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Livermore
Livermore
ZHEN

Baker Bros. Advisors LP

SEC CIK
0001263508
Latest filing
Aug 14, 2026

Holdings in Q2 2025

Holdings as of Jun 30, 2025, filed Aug 14, 2025. Long positions only; changes compare share counts with Q1 2025.

Institution overview
Positions
89
0 vs. Q1 2025
Portfolio value
$10.3B
+$1.27B (+14.1%) vs. Q1 2025
Filed
Aug 14, 2025
SEC
Holdings of Baker Bros. Advisors LP in Q2 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
CYVNYOpthea LtdSPONSORED ADS2,087,320$00.0%00.0%UnchangedHistory
Surrozen, Inc.86889P117*W EXP 08/01/203833,333$15.1K<0.1%00.0%Unchanged–
ACRVAcrivon Therapeutics, Inc.COMMON STOCK22,809$27.1K<0.1%00.0%UnchangedHistory
TYRATyra Biosciences, Inc.COM10,607$101.5K<0.1%00.0%UnchangedHistory
ALGSAligos Therapeutics, Inc.COM NEW83,055$598.8K<0.1%00.0%UnchangedHistory
GBIOGeneration Bio Co.COM1,944,945$622.6K<0.1%00.0%UnchangedHistory
NMRANeumora Therapeutics, Inc.COM1,034,600$758.7K<0.1%00.0%UnchangedHistory
HOOKHOOKIPA Pharma Inc.COM812,814$1.02M<0.1%00.0%UnchangedHistory
CTNMContineum Therapeutics, Inc.CL A312,500$1.24M<0.1%00.0%UnchangedHistory
RCKTRocket Pharmaceuticals, Inc.COM552,079$1.35M<0.1%−545,000−49.7%ReducedHistory
VTVTvTv Therapeutics Inc.CL A NEW97,314$1.46M<0.1%00.0%UnchangedHistory
TARAProtara Therapeutics, Inc.COM STK536,832$1.63M<0.1%00.0%UnchangedHistory
CADLCandel Therapeutics, Inc.COM355,112$1.80M<0.1%−2,082,077−85.4%ReducedHistory
TECXTectonic Therapeutic, Inc.COM100,000$1.99M<0.1%00.0%UnchangedHistory
WVEWave Life Sciences, Inc.SHS344,063$2.24M<0.1%00.0%UnchangedHistory
ELVNEnliven Therapeutics, Inc.COM114,833$2.30M<0.1%00.0%UnchangedHistory
VIRVir Biotechnology, Inc.COM542,539$2.73M<0.1%00.0%UnchangedHistory
FATEFate Therapeutics IncCOM2,485,018$2.78M<0.1%−773,384−23.7%ReducedHistory
RLAYRelay Therapeutics, Inc.COM1,160,117$4.01M<0.1%00.0%UnchangedHistory
TCRXTScan Therapeutics, Inc.COM2,784,792$4.04M<0.1%00.0%UnchangedHistory
IGMSIGM Biosciences, Inc.COM4,096,210$4.59M<0.1%+9530.0%AddedHistory
ALMSAlumis Inc.COM1,562,500$4.69M<0.1%00.0%UnchangedHistory
XNCRXencor IncCOM670,431$5.27M0.1%00.0%UnchangedHistory
SANASana Biotechnology, Inc.COM2,030,949$5.54M0.1%00.0%UnchangedHistory
KALAKALA BIO, Inc.COMM STK1,201,894$5.72M0.1%00.0%UnchangedHistory
DSGNDesign Therapeutics, Inc.COM1,712,882$5.77M0.1%−30,843−1.8%ReducedHistory
SKYESkye Bioscience, Inc.COM NEW1,450,638$6.06M0.1%00.0%UnchangedHistory
RAPPRapport Therapeutics, Inc.COM550,090$6.25M0.1%+550,090NewHistory
AGIOAgios Pharmaceuticals, Inc.COM189,866$6.31M0.1%+189,866NewHistory
SIONSionna Therapeutics, Inc.COM400,000$6.94M0.1%00.0%UnchangedHistory
SGMTSagimet Biosciences Inc.COM SER A952,996$7.26M0.1%00.0%UnchangedHistory
CTMXCytomX Therapeutics, Inc.COM3,484,226$7.91M0.1%+3,484,226NewHistory
CRNXCrinetics Pharmaceuticals, Inc.COM280,000$8.05M0.1%+280,000NewHistory
PRLDPrelude Therapeutics IncCOM10,123,824$8.19M0.1%00.0%UnchangedHistory
TSHATaysha Gene Therapies, Inc.COM SHS4,004,756$9.25M0.1%00.0%UnchangedHistory
SYRESpyre Therapeutics, Inc.COM NEW626,703$9.38M0.1%+626,703NewHistory
NUVLNuvalent, Inc.COM143,937$11.0M0.1%+143,937NewHistory
ACLXArcellx, Inc.COMMON STOCK166,825$11.0M0.1%+166,825NewHistory
CDTXCidara Therapeutics, Inc.COM NEW227,272$11.1M0.1%+227,272NewHistory
XENEXenon Pharmaceuticals Inc.COM370,208$11.6M0.1%+22,800+6.6%AddedHistory
DBVTDBV Technologies S.A.SPONSORED ADS1,461,425$13.4M0.1%00.0%UnchangedHistory
CLDXCelldex Therapeutics, Inc.COM NEW665,370$13.5M0.1%+417,726+168.7%AddedHistory
DNTHDianthus Therapeutics, Inc.COM789,759$14.7M0.1%+789,759NewHistory
NGNENeurogene Inc.COM991,691$14.8M0.1%−494,509−33.3%ReducedHistory
ARWRArrowhead Pharmaceuticals, Inc.COM939,174$14.8M0.1%+939,174NewHistory
SERASera Prognostics, Inc.CLASS A COM5,498,170$15.2M0.1%00.0%UnchangedHistory
BPMCBlueprint Medicines CorpCOM125,538$16.1M0.2%+125,538NewHistory
AKROAkero Therapeutics, Inc.COM324,630$17.3M0.2%−224,083−40.8%ReducedHistory
IRONDisc Medicine, Inc.COM337,050$17.9M0.2%+260,000+337.4%AddedHistory
CERSCerus CorpCOM12,883,844$18.2M0.2%−6,467,243−33.4%ReducedHistory
VERVVerve Therapeutics, Inc.COM1,691,530$19.0M0.2%00.0%UnchangedHistory
ARGXArgenx SESPONSORED ADR37,760$20.8M0.2%−40,000−51.4%ReducedHistory
PCVXVaxcyte, Inc.COM640,885$20.8M0.2%00.0%UnchangedHistory
VRNAVerona Pharma plcSPONSORED ADS223,843$21.2M0.2%00.0%UnchangedHistory
GLUEMonte Rosa Therapeutics, Inc.COM4,916,095$22.2M0.2%00.0%UnchangedHistory
VRDNViridian Therapeutics, Inc.COM1,744,406$24.4M0.2%+1,744,406NewHistory
NTLAIntellia Therapeutics, Inc.COM2,675,674$25.1M0.2%+2,031,558+315.4%AddedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW689,488$29.0M0.3%+357,955+108.0%AddedHistory
MRUSMerus N.V.COM574,377$30.2M0.3%+350,877+157.0%AddedHistory
TRDAEntrada Therapeutics, Inc.COM4,865,819$32.7M0.3%00.0%UnchangedHistory
BNTXBioNTech SESPONSORED ADS368,923$39.3M0.4%+323,892+719.3%AddedHistory
ROIVRoivant Sciences Ltd.SHS3,767,773$42.5M0.4%00.0%UnchangedHistory
NRIXNurix Therapeutics, Inc.COM3,882,125$44.2M0.4%00.0%UnchangedHistory
IDYAIDEAYA Biosciences, Inc.COM2,118,728$44.5M0.4%+1,056,605+99.5%AddedHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS2,508,767$52.0M0.5%+2,147,202+593.9%AddedHistory
DNLIDenali Therapeutics Inc.COM3,731,695$52.2M0.5%00.0%UnchangedHistory
STOKStoke Therapeutics, Inc.COM4,633,838$52.6M0.5%00.0%UnchangedHistory
IMTXImmatics N.V.SHS10,168,901$54.7M0.5%+2,893,071+39.8%AddedHistory
KODKodiak Sciences Inc.COM17,310,490$64.6M0.6%00.0%UnchangedHistory
CELCCelcuity Inc.COM5,450,445$72.8M0.7%+1,192,710+28.0%AddedHistory
IMCRImmunocore Holdings plcADS2,322,656$72.9M0.7%00.0%UnchangedHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS10,885,357$75.7M0.7%00.0%UnchangedHistory
KNSAKiniksa Pharmaceuticals International, plcORD SHS CL A2,824,669$78.2M0.8%+6,346+0.2%AddedHistory
GRALGRAIL, Inc.COM1,630,125$83.8M0.8%00.0%UnchangedHistory
IMVTImmunovant, Inc.COM5,457,881$87.3M0.8%00.0%UnchangedHistory
ABCLAbCellera Biologics Inc.COM27,525,640$94.4M0.9%00.0%UnchangedHistory
EWTXEdgewise Therapeutics, Inc.COM7,305,940$95.8M0.9%+1,150,000+18.7%AddedHistory
RAREUltragenyx Pharmaceutical Inc.COM2,772,692$100.8M1.0%+1,196,578+75.9%AddedHistory
REPLReplimune Group, Inc.COM11,045,336$102.6M1.0%00.0%UnchangedHistory
ALKSAlkermes plc.SHS6,410,603$183.4M1.8%+1,927,318+43.0%AddedHistory
KYMRKymera Therapeutics, Inc.COM6,651,429$290.3M2.8%+655,500+10.9%AddedHistory
RVMDRevolution Medicines, Inc.COM9,364,972$344.5M3.3%+1,428,000+18.0%AddedHistory
RYTMRhythm Pharmaceuticals, Inc.COM5,604,483$354.1M3.4%00.0%UnchangedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM1,976,018$598.0M5.8%+1,428+0.1%AddedHistory
SMMTSummit Therapeutics Inc.COM33,722,974$717.6M7.0%+9,298,109+38.1%AddedHistory
INSMINSMED IncCOM PAR $.017,712,900$776.2M7.5%+2,332,274+43.3%AddedHistory
ACADAcadia Pharmaceuticals IncCOM42,896,690$925.3M9.0%+18,7740.0%AddedHistory
INCYIncyte CorpCOM30,743,275$2.09B20.3%+3,3220.0%AddedHistory
ONCBeOne Medicines Ltd.ADR8,799,053$2.13B20.7%00.0%UnchangedHistory

Sold out since Q1 2025 (12)

Positions held at the end of Q1 2025 that are gone from this filing.

Positions of Baker Bros. Advisors LP sold out since Q1 2025
SecurityClassShares in Q1 2025Value in Q1 2025% of portfolio in Q1 2025History
INSMED Inc457669AB5NOTE 0.750% 6/0–$101.6M1.1%–
CRSPCRISPR Therapeutics AGNAMEN AKT654,099$22.3M0.2%History
CNTACentessa Pharmaceuticals plcSPONSORED ADS1,227,178$17.6M0.2%History
TSVT2seventy bio, Inc.COMMON STOCK2,497,526$12.3M0.1%History
BCAXBicara Therapeutics Inc.COM833,333$10.9M0.1%History
IONSIonis Pharmaceuticals IncCOM357,915$10.8M0.1%History
DYNDyne Therapeutics, Inc.COM672,096$7.03M0.1%History
RGLSRegulus Therapeutics Inc.COM2,694,044$4.71M0.1%History
PRMEPrime Medicine, Inc.COM1,028,466$2.05M<0.1%History
CMPXCompass Therapeutics, Inc.COM547,498$1.04M<0.1%History
CYPHCypherpunk Technologies Inc.COM NEW404,744$123.5K<0.1%History
IPSCCentury Therapeutics, Inc.COM241,684$115.0K<0.1%History