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Livermore
Livermore
ZHEN

Sphera Funds Management Ltd.

SEC CIK
0001496201
Latest filing
Aug 14, 2026

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed Feb 14, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
85
−22 vs. Q3 2021
Portfolio value
$842.0M
−$167.4M (−16.6%) vs. Q3 2021
Filed
Feb 14, 2022
SEC
Holdings of Sphera Funds Management Ltd. in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
ABBVAbbVie Inc.Stock464,194$62.9M7.5%−132,100−22.2%ReducedHistory
AZNAstraZeneca PLCSPONSORED ADR1,055,467$61.5M7.3%−236,200−18.3%ReducedHistory
SNYSanofiSPONSORED ADR1,083,400$54.3M6.4%+240,000+28.5%AddedHistory
LLYEli Lilly & CoStock159,695$44.1M5.2%−188,800−54.2%ReducedHistory
MRKMerck & Co., Inc.Stock346,423$26.6M3.2%+346,423NewHistory
JNJJohnson & JohnsonStock155,123$26.5M3.2%−83,825−35.1%ReducedHistory
SNDXSyndax Pharmaceuticals IncCOM1,176,585$25.8M3.1%+425,982+56.8%AddedHistory
SWTXSpringWorks Therapeutics, Inc.COM342,566$21.2M2.5%+94,649+38.2%AddedHistory
KYMRKymera Therapeutics, Inc.COM318,667$20.2M2.4%−40,593−11.3%ReducedHistory
BMRNBiomarin Pharmaceutical IncCOM216,977$19.2M2.3%+67,960+45.6%AddedHistory
Wix.com Ltd.92940WAD1NOTE 8/118,959,000$17.3M2.1%+7,859,000+70.8%Added–
MSFTMicrosoft CorpStock50,536$17.0M2.0%−17,000−25.2%ReducedHistory
GNRCGenerac Holdings Inc.Stock42,057$14.8M1.8%−28,956−40.8%ReducedHistory
AMZNAmazon Com IncStock4,200$14.0M1.7%+4,039+2,508.7%AddedHistory
METAMeta Platforms, Inc.Stock41,622$14.0M1.7%+7,222+21.0%AddedHistory
PFEPfizer IncStock228,528$13.5M1.6%−878,000−79.3%ReducedHistory
PANWPalo Alto Networks IncStock24,000$13.4M1.6%−7,000−22.6%ReducedHistory
CCCCC4 Therapeutics, Inc.COM STK398,469$12.8M1.5%+16,695+4.4%AddedHistory
Fiverr Intl Ltd33835LAA3NOTE 11/013,000,000$12.2M1.4%+13,000,000New–
BURLBurlington Stores, Inc.COM41,501$12.1M1.4%+41,501NewHistory
CRNXCrinetics Pharmaceuticals, Inc.COM423,248$12.0M1.4%−125,395−22.9%ReducedHistory
FIVNFive9, Inc.COM85,556$11.7M1.4%+85,556NewHistory
KURAKura Oncology, Inc.COM832,238$11.7M1.4%+43,503+5.5%AddedHistory
ALTAltimmune, Inc.COM NEW1,244,241$11.4M1.4%+155,387+14.3%AddedHistory
FATEFate Therapeutics IncCOM185,476$10.9M1.3%−33,823−15.4%ReducedHistory
MRUSMerus N.V.COM340,951$10.8M1.3%+31,524+10.2%AddedHistory
RLMDRelmada Therapeutics, Inc.COM478,208$10.8M1.3%+478,208NewHistory
VRNTVerint Systems IncCOM200,000$10.5M1.2%+50,000+33.3%AddedHistory
SSentinelOne, Inc.CL A199,824$10.1M1.2%+199,824NewHistory
ARYDARYA Sciences Acquisition Corp IVCL A1,000,000$9.93M1.2%00.0%UnchangedHistory
LESLLeslie's, Inc.COM372,569$8.81M1.0%+222,569+148.4%AddedHistory
IMTXImmatics N.V.SHS621,925$8.36M1.0%−178,118−22.3%ReducedHistory
LENZLENZ Therapeutics, Inc.COM663,194$8.24M1.0%+131,925+24.8%AddedHistory
ISEEIVERIC bio, Inc.COM485,001$8.11M1.0%00.0%UnchangedHistory
ABNBAirbnb, Inc.Stock47,689$7.94M0.9%+47,689NewHistory
VTGNVistagen Therapeutics, Inc.COM NEW4,024,938$7.85M0.9%+200,000+5.2%AddedHistory
HOWLWerewolf Therapeutics, Inc.COM648,391$7.72M0.9%−40,084−5.8%ReducedHistory
VINCVincerx Pharma, Inc.COM NEW720,161$7.34M0.9%+65,589+10.0%AddedHistory
CSTECaesarstone Ltd.ORD SHS644,146$7.30M0.9%00.0%UnchangedHistory
ASANAsana, Inc.CL A96,500$7.19M0.9%+96,500NewHistory
ZLABZai Lab LtdADR111,641$7.02M0.8%−34,341−23.5%ReducedHistory
KROSKeros Therapeutics, Inc.COM119,681$7.00M0.8%+119,681NewHistory
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS832,877$6.67M0.8%−10.0%ReducedHistory
CLDXCelldex Therapeutics, Inc.COM NEW166,766$6.44M0.8%+36,436+28.0%AddedHistory
IMUXImmunic, Inc.COM666,602$6.38M0.8%+276,790+71.0%AddedHistory
TEADTeads Holding Co.COM431,194$6.04M0.7%00.0%UnchangedHistory
EPIXESSA Pharma Inc.COM NEW422,461$6.00M0.7%−46,941−10.0%ReducedHistory
KZRKezar Life Sciences, Inc.COM337,293$5.64M0.7%+337,293NewHistory
IDYAIDEAYA Biosciences, Inc.COM235,695$5.57M0.7%−58,924−20.0%ReducedHistory
PERIPerion Network Ltd.SHS NEW225,000$5.41M0.6%+225,000NewHistory
VRNAVerona Pharma plcSPONSORED ADS801,256$5.38M0.6%00.0%UnchangedHistory
IOVAIovance Biotherapeutics, Inc.COM281,769$5.38M0.6%−213,040−43.1%ReducedHistory
PMVPPMV Pharmaceuticals, Inc.COM190,525$4.40M0.5%00.0%UnchangedHistory
STROSutro Biopharma, Inc.COM281,702$4.19M0.5%−13,123−4.5%ReducedHistory
KALVKalVista Pharmaceuticals, Inc.COM316,200$4.18M0.5%+316,200NewHistory
NAUTNautilus Biotechnology, Inc.COM800,000$4.14M0.5%00.0%UnchangedHistory
ALLTAllot Ltd.SHS340,912$4.05M0.5%−1550.0%ReducedHistory
OMGAOmega Therapeutics, Inc.COMMON STOCK352,948$4.00M0.5%−175,000−33.1%ReducedHistory
BCABBioAtla, Inc.COM180,006$3.53M0.4%−34,294−16.0%ReducedHistory
CAMTCamtek LtdORD75,000$3.45M0.4%+75,000NewHistory
PNTPOINT Biopharma Global Inc.COM592,592$3.32M0.4%−146,598−19.8%ReducedHistory
TPTXTurning Point Therapeutics, Inc.COM68,734$3.28M0.4%+68,734NewHistory
BIIBBiogen Inc.COM13,000$3.12M0.4%+13,000NewHistory
ONCROncorus, Inc.COM571,204$3.01M0.4%−309,498−35.1%ReducedHistory
INBXInhibrx Biosciences, Inc.COM61,931$2.71M0.3%−248,146−80.0%ReducedHistory
ACETAdicet Bio, Inc.COM150,000$2.62M0.3%+150,000NewHistory
OTMOOtonomo Technologies Ltd.ORDINARY SHARES593,650$2.43M0.3%−6,350−1.1%ReducedHistory
CMPXCompass Therapeutics, Inc.COM700,000$2.22M0.3%+700,000NewHistory
BCLS Acquisition CorpG0904B105COM CL A216,250$2.13M0.3%−471,650−68.6%Reduced–
AYLAOld Ayala, IncCOM250,000$2.13M0.3%+250,000NewHistory
Bio Green Med Solution, Inc.23254L603COM508,322$1.98M0.2%00.0%Unchanged–
ARYEARYA Sciences Acquisition Corp VCLASS A ORD SHS200,000$1.94M0.2%00.0%UnchangedHistory
KDNYChinook Therapeutics, Inc.COM111,653$1.82M0.2%+111,653NewHistory
LIANYLianBioSPONSORED ADS275,007$1.66M0.2%+275,007NewHistory
ARGXArgenx SESPONSORED ADR4,291$1.50M0.2%−4,958−53.6%ReducedHistory
ANNXAnnexon, Inc.COM123,637$1.42M0.2%00.0%UnchangedHistory
DYNDyne Therapeutics, Inc.COM105,204$1.25M0.1%−119,879−53.3%ReducedHistory
Magic Software Enterprises L559166103ORD57,704$1.21M0.1%00.0%Unchanged–
CYTCyteir Therapeutics, Inc.COM98,860$1.12M0.1%−36,285−26.8%ReducedHistory
ARBEArbe Robotics Ltd.COM120,400$1.12M0.1%+120,400NewHistory
VRTXVertex Pharmaceuticals IncStock4,411$969.0K0.1%+4,411NewHistory
Nice Sys Inc65366HAB9NOTE 1.250% 1/1250,000$921.0K0.1%00.0%Unchanged–
LVTXLAVA Therapeutics NVSHS137,857$758.0K0.1%−77,502−36.0%ReducedHistory
Immatics N.V.N44445117*W EXP 07/01/202100,000$439.0K0.1%00.0%Unchanged–
Outlook Therapeutics, Inc.69012T115*W EXP 02/18/202129,500$15.0K<0.1%00.0%Unchanged–

Options (5)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Sphera Funds Management Ltd. in Q4 2021
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF–$24.6M
FIVNFive9, Inc.COM–$24.5M
PTGXProtagonist Therapeutics, IncCOM–$8.55M
RUNSunrun Inc.COM–$7.82M
QUREuniQure N.V.SHS–$2.07M

Sold out since Q3 2021 (44)

Positions held at the end of Q3 2021 that are gone from this filing.

Positions of Sphera Funds Management Ltd. sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
SEDGSolaredge Technologies, Inc.COM50,000$13.3M1.3%History
TWLOTwilio IncCL A35,500$11.3M1.1%History
NICENICE Ltd.SPONSORED ADR37,786$10.7M1.1%History
KRNTKornit Digital Ltd.SHS72,076$10.4M1.0%History
AUDCAudiocodes LtdORD316,428$10.3M1.0%History
ALXOAlx Oncology Holdings IncCOM128,706$9.51M0.9%History
NKENIKE, Inc.Stock65,000$9.44M0.9%History
RUNSunrun Inc.COM189,000$8.32M0.8%History
ADSKAutodesk, Inc.COM27,500$7.84M0.8%History
Affimed N VN01045108COM1,117,619$6.91M0.7%–
ZENZendesk, Inc.COM53,910$6.28M0.6%History
RACBResearch Alliance Corp. IICOM CL A600,000$5.91M0.6%History
XENEXenon Pharmaceuticals Inc.COM373,510$5.71M0.6%History
QUREuniQure N.V.SHS172,000$5.51M0.5%History
CALXCalix, IncCOM105,290$5.20M0.5%History
CRBUCaribou Biosciences, Inc.COM200,000$4.77M0.5%History
FOLDAmicus Therapeutics, Inc.COM491,159$4.69M0.5%History
PTGXProtagonist Therapeutics, IncCOM260,379$4.61M0.5%History
Ironsource LtdM5R75Y101CL A ORD SHS367,070$3.99M0.4%–
ALGSAligos Therapeutics, Inc.COM249,197$3.87M0.4%History
DVAXDynavax Technologies CorpCOM NEW198,880$3.82M0.4%History
Eucrates Biomedical Acqu CorG3141W106SHS329,025$3.22M0.3%–
NTLAIntellia Therapeutics, Inc.COM23,647$3.17M0.3%History
DICEDICE Therapeutics, Inc.COM85,000$2.78M0.3%History
GLUEMonte Rosa Therapeutics, Inc.COM119,647$2.67M0.3%History
HIPOHippo Holdings Inc.COMMON STOCK564,967$2.64M0.3%History
RPTXRepare Therapeutics Inc.COM100,391$2.63M0.3%History
CVRXCVRx, Inc.COM150,000$2.48M0.2%History
Turmeric Acquisition CorpG9127T108CL A219,440$2.15M0.2%–
JYACJiya Acquisition Corp.COM CL A199,028$1.95M0.2%History
Achilles Therapeutics PLC00449L102SPONSORED ADS242,500$1.89M0.2%–
AMATApplied Materials IncStock14,500$1.87M0.2%History
MOLNMolecular Partners AGADS80,555$1.58M0.2%History
ERASErasca, Inc.COM70,000$1.49M0.1%History
FLACFrazier Lifesciences Acquisition CorpCL A SHS126,687$1.24M0.1%History
Omega Alpha SpacG6749V107CL A100,000$974.0K0.1%–
ACIUAC Immune SASHS121,019$812.0K0.1%History
KAKineta, Inc.COM75,836$783.0K0.1%History
CM Life Sciences III Inc125841205UNIT 04/30/202875,000$769.0K0.1%–
IONSIonis Pharmaceuticals IncCOM22,000$738.0K0.1%History
UPWKUpwork, IncCOM10,000$450.0K<0.1%History
Sarissa Capital Acquisitn CoG7823W102CL A23,900$236.0K<0.1%–
IMCRImmunocore Holdings plcADS4,235$157.0K<0.1%History
LogicBio Therapeutics, Inc.54142F102COM24,042$110.0K<0.1%–