| Baker Bros. Advisors LP | 17,019,294 | $4,204 萬 | 0.18% | – | – |
| BlackRock Inc. | 13,687,388 | $3,381 萬 | 0.00% | – | – |
| BVF Inc | 11,480,994 | $2,836 萬 | 1.06% | – | – |
| Consonance Capital Management LP | 11,201,412 | $2,767 萬 | 2.95% | – | – |
| Vanguard Group Inc | 8,854,196 | $2,187 萬 | 0.00% | – | – |
| State Street Corp | 2,813,752 | $695.0 萬 | 0.00% | – | – |
| Geode Capital Management, LLC | 2,743,112 | $677.5 萬 | 0.00% | – | – |
| Ikarian Capital, LLC | 2,694,394 | $665.5 萬 | 0.99% | – | – |
| Altium Capital Management LP | 2,573,222 | $635.6 萬 | 1.76% | – | – |
| Opaleye Management Inc. | 2,325,000 | $574.3 萬 | 0.84% | – | – |
| Acuta Capital Partners, LLC | 2,293,388 | $566.5 萬 | 2.04% | – | – |
| Two Sigma Investments, LP | 2,162,296 | $534.1 萬 | 0.02% | – | – |
| Two Sigma Advisers, LP | 2,115,600 | $522.6 萬 | 0.01% | – | – |
| Northern Trust Corp | 1,677,286 | $414.3 萬 | 0.00% | – | – |
| Silverarc Capital Management, LLC | 1,197,489 | $295.8 萬 | 1.66% | – | – |
| Dimensional Fund Advisors LP | 1,191,490 | $294.3 萬 | 0.00% | – | – |
| Renaissance Technologies LLC | 1,051,119 | $259.6 萬 | 0.00% | – | – |
| Panagora Asset Management Inc | 991,380 | $244.9 萬 | 0.01% | – | – |
| Jacobs Levy Equity Management, Inc | 927,107 | $229.0 萬 | 0.02% | – | – |
| D. E. Shaw & Co., Inc. | 841,203 | $207.8 萬 | 0.00% | – | – |
| Nuveen Asset Management, LLC | 698,855 | $172.6 萬 | 0.00% | – | – |
| Bank of New York Mellon Corp | 633,813 | $156.6 萬 | 0.00% | – | – |
| J. Goldman & Co LP | 576,565 | $142.4 萬 | 0.09% | – | – |
| Goldman Sachs Group Inc | 526,309 | $130.0 萬 | 0.00% | – | – |
| Charles Schwab Investment Management Inc | 433,589 | $107.1 萬 | 0.00% | – | – |
| JPMorgan Chase & Co | 366,902 | $90.7 萬 | 0.00% | – | – |
| Boothbay Fund Management, LLC | 361,838 | $89.4 萬 | 0.05% | – | – |
| California Public Employees Retirement System | 346,900 | $85.7 萬 | 0.00% | – | – |
| Boston Private Wealth LLC | 310,639 | $76.7 萬 | 0.01% | – | – |
| Alps Advisors Inc | 307,161 | $75.9 萬 | 0.01% | – | – |
| Stifel Financial Corp | 271,285 | $67.0 萬 | 0.00% | – | – |
| California State Teachers Retirement System | 257,254 | $63.5 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 253,168 | $62.5 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 237,000 | $58.5 萬 | 0.00% | – | – |
| Rhumbline Advisers | 201,234 | $49.7 萬 | 0.00% | – | – |
| Wells Fargo & Company | 194,302 | $48.1 萬 | 0.00% | – | – |
| IndexIQ Advisors LLC | 178,383 | $44.1 萬 | 0.02% | – | – |
| Russell Investments Group, Ltd. | 172,712 | $42.6 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 150,000 | $37.1 萬 | 0.00% | – | – |
| Barclays PLC | 143,628 | $35.5 萬 | 0.00% | – | – |
| Virtus ETF Advisers LLC | 132,300 | $32.7 萬 | 0.14% | – | – |
| Howland Capital Management LLC | 129,300 | $31.9 萬 | 0.02% | – | – |
| Deutsche Bank AG | 113,291 | $28.0 萬 | 0.00% | – | – |
| Manufacturers Life Insurance Company, The | 104,291 | $25.8 萬 | 0.00% | – | – |
| UBS Group AG | 104,030 | $25.7 萬 | 0.00% | – | – |
| Financial Engines Advisors L.L.C. | 100,000 | $24.7 萬 | 0.00% | – | – |
| Cordant, Inc. | 100,000 | $24.7 萬 | 0.16% | – | – |
| American International Group, Inc. | 99,433 | $24.6 萬 | 0.00% | – | – |
| Susquehanna International Group, LLP | 95,024 | $23.5 萬 | 0.00% | – | – |
| Personal Cfo Solutions, LLC | 88,141 | $21.8 萬 | 0.05% | – | – |
| Bank of America Corp | 80,679 | $19.9 萬 | 0.00% | – | – |
| Voya Investment Management LLC | 78,127 | $19.3 萬 | 0.00% | – | – |
| Los Angeles Capital Management LLC | 76,805 | $19.0 萬 | 0.00% | – | – |
| Cubist Systematic Strategies, LLC | 75,386 | $18.6 萬 | 0.00% | – | – |
| Telemetry Investments, L.L.C. | 75,000 | $18.5 萬 | 0.21% | – | – |
| Creative Planning | 71,047 | $17.5 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 69,083 | $17.1 萬 | 0.00% | – | – |
| Cambridge Investment Research Advisors, Inc. | 65,617 | $16.2 萬 | 0.00% | – | – |
| Principal Financial Group Inc | 63,343 | $15.6 萬 | 0.00% | – | – |
| Winton Group Ltd | 59,555 | $14.7 萬 | 0.01% | – | – |
| Raymond James & Associates | 55,175 | $13.6 萬 | 0.00% | – | – |
| BNP Paribas Arbitrage, SA | 53,626 | $13.2 萬 | 0.00% | – | – |
| Metropolitan Life Insurance Co | 52,876 | $13.1 萬 | 0.00% | – | – |
| Virtu Financial LLC | 49,990 | $12.3 萬 | 0.01% | – | – |
| Caption Management, LLC | 50,000 | $12.3 萬 | 0.02% | – | – |
| Invesco Ltd. | 47,919 | $11.8 萬 | 0.00% | – | – |
| State Board of Administration of Florida Retirement System | 45,909 | $11.3 萬 | 0.00% | – | – |
| ExodusPoint Capital Management, LP | 41,782 | $10.3 萬 | 0.00% | – | – |
| XTX Topco Ltd | 40,322 | $10.0 萬 | 0.05% | – | – |
| Morgan Stanley | 38,614 | $9.50 萬 | 0.00% | – | – |
| Public Employees Retirement System of Ohio | 36,500 | $9.00 萬 | 0.00% | – | – |
| Diversified Trust Co | 36,556 | $9.00 萬 | 0.00% | – | – |
| Commonwealth Equity Services, LLC | 36,050 | $8.90 萬 | 0.00% | – | – |
| Matisse Capital | 35,000 | $8.60 萬 | 0.02% | – | – |
| Aj Wealth Strategies, LLC | 34,166 | $8.40 萬 | 0.01% | – | – |
| Alliancebernstein L.P. | 31,700 | $7.80 萬 | 0.00% | – | – |
| McAdam, LLC | 31,054 | $7.70 萬 | 0.01% | – | – |
| Prudential Financial Inc | 30,286 | $7.50 萬 | 0.00% | – | – |
| Middleton & Co Inc | 30,000 | $7.40 萬 | 0.01% | – | – |
| Advisory Services Network, LLC | 30,075 | $7.40 萬 | 0.00% | – | – |
| Connor, Clark & Lunn Investment Management Ltd. | 28,804 | $7.10 萬 | 0.00% | – | – |
| Ameriprise Financial Inc | 28,570 | $7.00 萬 | 0.00% | – | – |
| Samalin Investment Counsel, LLC | 28,000 | $6.90 萬 | 0.05% | – | – |
| Kalos Management, Inc. | 25,250 | $6.80 萬 | 0.02% | – | – |
| SG Americas Securities, LLC | 25,942 | $6.40 萬 | 0.00% | – | – |
| Victory Capital Management Inc | 25,652 | $6.30 萬 | 0.00% | – | – |
| Advisor Group Holdings, Inc. | 25,388 | $6.30 萬 | 0.00% | – | – |
| Acadian Asset Management LLC | 25,207 | $6.20 萬 | 0.00% | – | – |
| Barrett Asset Management, LLC | 25,000 | $6.20 萬 | 0.00% | – | – |
| MetLife Investment Management | 24,110 | $5.96 萬 | 0.00% | – | – |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 24,023 | $5.90 萬 | 0.00% | – | – |
| Stratos Wealth Partners, LTD. | 24,000 | $5.90 萬 | 0.00% | – | – |
| HighTower Advisors, LLC | 23,514 | $5.70 萬 | 0.00% | – | – |
| Aries Wealth Management | 20,000 | $5.40 萬 | 0.02% | – | – |
| Bank of Montreal | 17,241 | $4.80 萬 | 0.00% | – | – |
| Amalgamated Bank | 19,186 | $4.70 萬 | 0.00% | – | – |
| Credit Suisse AG | 18,379 | $4.50 萬 | 0.00% | – | – |
| Parsons Capital Management Inc | 17,783 | $4.40 萬 | 0.00% | – | – |
| Beaumont Financial Partners, LLC | 18,000 | $4.40 萬 | 0.00% | – | – |
| Loring Wolcott & Coolidge Fiduciary Advisors LLP | 17,390 | $4.30 萬 | 0.00% | – | – |
