Baker Bros. Advisors LP
- SEC CIK
- 0001263508
- Latest filing
- Aug 14, 2026
Holdings in Q1 2025
Holdings as of Mar 31, 2025, filed May 15, 2025. Long positions only; changes compare share counts with Q4 2024.
- Positions
- 89
- −6 vs. Q4 2024
- Portfolio value
- $9.04B
- −$324.8M (−3.5%) vs. Q4 2024
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| ONCBeOne Medicines Ltd. | ADR | 8,799,053 | $2.39B | 26.5% | −732,827−7.7% | Reduced | History |
| INCYIncyte Corp | COM | 30,739,953 | $1.86B | 20.6% | +4870.0% | Added | History |
| ACADAcadia Pharmaceuticals Inc | COM | 42,877,916 | $712.2M | 7.9% | 00.0% | Unchanged | History |
| MDGLMadrigal Pharmaceuticals, Inc. | COM | 1,974,590 | $654.0M | 7.2% | 00.0% | Unchanged | History |
| SMMTSummit Therapeutics Inc. | COM | 24,424,865 | $471.2M | 5.2% | 00.0% | Unchanged | History |
| INSMINSMED Inc | COM PAR $.01 | 5,380,626 | $410.5M | 4.5% | +373,763+7.5% | Added | History |
| RYTMRhythm Pharmaceuticals, Inc. | COM | 5,604,483 | $296.9M | 3.3% | −479,766−7.9% | Reduced | History |
| RVMDRevolution Medicines, Inc. | COM | 7,936,972 | $280.7M | 3.1% | 00.0% | Unchanged | History |
| KYMRKymera Therapeutics, Inc. | COM | 5,995,929 | $164.1M | 1.8% | 00.0% | Unchanged | History |
| ALKSAlkermes plc. | SHS | 4,483,285 | $148.0M | 1.6% | +301,534+7.2% | Added | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 6,155,940 | $135.4M | 1.5% | 00.0% | Unchanged | History |
| REPLReplimune Group, Inc. | COM | 11,045,336 | $107.7M | 1.2% | 00.0% | Unchanged | History |
| INSMED Inc457669AB5 | NOTE 0.750% 6/0 | – | $101.6M | 1.1% | – | – | – |
| IMVTImmunovant, Inc. | COM | 5,457,881 | $93.3M | 1.0% | +3,750,000+219.6% | Added | History |
| BCYCBicycle Therapeutics PLC | SPONSORED ADS | 10,885,357 | $92.4M | 1.0% | 00.0% | Unchanged | History |
| IMCRImmunocore Holdings plc | ADS | 2,322,656 | $68.9M | 0.8% | +807,338+53.3% | Added | History |
| KNSAKiniksa Pharmaceuticals International, plc | ORD SHS CL A | 2,818,323 | $62.6M | 0.7% | 00.0% | Unchanged | History |
| ABCLAbCellera Biologics Inc. | COM | 27,525,640 | $61.4M | 0.7% | 00.0% | Unchanged | History |
| RAREUltragenyx Pharmaceutical Inc. | COM | 1,576,114 | $57.1M | 0.6% | 00.0% | Unchanged | History |
| DNLIDenali Therapeutics Inc. | COM | 3,731,695 | $50.7M | 0.6% | 00.0% | Unchanged | History |
| KODKodiak Sciences Inc. | COM | 17,310,490 | $48.6M | 0.5% | 00.0% | Unchanged | History |
| NRIXNurix Therapeutics, Inc. | COM | 3,882,125 | $46.1M | 0.5% | 00.0% | Unchanged | History |
| ARGXArgenx SE | SPONSORED ADR | 77,760 | $46.0M | 0.5% | −34,144−30.5% | Reduced | History |
| TRDAEntrada Therapeutics, Inc. | COM | 4,865,819 | $44.0M | 0.5% | 00.0% | Unchanged | History |
| CELCCelcuity Inc. | COM | 4,257,735 | $43.0M | 0.5% | +1,579,182+59.0% | Added | History |
| GRALGRAIL, Inc. | COM | 1,630,125 | $41.6M | 0.5% | 00.0% | Unchanged | History |
| ROIVRoivant Sciences Ltd. | SHS | 3,767,773 | $38.0M | 0.4% | 00.0% | Unchanged | History |
| IMTXImmatics N.V. | SHS | 7,275,830 | $32.8M | 0.4% | 00.0% | Unchanged | History |
| STOKStoke Therapeutics, Inc. | COM | 4,633,838 | $30.8M | 0.3% | 00.0% | Unchanged | History |
| CERSCerus Corp | COM | 19,351,087 | $26.9M | 0.3% | −126,252−0.6% | Reduced | History |
| PCVXVaxcyte, Inc. | COM | 640,885 | $24.2M | 0.3% | +592,000+1,211.0% | Added | History |
| GLUEMonte Rosa Therapeutics, Inc. | COM | 4,916,095 | $22.8M | 0.3% | 00.0% | Unchanged | History |
| CRSPCRISPR Therapeutics AG | NAMEN AKT | 654,099 | $22.3M | 0.2% | −653,912−50.0% | Reduced | History |
| AKROAkero Therapeutics, Inc. | COM | 548,713 | $22.2M | 0.2% | −548,369−50.0% | Reduced | History |
| SERASera Prognostics, Inc. | CLASS A COM | 5,498,170 | $20.2M | 0.2% | +63,771+1.2% | Added | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 1,227,178 | $17.6M | 0.2% | 00.0% | Unchanged | History |
| NGNENeurogene Inc. | COM | 1,486,200 | $17.4M | 0.2% | +811,750+120.4% | Added | History |
| IDYAIDEAYA Biosciences, Inc. | COM | 1,062,123 | $17.4M | 0.2% | 00.0% | Unchanged | History |
| VRNAVerona Pharma plc | SPONSORED ADS | 223,843 | $14.2M | 0.2% | +223,843 | New | History |
| CADLCandel Therapeutics, Inc. | COM | 2,437,189 | $13.8M | 0.2% | −544,794−18.3% | Reduced | History |
| PRAXPraxis Precision Medicines, Inc. | COM NEW | 331,533 | $12.6M | 0.1% | 00.0% | Unchanged | History |
| TSVT2seventy bio, Inc. | COMMON STOCK | 2,497,526 | $12.3M | 0.1% | 00.0% | Unchanged | History |
| XENEXenon Pharmaceuticals Inc. | COM | 347,408 | $11.7M | 0.1% | −646,271−65.0% | Reduced | History |
| BCAXBicara Therapeutics Inc. | COM | 833,333 | $10.9M | 0.1% | 00.0% | Unchanged | History |
| IONSIonis Pharmaceuticals Inc | COM | 357,915 | $10.8M | 0.1% | 00.0% | Unchanged | History |
| DBVTDBV Technologies S.A. | SPONSORED ADS | 1,461,425 | $9.97M | 0.1% | 00.0% | Unchanged | History |
| ALMSAlumis Inc. | COM | 1,562,500 | $9.59M | 0.1% | 00.0% | Unchanged | History |
| MRUSMerus N.V. | COM | 223,500 | $9.41M | 0.1% | −226,500−50.3% | Reduced | History |
| PRLDPrelude Therapeutics Inc | COM | 10,123,824 | $7.78M | 0.1% | 00.0% | Unchanged | History |
| VERVVerve Therapeutics, Inc. | COM | 1,691,530 | $7.73M | 0.1% | 00.0% | Unchanged | History |
| RCKTRocket Pharmaceuticals, Inc. | COM | 1,097,079 | $7.32M | 0.1% | +1,000,000+1,030.1% | Added | History |
| XNCRXencor Inc | COM | 670,431 | $7.13M | 0.1% | 00.0% | Unchanged | History |
| DYNDyne Therapeutics, Inc. | COM | 672,096 | $7.03M | 0.1% | 00.0% | Unchanged | History |
| KALAKALA BIO, Inc. | COMM STK | 1,201,894 | $6.89M | 0.1% | 00.0% | Unchanged | History |
| DSGNDesign Therapeutics, Inc. | COM | 1,743,725 | $6.73M | 0.1% | 00.0% | Unchanged | History |
| GPCRStructure Therapeutics Inc. | SPONSORED ADS | 361,565 | $6.26M | 0.1% | 00.0% | Unchanged | History |
| TSHATaysha Gene Therapies, Inc. | COM SHS | 4,004,756 | $5.57M | 0.1% | 00.0% | Unchanged | History |
| RGLSRegulus Therapeutics Inc. | COM | 2,694,044 | $4.71M | 0.1% | +2,694,044 | New | History |
| IGMSIGM Biosciences, Inc. | COM | 4,095,257 | $4.71M | 0.1% | +9530.0% | Added | History |
| NTLAIntellia Therapeutics, Inc. | COM | 644,116 | $4.58M | 0.1% | 00.0% | Unchanged | History |
| CLDXCelldex Therapeutics, Inc. | COM NEW | 247,644 | $4.49M | <0.1% | 00.0% | Unchanged | History |
| SIONSionna Therapeutics, Inc. | COM | 400,000 | $4.18M | <0.1% | +400,000 | New | History |
| BNTXBioNTech SE | SPONSORED ADS | 45,031 | $4.10M | <0.1% | 00.0% | Unchanged | History |
| TCRXTScan Therapeutics, Inc. | COM | 2,784,792 | $3.84M | <0.1% | 00.0% | Unchanged | History |
| IRONDisc Medicine, Inc. | COM | 77,050 | $3.82M | <0.1% | 00.0% | Unchanged | History |
| VIRVir Biotechnology, Inc. | COM | 542,539 | $3.52M | <0.1% | −542,000−50.0% | Reduced | History |
| SANASana Biotechnology, Inc. | COM | 2,030,949 | $3.41M | <0.1% | −350,000−14.7% | Reduced | History |
| SGMTSagimet Biosciences Inc. | COM SER A | 952,996 | $3.11M | <0.1% | 00.0% | Unchanged | History |
| RLAYRelay Therapeutics, Inc. | COM | 1,160,117 | $3.04M | <0.1% | 00.0% | Unchanged | History |
| WVEWave Life Sciences, Inc. | SHS | 344,063 | $2.78M | <0.1% | 00.0% | Unchanged | History |
| FATEFate Therapeutics Inc | COM | 3,258,402 | $2.57M | <0.1% | 00.0% | Unchanged | History |
| SKYESkye Bioscience, Inc. | COM NEW | 1,450,638 | $2.31M | <0.1% | 00.0% | Unchanged | History |
| TARAProtara Therapeutics, Inc. | COM STK | 536,832 | $2.29M | <0.1% | 00.0% | Unchanged | History |
| ELVNEnliven Therapeutics, Inc. | COM | 114,833 | $2.26M | <0.1% | 00.0% | Unchanged | History |
| CTNMContineum Therapeutics, Inc. | CL A | 312,500 | $2.18M | <0.1% | 00.0% | Unchanged | History |
| PRMEPrime Medicine, Inc. | COM | 1,028,466 | $2.05M | <0.1% | 00.0% | Unchanged | History |
| TECXTectonic Therapeutic, Inc. | COM | 100,000 | $1.77M | <0.1% | +100,000 | New | History |
| VTVTvTv Therapeutics Inc. | CL A NEW | 97,314 | $1.69M | <0.1% | 00.0% | Unchanged | History |
| CMPXCompass Therapeutics, Inc. | COM | 547,498 | $1.04M | <0.1% | −1,010,132−64.9% | Reduced | History |
| NMRANeumora Therapeutics, Inc. | COM | 1,034,600 | $1.03M | <0.1% | 00.0% | Unchanged | History |
| HOOKHOOKIPA Pharma Inc. | COM | 812,814 | $877.8K | <0.1% | 00.0% | Unchanged | History |
| GBIOGeneration Bio Co. | COM | 1,944,945 | $787.7K | <0.1% | 00.0% | Unchanged | History |
| ALGSAligos Therapeutics, Inc. | COM NEW | 83,055 | $685.2K | <0.1% | 00.0% | Unchanged | History |
| CYPHCypherpunk Technologies Inc. | COM NEW | 404,744 | $123.5K | <0.1% | −767,431−65.5% | Reduced | History |
| IPSCCentury Therapeutics, Inc. | COM | 241,684 | $115.0K | <0.1% | −555,776−69.7% | Reduced | History |
| TYRATyra Biosciences, Inc. | COM | 10,607 | $98.6K | <0.1% | 00.0% | Unchanged | History |
| ACRVAcrivon Therapeutics, Inc. | COMMON STOCK | 22,809 | $46.3K | <0.1% | −30,076−56.9% | Reduced | History |
| Surrozen, Inc.86889P117 | *W EXP 08/01/203 | 833,333 | $25.0K | <0.1% | 00.0% | Unchanged | – |
| CYVNYOpthea Ltd | SPONSORED ADS | 2,087,320 | $0 | 0.0% | −86,302−4.0% | Reduced | History |
Sold out since Q4 2024 (10)
Positions held at the end of Q4 2024 that are gone from this filing.
| Security | Class | Shares in Q4 2024 | Value in Q4 2024 | % of portfolio in Q4 2024 | History |
|---|---|---|---|---|---|
| Ionis Pharmaceuticals Inc462222AF7 | NOTE 1.750% 6/1 | – | $29.5M | 0.3% | – |
| KRYSKrystal Biotech, Inc. | COM | 169,934 | $26.6M | 0.3% | History |
| MIRMMirum Pharmaceuticals, Inc. | COM | 190,476 | $7.88M | 0.1% | History |
| ARVNArvinas, Inc. | COM | 405,576 | $7.77M | 0.1% | History |
| BMEABiomea Fusion, Inc. | COM | 1,451,990 | $5.63M | 0.1% | History |
| ARCTArcturus Therapeutics Holdings Inc. | COM | 151,329 | $2.57M | <0.1% | History |
| MRSNMersana Therapeutics, Inc. | COM | 1,086,115 | $1.55M | <0.1% | History |
| PTCTPTC Therapeutics, Inc. | COM | 20,400 | $920.9K | <0.1% | History |
| PMVPPMV Pharmaceuticals, Inc. | COM | 322,024 | $486.3K | <0.1% | History |
| FHTXFoghorn Therapeutics Inc. | COM | 45,027 | $212.5K | <0.1% | History |