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Livermore
Livermore
ZHEN

Baker Bros. Advisors LP

SEC CIK
0001263508
Latest filing
Aug 14, 2026

Holdings in Q4 2024

Holdings as of Dec 31, 2024, filed Feb 14, 2025. Long positions only; changes compare share counts with Q3 2024.

Institution overview
Positions
95
+2 vs. Q3 2024
Portfolio value
$9.36B
−$287.3M (−3.0%) vs. Q3 2024
Filed
Feb 14, 2025
SEC
Holdings of Baker Bros. Advisors LP in Q4 2024
SecurityClassSharesValue% of portfolioShare changeActionHistory
INCYIncyte CorpCOM30,739,466$2.12B22.7%+4460.0%AddedHistory
ONCBeOne Medicines Ltd.ADR9,531,880$1.76B18.8%−1,037,017−9.8%ReducedHistory
ACADAcadia Pharmaceuticals IncCOM42,877,916$786.8M8.4%00.0%UnchangedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM1,974,590$609.3M6.5%00.0%UnchangedHistory
SMMTSummit Therapeutics Inc.COM24,424,865$435.9M4.7%00.0%UnchangedHistory
RVMDRevolution Medicines, Inc.COM7,936,972$347.2M3.7%+367,882+4.9%AddedHistory
INSMINSMED IncCOM PAR $.015,006,863$345.7M3.7%+590,945+13.4%AddedHistory
RYTMRhythm Pharmaceuticals, Inc.COM6,084,249$340.6M3.6%−314,117−4.9%ReducedHistory
KYMRKymera Therapeutics, Inc.COM5,995,929$241.2M2.6%00.0%UnchangedHistory
KODKodiak Sciences Inc.COM17,310,490$172.2M1.8%00.0%UnchangedHistory
EWTXEdgewise Therapeutics, Inc.COM6,155,940$164.4M1.8%+315,881+5.4%AddedHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS10,885,357$152.4M1.6%+1,485,397+15.8%AddedHistory
REPLReplimune Group, Inc.COM11,045,336$133.8M1.4%00.0%UnchangedHistory
ALKSAlkermes plc.SHS4,181,751$120.3M1.3%00.0%UnchangedHistory
INSMED Inc457669AB5NOTE 0.750% 6/0–$92.9M1.0%–––
TRDAEntrada Therapeutics, Inc.COM4,865,819$84.1M0.9%00.0%UnchangedHistory
ABCLAbCellera Biologics Inc.COM27,525,640$80.7M0.9%00.0%UnchangedHistory
DNLIDenali Therapeutics Inc.COM3,731,695$76.1M0.8%00.0%UnchangedHistory
NRIXNurix Therapeutics, Inc.COM3,882,125$73.1M0.8%00.0%UnchangedHistory
ARGXArgenx SESPONSORED ADR111,904$68.8M0.7%00.0%UnchangedHistory
RAREUltragenyx Pharmaceutical Inc.COM1,576,114$66.3M0.7%00.0%UnchangedHistory
KNSAKiniksa Pharmaceuticals International, plcORD SHS CL A2,818,323$55.7M0.6%00.0%UnchangedHistory
IMTXImmatics N.V.SHS7,275,830$51.7M0.6%+832,432+12.9%AddedHistory
CRSPCRISPR Therapeutics AGNAMEN AKT1,308,011$51.5M0.5%+464,936+55.1%AddedHistory
STOKStoke Therapeutics, Inc.COM4,633,838$51.1M0.5%+265,395+6.1%AddedHistory
IMCRImmunocore Holdings plcADS1,515,318$44.7M0.5%00.0%UnchangedHistory
ROIVRoivant Sciences Ltd.SHS3,767,773$44.6M0.5%+969,057+34.6%AddedHistory
SERASera Prognostics, Inc.CLASS A COM5,434,399$44.2M0.5%00.0%UnchangedHistory
IMVTImmunovant, Inc.COM1,707,881$42.3M0.5%+482,471+39.4%AddedHistory
XENEXenon Pharmaceuticals Inc.COM993,679$39.0M0.4%00.0%UnchangedHistory
CELCCelcuity Inc.COM2,678,553$35.1M0.4%+803,575+42.9%AddedHistory
GLUEMonte Rosa Therapeutics, Inc.COM4,916,095$34.1M0.4%00.0%UnchangedHistory
AKROAkero Therapeutics, Inc.COM1,097,082$30.5M0.3%00.0%UnchangedHistory
CERSCerus CorpCOM19,477,339$30.0M0.3%00.0%UnchangedHistory
Ionis Pharmaceuticals Inc462222AF7NOTE 1.750% 6/1–$29.5M0.3%–New–
GRALGRAIL, Inc.COM1,630,125$29.1M0.3%+1,630,125NewHistory
IDYAIDEAYA Biosciences, Inc.COM1,062,123$27.3M0.3%00.0%UnchangedHistory
KRYSKrystal Biotech, Inc.COM169,934$26.6M0.3%00.0%UnchangedHistory
CADLCandel Therapeutics, Inc.COM2,981,983$25.9M0.3%+2,981,983NewHistory
PRAXPraxis Precision Medicines, Inc.COM NEW331,533$25.5M0.3%+8,428+2.6%AddedHistory
IGMSIGM Biosciences, Inc.COM4,094,304$25.0M0.3%+1,9940.0%AddedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS1,227,178$20.6M0.2%00.0%UnchangedHistory
MRUSMerus N.V.COM450,000$18.9M0.2%+150,000+50.0%AddedHistory
DYNDyne Therapeutics, Inc.COM672,096$15.8M0.2%00.0%UnchangedHistory
NGNENeurogene Inc.COM674,450$15.4M0.2%+218,435+47.9%AddedHistory
XNCRXencor IncCOM670,431$15.4M0.2%00.0%UnchangedHistory
BCAXBicara Therapeutics Inc.COM833,333$14.5M0.2%00.0%UnchangedHistory
PRLDPrelude Therapeutics IncCOM10,123,824$12.9M0.1%00.0%UnchangedHistory
IONSIonis Pharmaceuticals IncCOM357,915$12.5M0.1%+134,445+60.2%AddedHistory
ALMSAlumis Inc.COM1,562,500$12.3M0.1%00.0%UnchangedHistory
NMRANeumora Therapeutics, Inc.COM1,034,600$11.0M0.1%00.0%UnchangedHistory
DSGNDesign Therapeutics, Inc.COM1,743,725$10.8M0.1%00.0%UnchangedHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS361,565$9.81M0.1%+276,065+322.9%AddedHistory
VERVVerve Therapeutics, Inc.COM1,691,530$9.54M0.1%00.0%UnchangedHistory
CYVNYOpthea LtdSPONSORED ADS2,173,622$8.54M0.1%00.0%UnchangedHistory
TCRXTScan Therapeutics, Inc.COM2,784,792$8.47M0.1%00.0%UnchangedHistory
KALAKALA BIO, Inc.COMM STK1,201,894$8.34M0.1%+310,559+34.8%AddedHistory
VIRVir Biotechnology, Inc.COM1,084,539$7.96M0.1%+1,084,539NewHistory
MIRMMirum Pharmaceuticals, Inc.COM190,476$7.88M0.1%00.0%UnchangedHistory
ARVNArvinas, Inc.COM405,576$7.77M0.1%00.0%UnchangedHistory
NTLAIntellia Therapeutics, Inc.COM644,116$7.51M0.1%+644,116NewHistory
TSVT2seventy bio, Inc.COMMON STOCK2,497,526$7.34M0.1%00.0%UnchangedHistory
TSHATaysha Gene Therapies, Inc.COM SHS4,004,756$6.93M0.1%00.0%UnchangedHistory
CLDXCelldex Therapeutics, Inc.COM NEW247,644$6.26M0.1%00.0%UnchangedHistory
BMEABiomea Fusion, Inc.COM1,451,990$5.63M0.1%−656,959−31.2%ReducedHistory
FATEFate Therapeutics IncCOM3,258,402$5.38M0.1%+260,630+8.7%AddedHistory
BNTXBioNTech SESPONSORED ADS45,031$5.13M0.1%+45,031NewHistory
IRONDisc Medicine, Inc.COM77,050$4.88M0.1%+77,050NewHistory
RLAYRelay Therapeutics, Inc.COM1,160,117$4.78M0.1%00.0%UnchangedHistory
CTNMContineum Therapeutics, Inc.CL A312,500$4.58M<0.1%00.0%UnchangedHistory
DBVTDBV Technologies S.A.SPONSORED ADS1,461,425$4.52M<0.1%00.0%UnchangedConverted for a 1-for-5 splitHistory
SGMTSagimet Biosciences Inc.COM SER A952,996$4.29M<0.1%−428,902−31.0%ReducedHistory
WVEWave Life Sciences, Inc.SHS344,063$4.26M<0.1%00.0%UnchangedHistory
SKYESkye Bioscience, Inc.COM NEW1,450,638$4.11M<0.1%+16,004+1.1%AddedHistory
PCVXVaxcyte, Inc.COM48,885$4.00M<0.1%00.0%UnchangedHistory
SANASana Biotechnology, Inc.COM2,380,949$3.88M<0.1%00.0%UnchangedHistory
CYPHCypherpunk Technologies Inc.COM NEW1,172,175$3.37M<0.1%00.0%UnchangedHistory
ALGSAligos Therapeutics, Inc.COM NEW83,055$3.31M<0.1%00.0%UnchangedHistory
PRMEPrime Medicine, Inc.COM1,028,466$3.00M<0.1%00.0%UnchangedHistory
TARAProtara Therapeutics, Inc.COM STK536,832$2.83M<0.1%00.0%UnchangedHistory
ELVNEnliven Therapeutics, Inc.COM114,833$2.58M<0.1%00.0%UnchangedHistory
ARCTArcturus Therapeutics Holdings Inc.COM151,329$2.57M<0.1%00.0%UnchangedHistory
CMPXCompass Therapeutics, Inc.COM1,557,630$2.26M<0.1%00.0%UnchangedHistory
GBIOGeneration Bio Co.COM1,944,945$2.06M<0.1%00.0%UnchangedHistory
HOOKHOOKIPA Pharma Inc.COM812,814$1.63M<0.1%00.0%UnchangedHistory
MRSNMersana Therapeutics, Inc.COM1,086,115$1.55M<0.1%00.0%UnchangedHistory
VTVTvTv Therapeutics Inc.CL A NEW97,314$1.34M<0.1%00.0%UnchangedHistory
RCKTRocket Pharmaceuticals, Inc.COM97,079$1.22M<0.1%+97,079NewHistory
PTCTPTC Therapeutics, Inc.COM20,400$920.9K<0.1%+20,400NewHistory
IPSCCentury Therapeutics, Inc.COM797,460$805.4K<0.1%00.0%UnchangedHistory
PMVPPMV Pharmaceuticals, Inc.COM322,024$486.3K<0.1%00.0%UnchangedHistory
ACRVAcrivon Therapeutics, Inc.COMMON STOCK52,885$318.4K<0.1%00.0%UnchangedHistory
FHTXFoghorn Therapeutics Inc.COM45,027$212.5K<0.1%00.0%UnchangedHistory
TYRATyra Biosciences, Inc.COM10,607$147.4K<0.1%00.0%UnchangedHistory
Surrozen, Inc.86889P117*W EXP 08/01/203833,333$17.8K<0.1%00.0%Unchanged–

Sold out since Q3 2024 (7)

Positions held at the end of Q3 2024 that are gone from this filing.

Positions of Baker Bros. Advisors LP sold out since Q3 2024
SecurityClassShares in Q3 2024Value in Q3 2024% of portfolio in Q3 2024History
TNGXTango Therapeutics, Inc.COM750,000$5.78M0.1%History
CRNXCrinetics Pharmaceuticals, Inc.COM103,927$5.31M0.1%History
ALECAlector, Inc.COM927,264$4.32M<0.1%History
NAMSNewAmsterdam Pharma Co N.V.ORDINARY SHARES96,711$1.61M<0.1%History
JBIOJade Biosciences, Inc.COM628,939$1.31M<0.1%History
PFEPfizer IncStock35,000$1.01M<0.1%History
BCRXBiocryst Pharmaceuticals IncCOM75,778$575.9K<0.1%History