Xenon Pharmaceuticals Inc.

XENE

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001582313

SEC filings (opens in a new tab)

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 2 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

Q2 2026 vs. Q1 2026

How the institutions holding Xenon Pharmaceuticals Inc. changed between Q1 2026 and Q2 2026.

All holders in Q2 2026 All holders in Q1 2026

13F holders of XENE: Q1 2026 compared with Q2 2026
Measure	Q1 2026	Of which not filed for Q2 2026	Q2 2026	Change
Holders	290	2	315	+27
Shares	100.2M	4.18M	101.1M	+5.07M (+5.3%)
Value	$5.80B	$242.9M	$6.10B	+$538.5M (+9.7%)

2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so the changes leave them out.

New holders (49)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q2 2026 but not at the end of Q1 2026.

Institutions new to XENE in Q2 2026
Institution	Shares	Value	% of portfolio
Jupiter Topco LLC	4,186,519	$252.7M	0.10%
Marshall Wace, LLP	689,342	$41.6M	0.04%
Panagora Asset Management Inc	664,031	$40.1M	0.12%
Jones Hill Capital LP	367,900	$22.2M	4.72%
Man Group plc	310,617	$18.7M	0.03%
Point72 Asset Management, L.P.	130,378	$7.87M	0.01%
Squarepoint Ops LLC	112,869	$6.81M	0.01%
Capital Fund Management S.A.	84,470	$5.10M	0.04%
Walleye Capital LLC	76,955	$4.65M	0.02%
Royce & Associates LP	65,032	$3.93M	0.03%
Diversified Trust Co	39,222	$2.37M	0.04%
Oak Ridge Investments LLC	38,559	$2.33M	0.13%
Dimensional Fund Advisors LP	36,595	$2.21M	0.00%
Seven Fleet Capital Management LP	33,300	$2.08M	0.34%
Dark Forest Capital Management LP	22,234	$1.34M	0.09%
Capricorn Fund Managers Ltd	20,900	$1.26M	0.10%
Magnetar Financial LLC	18,213	$1.10M	0.01%
IMC-Chicago, LLC	15,083	$910.4K	0.01%
Fieldview Capital Management, LLC	13,930	$840.8K	0.24%
Capstone Investment Advisors, LLC	8,925	$538.7K	0.00%
Allstate Corp	8,180	$493.7K	0.00%
Himension Fund	7,666	$462.7K	0.03%
Blackstone Group Inc.	7,608	$459.2K	0.00%
Blair William & Co	6,730	$406.2K	0.00%
Gsa Capital Partners LLP	6,293	$380.0K	0.02%
Captrust Financial Advisors	5,572	$336.3K	0.00%
Mercer Global Advisors Inc	4,193	$253.1K	0.00%
Abel Hall, LLC	3,809	$229.9K	0.04%
Inscription Capital, LLC	3,431	$207.1K	0.02%
Susquehanna Fundamental Investments, LLC	3,405	$205.5K	0.00%
Natixis	2,037	$123.0K	0.00%
Harbor Investment Advisory, LLC	1,393	$84.1K	0.01%
Nykredit A/S	1,102	$66.5K	0.00%
Global Retirement Partners, LLC	873	$52.7K	0.00%
Optiver Holding B.V.	449	$27.1K	0.00%
SRS Capital Advisors, Inc.	441	$26.6K	0.00%
Versant Capital Management, Inc	221	$13.3K	0.00%
IFG Advisory, LLC	215	$13.0K	0.00%
Flagship Wealth Advisors, LLC	100	$6.04K	0.00%
Clearstead Advisors, LLC	94	$5.67K	0.00%
Continuum Advisory, LLC	48	$2.90K	0.00%
Silver Grove Financial Group, Inc.	39	$2.35K	0.00%
Cape Investment Advisory, Inc.	38	$2.29K	0.00%
SJS Investment Consulting Inc.	37	$2.23K	0.00%
Ameritas Advisory Services, LLC	35	$2.11K	0.00%
Bessemer Group Inc	14	$1.00K	0.00%
Ares Financial Consulting, LLC	12	$724	0.00%
SHP Wealth Management	11	$664	0.00%
Cornerstone Financial Management LLC	10	$604	0.00%

Sold out (22)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q1 2026 and filed for Q2 2026 without it.

Institutions that sold out of XENE in Q2 2026
Institution	Shares, Q1 2026	Value, Q1 2026
Holocene Advisors, LP	1,518,686	$88.3M
Commodore Capital LP	825,000	$48.0M
MPM Oncology Impact Management LP	588,706	$34.2M
Sofinnova Investments, Inc.	305,216	$17.7M
Y-Intercept (Hong Kong) Ltd	85,388	$4.97M
Atika Capital Management LLC	59,900	$3.48M
LMR Partners LLP	56,200	$3.27M
Qube Research & Technologies Ltd	44,044	$2.56M
Calamos Advisors LLC	30,374	$1.77M
SummitTX Capital, L.P.	26,186	$1.52M
Sanders Morris Harris LLC	21,500	$1.25M
Neo Ivy Capital Management	13,710	$797.2K
Covalis Capital LLP	10,000	$581.5K
Longaeva Partners L.P.	6,250	$363.4K
DRW Securities, LLC	5,461	$317.6K
Seeds Investor LLC	3,423	$203.2K
Jane Street Group, LLC	3,468	$201.7K
Acadian Asset Management LLC	677	$39.0K
MAI Capital Management	392	$22.8K
Root Financial Partners, LLC	40	$2.33K
Golden State Equity Partners	35	$2.04K
Twin Peaks Wealth Advisors, LLC	32	$1.86K

Not filed for Q2 2026 yet (2)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q1 2026 and haven't filed a 13F for Q2 2026. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding XENE in Q1 2026 that haven't filed for Q2 2026
Institution	Shares, Q1 2026	Value, Q1 2026
Janus Henderson Group PLC	4,175,982	$242.9M
CWM, LLC	510	$29.7K