Lexeo Therapeutics, Inc.
LXEO- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001907108
In the last 90 days, Lexeo Therapeutics, Inc. insiders filed 0 open-market purchases and 7 sales; 141 institutions reported holding it in 13F filings for Q2 2026, worth $410.9M in total; no superinvestor holds it.
Holders of 5% or more of LXEO
Holders whose latest Schedule 13D or 13G filing reports 5% or more of Lexeo Therapeutics, Inc., largest stake first. The change is against the holder's previous filing.
| Holder | Latest form | Stake | Change | First filed | Latest filing | Filing |
|---|---|---|---|---|---|---|
| Janus Henderson Group PLC | 13G/A | 9.99%7.29M shares | −1.31 ppfrom 11.30% | Feb 14, 20255 filings | Dec 8, 2025 | SEC |
| Balyasny Asset Management LLC | 13G/A | 9.99%5.39M shares | 0.00 ppfrom 9.99% | Aug 14, 20252 filings | Nov 14, 2025 | SEC |
| Citadel Advisors LLC | 13G/A | 9.60%5.33M shares | – | Aug 14, 20251 filing | Aug 14, 2025 | SEC |
| Affinity Asset Advisors, LLC | 13G | 7.75%4.25M shares | New | Jun 4, 20251 filing | Jun 4, 2025 | SEC |
| Vestal Point Capital, LP | 13G/A | 7.50%4.12M shares | +1.50 ppfrom 6.00% | Aug 14, 20252 filings | Nov 14, 2025 | SEC |
| Ra Capital Management, L.P. | 13G | 6.90%5.00M shares | New | Oct 27, 20251 filing | Oct 27, 2025 | SEC |
| Mizuho Financial Group Inc | 13G/A | 6.60%2.20M shares | +0.80 ppfrom 5.80% | Feb 13, 20252 filings | May 13, 2025 | SEC |
| Frazier Life Sciences Public Fund, L.P. | 13G/A | 5.70%3.07M shares | −4.20 ppfrom 9.90% | Jun 4, 20252 filings | Aug 14, 2025 | SEC |
| Paradigm Biocapital Advisors LP | 13G | 5.00%3.67M shares | New | Nov 20, 20251 filing | Nov 20, 2025 | SEC |
Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.
13D and 13G filings
29 Schedule 13D and 13G filings on Lexeo Therapeutics, Inc., newest first, including old-format filings without a stake.
| Filed (ET) | Filer | Form | Stake | Change | Event date | Filing |
|---|---|---|---|---|---|---|
| Mar 27, 202610:16 AM ET | Vanguard Group Inc | 13G/A | 0.00%0 shares | –Below 5% | Mar 13, 2026 | SEC |
| Dec 8, 202511:45 AM ET | Janus Henderson Group PLC | 13G/A | 9.99%7.29M shares | −1.31 ppfrom 11.30% | Nov 28, 2025 | SEC |
| Nov 20, 20254:30 PM ET | Paradigm Biocapital Advisors LPand 3 others | 13G | 5.00%3.67M shares | New | Nov 13, 2025 | SEC |
| Nov 14, 20254:17 PM ET | Longitude Capital Partners IV, LLCand 3 others | 13G/A | 3.80%2.77M shares | –Below 5% | Sep 30, 2025 | SEC |
| Nov 14, 20254:00 PM ET | Vestal Point Capital, LPand 1 other | 13G/A | 7.50%4.12M shares | +1.50 ppfrom 6.00% | Sep 30, 2025 | SEC |
| Nov 14, 202512:49 PM ET | Janus Henderson Group PLCand 1 other | 13G/A | 11.30%6.11M shares | +0.20 ppfrom 11.10% | Sep 30, 2025 | SEC |
| Nov 14, 20256:04 AM ET | Balyasny Asset Management LLCand 4 others | 13G/A | 9.99%5.39M shares | 0.00 ppfrom 9.99% | Sep 30, 2025 | SEC |
| Nov 7, 20254:42 PM ET | Integrated Core Strategies (US) LLCand 3 others | 13G/A | 3.20%2.31M shares | −2.10 ppfrom 5.30%Below 5% | Sep 30, 2025 | SEC |
| Oct 27, 20254:07 PM ET | Ra Capital Management, L.P.and 3 others | 13G | 6.90%5.00M shares | New | Oct 20, 2025 | SEC |
| Oct 17, 20256:13 PM ET | BlackRock, Inc. | 13G/A | 4.00%2.17M shares | −1.50 ppfrom 5.50%Below 5% | Sep 30, 2025 | SEC |
| Aug 14, 20254:58 PM ET | Citadel Advisors LLCand 6 others | 13G/A | 9.60%5.33M shares | – | Jun 30, 2025 | SEC |
| Aug 14, 20253:51 PM ET | Vestal Point Capital, LPand 1 other | 13G | 6.00%3.23M shares | New | Jun 30, 2025 | SEC |
| Aug 14, 20251:40 PM ET | Frazier Life Sciences Public Fund, L.P.and 19 others | 13G/A | 5.70%3.07M shares | −4.20 ppfrom 9.90% | Jun 30, 2025 | SEC |
| Aug 14, 202511:46 AM ET | Janus Henderson Group PLCand 1 other | 13G/A | 11.10%3.68M shares | −2.60 ppfrom 13.70% | Jun 30, 2025 | SEC |
| Aug 14, 20256:40 AM ET | Balyasny Asset Management LLCand 4 others | 13G | 9.99%8.35M shares | New | Jun 30, 2025 | SEC |
| Aug 7, 20254:18 PM ET | Integrated Core Strategies (US) LLCand 3 others | 13G/A | 5.30%2.84M shares | −0.50 ppfrom 5.80% | Jun 30, 2025 | SEC |
| Jun 4, 20254:51 PM ET | Frazier Life Sciences Public Fund, L.P.and 19 others | 13G | 9.90%5.50M shares | New | May 28, 2025 | SEC |
| Jun 4, 20254:04 PM ET | Affinity Asset Advisors, LLCand 1 other | 13G | 7.75%4.25M shares | New | May 28, 2025 | SEC |
| May 15, 20259:58 AM ET | D1 Capital Partners L.P.and 1 otherSuperinvestorD1 Capital Partners | 13G/A | 2.90%978.7K shares | –Below 5% | Mar 31, 2025 | SEC |
| May 14, 202512:00 PM ET | Janus Henderson Group PLCand 1 other | 13G/A | 13.70%4.56M shares | +0.60 ppfrom 13.10% | Mar 31, 2025 | SEC |
| May 13, 20256:55 AM ET | Mizuho Financial Group Inc | 13G/A | 6.60%2.20M shares | +0.80 ppfrom 5.80% | Mar 31, 2025 | SEC |
| May 12, 20259:00 AM ET | Adage Capital Management, L.P.and 2 others | 13G/A | 0.70%238.0K shares | −5.98 ppfrom 6.68%Below 5% | Mar 31, 2025 | SEC |
| Apr 28, 20254:03 PM ET | Integrated Core Strategies (US) LLCand 3 others | 13G | 5.80%1.93M shares | New | Apr 22, 2025 | SEC |
| Feb 14, 202512:03 PM ET | Eventide Asset Management, LLCand 2 others | 13G/A | 3.73%1.23M shares | –Below 5% | Dec 31, 2024 | SEC |
| Feb 14, 202511:55 AM ET | Janus Henderson Group PLCand 1 other | 13G/A | 13.10%4.34M shares | – | Dec 31, 2024 | SEC |
| Feb 14, 20259:00 AM ET | Omega Fund VI, L.P.and 5 others | 13G/A | 3.60%1.18M shares | –Below 5% | Dec 31, 2024 | SEC |
| Feb 13, 202510:24 AM ET | Mizuho Financial Group Inc | 13G | 5.80%1.93M shares | New | Dec 31, 2024 | SEC |
| Feb 12, 20259:35 AM ET | Adage Capital Management, L.P.and 2 others | 13G/A | 6.68%2.21M shares | – | Dec 31, 2024 | SEC |
| Feb 4, 20253:45 PM ET | BlackRock, Inc. | 13G | 5.50%1.82M shares | New | Dec 31, 2024 | SEC |
Form 144: proposed insider sales
Notices from officers, directors and other affiliates planning to sell Lexeo Therapeutics, Inc. shares.
No Form 144 notices for Lexeo Therapeutics, Inc. are on file.