| Baker Bros. Advisors LP | 26,453,422 | $1.64 億 | 0.71% | – | – |
| Eversept Partners, LP | 16,896,796 | $1.05 億 | 8.60% | – | – |
| Grosvenor Holdings, L.L.C. | 6,790,071 | $4,217 萬 | 3.10% | – | – |
| Morgan Stanley | 6,339,079 | $3,937 萬 | 0.01% | – | – |
| Boxer Capital, LLC | 6,000,000 | $3,726 萬 | 1.26% | – | – |
| Avoro Capital Advisors LLC | 6,000,000 | $3,726 萬 | 0.64% | – | – |
| SCP Investment, LP | 5,500,000 | $3,416 萬 | 10.21% | – | – |
| Rock Springs Capital Management LP | 4,195,000 | $2,605 萬 | 0.57% | – | – |
| Clearbridge Investments, LLC | 4,084,039 | $2,536 萬 | 0.02% | – | – |
| Federated Hermes, Inc. | 3,500,000 | $2,174 萬 | 0.04% | – | – |
| BlackRock Inc. | 3,377,735 | $2,098 萬 | 0.00% | – | – |
| DG Capital Management, LLC | 3,177,146 | $1,973 萬 | 4.99% | – | – |
| Susquehanna International Group, LLP | 3,130,597 | $1,944 萬 | 0.03% | – | – |
| Millennium Management LLC | 3,081,848 | $1,914 萬 | 0.03% | – | – |
| Citadel Advisors LLC | 2,765,964 | $1,718 萬 | 0.02% | – | – |
| D. E. Shaw & Co., Inc. | 2,540,331 | $1,578 萬 | 0.02% | – | – |
| Oracle Investment Management Inc | 2,084,839 | $1,295 萬 | 1.94% | – | – |
| Renaissance Technologies LLC | 1,932,600 | $1,200 萬 | 0.01% | – | – |
| Pictet Asset Management Ltd | 1,757,999 | $1,092 萬 | 0.01% | – | – |
| BVF Inc | 1,715,981 | $1,066 萬 | 0.40% | – | – |
| Edgestream Partners, L.P. | 1,705,210 | $1,059 萬 | 0.59% | – | – |
| Fairmount Funds Management LLC | 1,608,237 | $998.7 萬 | 4.21% | – | – |
| Longitude (Cayman) Ltd. | 1,570,000 | $975.0 萬 | 5.67% | – | – |
| Ameriprise Financial Inc | 1,563,732 | $970.7 萬 | 0.00% | – | – |
| Point72 Asset Management, L.P. | 1,508,000 | $936.5 萬 | 0.05% | – | – |
| Agf Investments Inc. | 1,301,492 | $808.2 萬 | 0.06% | – | – |
| Sofinnova Investments, Inc. | 1,170,584 | $726.9 萬 | 0.46% | – | – |
| Private Advisor Group, LLC | 1,020,810 | $633.9 萬 | 0.06% | – | – |
| UBS Group AG | 806,775 | $501.0 萬 | 0.00% | – | – |
| California Public Employees Retirement System | 714,220 | $443.5 萬 | 0.00% | – | – |
| Resources Investment Advisors, LLC. | 700,245 | $434.9 萬 | 0.20% | – | – |
| Bank of America Corp | 663,846 | $412.3 萬 | 0.00% | – | – |
| Gratus Capital LLC | 661,005 | $410.5 萬 | 0.49% | – | – |
| Cutter & CO Brokerage, Inc. | 607,250 | $377.1 萬 | 0.92% | – | – |
| Goldman Sachs Group Inc | 505,243 | $313.8 萬 | 0.00% | – | – |
| Integral Health Asset Management, LLC | 500,000 | $310.5 萬 | 0.89% | – | – |
| Two Sigma Investments, LP | 402,026 | $249.7 萬 | 0.01% | – | – |
| Raymond James Financial Services Advisors, Inc. | 375,051 | $232.9 萬 | 0.01% | – | – |
| Quinn Opportunity Partners LLC | 363,000 | $225.4 萬 | 0.14% | – | – |
| Cubist Systematic Strategies, LLC | 361,033 | $224.2 萬 | 0.03% | – | – |
| LPL Financial LLC | 338,054 | $209.9 萬 | 0.00% | – | – |
| Van Eck Associates Corp | 326,799 | $202.9 萬 | 0.01% | – | – |
| Geode Capital Management, LLC | 302,116 | $187.6 萬 | 0.00% | – | – |
| Birchview Capital, LP | 300,000 | $186.3 萬 | 1.11% | – | – |
| Oregon Public Employees Retirement Fund | 281,225 | $174.6 萬 | 0.02% | – | – |
| Group One Trading, L.P. | 276,778 | $171.9 萬 | 0.04% | – | – |
| Apis Capital Advisors, LLC | 270,000 | $167.7 萬 | 1.52% | – | – |
| Monetta Financial Services Inc | 265,000 | $164.6 萬 | 1.30% | – | – |
| Wells Fargo & Company | 258,922 | $160.8 萬 | 0.00% | – | – |
| State Street Corp | 251,340 | $156.1 萬 | 0.00% | – | – |
| Spring Creek Investment Management, LLC | 222,974 | $138.5 萬 | 2.26% | – | – |
| Erste Asset Management GmbH | 198,000 | $126.1 萬 | 0.03% | – | – |
| Quantitative Investment Management, LLC | 198,867 | $123.4 萬 | 0.10% | – | – |
| Macquarie Group Ltd | 190,000 | $118.0 萬 | 0.00% | – | – |
| Deutsche Bank AG | 180,000 | $111.8 萬 | 0.00% | – | – |
| DCF Advisers, LLC | 177,000 | $109.9 萬 | 0.56% | – | – |
| Sabby Management, LLC | 169,136 | $105.0 萬 | 0.77% | – | – |
| Wolverine Trading, LLC | 157,957 | $100.6 萬 | 0.02% | – | – |
| Hayek Kallen Investment Management | 155,487 | $96.6 萬 | 0.44% | – | – |
| Avantax Advisory Services, Inc. | 148,915 | $92.4 萬 | 0.02% | – | – |
| Commonwealth Equity Services, LLC | 147,641 | $91.6 萬 | 0.00% | – | – |
| Financial Advocates Investment Management | 147,430 | $91.5 萬 | 0.07% | – | – |
| Price T Rowe Associates Inc | 146,238 | $90.8 萬 | 0.00% | – | – |
| DekaBank Deutsche Girozentrale | 144,600 | $90.4 萬 | 0.00% | – | – |
| Advisor Group Holdings, Inc. | 143,867 | $89.4 萬 | 0.00% | – | – |
| Northern Trust Corp | 140,448 | $87.2 萬 | 0.00% | – | – |
| Jump Financial, LLC | 136,591 | $84.8 萬 | 0.08% | – | – |
| Davenport & Co LLC | 132,190 | $82.1 萬 | 0.01% | – | – |
| Kornitzer Capital Management Inc | 119,250 | $74.1 萬 | 0.01% | – | – |
| Jane Street Group, LLC | 116,372 | $72.3 萬 | 0.00% | – | – |
| Geneos Wealth Management Inc. | 131,775 | $67.0 萬 | 0.02% | – | – |
| Checchi Capital Advisers, LLC | 104,785 | $65.1 萬 | 0.09% | – | – |
| Stratos Wealth Partners, LTD. | 104,202 | $64.7 萬 | 0.02% | – | – |
| Laurel Wealth Advisors, Inc. | 93,943 | $58.3 萬 | 0.09% | – | – |
| Squarepoint Ops LLC | 93,613 | $58.1 萬 | 0.01% | – | – |
| Williams Jones Wealth Management, LLC. | 91,450 | $56.8 萬 | 0.01% | – | – |
| NJ State Employees Deferred Compensation Plan | 88,000 | $54.7 萬 | 0.08% | – | – |
| JPMorgan Chase & Co | 74,678 | $46.4 萬 | 0.00% | – | – |
| IMC-Chicago, LLC | 73,649 | $45.7 萬 | 0.04% | – | – |
| Hudson Bay Capital Management LP | 65,000 | $40.4 萬 | 0.01% | – | – |
| Creative Planning | 64,837 | $40.3 萬 | 0.00% | – | – |
| Handelsbanken Fonder AB | 63,300 | $39.3 萬 | 0.00% | – | – |
| Kestra Advisory Services, LLC | 63,330 | $39.3 萬 | 0.00% | – | – |
| Barclays PLC | 62,967 | $39.1 萬 | 0.00% | – | – |
| Capital Advisors, Ltd. LLC | 59,985 | $37.3 萬 | 0.07% | – | – |
| Jefferies Group LLC | 57,644 | $35.8 萬 | 0.01% | – | – |
| Nomura Holdings Inc | 55,750 | $35.5 萬 | 0.00% | – | – |
| Quantitative Systematic Strategies LLC | 55,556 | $34.5 萬 | 0.05% | – | – |
| ProShare Advisors LLC | 53,707 | $33.4 萬 | 0.00% | – | – |
| Bridgefront Capital, LLC | 51,310 | $31.9 萬 | 0.10% | – | – |
| M&T Bank Corp | 51,165 | $31.8 萬 | 0.00% | – | – |
| Johnson Financial Group, Inc. | 50,500 | $31.4 萬 | 0.02% | – | – |
| Independent Financial Group, LLC | 48,417 | $30.1 萬 | 0.04% | – | – |
| Black Maple Capital Management LP | 47,000 | $29.2 萬 | 0.44% | – | – |
| Cambridge Investment Research Advisors, Inc. | 45,974 | $28.5 萬 | 0.00% | – | – |
| HighTower Advisors, LLC | 44,355 | $27.4 萬 | 0.00% | – | – |
| Royal Bank of Canada | 43,840 | $27.3 萬 | 0.00% | – | – |
| US Bancorp | 43,474 | $27.0 萬 | 0.00% | – | – |
| LCM Capital Management Inc | 41,360 | $25.7 萬 | 0.23% | – | – |
| Adalta Capital Management LLC | 41,265 | $25.6 萬 | 0.15% | – | – |
