Lexeo Therapeutics, Inc.
LXEO- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001907108
In the last 90 days, Lexeo Therapeutics, Inc. insiders filed 0 open-market purchases and 7 sales; 141 institutions reported holding it in 13F filings for Q2 2026, worth $410.9M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Lexeo Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 146
- +38 vs. Q3 2025
- Shares held
- 76.5M
- +27.1M (+55.0%) vs. Q3 2025
- Total value
- $759.2M
- +$431.7M (+131.8%) vs. Q3 2025
- New holders
- 47
- 61 more added
- Sold out
- 9
- 26 more reduced
1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXEO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 141 | $410.9M |
| Q1 2026 | 139 | $458.7M |
| Q4 2025 | 146 | $759.2M |
| Q3 2025 | 109 | $327.5M |
| Q2 2025 | 90 | $169.9M |
| Q1 2025 | 88 | $100.0M |
| Q4 2024 | 90 | $194.2M |
| Q3 2024 | 69 | $268.8M |
| Q2 2024 | 60 | $426.3M |
| Q1 2024 | 54 | $361.5M |
| Q4 2023 | 31 | $217.1M |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Lexeo Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Janus Henderson Group PLC | 5,509,635 | $54.7M | 0.02% | −595,892−9.8% | Reduced |
| Ra Capital Management, L.P. | 5,000,000 | $49.6M | 0.51% | +5,000,000 | New |
| BlackRock, Inc. | 4,907,563 | $48.7M | 0.00% | +2,736,471+126.0% | Added |
| Paradigm Biocapital Advisors LP | 4,763,198 | $47.3M | 1.27% | +4,763,198 | New |
| Vestal Point Capital, LP | 4,475,000 | $44.4M | 1.63% | +1,225,000+37.7% | Added |
| Frazier Life Sciences Management, L.P. | 4,424,725 | $43.9M | 1.18% | 00.0% | Unchanged |
| Vanguard Group Inc | 3,894,310 | $38.7M | 0.00% | +1,668,020+74.9% | Added |
| Citadel Advisors LLC | 3,774,317 | $37.5M | 0.03% | +55,274+1.5% | Added |
| Avoro Capital Advisors LLC | 3,300,000 | $32.8M | 0.32% | +3,300,000 | New |
| Affinity Asset Advisors, LLC | 3,200,000 | $31.8M | 2.28% | −670,527−17.3% | Reduced |
| Woodline Partners LP | 3,197,760 | $31.8M | 0.12% | +625,598+24.3% | Added |
| State Street Corp | 3,187,722 | $31.7M | 0.00% | +2,642,877+485.1% | Added |
| OrbiMed Advisors LLC | 2,125,000 | $21.1M | 0.43% | +2,125,000 | New |
| Point72 Asset Management, L.P. | 1,894,722 | $18.8M | 0.03% | −47,127−2.4% | Reduced |
| Octagon Capital Advisors LP | 1,725,000 | $17.1M | 2.14% | +1,725,000 | New |
| Balyasny Asset Management LLC | 1,635,026 | $16.2M | 0.03% | −2,278,762−58.2% | Reduced |
| Geode Capital Management, LLC | 1,445,887 | $14.4M | 0.00% | +724,006+100.3% | Added |
| ADAR1 Capital Management, LLC | 1,393,161 | $13.8M | 1.03% | −138,792−9.1% | Reduced |
| Suvretta Capital Management, LLC | 1,250,000 | $12.4M | 0.31% | +1,250,000 | New |
| 683 Capital Management, LLC | 1,120,000 | $11.1M | 0.92% | +197,338+21.4% | Added |
| Nantahala Capital Management, LLC | 1,000,000 | $9.93M | 0.59% | +1,000,000 | New |
| Millennium Management LLC | 908,024 | $9.02M | 0.01% | −1,405,618−60.8% | Reduced |
| Blackstone Group Inc. | 904,959 | $8.99M | 0.04% | −219,963−19.6% | Reduced |
| Dimensional Fund Advisors LP | 862,892 | $8.57M | 0.00% | −49,641−5.4% | Reduced |
| Goldman Sachs Group Inc | 781,855 | $7.76M | 0.00% | +639,453+449.0% | Added |
| Siren, L.L.C. | 720,622 | $7.16M | 0.21% | +117,187+19.4% | Added |
| Silverarc Capital Management, LLC | 617,608 | $6.13M | 0.89% | −161,003−20.7% | Reduced |
| Ikarian Capital, LLC | 513,011 | $5.09M | 0.66% | −54,590−9.6% | Reduced |
| D. E. Shaw & Co., Inc. | 480,205 | $4.77M | 0.00% | +467,387+3,646.3% | Added |
| Invesco Ltd. | 463,029 | $4.60M | 0.00% | +463,029 | New |
| Northern Trust Corp | 457,052 | $4.54M | 0.00% | +220,599+93.3% | Added |
| Verition Fund Management LLC | 428,458 | $4.25M | 0.02% | +13,595+3.3% | Added |
| Two Sigma Investments, LP | 400,567 | $3.98M | 0.01% | +315,804+372.6% | Added |
| DAFNA Capital Management LLC | 340,859 | $3.38M | 0.79% | −17,224−4.8% | Reduced |
| AQR Capital Management LLC | 337,386 | $3.35M | 0.00% | −10,537−3.0% | Reduced |
| UBS Group AG | 281,083 | $2.79M | 0.00% | +31,174+12.5% | Added |
| BNP Paribas Arbitrage, SA | 257,417 | $2.56M | 0.00% | +226,690+737.8% | Added |
| Ameriprise Financial Inc | 243,294 | $2.42M | 0.00% | +76,756+46.1% | Added |
| Y-Intercept (Hong Kong) Ltd | 231,163 | $2.30M | 0.05% | +231,163 | New |
| Renaissance Technologies LLC | 217,772 | $2.16M | 0.00% | +68,472+45.9% | Added |
| Nuveen, LLC | 211,529 | $2.10M | 0.00% | +178,427+539.0% | Added |
| Privium Fund Management B.V. | 192,550 | $1.91M | 0.35% | +194+0.1% | Added |
| Charles Schwab Investment Management Inc | 192,210 | $1.91M | 0.00% | +86,450+81.7% | Added |
| Barclays PLC | 188,754 | $1.87M | 0.00% | +77,175+69.2% | Added |
| Spruce Street Capital LP | 175,000 | $1.74M | 0.57% | +175,000 | New |
| Bank of New York Mellon Corp | 166,749 | $1.66M | 0.00% | +95,072+132.6% | Added |
| Bank of America Corp | 160,288 | $1.59M | 0.00% | +132,009+466.8% | Added |
| Morgan Stanley | 140,181 | $1.39M | 0.00% | +42,124+43.0% | Added |
| Jane Street Group, LLC | 140,096 | $1.39M | 0.00% | +10,624+8.2% | Added |
| Perceptive Advisors LLC | 139,835 | $1.39M | 0.03% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 136,377 | $1.35M | 0.04% | −44,367−24.5% | Reduced |
| Qube Research & Technologies Ltd | 133,257 | $1.32M | 0.00% | +133,257 | New |
| Burkehill Global Management, LP | 125,000 | $1.24M | 0.08% | +125,000 | New |
| Rafferty Asset Management, LLC | 102,159 | $1.01M | 0.00% | +102,159 | New |
| Squarepoint Ops LLC | 92,608 | $919.6K | 0.00% | +92,608 | New |
| Wellington Management Group LLP | 83,230 | $826.5K | 0.00% | +83,230 | New |
| Two Sigma Advisers, LP | 81,300 | $807.3K | 0.00% | +81,300 | New |
| Wells Fargo & Company | 70,736 | $702.4K | 0.00% | +51,474+267.2% | Added |
| Rhumbline Advisers | 69,369 | $688.8K | 0.00% | +37,605+118.4% | Added |
| Atom Investors LP | 68,491 | $680.1K | 0.05% | +68,491 | New |
| Alliancebernstein L.P. | 61,810 | $613.8K | 0.00% | +32,440+110.5% | Added |
| Deutsche Bank AG | 57,166 | $567.7K | 0.00% | +32,844+135.0% | Added |
| Acadian Asset Management LLC | 50,909 | $505.0K | 0.00% | +50,909 | New |
| American Century Companies Inc | 45,988 | $456.7K | 0.00% | +9,834+27.2% | Added |
| Profund Advisors LLC | 38,054 | $377.9K | 0.01% | +38,054 | New |
| Susquehanna International Group, LLP | 37,009 | $367.5K | 0.00% | +8,078+27.9% | Added |
| MetLife Investment Management | 35,721 | $354.7K | 0.00% | +35,721 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 35,257 | $349.0K | 0.00% | +23,804+207.8% | Added |
| Panagora Asset Management Inc | 34,297 | $340.6K | 0.00% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 33,872 | $337.0K | 0.00% | +21,907+183.1% | Added |
| Graham Capital Management, L.P. | 32,898 | $326.7K | 0.01% | +32,898 | New |
| JPMorgan Chase & Co | 29,861 | $296.5K | 0.00% | +15,502+108.0% | Added |
| Virtus Investment Advisers, Inc. | 27,230 | $270.4K | 0.07% | +27,230 | New |
| Winton Group Ltd | 26,900 | $267.1K | 0.01% | +26,900 | New |
| Susquehanna Portfolio Strategies, LLC | 26,205 | $260.2K | 0.00% | +3,296+14.4% | Added |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 26,209 | $251.9K | 0.00% | +26,209 | New |
| Ieq Capital, LLC | 24,692 | $245.2K | 0.00% | −8,889−26.5% | Reduced |
| Cerity Partners LLC | 22,439 | $222.8K | 0.00% | −1,151−4.9% | Reduced |
| Pale Fire Capital SE | 22,302 | $221.5K | 0.03% | −11,348−33.7% | Reduced |
| Omers Administration Corp | 20,900 | $207.5K | 0.00% | +20,900 | New |
| Soltis Investment Advisors LLC | 20,000 | $198.6K | 0.01% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 19,887 | $197.5K | 0.00% | +15,700+375.0% | Added |
| Manufacturers Life Insurance Company, The | 19,147 | $190.1K | 0.00% | +19,147 | New |
| CWM, LLC | 18,953 | $188.0K | 0.00% | +89+0.5% | Added |
| SG Americas Securities, LLC | 18,640 | $185.0K | 0.00% | +18,640 | New |
| JustInvest LLC | 16,436 | $163.2K | 0.00% | −159−1.0% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 16,373 | $162.6K | 0.00% | +10,333+171.1% | Added |
| Persistent Asset Partners Ltd | 16,025 | $159.1K | 0.08% | +16,025 | New |
| Citigroup Inc | 15,293 | $151.9K | 0.00% | +7,861+105.8% | Added |
| ProShare Advisors LLC | 14,752 | $146.5K | 0.00% | +14,752 | New |
| Intech Investment Management LLC | 14,188 | $140.9K | 0.00% | +2,317+19.5% | Added |
| Caxton Corp | 13,943 | $138.5K | 3.24% | −3,389−19.6% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 14,330 | $136.3K | 0.00% | +86+0.6% | Added |
| Bridgeway Capital Management, LLC | 13,400 | $133.1K | 0.00% | −35,000−72.3% | Reduced |
| FMR LLC | 13,388 | $132.9K | 0.00% | −45−0.3% | Reduced |
| Simplex Trading, LLC | 13,031 | $129.4K | 0.00% | +12,532+2,511.4% | Added |
| Raymond James Financial Inc | 12,538 | $124.5K | 0.00% | +12,538 | New |
| China Universal Asset Management Co., Ltd. | 11,893 | $118.1K | 0.01% | +2,427+25.6% | Added |
| Quest Partners LLC | 11,726 | $116.4K | 0.01% | +11,726 | New |
| Gsa Capital Partners LLP | 11,463 | $114.0K | 0.01% | +11,463 | New |