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Livermore
Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q3 2025

Holdings as of Sep 30, 2025, filed Nov 14, 2025. Long positions only; changes compare share counts with Q2 2025.

Institution overview
Positions
99
+2 vs. Q2 2025
Portfolio value
$4.17B
+$193.1M (+4.9%) vs. Q2 2025
Filed
Nov 14, 2025
SEC
Holdings of OrbiMed Advisors LLC in Q3 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
EWTXEdgewise Therapeutics, Inc.COM15,518,492$251.7M6.0%00.0%UnchangedHistory
BSXBoston Scientific CorpStock2,429,300$237.2M5.7%−383,900−13.6%ReducedHistory
LLYEli Lilly & CoStock301,200$229.8M5.5%−36,400−10.8%ReducedHistory
SVASinovac Biotech LtdSHS2,718,735$184.5M4.4%00.0%UnchangedHistory
ELVNEnliven Therapeutics, Inc.COM7,959,538$162.9M3.9%00.0%UnchangedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM301,600$137.5M3.3%−40,300−11.8%ReducedHistory
SYKStryker CorpStock359,200$132.8M3.2%00.0%UnchangedHistory
EWEdwards Lifesciences CorpStock1,684,000$131.0M3.1%−24,000−1.4%ReducedHistory
ISRGIntuitive Surgical IncCOM NEW287,200$128.4M3.1%−3,800−1.3%ReducedHistory
ARGXArgenx SESPONSORED ADR172,300$127.1M3.0%−35,700−17.2%ReducedHistory
SIONSionna Therapeutics, Inc.COM3,704,959$109.0M2.6%00.0%UnchangedHistory
UPBUpstream Bio, Inc.COM5,693,589$107.1M2.6%00.0%UnchangedHistory
IRONDisc Medicine, Inc.COM1,415,020$93.5M2.2%00.0%UnchangedHistory
CAICaris Life Sciences, Inc.COM3,034,858$91.8M2.2%00.0%UnchangedHistory
SPRYARS Pharmaceuticals, Inc.COM8,288,510$83.3M2.0%00.0%UnchangedHistory
Avidity Biosciences, Inc.05370A108COM1,638,886$71.4M1.7%−174,000−9.6%Reduced–
MBXMBX Biosciences, Inc.COM4,002,887$70.1M1.7%00.0%UnchangedHistory
CGONCG Oncology, Inc.COM1,726,850$69.6M1.7%−151,000−8.0%ReducedHistory
NTRANatera, Inc.COM429,300$69.1M1.7%−164,134−27.7%ReducedHistory
AXSMAxsome Therapeutics, Inc.COM531,800$64.6M1.5%+103,900+24.3%AddedHistory
TERNTerns Pharmaceuticals, Inc.COM7,562,971$56.8M1.4%00.0%UnchangedHistory
AVBPArriVent BioPharma, Inc.COM3,027,328$55.9M1.3%00.0%UnchangedHistory
MLYSMineralys Therapeutics, Inc.COM1,469,494$55.7M1.3%+709,143+93.3%AddedHistory
EXASExact Sciences CorpCOM994,616$54.4M1.3%+387,300+63.8%AddedHistory
CMPXCompass Therapeutics, Inc.COM15,219,994$53.3M1.3%00.0%UnchangedHistory
CRVSCorvus Pharmaceuticals, Inc.COM7,165,006$52.8M1.3%00.0%UnchangedHistory
APLSApellis Pharmaceuticals, Inc.COM2,323,368$52.6M1.3%+841,068+56.7%AddedHistory
DHRDanaher CorpStock263,100$52.2M1.3%+263,100NewHistory
NBIXNeurocrine Biosciences IncStock353,640$49.6M1.2%−84,900−19.4%ReducedHistory
UTHRUnited Therapeutics CorpCOM114,900$48.2M1.2%+114,900NewHistory
CICigna GroupStock162,800$46.9M1.1%+162,800NewHistory
CRNXCrinetics Pharmaceuticals, Inc.COM1,099,000$45.8M1.1%−50,000−4.4%ReducedHistory
ORICOric Pharmaceuticals, Inc.COM3,641,756$43.7M1.0%+2,742,475+305.0%AddedHistory
JANXJanux Therapeutics, Inc.COM1,766,100$43.2M1.0%+555,800+45.9%AddedHistory
ROIVRoivant Sciences Ltd.SHS2,714,798$41.1M1.0%−64,629−2.3%ReducedHistory
ASNDAscendis Pharma A/SSPONSORED ADR191,905$38.2M0.9%+157,505+457.9%AddedHistory
SIBNSI-BONE, Inc.COM2,578,979$38.0M0.9%00.0%UnchangedHistory
SCPHscPharmaceuticals Inc.COM6,059,528$34.4M0.8%00.0%UnchangedHistory
ABVXAbivax S.A.SPONSORED ADS380,000$32.3M0.8%+380,000NewHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS1,139,300$31.9M0.8%−60,000−5.0%ReducedHistory
TRVITrevi Therapeutics, Inc.COM3,308,400$30.3M0.7%00.0%UnchangedHistory
ITGRInteger Holdings CorpCOM290,000$30.0M0.7%−143,400−33.1%ReducedHistory
DYNDyne Therapeutics, Inc.COM2,314,184$29.3M0.7%+1,282,784+124.4%AddedHistory
RAPTRAPT Therapeutics, Inc.COM NEW1,086,618$28.0M0.7%−555,288−33.8%ReducedHistory
CTMXCytomX Therapeutics, Inc.COM8,461,500$27.0M0.6%00.0%UnchangedHistory
NPCENeuroPace IncCOM2,614,184$27.0M0.6%00.0%UnchangedHistory
QUREuniQure N.V.SHS458,500$26.8M0.6%+458,500NewHistory
EYPTEyePoint, Inc.COM NEW1,796,000$25.6M0.6%+1,796,000NewHistory
AKROAkero Therapeutics, Inc.COM526,200$25.0M0.6%+314,900+149.0%AddedHistory
ADCTADC Therapeutics SASHS5,907,351$23.6M0.6%00.0%UnchangedHistory
TMOThermo Fisher Scientific Inc.Stock46,500$22.6M0.5%00.0%UnchangedHistory
RYTMRhythm Pharmaceuticals, Inc.COM215,152$21.7M0.5%−33,360−13.4%ReducedHistory
KRYSKrystal Biotech, Inc.COM102,745$18.1M0.4%+93,545+1,016.8%AddedHistory
FBRXForte Biosciences, Inc.COM NEW1,196,955$18.0M0.4%00.0%UnchangedHistory
AVTXAvalo Therapeutics, Inc.COM NEW1,349,300$17.1M0.4%+382,300+39.5%AddedHistory
XENEXenon Pharmaceuticals Inc.COM419,600$16.8M0.4%−528,277−55.7%ReducedHistory
CARLCarlsmed, Inc.COM1,252,600$16.8M0.4%+1,252,600NewHistory
KROSKeros Therapeutics, Inc.COM1,018,734$16.1M0.4%00.0%UnchangedHistory
PRLDPrelude Therapeutics IncCOM10,909,256$15.7M0.4%00.0%UnchangedHistory
STTKShattuck Labs, Inc.COM6,306,127$15.1M0.4%+6,306,127NewHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW1,172,287$14.8M0.4%00.0%UnchangedHistory
URGNUroGen Pharma Ltd.COM689,000$13.7M0.3%+210,600+44.0%AddedHistory
VIRVir Biotechnology, Inc.COM2,380,715$13.6M0.3%00.0%UnchangedHistory
FOLDAmicus Therapeutics, Inc.COM1,645,400$13.0M0.3%−640,000−28.0%ReducedHistory
0000000000Stock6,210,899$12.5M0.3%−5,837,874−48.5%Reduced–
TARSTarsus Pharmaceuticals, Inc.COM197,900$11.8M0.3%00.0%UnchangedHistory
CCCCC4 Therapeutics, Inc.COM STK5,235,146$11.6M0.3%−1,595,154−23.4%ReducedHistory
CGEMCullinan Therapeutics, Inc.COM1,923,855$11.4M0.3%00.0%UnchangedHistory
VTGNVistagen Therapeutics, Inc.COM3,060,000$10.9M0.3%+3,060,000NewHistory
AMLXAmylyx Pharmaceuticals, Inc.COM750,600$10.2M0.2%+437,400+139.7%AddedHistory
ACETAdicet Bio, Inc.COM11,447,140$9.27M0.2%00.0%UnchangedHistory
PMVPPMV Pharmaceuticals, Inc.COM5,975,291$8.37M0.2%−500,000−7.7%ReducedHistory
WHWKWhitehawk Therapeutics, Inc.COM4,166,000$7.92M0.2%00.0%UnchangedHistory
VSTMVerastem, Inc.COM NEW887,561$7.84M0.2%+887,561NewHistory
BTSGBrightSpring Health Services, Inc.COM263,800$7.80M0.2%+263,800NewHistory
ALMSAlumis Inc.COM1,926,423$7.69M0.2%00.0%UnchangedHistory
BCRXBiocryst Pharmaceuticals IncCOM901,500$6.84M0.2%+901,500NewHistory
MISTMilestone Pharmaceuticals Inc.COM3,221,828$6.44M0.2%+3,221,828NewHistory
RPTXRepare Therapeutics Inc.COM3,322,488$5.85M0.1%00.0%UnchangedHistory
NSPRInspireMD, Inc.COM2,133,405$5.14M0.1%00.0%UnchangedHistory
BIOABioAge Labs, Inc.COM790,901$4.65M0.1%−131,058−14.2%ReducedHistory
JBIOJade Biosciences, Inc.COM NEW531,163$4.58M0.1%00.0%UnchangedHistory
QTTBQ32 Bio Inc.COM2,252,987$4.46M0.1%00.0%UnchangedHistory
DFTXDefinium Therapeutics, Inc.Stock367,824$4.34M0.1%+367,824NewHistory
CELCCelcuity Inc.COM84,020$4.15M0.1%+84,020NewHistory
IMTXImmatics N.V.SHS466,601$3.98M0.1%−253,300−35.2%ReducedHistory
IMAImageneBio, Inc.COM378,556$3.09M0.1%+83,610+28.3%AddedConverted for a 1-for-12 splitHistory
Celcuity Inc.15102KAA8NOTE 2.750% 8/0–$2.68M0.1%–New–
INSMINSMED IncCOM PAR $.0113,459$1.94M<0.1%00.0%UnchangedHistory
ATAIAtai Beckley N.V.SHS347,000$1.84M<0.1%+347,000NewHistory
KRROKorro Bio, Inc.COM32,400$1.55M<0.1%00.0%UnchangedHistory
MURAMural Oncology plcORD SHS588,800$1.22M<0.1%00.0%UnchangedHistory
TRAWTraws Pharma, Inc.COM NEW605,531$1.12M<0.1%00.0%UnchangedHistory
ANROAlto Neuroscience, Inc.COM SHS250,000$1.00M<0.1%00.0%UnchangedHistory
LYELLyell Immunopharma, Inc.COM NEW51,727$840.0K<0.1%00.0%UnchangedHistory
KZRKezar Life Sciences, Inc.COM192,700$751.5K<0.1%00.0%UnchangedHistory
XERSXeris Biopharma Holdings, Inc.COM80,420$654.6K<0.1%00.0%UnchangedHistory
PASGPassage BIO, Inc.COM59,046$474.1K<0.1%−243,719−80.5%ReducedConverted for a 1-for-20 splitHistory
DHAIDih Holding US, Inc.CL A1,915,000$358.1K<0.1%00.0%UnchangedHistory

Options (10)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q3 2025
SecurityClassPutsCalls
ABTAbbott LaboratoriesStock–$20.1M
BSXBoston Scientific CorpStock–$19.5M
PFEPfizer IncStock–$12.7M
AZNAstraZeneca PLCSPONSORED ADR–$11.5M
APLSApellis Pharmaceuticals, Inc.COM–$5.66M
BTSGBrightSpring Health Services, Inc.COM–$4.43M
CRNXCrinetics Pharmaceuticals, Inc.COM$4.17M–
SRRKScholar Rock Holding CorpCOM–$3.72M
TGTXTG Therapeutics, Inc.COM–$3.61M
VTGNVistagen Therapeutics, Inc.COM–$160.5K

Sold out since Q2 2025 (15)

Positions held at the end of Q2 2025 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q2 2025
SecurityClassShares in Q2 2025Value in Q2 2025% of portfolio in Q2 2025History
UNHUnitedHealth Group IncStock336,300$104.9M2.6%History
VRTXVertex Pharmaceuticals IncStock210,287$93.6M2.4%History
THCTenet Healthcare CorpCOM NEW465,000$81.8M2.1%History
CYTKCytokinetics IncCOM NEW1,077,000$35.6M0.9%History
THRDThird Harmonic Bio, Inc.COM5,779,071$31.4M0.8%History
AGIOAgios Pharmaceuticals, Inc.COM557,900$18.6M0.5%History
ABCLAbCellera Biologics Inc.COM3,344,568$11.5M0.3%History
CPRXCatalyst Pharmaceuticals, Inc.COM416,900$9.05M0.2%History
ZLABZai Lab LtdADR231,000$8.08M0.2%History
TYRATyra Biosciences, Inc.COM804,603$7.70M0.2%History
ITOSiTeos Therapeutics, Inc.COM700,000$6.98M0.2%History
ENGNenGene Therapeutics Inc.COM677,977$2.47M0.1%History
TSBXTurnstone Biologics Corp.COM3,099,265$1.11M<0.1%History
CMMBChemomab Therapeutics Ltd.SPONSORED ADS940,990$1.09M<0.1%History
Lakeshore Biopharma Co LtdG9845F208ORD SHS NEW54,799$55.9K<0.1%–