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Livermore
ZHEN

Sphera Funds Management Ltd.

SEC CIK
0001496201
Latest filing
Aug 14, 2026

Holdings in Q3 2021

Holdings as of Sep 30, 2021, filed Nov 15, 2021. Long positions only; changes compare share counts with Q2 2021.

Institution overview
Positions
107
−14 vs. Q2 2021
Portfolio value
$1.01B
−$41.5M (−3.9%) vs. Q2 2021
Filed
Nov 15, 2021
SEC
Holdings of Sphera Funds Management Ltd. in Q3 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
LLYEli Lilly & CoStock348,495$80.5M8.0%+166,600+91.6%AddedHistory
AZNAstraZeneca PLCSPONSORED ADR1,291,667$77.6M7.7%+143,994+12.5%AddedHistory
ABBVAbbVie Inc.Stock596,294$64.3M6.4%+230,100+62.8%AddedHistory
PFEPfizer IncStock1,106,528$47.6M4.7%+1,106,528NewHistory
SNYSanofiSPONSORED ADR843,400$40.7M4.0%00.0%UnchangedHistory
JNJJohnson & JohnsonStock238,948$38.6M3.8%−166,660−41.1%ReducedHistory
GNRCGenerac Holdings Inc.Stock71,013$29.0M2.9%−33,350−32.0%ReducedHistory
KYMRKymera Therapeutics, Inc.COM359,260$21.1M2.1%+99,365+38.2%AddedHistory
MSFTMicrosoft CorpStock67,536$19.0M1.9%00.0%UnchangedHistory
CCCCC4 Therapeutics, Inc.COM STK381,774$17.1M1.7%−136,837−26.4%ReducedHistory
SWTXSpringWorks Therapeutics, Inc.COM247,917$15.7M1.6%+52,800+27.1%AddedHistory
ZLABZai Lab LtdADR145,982$15.4M1.5%+48,036+49.0%AddedHistory
PANWPalo Alto Networks IncStock31,000$14.8M1.5%+31,000NewHistory
KURAKura Oncology, Inc.COM788,735$14.8M1.5%−80,151−9.2%ReducedHistory
SNDXSyndax Pharmaceuticals IncCOM750,603$14.3M1.4%+203,416+37.2%AddedHistory
SEDGSolaredge Technologies, Inc.COM50,000$13.3M1.3%+17,800+55.3%AddedHistory
FATEFate Therapeutics IncCOM219,299$13.0M1.3%+54,000+32.7%AddedHistory
ALTAltimmune, Inc.COM NEW1,088,854$12.3M1.2%+405,459+59.3%AddedHistory
IOVAIovance Biotherapeutics, Inc.COM494,809$12.2M1.2%+116,167+30.7%AddedHistory
HOWLWerewolf Therapeutics, Inc.COM688,475$11.8M1.2%−17,819−2.5%ReducedHistory
METAMeta Platforms, Inc.Stock34,400$11.7M1.2%+7,400+27.4%AddedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM548,643$11.5M1.1%−85,445−13.5%ReducedHistory
BMRNBiomarin Pharmaceutical IncCOM149,017$11.5M1.1%+149,017NewHistory
TWLOTwilio IncCL A35,500$11.3M1.1%+9,000+34.0%AddedHistory
NICENICE Ltd.SPONSORED ADR37,786$10.7M1.1%−39,000−50.8%ReducedHistory
Wix.com Ltd.92940WAD1NOTE 8/111,100,000$10.7M1.1%+11,100,000New–
VINCVincerx Pharma, Inc.COM NEW654,572$10.6M1.0%+427,122+187.8%AddedHistory
VTGNVistagen Therapeutics, Inc.COM NEW3,824,938$10.5M1.0%−255,735−6.3%ReducedHistory
KRNTKornit Digital Ltd.SHS72,076$10.4M1.0%−75,717−51.2%ReducedHistory
IMTXImmatics N.V.SHS800,043$10.4M1.0%+800,043NewHistory
INBXInhibrx Biosciences, Inc.COM310,077$10.3M1.0%+120,994+64.0%AddedHistory
AUDCAudiocodes LtdORD316,428$10.3M1.0%−68,766−17.9%ReducedHistory
ARYDARYA Sciences Acquisition Corp IVCL A1,000,000$10.1M1.0%+500,000+100.0%AddedHistory
OMGAOmega Therapeutics, Inc.COMMON STOCK527,948$9.95M1.0%+527,948NewHistory
ALXOAlx Oncology Holdings IncCOM128,706$9.51M0.9%−64,022−33.2%ReducedHistory
NKENIKE, Inc.Stock65,000$9.44M0.9%+65,000NewHistory
LENZLENZ Therapeutics, Inc.COM531,269$8.71M0.9%+506,312+2,028.7%AddedHistory
RUNSunrun Inc.COM189,000$8.32M0.8%+117,000+162.5%AddedHistory
ONCROncorus, Inc.COM880,702$8.23M0.8%−12,846−1.4%ReducedHistory
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS832,878$8.11M0.8%00.0%UnchangedHistory
CSTECaesarstone Ltd.ORD SHS644,146$8.00M0.8%00.0%UnchangedHistory
ISEEIVERIC bio, Inc.COM485,001$7.88M0.8%−14,999−3.0%ReducedHistory
ADSKAutodesk, Inc.COM27,500$7.84M0.8%+27,500NewHistory
IDYAIDEAYA Biosciences, Inc.COM294,619$7.51M0.7%−40,175−12.0%ReducedHistory
CLDXCelldex Therapeutics, Inc.COM NEW130,330$7.04M0.7%+130,330NewHistory
Affimed N VN01045108COM1,117,619$6.91M0.7%−159,083−12.5%Reduced–
BCLS Acquisition CorpG0904B105COM CL A687,900$6.88M0.7%00.0%Unchanged–
MRUSMerus N.V.COM309,427$6.81M0.7%+22,921+8.0%AddedHistory
VRNTVerint Systems IncCOM150,000$6.72M0.7%00.0%UnchangedHistory
TEADTeads Holding Co.COM431,194$6.38M0.6%+431,194NewHistory
BCABBioAtla, Inc.COM214,300$6.31M0.6%+214,300NewHistory
ZENZendesk, Inc.COM53,910$6.28M0.6%+53,910NewHistory
RACBResearch Alliance Corp. IICOM CL A600,000$5.91M0.6%00.0%UnchangedHistory
XENEXenon Pharmaceuticals Inc.COM373,510$5.71M0.6%+97,380+35.3%AddedHistory
PNTPOINT Biopharma Global Inc.COM739,190$5.68M0.6%+739,190NewHistory
PMVPPMV Pharmaceuticals, Inc.COM190,525$5.68M0.6%+106,451+126.6%AddedHistory
STROSutro Biopharma, Inc.COM294,825$5.57M0.6%00.0%UnchangedHistory
QUREuniQure N.V.SHS172,000$5.51M0.5%00.0%UnchangedHistory
CALXCalix, IncCOM105,290$5.20M0.5%+105,290NewHistory
ALLTAllot Ltd.SHS341,067$5.07M0.5%+64,880+23.5%AddedHistory
NAUTNautilus Biotechnology, Inc.COM800,000$4.91M0.5%00.0%UnchangedHistory
CRBUCaribou Biosciences, Inc.COM200,000$4.77M0.5%+200,000NewHistory
FOLDAmicus Therapeutics, Inc.COM491,159$4.69M0.5%+491,159NewHistory
PTGXProtagonist Therapeutics, IncCOM260,379$4.61M0.5%−42,586−14.1%ReducedHistory
VRNAVerona Pharma plcSPONSORED ADS801,256$4.39M0.4%00.0%UnchangedHistory
Ironsource LtdM5R75Y101CL A ORD SHS367,070$3.99M0.4%+367,070New–
ALGSAligos Therapeutics, Inc.COM249,197$3.87M0.4%+249,197NewHistory
DVAXDynavax Technologies CorpCOM NEW198,880$3.82M0.4%+198,880NewHistory
EPIXESSA Pharma Inc.COM NEW469,402$3.75M0.4%−178,901−27.6%ReducedHistory
DYNDyne Therapeutics, Inc.COM225,083$3.65M0.4%−144,631−39.1%ReducedHistory
IMUXImmunic, Inc.COM389,812$3.45M0.3%+389,812NewHistory
Eucrates Biomedical Acqu CorG3141W106SHS329,025$3.22M0.3%00.0%Unchanged–
NTLAIntellia Therapeutics, Inc.COM23,647$3.17M0.3%−28,903−55.0%ReducedHistory
LESLLeslie's, Inc.COM150,000$3.08M0.3%+150,000NewHistory
OTMOOtonomo Technologies Ltd.ORDINARY SHARES600,000$2.87M0.3%+600,000NewHistory
ARGXArgenx SESPONSORED ADR9,249$2.79M0.3%00.0%UnchangedHistory
DICEDICE Therapeutics, Inc.COM85,000$2.78M0.3%+85,000NewHistory
Bio Green Med Solution, Inc.23254L603COM508,322$2.68M0.3%00.0%Unchanged–
GLUEMonte Rosa Therapeutics, Inc.COM119,647$2.67M0.3%+19,647+19.6%AddedHistory
HIPOHippo Holdings Inc.COMMON STOCK564,967$2.64M0.3%+564,967NewHistory
RPTXRepare Therapeutics Inc.COM100,391$2.63M0.3%00.0%UnchangedHistory
CVRXCVRx, Inc.COM150,000$2.48M0.2%00.0%UnchangedHistory
CYTCyteir Therapeutics, Inc.COM135,145$2.37M0.2%+10,145+8.1%AddedHistory
ANNXAnnexon, Inc.COM123,637$2.30M0.2%−24,681−16.6%ReducedHistory
Turmeric Acquisition CorpG9127T108CL A219,440$2.15M0.2%00.0%Unchanged–
ARYEARYA Sciences Acquisition Corp VCLASS A ORD SHS200,000$1.98M0.2%+200,000NewHistory
JYACJiya Acquisition Corp.COM CL A199,028$1.95M0.2%00.0%UnchangedHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS242,500$1.89M0.2%−49,694−17.0%Reduced–
AMATApplied Materials IncStock14,500$1.87M0.2%+14,500NewHistory
MOLNMolecular Partners AGADS80,555$1.58M0.2%+80,555NewHistory
ERASErasca, Inc.COM70,000$1.49M0.1%+70,000NewHistory
LVTXLAVA Therapeutics NVSHS215,359$1.27M0.1%00.0%UnchangedHistory
FLACFrazier Lifesciences Acquisition CorpCL A SHS126,687$1.24M0.1%00.0%UnchangedHistory
Magic Software Enterprises L559166103ORD57,704$1.15M0.1%+41,728+261.2%Added–
Omega Alpha SpacG6749V107CL A100,000$974.0K0.1%00.0%Unchanged–
Nice Sys Inc65366HAB9NOTE 1.250% 1/1250,000$846.0K0.1%00.0%Unchanged–
ACIUAC Immune SASHS121,019$812.0K0.1%+121,019NewHistory
KAKineta, Inc.COM75,836$783.0K0.1%−39,462−34.2%ReducedHistory
CM Life Sciences III Inc125841205UNIT 04/30/202875,000$769.0K0.1%00.0%Unchanged–
IONSIonis Pharmaceuticals IncCOM22,000$738.0K0.1%+22,000NewHistory

Options (9)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Sphera Funds Management Ltd. in Q3 2021
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF$50.3M–
iShares Russell 2000 ETF464287655ETF$45.9M–
BMYBristol Myers Squibb CoStock–$29.6M
BIIBBiogen Inc.COM–$14.1M
IONSIonis Pharmaceuticals IncCOM–$11.7M
ALTAltimmune, Inc.COM NEW–$11.3M
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS–$10.2M
PTGXProtagonist Therapeutics, IncCOM–$4.43M
QUREuniQure N.V.SHS–$3.20M

Sold out since Q2 2021 (47)

Positions held at the end of Q2 2021 that are gone from this filing.

Positions of Sphera Funds Management Ltd. sold out since Q2 2021
SecurityClassShares in Q2 2021Value in Q2 2021% of portfolio in Q2 2021History
MRKMerck & Co., Inc.Stock772,601$60.1M5.7%History
LPSNLiveperson IncCOM225,000$14.2M1.4%History
VRNSVaronis Systems IncCOM218,013$12.6M1.2%History
Therapeutics Acquisition Cor88339T103COM CL A1,009,497$10.4M1.0%–
BIIBBiogen Inc.COM23,995$8.31M0.8%History
NKTXNkarta, Inc.COM252,478$8.00M0.8%History
STTKShattuck Labs, Inc.COM274,214$7.95M0.8%History
ONTOOnto Innovation Inc.COM107,548$7.86M0.7%History
STOKStoke Therapeutics, Inc.COM233,135$7.85M0.7%History
MRTXMirati Therapeutics, Inc.COM47,309$7.64M0.7%History
ONCBeOne Medicines Ltd.ADR20,900$7.17M0.7%History
NRIXNurix Therapeutics, Inc.COM244,157$6.48M0.6%History
ORTXOrchard Therapeutics plcADS1,366,564$6.00M0.6%History
ATERAterian, Inc.Equity399,999$5.85M0.6%History
SPRYARS Pharmaceuticals, Inc.COM173,891$5.37M0.5%History
FVRRFiverr International Ltd.ORD SHS21,500$5.21M0.5%History
CRISCuris IncCOM NEW588,264$4.75M0.5%History
NBPNovaBridge BiosciencesSPONSORED ADS46,350$3.89M0.4%History
SGTXSigilon Therapeutics, Inc.COM360,239$3.87M0.4%History
BEAMBeam Therapeutics Inc.COM28,425$3.66M0.3%History
PLTKPlaytika Holding Corp.COM150,000$3.58M0.3%History
ARKOARKO Corp.COM369,875$3.40M0.3%History
Gracell Biotechnologies Inc38406L103SPONSORED ADS233,850$3.04M0.3%–
NEXNNexxen International Ltd.ADS150,000$2.98M0.3%History
SSentinelOne, Inc.CL A68,400$2.91M0.3%History
KRROKorro Bio, Inc.COM275,160$2.74M0.3%History
PRGOPERRIGO Co plcSHS52,500$2.41M0.2%History
TWSTTwist Bioscience CorpCOM18,000$2.40M0.2%History
Cerevel Therapeutics HLDNG I15678U102*W EXP 06/09/202165,295$2.38M0.2%–
IPSCCentury Therapeutics, Inc.COM80,000$2.35M0.2%History
HYPRHyperfine, Inc.CL A SHS200,000$1.97M0.2%History
Healthcare Capital Corp42228C200UNIT 12/31/2025196,610$1.96M0.2%–
ALDXAldeyra Therapeutics, Inc.COM150,000$1.70M0.2%History
WIXWix.com Ltd.SHS5,700$1.66M0.2%History
PLRXPliant Therapeutics, Inc.COM51,000$1.49M0.1%History
OMICSingular Genomics Systems, Inc.COM53,867$1.48M0.1%History
Clarim Acquisition Corp18049C207UNIT 99/99/9999148,886$1.48M0.1%–
PRAXPraxis Precision Medicines, Inc.COM75,600$1.38M0.1%History
DFPHStarling Oncology, Inc.COM CL A126,491$1.26M0.1%History
Lefteris Acquisition Corp52470X109COM CL A114,428$1.12M0.1%–
CELCCelcuity Inc.COM45,000$1.08M0.1%History
MSPRMSP Recovery, Inc.COM CL A99,859$986.0K0.1%History
E Merge Technology Acquisiti26873Y104COM CL A100,000$976.0K0.1%–
Apollo Strategic Growth CaptG0411R106SHS CL A73,055$714.0K0.1%–
Tailwind Internatnal Acq CorG8662F127UNIT 99/99/999948,342$483.0K<0.1%–
ELEVElevation Acquisition Group Inc.COM30,000$407.0K<0.1%History
CERECerevel Therapeutics Holdings, Inc.COM9,212$236.0K<0.1%History