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Livermore
Livermore
ZHEN

Sphera Funds Management Ltd.

SEC CIK
0001496201
Latest filing
Aug 14, 2026

Holdings in Q2 2021

Holdings as of Jun 30, 2021, filed Aug 17, 2021. Long positions only; changes compare share counts with Q1 2021.

Institution overview
Positions
121
−37 vs. Q1 2021
Portfolio value
$1.05B
−$37.4M (−3.4%) vs. Q1 2021
Filed
Aug 17, 2021
SEC
Holdings of Sphera Funds Management Ltd. in Q2 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
AZNAstraZeneca PLCSPONSORED ADR1,147,673$68.7M6.5%+187,200+19.5%AddedHistory
JNJJohnson & JohnsonStock405,608$66.8M6.4%−48,292−10.6%ReducedHistory
MRKMerck & Co., Inc.Stock772,601$60.1M5.7%−36,207−4.5%ReducedHistory
SNYSanofiSPONSORED ADR843,400$44.4M4.2%−154,500−15.5%ReducedHistory
GNRCGenerac Holdings Inc.Stock104,363$43.3M4.1%−1,300−1.2%ReducedHistory
LLYEli Lilly & CoStock181,895$41.7M4.0%−247,305−57.6%ReducedHistory
ABBVAbbVie Inc.Stock366,194$41.2M3.9%−233,306−38.9%ReducedHistory
CCCCC4 Therapeutics, Inc.COM STK518,611$19.6M1.9%+21,475+4.3%AddedHistory
NICENICE Ltd.SPONSORED ADR76,786$19.0M1.8%+37,305+94.5%AddedHistory
EPIXESSA Pharma Inc.COM NEW648,303$18.5M1.8%+179,062+38.2%AddedHistory
KRNTKornit Digital Ltd.SHS147,793$18.4M1.7%−588−0.4%ReducedHistory
MSFTMicrosoft CorpStock67,536$18.3M1.7%00.0%UnchangedHistory
KURAKura Oncology, Inc.COM868,886$18.1M1.7%+151,135+21.1%AddedHistory
ZLABZai Lab LtdADR97,946$17.3M1.6%+32,158+48.9%AddedHistory
SWTXSpringWorks Therapeutics, Inc.COM195,117$16.1M1.5%+57,445+41.7%AddedHistory
FATEFate Therapeutics IncCOM165,299$14.3M1.4%+55,492+50.5%AddedHistory
LPSNLiveperson IncCOM225,000$14.2M1.4%−35,000−13.5%ReducedHistory
AMZNAmazon Com IncStock4,061$14.0M1.3%+1,300+47.1%AddedHistory
PTGXProtagonist Therapeutics, IncCOM302,965$13.6M1.3%+100,831+49.9%AddedHistory
VTGNVistagen Therapeutics, Inc.COM NEW4,080,673$12.9M1.2%−96,485−2.3%ReducedHistory
AUDCAudiocodes LtdORD385,194$12.7M1.2%−90,430−19.0%ReducedHistory
KYMRKymera Therapeutics, Inc.COM259,895$12.6M1.2%+12,368+5.0%AddedHistory
VRNSVaronis Systems IncCOM218,013$12.6M1.2%+79,338+57.2%AddedHistory
ONCROncorus, Inc.COM893,548$12.3M1.2%−9,563−1.1%ReducedHistory
HOWLWerewolf Therapeutics, Inc.COM706,294$12.0M1.1%+706,294NewHistory
CRNXCrinetics Pharmaceuticals, Inc.COM634,088$12.0M1.1%+349,864+123.1%AddedHistory
Affimed N VN01045108COM1,276,702$10.9M1.0%+257,737+25.3%Added–
ALXOAlx Oncology Holdings IncCOM192,728$10.5M1.0%+62,377+47.9%AddedHistory
TWLOTwilio IncCL A26,500$10.4M1.0%+26,500NewHistory
Therapeutics Acquisition Cor88339T103COM CL A1,009,497$10.4M1.0%+289,497+40.2%Added–
IOVAIovance Biotherapeutics, Inc.COM378,642$9.85M0.9%+378,642NewHistory
CSTECaesarstone Ltd.ORD SHS644,146$9.51M0.9%+108,998+20.4%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM547,187$9.39M0.9%−90,906−14.2%ReducedHistory
METAMeta Platforms, Inc.Stock27,000$9.39M0.9%+27,000NewHistory
SEDGSolaredge Technologies, Inc.COM32,200$8.90M0.8%+32,200NewHistory
NTLAIntellia Therapeutics, Inc.COM52,550$8.51M0.8%+52,550NewHistory
BIIBBiogen Inc.COM23,995$8.31M0.8%+17,195+252.9%AddedHistory
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS832,878$8.24M0.8%00.0%UnchangedHistory
NAUTNautilus Biotechnology, Inc.COM800,000$8.08M0.8%+800,000NewHistory
NKTXNkarta, Inc.COM252,478$8.00M0.8%+151,472+150.0%AddedHistory
STTKShattuck Labs, Inc.COM274,214$7.95M0.8%+133,549+94.9%AddedHistory
ONTOOnto Innovation Inc.COM107,548$7.86M0.7%−17,452−14.0%ReducedHistory
STOKStoke Therapeutics, Inc.COM233,135$7.85M0.7%+82,406+54.7%AddedHistory
DYNDyne Therapeutics, Inc.COM369,714$7.78M0.7%−80,350−17.9%ReducedHistory
MRTXMirati Therapeutics, Inc.COM47,309$7.64M0.7%+17,530+58.9%AddedHistory
BCLS Acquisition CorpG0904B105COM CL A687,900$7.24M0.7%00.0%Unchanged–
ONCBeOne Medicines Ltd.ADR20,900$7.17M0.7%00.0%UnchangedHistory
IDYAIDEAYA Biosciences, Inc.COM334,794$7.03M0.7%+132,810+65.8%AddedHistory
VRNTVerint Systems IncCOM150,000$6.76M0.6%+150,000NewHistory
ALTAltimmune, Inc.COM NEW683,395$6.73M0.6%+683,395NewHistory
NRIXNurix Therapeutics, Inc.COM244,157$6.48M0.6%+29,081+13.5%AddedHistory
MRUSMerus N.V.COM286,506$6.04M0.6%+209,514+272.1%AddedHistory
RACBResearch Alliance Corp. IICOM CL A600,000$6.00M0.6%00.0%UnchangedHistory
ORTXOrchard Therapeutics plcADS1,366,564$6.00M0.6%00.0%UnchangedHistory
ATERAterian, Inc.Equity399,999$5.85M0.6%+399,999NewHistory
STROSutro Biopharma, Inc.COM294,825$5.48M0.5%00.0%UnchangedHistory
ALLTAllot Ltd.SHS276,187$5.48M0.5%−144,018−34.3%ReducedHistory
SPRYARS Pharmaceuticals, Inc.COM173,891$5.37M0.5%+6,092+3.6%AddedHistory
ARYDARYA Sciences Acquisition Corp IVCL A500,000$5.36M0.5%00.0%UnchangedHistory
QUREuniQure N.V.SHS172,000$5.30M0.5%+172,000NewHistory
VRNAVerona Pharma plcSPONSORED ADS801,256$5.24M0.5%00.0%UnchangedHistory
FVRRFiverr International Ltd.ORD SHS21,500$5.21M0.5%+21,500NewHistory
INBXInhibrx Biosciences, Inc.COM189,083$5.20M0.5%+74,440+64.9%AddedHistory
CRISCuris IncCOM NEW588,264$4.75M0.5%−297,574−33.6%ReducedHistory
CVRXCVRx, Inc.COM150,000$4.20M0.4%+150,000NewHistory
RUNSunrun Inc.COM72,000$4.02M0.4%+72,000NewHistory
NBPNovaBridge BiosciencesSPONSORED ADS46,350$3.89M0.4%−8,612−15.7%ReducedHistory
SGTXSigilon Therapeutics, Inc.COM360,239$3.87M0.4%−2,000−0.6%ReducedHistory
BEAMBeam Therapeutics Inc.COM28,425$3.66M0.3%+28,425NewHistory
PLTKPlaytika Holding Corp.COM150,000$3.58M0.3%+150,000NewHistory
ARKOARKO Corp.COM369,875$3.40M0.3%−38,125−9.3%ReducedHistory
ANNXAnnexon, Inc.COM148,318$3.34M0.3%+148,318NewHistory
Eucrates Biomedical Acqu CorG3141W106SHS329,025$3.24M0.3%+25,000+8.2%Added–
ISEEIVERIC bio, Inc.COM500,000$3.15M0.3%+500,000NewHistory
RPTXRepare Therapeutics Inc.COM100,391$3.13M0.3%−147,709−59.5%ReducedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS233,850$3.04M0.3%+21,250+10.0%Added–
Bio Green Med Solution, Inc.23254L603COM508,322$3.01M0.3%00.0%Unchanged–
NEXNNexxen International Ltd.ADS150,000$2.98M0.3%+150,000NewHistory
VINCVincerx Pharma, Inc.COM NEW227,450$2.96M0.3%+133,742+142.7%AddedHistory
SSentinelOne, Inc.CL A68,400$2.91M0.3%+68,400NewHistory
PMVPPMV Pharmaceuticals, Inc.COM84,074$2.87M0.3%+40,718+93.9%AddedHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS292,194$2.86M0.3%−7,806−2.6%Reduced–
ARGXArgenx SESPONSORED ADR9,249$2.79M0.3%00.0%UnchangedHistory
KRROKorro Bio, Inc.COM275,160$2.74M0.3%+275,160NewHistory
CYTCyteir Therapeutics, Inc.COM125,000$2.67M0.3%+125,000NewHistory
PRGOPERRIGO Co plcSHS52,500$2.41M0.2%+52,500NewHistory
TWSTTwist Bioscience CorpCOM18,000$2.40M0.2%+18,000NewHistory
Cerevel Therapeutics HLDNG I15678U102*W EXP 06/09/202165,295$2.38M0.2%−1,037−0.6%Reduced–
IPSCCentury Therapeutics, Inc.COM80,000$2.35M0.2%+80,000NewHistory
LVTXLAVA Therapeutics NVSHS215,359$2.34M0.2%+1,465+0.7%AddedHistory
GLUEMonte Rosa Therapeutics, Inc.COM100,000$2.27M0.2%+100,000NewHistory
Turmeric Acquisition CorpG9127T108CL A219,440$2.17M0.2%00.0%Unchanged–
JYACJiya Acquisition Corp.COM CL A199,028$1.98M0.2%00.0%UnchangedHistory
HYPRHyperfine, Inc.CL A SHS200,000$1.97M0.2%00.0%UnchangedHistory
Healthcare Capital Corp42228C200UNIT 12/31/2025196,610$1.96M0.2%−203,390−50.8%Reduced–
ALDXAldeyra Therapeutics, Inc.COM150,000$1.70M0.2%+150,000NewHistory
WIXWix.com Ltd.SHS5,700$1.66M0.2%00.0%UnchangedHistory
PLRXPliant Therapeutics, Inc.COM51,000$1.49M0.1%+51,000NewHistory
OMICSingular Genomics Systems, Inc.COM53,867$1.48M0.1%+53,867NewHistory
Clarim Acquisition Corp18049C207UNIT 99/99/9999148,886$1.48M0.1%−151,114−50.4%Reduced–

Options (13)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Sphera Funds Management Ltd. in Q2 2021
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF$84.6M–
MRKMerck & Co., Inc.Stock$60.1M–
ENPHEnphase Energy, Inc.Stock–$42.2M
iShares Tr464287515EXPANDED TECH$41.0M–
State Street Technology Select Sector SPDR ETF81369Y803ETF$31.0M–
iShares Russell 2000 ETF464287655ETF$24.1M–
FVRRFiverr International Ltd.ORD SHS–$19.2M
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS–$18.9M
Invesco Exch Traded FD Tr II46138G706SOLAR ETF–$18.8M
BIIBBiogen Inc.COM–$17.3M
IONSIonis Pharmaceuticals IncCOM–$7.44M
AGIOAgios Pharmaceuticals, Inc.COM–$6.39M
ATERAterian, Inc.Equity–$5.20M

Sold out since Q1 2021 (73)

Positions held at the end of Q1 2021 that are gone from this filing.

Positions of Sphera Funds Management Ltd. sold out since Q1 2021
SecurityClassShares in Q1 2021Value in Q1 2021% of portfolio in Q1 2021History
BMYBristol Myers Squibb CoStock200,000$12.6M1.2%History
PANWPalo Alto Networks IncStock32,300$10.4M1.0%History
BOLTBolt Biotherapeutics, Inc.COM241,000$7.93M0.7%History
ZNTLZentalis Pharmaceuticals, Inc.COM175,140$7.60M0.7%History
Mohawk Group Hldgs Inc608189106COM251,015$7.41M0.7%–
Trillium Therapeutics Inc.89620X506COM NEW670,459$7.20M0.7%–
Cyberark Software LtdM2682V108SHS55,000$7.11M0.7%–
COGTCogent Biosciences, Inc.COM762,569$6.70M0.6%History
KALVKalVista Pharmaceuticals, Inc.COM258,880$6.65M0.6%History
IONSIonis Pharmaceuticals IncCOM145,476$6.54M0.6%History
Arya Sciences Acquisition CoG3166W106COM CL A400,000$5.51M0.5%–
BIDUBaidu, Inc.ADR25,000$5.44M0.5%History
Rada Electr Inds LtdM81863124COM PAR NEW407,925$4.90M0.5%–
Reinvent Technology PartnersG74847107SHS CL A468,012$4.68M0.4%–
CLDXCelldex Therapeutics, Inc.COM NEW220,320$4.54M0.4%History
MREOMereo BioPharma Group plcSPON ADS1,312,415$4.42M0.4%History
Farfetch Ltd30744W107ORD SH CL A80,000$4.24M0.4%–
ORICOric Pharmaceuticals, Inc.COM169,900$4.16M0.4%History
Foresight Acquisition Corp34552Y205UNIT 01/29/2026420,000$4.16M0.4%–
IFRXInflaRx N.V.COM1,000,000$3.90M0.4%History
Catabasis Pharmaceuticals IN14875P206COM NEW1,294,000$3.74M0.3%–
EWTXEdgewise Therapeutics, Inc.COM100,000$3.25M0.3%History
Longview Acquisition Corp. II54319Q204UNIT 99/99/9999300,000$3.01M0.3%–
GRTXGalera Therapeutics, Inc.COM323,348$2.85M0.3%History
DMRADamora Therapeutics, Inc.COM448,016$2.72M0.3%History
PHASPhaseBio Pharmaceuticals IncCOM750,000$2.60M0.2%History
IMVTImmunovant, Inc.COM158,500$2.54M0.2%History
SNCEScience 37 Holdings, Inc.COM244,000$2.47M0.2%History
FNCHFinch Therapeutics Group, Inc.COM150,000$2.39M0.2%History
CAMTCamtek LtdORD79,746$2.38M0.2%History
TILInstil Bio, Inc.COM95,000$2.38M0.2%History
ALPNAlpine Immune Sciences, Inc.COM198,260$2.10M0.2%History
Highcape Cap Acquisition Cor42984L105COM CL A172,396$2.06M0.2%–
ALITAlight, Inc. / DelawareCOM CL A200,000$2.01M0.2%History
EQEquillium, Inc.COM254,184$1.82M0.2%History
GIGCAPITAL4 Inc37518G200UNIT 99/99/9999175,000$1.73M0.2%–
Starboard Value Acquisitn Co85521J109COM CL A170,937$1.70M0.2%–
Pieris Pharmaceuticals Inc720795103COM650,000$1.67M0.2%–
KDNYChinook Therapeutics, Inc.COM101,666$1.58M0.1%History
NSTBNorthern Star Investment Corp. IICOM CLASS A155,367$1.55M0.1%History
TERNTerns Pharmaceuticals, Inc.COM70,000$1.54M0.1%History
IMCRImmunocore Holdings plcADS36,000$1.53M0.1%History
Forum Merger IV Corp349875203UNIT 03/15/2028150,000$1.49M0.1%–
Landcadia Holdings IV, Inc.51477A203UNIT 05/01/2025150,000$1.49M0.1%–
Alkuri Global Acquisition Corp.66981N202UNIT 01/01/2028150,000$1.48M0.1%–
BBIOBridgeBio Pharma, Inc.COM23,890$1.47M0.1%History
LRMRLarimar Therapeutics, Inc.COM100,000$1.46M0.1%History
GMDAGamida Cell Ltd.SHS178,450$1.44M0.1%History
VRTXVertex Pharmaceuticals IncStock5,530$1.19M0.1%History
OBIOOrchestra BioMed Holdings, Inc.ORD SHS100,000$1.12M0.1%History
Revolution Accelertn Acqu Co76156P106COM CL A109,994$1.11M0.1%–
SWBKSwitchback II CorpCOM CL A103,698$1.02M0.1%History
Falcon Capital Acquisitn Cor30606L108COM CL A100,010$997.0K0.1%–
Mcap Acquisition Corp55282T208UNIT 02/18/2030100,000$995.0K0.1%–
VPC Impact Acqu Holdi III IN91835J207UNIT 99/99/9999100,000$987.0K0.1%–
VPC Impact Acquisition HldgG9460L100UNIT 03/05/2026100,000$986.0K0.1%–
890 5th Ave Partners Inc28250A204UNIT 01/12/202698,828$983.0K0.1%–
CNTBConnect Biopharma Holdings LtdADS50,000$925.0K0.1%History
Glass Houses Acquisition Cor37714P202UNIT 03/25/202889,884$902.0K0.1%–
NVMINova Ltd.COM8,556$779.0K0.1%History
Live Oak Mobility Acquisi Co538126202UNIT 03/01/202875,000$749.0K0.1%–
LABPLandos Biopharma, Inc.COM70,000$674.0K0.1%History
Spartan Acquisition Corp II846775104COM50,000$523.0K<0.1%–
Vectoiq Acquisition Corp II92244F208UNIT 99/99/999950,000$507.0K<0.1%–
Stratim Cloud Acquisition Corp.86309R206UNIT 03/05/202650,000$500.0K<0.1%–
Z-Work Acquisition Corp98880C201UNIT 99/99/999950,000$498.0K<0.1%–
EJF Acquisition Corp.G2955B117UNIT 03/10/202649,900$497.0K<0.1%–
Agile Growth Corp.G01202129UNIT 03/09/202650,000$496.0K<0.1%–
MDH Acquisition Corp55283P205UNIT 99/99/999931,000$308.0K<0.1%–
CM Life Sciences Inc18978W109COM CL A20,000$298.0K<0.1%–
Noble Rock Acquisition CorpG6546R127UNIT 01/31/202828,000$277.0K<0.1%–
Fintech Evolution Acquis GroG3R19A112UNIT 99/99/999925,000$247.0K<0.1%–
NBSENeuBase Therapeutics, Inc.COM31,900$236.0K<0.1%History