Baker Bros. Advisors LP
- SEC CIK
- 0001263508
- Latest filing
- Aug 14, 2026
Holdings in Q3 2025
Holdings as of Sep 30, 2025, filed Nov 14, 2025. Long positions only; changes compare share counts with Q2 2025.
- Positions
- 91
- +2 vs. Q2 2025
- Portfolio value
- $13.8B
- +$3.53B (+34.3%) vs. Q2 2025
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| ONCBeOne Medicines Ltd. | ADR | 8,799,053 | $3.00B | 21.7% | 00.0% | Unchanged | History |
| INCYIncyte Corp | COM | 30,743,663 | $2.61B | 18.8% | +3880.0% | Added | History |
| MDGLMadrigal Pharmaceuticals, Inc. | COM | 2,141,701 | $982.3M | 7.1% | +165,683+8.4% | Added | History |
| INSMINSMED Inc | COM PAR $.01 | 6,703,484 | $965.4M | 7.0% | −1,009,416−13.1% | Reduced | History |
| ACADAcadia Pharmaceuticals Inc | COM | 42,896,690 | $915.4M | 6.6% | 00.0% | Unchanged | History |
| SMMTSummit Therapeutics Inc. | COM | 33,722,974 | $696.7M | 5.0% | 00.0% | Unchanged | History |
| RYTMRhythm Pharmaceuticals, Inc. | COM | 5,604,483 | $566.0M | 4.1% | 00.0% | Unchanged | History |
| RVMDRevolution Medicines, Inc. | COM | 9,455,357 | $441.6M | 3.2% | +90,385+1.0% | Added | History |
| CELCCelcuity Inc. | COM | 7,915,792 | $391.0M | 2.8% | +2,465,347+45.2% | Added | History |
| KYMRKymera Therapeutics, Inc. | COM | 6,651,429 | $376.5M | 2.7% | 00.0% | Unchanged | History |
| KODKodiak Sciences Inc. | COM | 17,310,490 | $283.4M | 2.0% | 00.0% | Unchanged | History |
| ALKSAlkermes plc. | SHS | 8,091,351 | $242.7M | 1.8% | +1,680,748+26.2% | Added | History |
| ABCLAbCellera Biologics Inc. | COM | 27,525,640 | $138.5M | 1.0% | 00.0% | Unchanged | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 7,305,940 | $118.5M | 0.9% | 00.0% | Unchanged | History |
| KNSAKiniksa Pharmaceuticals International, plc | ORD SHS CL A | 2,824,669 | $109.7M | 0.8% | 00.0% | Unchanged | History |
| STOKStoke Therapeutics, Inc. | COM | 4,633,838 | $108.9M | 0.8% | 00.0% | Unchanged | History |
| IMTXImmatics N.V. | SHS | 12,094,094 | $103.0M | 0.7% | +1,925,193+18.9% | Added | History |
| GRALGRAIL, Inc. | COM | 1,630,125 | $96.4M | 0.7% | 00.0% | Unchanged | History |
| IDYAIDEAYA Biosciences, Inc. | COM | 3,275,444 | $89.1M | 0.6% | +1,156,716+54.6% | Added | History |
| IMVTImmunovant, Inc. | COM | 5,457,881 | $88.0M | 0.6% | 00.0% | Unchanged | History |
| IMCRImmunocore Holdings plc | ADS | 2,322,656 | $84.4M | 0.6% | 00.0% | Unchanged | History |
| BCYCBicycle Therapeutics PLC | SPONSORED ADS | 10,885,357 | $84.3M | 0.6% | 00.0% | Unchanged | History |
| RAREUltragenyx Pharmaceutical Inc. | COM | 2,772,692 | $83.4M | 0.6% | 00.0% | Unchanged | History |
| ABVXAbivax S.A. | SPONSORED ADS | 875,796 | $74.4M | 0.5% | +875,796 | New | History |
| ARWRArrowhead Pharmaceuticals, Inc. | COM | 1,670,762 | $57.6M | 0.4% | +731,588+77.9% | Added | History |
| ROIVRoivant Sciences Ltd. | SHS | 3,767,773 | $57.0M | 0.4% | 00.0% | Unchanged | History |
| DNLIDenali Therapeutics Inc. | COM | 3,731,695 | $54.2M | 0.4% | 00.0% | Unchanged | History |
| MRUSMerus N.V. | COM | 574,377 | $54.1M | 0.4% | 00.0% | Unchanged | History |
| NTLAIntellia Therapeutics, Inc. | COM | 2,746,674 | $47.4M | 0.3% | +71,000+2.7% | Added | History |
| REPLReplimune Group, Inc. | COM | 11,045,336 | $46.3M | 0.3% | 00.0% | Unchanged | History |
| RAPPRapport Therapeutics, Inc. | COM | 1,547,090 | $45.9M | 0.3% | +997,000+181.2% | Added | History |
| GPCRStructure Therapeutics Inc. | SPONSORED ADS | 1,556,109 | $43.6M | 0.3% | −952,658−38.0% | Reduced | History |
| Celcuity Inc.15102KAA8 | NOTE 2.750% 8/0 | – | $40.9M | 0.3% | – | New | – |
| VRDNViridian Therapeutics, Inc. | COM | 1,744,406 | $37.6M | 0.3% | 00.0% | Unchanged | History |
| IONSIonis Pharmaceuticals Inc | COM | 566,798 | $37.1M | 0.3% | +566,798 | New | History |
| PRAXPraxis Precision Medicines, Inc. | COM NEW | 689,488 | $36.5M | 0.3% | 00.0% | Unchanged | History |
| GLUEMonte Rosa Therapeutics, Inc. | COM | 4,916,095 | $36.4M | 0.3% | 00.0% | Unchanged | History |
| BNTXBioNTech SE | SPONSORED ADS | 368,923 | $36.4M | 0.3% | 00.0% | Unchanged | History |
| NRIXNurix Therapeutics, Inc. | COM | 3,882,125 | $35.9M | 0.3% | 00.0% | Unchanged | History |
| DNTHDianthus Therapeutics, Inc. | COM | 789,759 | $31.1M | 0.2% | 00.0% | Unchanged | History |
| TRDAEntrada Therapeutics, Inc. | COM | 4,865,819 | $28.2M | 0.2% | 00.0% | Unchanged | History |
| ARGXArgenx SE | SPONSORED ADR | 37,760 | $27.9M | 0.2% | 00.0% | Unchanged | History |
| Avidity Biosciences, Inc.05370A108 | COM | 625,000 | $27.2M | 0.2% | +625,000 | New | – |
| PCVXVaxcyte, Inc. | COM | 640,885 | $23.1M | 0.2% | 00.0% | Unchanged | History |
| IRONDisc Medicine, Inc. | COM | 337,050 | $22.3M | 0.2% | 00.0% | Unchanged | History |
| CDTXCidara Therapeutics, Inc. | COM NEW | 227,272 | $21.8M | 0.2% | 00.0% | Unchanged | History |
| CLDXCelldex Therapeutics, Inc. | COM NEW | 665,370 | $17.2M | 0.1% | 00.0% | Unchanged | History |
| NGNENeurogene Inc. | COM | 991,691 | $17.2M | 0.1% | 00.0% | Unchanged | History |
| SERASera Prognostics, Inc. | CLASS A COM | 5,498,170 | $16.8M | 0.1% | 00.0% | Unchanged | History |
| SYRESpyre Therapeutics, Inc. | COM NEW | 1,000,000 | $16.8M | 0.1% | +373,297+59.6% | Added | History |
| CERSCerus Corp | COM | 10,008,345 | $15.9M | 0.1% | −2,875,499−22.3% | Reduced | History |
| AKROAkero Therapeutics, Inc. | COM | 324,630 | $15.4M | 0.1% | 00.0% | Unchanged | History |
| XENEXenon Pharmaceuticals Inc. | COM | 370,208 | $14.9M | 0.1% | 00.0% | Unchanged | History |
| DBVTDBV Technologies S.A. | SPONSORED ADS | 1,461,425 | $14.6M | 0.1% | 00.0% | Unchanged | History |
| PRLDPrelude Therapeutics Inc | COM | 10,123,824 | $14.6M | 0.1% | 00.0% | Unchanged | History |
| ACLXArcellx, Inc. | COMMON STOCK | 166,825 | $13.7M | 0.1% | 00.0% | Unchanged | History |
| CTMXCytomX Therapeutics, Inc. | COM | 4,250,826 | $13.6M | 0.1% | +766,600+22.0% | Added | History |
| TSHATaysha Gene Therapies, Inc. | COM SHS | 4,004,756 | $13.1M | 0.1% | 00.0% | Unchanged | History |
| XNCRXencor Inc | COM | 1,102,106 | $12.9M | 0.1% | +431,675+64.4% | Added | History |
| DSGNDesign Therapeutics, Inc. | COM | 1,712,882 | $12.9M | 0.1% | 00.0% | Unchanged | History |
| NUVLNuvalent, Inc. | COM | 143,937 | $12.4M | 0.1% | 00.0% | Unchanged | History |
| SIONSionna Therapeutics, Inc. | COM | 400,000 | $11.8M | 0.1% | 00.0% | Unchanged | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 280,000 | $11.7M | 0.1% | 00.0% | Unchanged | History |
| VKTXViking Therapeutics, Inc. | COM | 366,083 | $9.62M | 0.1% | +366,083 | New | History |
| PHVSPharvaris N.V. | COM | 375,000 | $9.36M | 0.1% | +375,000 | New | History |
| AGIOAgios Pharmaceuticals, Inc. | COM | 189,866 | $7.62M | 0.1% | 00.0% | Unchanged | History |
| SANASana Biotechnology, Inc. | COM | 2,030,949 | $7.21M | 0.1% | 00.0% | Unchanged | History |
| SGMTSagimet Biosciences Inc. | COM SER A | 952,996 | $6.54M | <0.1% | 00.0% | Unchanged | History |
| ALMSAlumis Inc. | COM | 1,562,500 | $6.23M | <0.1% | 00.0% | Unchanged | History |
| RLAYRelay Therapeutics, Inc. | COM | 1,160,117 | $6.06M | <0.1% | 00.0% | Unchanged | History |
| SKYESkye Bioscience, Inc. | COM NEW | 1,450,638 | $5.70M | <0.1% | 00.0% | Unchanged | History |
| HRTXHeron Therapeutics, Inc. | COM | 4,251,951 | $5.36M | <0.1% | +4,251,951 | New | History |
| TCRXTScan Therapeutics, Inc. | COM | 2,784,792 | $5.07M | <0.1% | 00.0% | Unchanged | History |
| MBXMBX Biosciences, Inc. | COM | 277,777 | $4.86M | <0.1% | +277,777 | New | History |
| VTVTvTv Therapeutics Inc. | CL A NEW | 148,314 | $3.46M | <0.1% | +51,000+52.4% | Added | History |
| VTYXVentyx Biosciences, Inc. | COM | 1,023,130 | $3.18M | <0.1% | +1,023,130 | New | History |
| LBRXLB Pharmaceuticals Inc | COM SHS | 200,000 | $3.16M | <0.1% | +200,000 | New | History |
| VIRVir Biotechnology, Inc. | COM | 542,539 | $3.10M | <0.1% | 00.0% | Unchanged | History |
| WVEWave Life Sciences, Inc. | SHS | 344,063 | $2.52M | <0.1% | 00.0% | Unchanged | History |
| ELVNEnliven Therapeutics, Inc. | COM | 114,833 | $2.35M | <0.1% | 00.0% | Unchanged | History |
| TARAProtara Therapeutics, Inc. | COM STK | 536,832 | $2.34M | <0.1% | 00.0% | Unchanged | History |
| TECXTectonic Therapeutic, Inc. | COM | 100,000 | $1.57M | <0.1% | 00.0% | Unchanged | History |
| KALAKALA BIO, Inc. | COMM STK | 985,093 | $1.51M | <0.1% | −216,801−18.0% | Reduced | History |
| GBIOGeneration Bio Co. | COMMON STOCK | 194,493 | $1.19M | <0.1% | 00.0% | UnchangedConverted for a 1-for-10 split | History |
| CTNMContineum Therapeutics, Inc. | CL A | 77,670 | $912.6K | <0.1% | −234,830−75.1% | Reduced | History |
| ALGSAligos Therapeutics, Inc. | COM NEW | 83,055 | $813.9K | <0.1% | 00.0% | Unchanged | History |
| YARWYarrow Bioscience, Inc. | COM | 851,353 | $285.2K | <0.1% | +851,353 | New | History |
| TYRATyra Biosciences, Inc. | COM | 10,607 | $148.4K | <0.1% | 00.0% | Unchanged | History |
| ACRVAcrivon Therapeutics, Inc. | COMMON STOCK | 22,809 | $41.3K | <0.1% | 00.0% | Unchanged | History |
| Surrozen, Inc.86889P117 | *W EXP 08/01/203 | 833,333 | $14.8K | <0.1% | 00.0% | Unchanged | – |
| CYVNYOpthea Ltd | SPONSORED ADS | 2,087,320 | $0 | 0.0% | 00.0% | Unchanged | History |
Sold out since Q2 2025 (9)
Positions held at the end of Q2 2025 that are gone from this filing.
| Security | Class | Shares in Q2 2025 | Value in Q2 2025 | % of portfolio in Q2 2025 | History |
|---|---|---|---|---|---|
| VRNAVerona Pharma plc | SPONSORED ADS | 223,843 | $21.2M | 0.2% | History |
| VERVVerve Therapeutics, Inc. | COM | 1,691,530 | $19.0M | 0.2% | History |
| BPMCBlueprint Medicines Corp | COM | 125,538 | $16.1M | 0.2% | History |
| IGMSIGM Biosciences, Inc. | COM | 4,096,210 | $4.59M | <0.1% | History |
| FATEFate Therapeutics Inc | COM | 2,485,018 | $2.78M | <0.1% | History |
| CADLCandel Therapeutics, Inc. | COM | 355,112 | $1.80M | <0.1% | History |
| RCKTRocket Pharmaceuticals, Inc. | COM | 552,079 | $1.35M | <0.1% | History |
| HOOKHOOKIPA Pharma Inc. | COM | 812,814 | $1.02M | <0.1% | History |
| NMRANeumora Therapeutics, Inc. | COM | 1,034,600 | $758.7K | <0.1% | History |