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Livermore
Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q4 2025

Holdings as of Dec 31, 2025, filed Feb 17, 2026. Long positions only; changes compare share counts with Q3 2025.

Institution overview
Positions
105
+6 vs. Q3 2025
Portfolio value
$4.89B
+$716.8M (+17.2%) vs. Q3 2025
Filed
Feb 17, 2026
SEC
Holdings of OrbiMed Advisors LLC in Q4 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
EWTXEdgewise Therapeutics, Inc.COM15,518,492$385.1M7.9%00.0%UnchangedHistory
LLYEli Lilly & CoStock301,200$323.7M6.6%00.0%UnchangedHistory
BSXBoston Scientific CorpStock2,419,300$230.7M4.7%−10,000−0.4%ReducedHistory
SVASinovac Biotech LtdSHS2,718,735$184.5M3.8%00.0%UnchangedHistory
EWEdwards Lifesciences CorpStock1,842,900$157.1M3.2%+158,900+9.4%AddedHistory
UPBUpstream Bio, Inc.COM5,693,589$154.6M3.2%00.0%UnchangedHistory
ISRGIntuitive Surgical IncCOM NEW263,400$149.2M3.1%−23,800−8.3%ReducedHistory
SIONSionna Therapeutics, Inc.COM3,561,655$146.5M3.0%−143,304−3.9%ReducedHistory
MBXMBX Biosciences, Inc.COM3,935,203$124.1M2.5%−67,684−1.7%ReducedHistory
ARGXArgenx SESPONSORED ADR146,000$122.8M2.5%−26,300−15.3%ReducedHistory
ELVNEnliven Therapeutics, Inc.COM7,959,538$122.6M2.5%00.0%UnchangedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM288,800$114.8M2.4%−12,800−4.2%ReducedHistory
SYKStryker CorpStock325,000$114.2M2.3%−34,200−9.5%ReducedHistory
SPRYARS Pharmaceuticals, Inc.COM8,288,510$96.6M2.0%00.0%UnchangedHistory
TERNTerns Pharmaceuticals, Inc.COM2,153,300$87.0M1.8%−5,409,671−71.5%ReducedHistory
IRONDisc Medicine, Inc.COM1,067,550$84.8M1.7%−347,470−24.6%ReducedHistory
CAICaris Life Sciences, Inc.COM3,116,011$84.1M1.7%+81,153+2.7%AddedHistory
NTRANatera, Inc.COM365,800$83.8M1.7%−63,500−14.8%ReducedHistory
CMPXCompass Therapeutics, Inc.COM15,219,994$81.7M1.7%00.0%UnchangedHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS1,161,803$80.8M1.7%+22,503+2.0%AddedHistory
DHRDanaher CorpStock299,800$68.6M1.4%+36,700+13.9%AddedHistory
CGONCG Oncology, Inc.COM1,516,550$63.0M1.3%−210,300−12.2%ReducedHistory
APLSApellis Pharmaceuticals, Inc.COM2,429,868$61.0M1.2%+106,500+4.6%AddedHistory
AVBPArriVent BioPharma, Inc.COM3,027,328$60.9M1.2%00.0%UnchangedHistory
CICigna GroupStock205,000$56.4M1.2%+42,200+25.9%AddedHistory
RAPTRAPT Therapeutics, Inc.COM NEW1,642,891$55.6M1.1%+556,273+51.2%AddedHistory
CRVSCorvus Pharmaceuticals, Inc.COM7,165,006$55.2M1.1%00.0%UnchangedHistory
UTHRUnited Therapeutics CorpCOM105,200$51.3M1.0%−9,700−8.4%ReducedHistory
ABVXAbivax S.A.SPONSORED ADS367,900$49.6M1.0%−12,100−3.2%ReducedHistory
ROIVRoivant Sciences Ltd.SHS2,190,907$47.5M1.0%−523,891−19.3%ReducedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM999,000$46.5M1.0%−100,000−9.1%ReducedHistory
AXSMAxsome Therapeutics, Inc.COM253,121$46.2M0.9%−278,679−52.4%ReducedHistory
EYPTEyePoint, Inc.COM NEW2,468,314$45.1M0.9%+672,314+37.4%AddedHistory
Avidity Biosciences, Inc.05370A108COM619,530$44.7M0.9%−1,019,356−62.2%Reduced–
NBIXNeurocrine Biosciences IncStock314,240$44.6M0.9%−39,400−11.1%ReducedHistory
DYNDyne Therapeutics, Inc.COM2,202,184$43.1M0.9%−112,000−4.8%ReducedHistory
BMYBristol Myers Squibb CoStock775,000$41.8M0.9%+775,000NewHistory
PFEPfizer IncStock1,652,900$41.2M0.8%+1,652,900NewHistory
TRVITrevi Therapeutics, Inc.COM3,190,700$39.9M0.8%−117,700−3.6%ReducedHistory
NPCENeuroPace IncCOM2,406,335$37.2M0.8%−207,849−8.0%ReducedHistory
ASNDAscendis Pharma A/SSPONSORED ADR171,977$36.7M0.8%−19,928−10.4%ReducedHistory
EXASExact Sciences CorpCOM351,716$35.7M0.7%−642,900−64.6%ReducedHistory
MLYSMineralys Therapeutics, Inc.COM980,400$35.6M0.7%−489,094−33.3%ReducedHistory
ELVElevance Health, Inc.Stock99,100$34.7M0.7%+99,100NewHistory
FBRXForte Biosciences, Inc.COM NEW1,196,955$32.6M0.7%00.0%UnchangedHistory
PRLDPrelude Therapeutics IncCOM10,909,256$31.6M0.6%00.0%UnchangedHistory
HELPCybin Inc.COM NEW3,840,500$31.4M0.6%+3,840,500NewHistory
ORICOric Pharmaceuticals, Inc.COM3,641,756$29.8M0.6%00.0%UnchangedHistory
KRYSKrystal Biotech, Inc.COM119,800$29.5M0.6%+17,055+16.6%AddedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW94,500$27.9M0.6%+94,500NewHistory
JANXJanux Therapeutics, Inc.COM1,954,426$27.0M0.6%+188,326+10.7%AddedHistory
TMOThermo Fisher Scientific Inc.Stock46,500$26.9M0.6%00.0%UnchangedHistory
BRKRBruker CorpCOM555,789$26.2M0.5%+555,789NewHistory
RYTMRhythm Pharmaceuticals, Inc.COM239,800$25.7M0.5%+24,648+11.5%AddedHistory
STTKShattuck Labs, Inc.COM6,306,127$23.0M0.5%00.0%UnchangedHistory
ESPREsperion Therapeutics, Inc.COM5,965,498$22.1M0.5%+5,965,498NewHistory
AVTXAvalo Therapeutics, Inc.COM NEW1,187,300$21.6M0.4%−162,000−12.0%ReducedHistory
LXEOLexeo Therapeutics, Inc.COM2,125,000$21.1M0.4%+2,125,000NewHistory
ADCTADC Therapeutics SASHS5,822,854$20.6M0.4%−84,497−1.4%ReducedHistory
URGNUroGen Pharma Ltd.COM875,487$20.5M0.4%+186,487+27.1%AddedHistory
0000000000Stock6,210,899$20.1M0.4%00.0%Unchanged–
XENEXenon Pharmaceuticals Inc.COM447,200$20.0M0.4%+27,600+6.6%AddedHistory
BTSGBrightSpring Health Services, Inc.COM488,500$18.3M0.4%+224,700+85.2%AddedHistory
VERAVera Therapeutics, Inc.CL A353,500$17.9M0.4%+353,500NewHistory
QUREuniQure N.V.SHS737,400$17.6M0.4%+278,900+60.8%AddedHistory
DFTXDefinium Therapeutics, Inc.Stock1,226,700$16.4M0.3%+858,876+233.5%AddedHistory
KROSKeros Therapeutics, Inc.COM804,212$16.4M0.3%−214,522−21.1%ReducedHistory
CARLCarlsmed, Inc.COM1,252,600$15.5M0.3%00.0%UnchangedHistory
CTMXCytomX Therapeutics, Inc.COM3,525,650$15.0M0.3%−4,935,850−58.3%ReducedHistory
VIRVir Biotechnology, Inc.COM2,380,715$14.4M0.3%00.0%UnchangedHistory
BCRXBiocryst Pharmaceuticals IncCOM1,741,800$13.6M0.3%+840,300+93.2%AddedHistory
COGTCogent Biosciences, Inc.COM371,000$13.2M0.3%+371,000NewHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW1,597,287$13.0M0.3%+425,000+36.3%AddedHistory
TARSTarsus Pharmaceuticals, Inc.COM154,400$12.6M0.3%−43,500−22.0%ReducedHistory
RLMDRelmada Therapeutics, Inc.COM2,610,600$12.6M0.3%+2,610,600NewHistory
TECXTectonic Therapeutic, Inc.COM574,600$12.0M0.2%+574,600NewHistory
ALMSAlumis Inc.COM1,102,730$10.8M0.2%−823,693−42.8%ReducedHistory
BIOABioAge Labs, Inc.COM790,901$10.5M0.2%00.0%UnchangedHistory
FOLDAmicus Therapeutics, Inc.COM729,900$10.4M0.2%−915,500−55.6%ReducedHistory
WHWKWhitehawk Therapeutics, Inc.COM4,166,000$10.1M0.2%00.0%UnchangedHistory
ACETAdicet Bio, Inc.COM NEW1,027,944$8.66M0.2%+1,027,944NewHistory
RPTXRepare Therapeutics Inc.COM3,322,488$8.64M0.2%00.0%UnchangedHistory
CELCCelcuity Inc.COM85,664$8.54M0.2%+1,644+2.0%AddedHistory
JBIOJade Biosciences, Inc.COM NEW531,163$8.20M0.2%00.0%UnchangedHistory
KNSAKiniksa Pharmaceuticals International, plcORD SHS CL A187,199$7.72M0.2%+187,199NewHistory
QTTBQ32 Bio Inc.COM2,252,987$7.48M0.2%00.0%UnchangedHistory
PMVPPMV Pharmaceuticals, Inc.COM4,975,291$6.22M0.1%−1,000,000−16.7%ReducedHistory
KALVKalVista Pharmaceuticals, Inc.COM382,400$6.18M0.1%+382,400NewHistory
PHVSPharvaris N.V.COM205,400$5.70M0.1%+205,400NewHistory
NSPRInspireMD, Inc.COM3,133,405$5.58M0.1%+1,000,000+46.9%AddedHistory
INSMINSMED IncCOM PAR $.0125,400$4.42M0.1%+11,941+88.7%AddedHistory
PALIPalisade Bio, Inc.COM1,871,420$4.40M0.1%+1,871,420NewHistory
BCAXBicara Therapeutics Inc.COM209,100$3.52M0.1%+209,100NewHistory
CGEMCullinan Therapeutics, Inc.COM270,006$2.79M0.1%−1,653,849−86.0%ReducedHistory
CCCCC4 Therapeutics, Inc.COM STK1,404,902$2.68M0.1%−3,830,244−73.2%ReducedHistory
IMAImageneBio, Inc.COM378,556$2.61M0.1%00.0%UnchangedHistory
ANROAlto Neuroscience, Inc.COM SHS125,000$2.23M<0.1%−125,000−50.0%ReducedHistory
RVMDRevolution Medicines, Inc.COM25,900$2.06M<0.1%+25,900NewHistory
VTGNVistagen Therapeutics, Inc.COM3,060,000$2.03M<0.1%00.0%UnchangedHistory
OCULOcular Therapeutix, IncCOM157,300$1.91M<0.1%+157,300NewHistory

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q4 2025
SecurityClassPutsCalls
EWEdwards Lifesciences CorpStock–$12.8M
VTGNVistagen Therapeutics, Inc.COM–$29.9K

Sold out since Q3 2025 (18)

Positions held at the end of Q3 2025 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q3 2025
SecurityClassShares in Q3 2025Value in Q3 2025% of portfolio in Q3 2025History
SIBNSI-BONE, Inc.COM2,578,979$38.0M0.9%History
SCPHscPharmaceuticals Inc.COM6,059,528$34.4M0.8%History
ITGRInteger Holdings CorpCOM290,000$30.0M0.7%History
AKROAkero Therapeutics, Inc.COM526,200$25.0M0.6%History
AMLXAmylyx Pharmaceuticals, Inc.COM750,600$10.2M0.2%History
ACETAdicet Bio, Inc.COM11,447,140$9.27M0.2%History
VSTMVerastem, Inc.COM NEW887,561$7.84M0.2%History
MISTMilestone Pharmaceuticals Inc.COM3,221,828$6.44M0.2%History
IMTXImmatics N.V.SHS466,601$3.98M0.1%History
Celcuity Inc.15102KAA8NOTE 2.750% 8/0–$2.68M0.1%–
ATAIAtai Beckley N.V.SHS347,000$1.84M<0.1%History
KRROKorro Bio, Inc.COM32,400$1.55M<0.1%History
MURAMural Oncology plcORD SHS588,800$1.22M<0.1%History
LYELLyell Immunopharma, Inc.COM NEW51,727$840.0K<0.1%History
KZRKezar Life Sciences, Inc.COM192,700$751.5K<0.1%History
XERSXeris Biopharma Holdings, Inc.COM80,420$654.6K<0.1%History
PASGPassage BIO, Inc.COM59,046$474.1K<0.1%History
DHAIDih Holding US, Inc.CL A1,915,000$358.1K<0.1%History