Perceptive Advisors LLC
- SEC CIK
- 0001224962
- Latest filing
- Aug 14, 2026
Holdings in Q3 2025
Holdings as of Sep 30, 2025, filed Nov 14, 2025. Long positions only; changes compare share counts with Q2 2025.
- Positions
- 91
- +9 vs. Q2 2025
- Portfolio value
- $3.46B
- +$796.1M (+29.9%) vs. Q2 2025
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| Surrozen, Inc.86889P117 | *W EXP 08/01/203 | 166,666 | $2.97K | <0.1% | 00.0% | Unchanged | – |
| RVMDWRevolution Medicines, Inc. | *W EXP 12/17/202 | 250,000 | $75.0K | <0.1% | 00.0% | Unchanged | History |
| ENSCEnsysce Biosciences, Inc. | COM NEW | 86,666 | $205.4K | <0.1% | 00.0% | Unchanged | History |
| APYXApyx Medical Corp | COM | 150,000 | $321.0K | <0.1% | 00.0% | Unchanged | History |
| ANROAlto Neuroscience, Inc. | COM SHS | 155,366 | $624.6K | <0.1% | +155,366 | New | History |
| BDSXBiodesix Inc | COM | 108,694 | $820.6K | <0.1% | 00.0% | UnchangedConverted for a 1-for-20 split | History |
| LXEOLexeo Therapeutics, Inc. | COM | 139,835 | $928.5K | <0.1% | 00.0% | Unchanged | History |
| QUREuniQure N.V. | SHS | 20,000 | $1.17M | <0.1% | +20,000 | New | History |
| LYRALyra Therapeutics, Inc. | COM NEW | 229,382 | $1.50M | <0.1% | −25,768−10.1% | Reduced | History |
| NVNOenVVeno Medical Corp | COMMON STOCK | 1,759,035 | $1.59M | <0.1% | +474,069+36.9% | Added | History |
| AVTXAvalo Therapeutics, Inc. | COM NEW | 139,667 | $1.78M | 0.1% | 00.0% | Unchanged | History |
| TRIBTrinity Biotech PLC | SPONS ADR NEW | 1,790,000 | $1.86M | 0.1% | 00.0% | Unchanged | History |
| LONALeonaBio, Inc. | COM | 540,296 | $2.24M | 0.1% | 00.0% | UnchangedConverted for a 1-for-10 split | History |
| PYXSPyxis Oncology, Inc. | COMMON STOCK | 1,178,307 | $2.62M | 0.1% | +1,178,307 | New | History |
| VKTXViking Therapeutics, Inc. | COM | 105,597 | $2.78M | 0.1% | −275,103−72.3% | Reduced | History |
| SCPHscPharmaceuticals Inc. | COM | 583,142 | $3.31M | 0.1% | +83,142+16.6% | Added | History |
| BLTEBelite Bio, Inc | SPONSORED ADS | 49,788 | $3.68M | 0.1% | +49,788 | New | History |
| PEPGPepGen Inc. | COM | 829,870 | $3.83M | 0.1% | +829,870 | New | History |
| RAPTRAPT Therapeutics, Inc. | COM NEW | 183,890 | $4.74M | 0.1% | 00.0% | Unchanged | History |
| HTFLHeartflow, Inc. | COM | 150,000 | $5.05M | 0.1% | +150,000 | New | History |
| CBIOCrescent Biopharma, Inc. | COM | 453,686 | $5.39M | 0.2% | 00.0% | Unchanged | History |
| BBNXBeta Bionics, Inc. | COM | 277,944 | $5.52M | 0.2% | −1,315,664−82.6% | Reduced | History |
| KRYSKrystal Biotech, Inc. | COM | 35,000 | $6.18M | 0.2% | +35,000 | New | History |
| DYNDyne Therapeutics, Inc. | COM | 540,444 | $6.84M | 0.2% | −1,706,946−76.0% | Reduced | History |
| TEMTempus AI, Inc. | CL A | 85,000 | $6.86M | 0.2% | +85,000 | New | History |
| IRDOpus Genetics, Inc. | COM | 4,325,000 | $7.14M | 0.2% | 00.0% | Unchanged | History |
| JANXJanux Therapeutics, Inc. | COM | 292,686 | $7.15M | 0.2% | 00.0% | Unchanged | History |
| AVRAnteris Technologies Global Corp. | COM | 1,705,130 | $7.67M | 0.2% | 00.0% | Unchanged | History |
| XENEXenon Pharmaceuticals Inc. | COM | 200,791 | $8.06M | 0.2% | 00.0% | Unchanged | History |
| CTNMContineum Therapeutics, Inc. | CL A | 714,592 | $8.40M | 0.2% | +15,106+2.2% | Added | History |
| Celcuity Inc.15102KAA8 | NOTE 2.750% 8/0 | – | $8.72M | 0.3% | – | New | – |
| IKTInhibikase Therapeutics, Inc. | COM NEW | 5,421,568 | $8.78M | 0.3% | −10,725−0.2% | Reduced | History |
| KYMRKymera Therapeutics, Inc. | COM | 169,796 | $9.61M | 0.3% | −40,310−19.2% | Reduced | History |
| GOSSGossamer Bio, Inc. | COM | 3,812,797 | $10.0M | 0.3% | +3,812,797 | New | History |
| SEPNSepterna, Inc. | COM | 541,450 | $10.2M | 0.3% | 00.0% | Unchanged | History |
| KODKodiak Sciences Inc. | COM | 634,577 | $10.4M | 0.3% | +634,577 | New | History |
| CRVSCorvus Pharmaceuticals, Inc. | COM | 1,438,595 | $10.6M | 0.3% | 00.0% | Unchanged | History |
| NAUTNautilus Biotechnology, Inc. | COM | 12,594,211 | $10.6M | 0.3% | 00.0% | Unchanged | History |
| OMOutset Medical, Inc. | COM NEW | 833,333 | $11.8M | 0.3% | 00.0% | Unchanged | History |
| RAPPRapport Therapeutics, Inc. | COM | 403,923 | $12.0M | 0.3% | +403,923 | New | History |
| NRIXNurix Therapeutics, Inc. | COM | 1,416,149 | $13.1M | 0.4% | +319,164+29.1% | Added | History |
| OBIOOrchestra BioMed Holdings, Inc. | COM | 5,292,556 | $13.1M | 0.4% | +700,000+15.2% | Added | History |
| ENGNenGene Therapeutics Inc. | COM | 2,097,236 | $14.3M | 0.4% | +2,097,236 | New | History |
| ADMAAdma Biologics, Inc. | COM | 1,153,468 | $16.9M | 0.5% | −150,000−11.5% | Reduced | History |
| AXSMAxsome Therapeutics, Inc. | COM | 148,900 | $18.1M | 0.5% | −49,634−25.0% | Reduced | History |
| ADGMAdagio Medical Holdings, Inc. | COM | 9,876,576 | $19.2M | 0.6% | 00.0% | Unchanged | History |
| SYRESpyre Therapeutics, Inc. | COM NEW | 1,229,445 | $20.6M | 0.6% | −300,000−19.6% | Reduced | History |
| AQSTAquestive Therapeutics, Inc. | COM | 3,760,099 | $21.0M | 0.6% | +1,569,679+71.7% | Added | History |
| IRTCiRhythm Holdings, Inc. | COM | 123,000 | $21.2M | 0.6% | +123,000 | New | History |
| ISRGIntuitive Surgical Inc | COM NEW | 52,119 | $23.3M | 0.7% | +7,000+15.5% | Added | History |
| ORKAOruka Therapeutics, Inc. | COM | 1,268,021 | $24.4M | 0.7% | +1,268,021 | New | History |
| PVLAPalvella Therapeutics, Inc. | COM | 395,093 | $24.8M | 0.7% | +395,093 | New | History |
| EXASExact Sciences Corp | COM | 465,487 | $25.5M | 0.7% | +465,487 | New | History |
| IMVTImmunovant, Inc. | COM | 1,587,890 | $25.6M | 0.7% | −550,000−25.7% | Reduced | History |
| DRUGBright Minds Biosciences Inc. | COM NEW | 449,290 | $27.3M | 0.8% | +28,600+6.8% | Added | History |
| ALDXAldeyra Therapeutics, Inc. | COM | 5,222,311 | $27.3M | 0.8% | +1,170,680+28.9% | Added | History |
| BSXBoston Scientific Corp | Stock | 310,000 | $30.3M | 0.9% | +30,000+10.7% | Added | History |
| CTMXCytomX Therapeutics, Inc. | COM | 9,680,185 | $30.9M | 0.9% | +2,686,539+38.4% | Added | History |
| VRDNViridian Therapeutics, Inc. | COM | 1,462,400 | $31.6M | 0.9% | +1,014,893+226.8% | Added | History |
| ABVXAbivax S.A. | SPONSORED ADS | 388,608 | $33.0M | 1.0% | +388,608 | New | History |
| CAICaris Life Sciences, Inc. | COM | 1,098,163 | $33.2M | 1.0% | 00.0% | Unchanged | History |
| SIONSionna Therapeutics, Inc. | COM | 1,179,098 | $34.7M | 1.0% | −36,947−3.0% | Reduced | History |
| ZYMEZymeworks Inc. | COM | 2,090,663 | $35.7M | 1.0% | +815,389+63.9% | Added | History |
| RGENRepligen Corp | COM | 270,428 | $36.1M | 1.0% | +104,428+62.9% | Added | History |
| INBXInhibrx Biosciences, Inc. | COM | 1,327,707 | $44.7M | 1.3% | +349,815+35.8% | Added | History |
| ATXSAstria Therapeutics, Inc. | COM | 6,485,420 | $47.2M | 1.4% | 00.0% | Unchanged | History |
| FOLDAmicus Therapeutics, Inc. | COM | 6,370,851 | $50.2M | 1.5% | −1,041,979−14.1% | Reduced | History |
| OMDAOmada Health, Inc. | COM | 2,396,330 | $53.0M | 1.5% | −30,000−1.2% | Reduced | History |
| APGEApogee Therapeutics, Inc. | COM | 1,351,989 | $53.7M | 1.6% | +169,841+14.4% | Added | History |
| AKROAkero Therapeutics, Inc. | COM | 1,135,766 | $53.9M | 1.6% | +219,879+24.0% | Added | History |
| PENPenumbra Inc | COM | 220,547 | $55.9M | 1.6% | +187,750+572.5% | Added | History |
| VRNAVerona Pharma plc | SPONSORED ADS | 524,088 | $55.9M | 1.6% | −4,983,503−90.5% | Reduced | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 3,795,894 | $61.6M | 1.8% | −844,055−18.2% | Reduced | History |
| NBIXNeurocrine Biosciences Inc | Stock | 450,050 | $63.2M | 1.8% | +195,000+76.5% | Added | History |
| PTGXProtagonist Therapeutics, Inc | COM | 1,030,134 | $68.4M | 2.0% | −44,314−4.1% | Reduced | History |
| SLDBSolid Biosciences Inc. | COM NEW | 11,833,539 | $73.0M | 2.1% | −73,107−0.6% | Reduced | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 3,100,902 | $75.2M | 2.2% | +1,953,967+170.4% | Added | History |
| IMTXImmatics N.V. | SHS | 9,383,456 | $79.9M | 2.3% | 00.0% | Unchanged | History |
| PRAXPraxis Precision Medicines, Inc. | COM NEW | 1,564,554 | $82.9M | 2.4% | +811,633+107.8% | Added | History |
| AORTArtivion, Inc. | COM | 2,020,000 | $85.5M | 2.5% | −773,703−27.7% | Reduced | History |
| TVTXTravere Therapeutics, Inc. | COM | 3,794,615 | $90.7M | 2.6% | +2,960,363+354.9% | Added | History |
| INSMINSMED Inc | COM PAR $.01 | 702,130 | $101.1M | 2.9% | +51,878+8.0% | Added | History |
| MGTXMeiraGTx Holdings plc | COM | 12,626,103 | $103.8M | 3.0% | 00.0% | Unchanged | History |
| ROIVRoivant Sciences Ltd. | SHS | 7,368,461 | $111.5M | 3.2% | +4,036,996+121.2% | Added | History |
| AMLXAmylyx Pharmaceuticals, Inc. | COM | 8,952,365 | $121.7M | 3.5% | +1,050,000+13.3% | Added | History |
| MRUSMerus N.V. | COM | 1,353,093 | $127.4M | 3.7% | +644,917+91.1% | Added | History |
| NUVLNuvalent, Inc. | COM | 1,562,336 | $135.1M | 3.9% | +187,156+13.6% | Added | History |
| CELCCelcuity Inc. | COM | 2,956,319 | $146.0M | 4.2% | +1,323,111+81.0% | Added | History |
| ACLXArcellx, Inc. | COMMON STOCK | 2,468,353 | $202.7M | 5.9% | −9,647−0.4% | Reduced | History |
| ASNDAscendis Pharma A/S | SPONSORED ADR | 1,088,501 | $216.4M | 6.3% | +124,615+12.9% | Added | History |
| RYTMRhythm Pharmaceuticals, Inc. | COM | 2,438,969 | $288.4M | 8.3% | +20,670+0.9% | Added | History |
Options (1)
Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.
| Security | Class | Puts | Calls |
|---|---|---|---|
| SPRYARS Pharmaceuticals, Inc. | COM | $2.01M | – |
Sold out since Q2 2025 (9)
Positions held at the end of Q2 2025 that are gone from this filing.
| Security | Class | Shares in Q2 2025 | Value in Q2 2025 | % of portfolio in Q2 2025 | History |
|---|---|---|---|---|---|
| SLNOSoleno Therapeutics Inc | COM | 430,439 | $36.1M | 1.4% | History |
| EOLSEvolus, Inc. | COM | 2,474,843 | $22.8M | 0.9% | History |
| PODDInsulet Corp | Stock | 60,387 | $19.0M | 0.7% | History |
| CRLCharles River Laboratories International, Inc. | COM | 100,000 | $15.2M | 0.6% | History |
| RAREUltragenyx Pharmaceutical Inc. | COM | 270,000 | $9.82M | 0.4% | History |
| GMEDGlobus Medical Inc | Stock | 88,500 | $5.22M | 0.2% | History |
| BBOTBridgeBio Oncology Therapeutics, Inc. | CL A ORD SHS | 398,000 | $4.23M | 0.2% | History |
| FBRXForte Biosciences, Inc. | COM NEW | 68,192 | $881.7K | <0.1% | History |
| KALAKALA BIO, Inc. | COMM STK | 55,227 | $262.9K | <0.1% | History |