc.COM NEW1,537,274$11.5M0.3%+500,000+48.2%AddedHistory
AVRAnteris Technologies Global Corp.COM2,140,000$11.9M0.3%+2,140,000NewHistory
CGONCG Oncology, Inc.COM419,450$12.0M0.3%−314,245−42.8%ReducedHistory
MRUSMerus N.V.COM300,000$12.6M0.4%00.0%UnchangedHistory
XENEXenon Pharmaceuticals Inc.COM325,324$12.8M0.4%−199,606−38.0%ReducedHistory
DYNDyne Therapeutics, Inc.COM543,277$12.8M0.4%−174,867−24.3%ReducedHistory
NBIXNeurocrine Biosciences IncStock100,050$13.7M0.4%−112,178−52.9%ReducedHistory
ARVNArvinas, Inc.COM740,749$14.2M0.4%−287,000−27.9%ReducedHistory
DRUGBright Minds Biosciences Inc.COM NEW403,649$14.5M0.4%+403,649NewHistory
ADMAAdma Biologics, Inc.COM890,280$15.3M0.4%−169,920−16.0%ReducedHistory
INBXInhibrx Biosciences, Inc.COM1,064,026$16.4M0.5%00.0%UnchangedHistory
ORKAOruka Therapeutics, Inc.COM845,567$16.4M0.5%−389,620−31.5%ReducedHistory
SEPNSepterna, Inc.COM750,000$17.2M0.5%+750,000NewHistory
PENPenumbra IncCOM73,338$17.4M0.5%+73,338NewHistory
OBIOOrchestra BioMed Holdings, Inc.COM4,592,556$18.4M0.5%00.0%UnchangedHistory
IKTInhibikase Therapeutics, Inc.COM NEW5,925,000$19.3M0.5%+5,925,000NewHistory
NTRANatera, Inc.COM125,000$19.8M0.6%−95,000−43.2%ReducedHistory
CTNMContineum Therapeutics, Inc.CL A1,441,249$21.1M0.6%−75,419−5.0%ReducedHistory
NAUTNautilus Biotechnology, Inc.COM12,594,211$21.2M0.6%00.0%UnchangedHistory
PRCTPROCEPT BioRobotics CorpCOM290,659$23.4M0.7%−25,000−7.9%ReducedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM6,774,348$25.6M0.7%+4,648,699+218.7%AddedHistory
SLDBSolid Biosciences Inc.COM NEW6,906,646$27.6M0.8%00.0%UnchangedHistory
VRDNViridian Therapeutics, Inc.COM1,486,508$28.5M0.8%−1,326,157−47.1%ReducedHistory
CELCCelcuity Inc.COM2,362,279$30.9M0.9%00.0%UnchangedHistory
ZYMEZymeworks Inc.COM2,130,020$31.2M0.9%−50,000−2.3%ReducedHistory
ACRVAcrivon Therapeutics, Inc.COMMON STOCK5,360,858$32.3M0.9%00.0%UnchangedHistory
ISRGIntuitive Surgical IncCOM NEW63,119$32.9M0.9%+5,000+8.6%AddedHistory
AKROAkero Therapeutics, Inc.COM1,185,592$33.0M0.9%−529,214−30.9%ReducedHistory
VKTXViking Therapeutics, Inc.COM995,894$40.1M1.1%−704,093−41.4%ReducedHistory
ARGXArgenx SESPONSORED ADR67,471$41.5M1.2%−51,368−43.2%ReducedHistory
JANXJanux Therapeutics, Inc.COM817,895$43.8M1.2%+817,895NewHistory
ALDXAldeyra Therapeutics, Inc.COM9,275,851$46.3M1.3%00.0%UnchangedHistory
APGEApogee Therapeutics, Inc.COM1,047,232$47.4M1.3%−967,775−48.0%ReducedHistory
PTGXProtagonist Therapeutics, IncCOM1,271,662$49.1M1.4%−102,901−7.5%ReducedHistory
IMVTImmunovant, Inc.COM2,139,199$53.0M1.5%−239,563−10.1%ReducedHistory
CRGXCARGO Therapeutics, Inc.COM3,683,004$53.1M1.5%00.0%UnchangedHistory
AXSMAxsome Therapeutics, Inc.COM664,074$56.2M1.6%−118,770−15.2%ReducedHistory
EOLSEvolus, Inc.COM5,145,846$56.8M1.6%−210,776−3.9%ReducedHistory
ATXSAstria Therapeutics, Inc.COM6,485,420$58.0M1.6%00.0%UnchangedHistory
SYRESpyre Therapeutics, Inc.COM NEW2,574,723$59.9M1.7%−297,824−10.4%ReducedHistory
PODDInsulet CorpStock232,269$60.6M1.7%+90,000+63.3%AddedHistory
IMTXImmatics N.V.SHS9,383,456$66.7M1.9%+1,297,297+16.0%AddedHistory
SLNOSoleno Therapeutics IncCOM1,501,040$67.5M1.9%−1,703,936−53.2%ReducedHistory
EWTXEdgewise Therapeutics, Inc.COM2,685,537$71.7M2.0%+355,243+15.2%AddedHistory
MGTXMeiraGTx Holdings plcCOM12,581,103$76.6M2.1%00.0%UnchangedHistory
AORTArtivion, Inc.COM2,793,703$79.9M2.2%00.0%UnchangedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW1,329,735$102.3M2.9%+165,700+14.2%AddedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS6,349,220$106.3M3.0%+66,930+1.1%AddedHistory
ITCIIntra-Cellular Therapies, Inc.COM1,288,328$107.6M3.0%−333,887−20.6%ReducedHistory
PCVXVaxcyte, Inc.COM1,718,417$140.7M3.9%−309,191−15.2%ReducedHistory
IOVAIovance Biotherapeutics, Inc.COM22,112,266$163.6M4.6%−4,505,443−16.9%ReducedHistory
NUVLNuvalent, Inc.COM2,619,977$205.1M5.7%−359,258−12.1%ReducedHistory
RYTMRhythm Pharmaceuticals, Inc.COM3,680,473$206.0M5.7%+120,259+3.4%AddedHistory
FOLDAmicus Therapeutics, Inc.COM24,245,952$228.4M6.4%−3,811,504−13.6%ReducedHistory
ACLXArcellx, Inc.COMMON STOCK3,478,888$266.8M7.4%−409,781−10.5%ReducedHistory
VRNAVerona Pharma plcSPONSORED ADS6,392,106$296.8M8.3%+76,173+1.2%AddedHistory

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Perceptive Advisors LLC in Q4 2024
SecurityClassPutsCalls
PRAXPraxis Precision Medicines, Inc.COM NEW–$38.5M
NVAXNovavax IncCOM NEW$804.0K–

Sold out since Q3 2024 (26)

Positions held at the end of Q3 2024 that are gone from this filing.

Positions of Perceptive Advisors LLC sold out since Q3 2024
SecurityClassShares in Q3 2024Value in Q3 2024% of portfolio in Q3 2024History
BHVNBiohaven Ltd.COM1,485,232$74.2M1.6%History
TILInstil Bio, Inc.COM NEW345,545$23.3M0.5%History
LIVNLivaNova PLCSHS429,000$22.5M0.5%History
SWTXSpringWorks Therapeutics, Inc.COM692,263$22.2M0.5%History
MDTMedtronic plcStock245,332$22.1M0.5%History
IRONDisc Medicine, Inc.COM387,017$19.0M0.4%History
ICLRIcon PLCCOM44,353$12.7M0.3%History
ARQTArcutis Biotherapeutics, Inc.COM1,358,500$12.6M0.3%History
TYRATyra Biosciences, Inc.COM511,226$12.0M0.3%History
XNCRXencor IncCOM527,671$10.6M0.2%History
ROIVRoivant Sciences Ltd.SHS847,745$9.78M0.2%History
AVBPArriVent BioPharma, Inc.COM415,000$9.75M0.2%History
EXASExact Sciences CorpCOM125,000$8.52M0.2%History
ALLOAllogene Therapeutics, Inc.COM2,725,000$7.63M0.2%History
DTILPrecision Biosciences IncCOM NEW426,293$3.82M0.1%History
ABSIAbsci CorpCOM700,000$2.67M0.1%History
XFORX4 Pharmaceuticals, IncCOM3,545,454$2.37M0.1%History
NVNOenVVeno Medical CorpCOMMON STOCK694,315$2.33M0.1%History
KYMRKymera Therapeutics, Inc.COM46,213$2.19M<0.1%History
GPCRStructure Therapeutics Inc.SPONSORED ADS34,852$1.53M<0.1%History
FATEFate Therapeutics IncCOM345,575$1.21M<0.1%History
OMICSingular Genomics Systems, Inc.COM NEW50,896$797.5K<0.1%History
KYTXKyverna Therapeutics, Inc.COM150,000$733.5K<0.1%History
SYRSSyros Pharmaceuticals, Inc.COM NEW116,754$251.0K<0.1%History
CMAXCareMax, Inc.COMM STK100,000$170.0K<0.1%History
CareMax, Inc.14171W111*W EXP 06/08/20260,000$594<0.1%–