Zentalis Pharmaceuticals, Inc.
ZNTL- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001725160
In the last 90 days, Zentalis Pharmaceuticals, Inc. insiders filed 1 open-market purchase and 0 sales; 114 institutions reported holding it in 13F filings for Q2 2026, worth $228.9M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Zentalis Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 86
- −10 vs. Q3 2025
- Shares held
- 40.6M
- −11.1M (−21.5%) vs. Q3 2025
- Total value
- $54.9M
- −$23.2M (−29.7%) vs. Q3 2025
- New holders
- 8
- 28 more added
- Sold out
- 18
- 30 more reduced
3 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ZNTL on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 114 | $228.9M |
| Q1 2026 | 102 | $101.7M |
| Q4 2025 | 86 | $54.9M |
| Q3 2025 | 99 | $79.7M |
| Q2 2025 | 117 | $64.5M |
| Q1 2025 | 132 | $92.9M |
| Q4 2024 | 142 | $195.2M |
| Q3 2024 | 136 | $261.2M |
| Q2 2024 | 145 | $314.3M |
| Q1 2024 | 142 | $1.34B |
| Q4 2023 | 120 | $1.23B |
| Q3 2023 | 137 | $1.61B |
| Q2 2023 | 134 | $2.32B |
| Q1 2023 | 110 | $1.15B |
| Q4 2022 | 106 | $1.30B |
| Q3 2022 | 121 | $1.27B |
| Q2 2022 | 122 | $1.64B |
| Q1 2022 | 128 | $2.05B |
| Q4 2021 | 139 | $3.61B |
| Q3 2021 | 116 | $2.75B |
| Q2 2021 | 120 | $2.13B |
| Q1 2021 | 95 | $1.58B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Zentalis Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| 5AM Venture Management, LLC | 3,947,913 | $5.33M | 1.68% | +3,457,913+705.7% | Added |
| Renaissance Technologies LLC | 2,883,745 | $3.89M | 0.01% | +558,390+24.0% | Added |
| Vanguard Group Inc | 2,855,590 | $3.86M | 0.00% | −48,810−1.7% | Reduced |
| Acadian Asset Management LLC | 2,849,294 | $3.84M | 0.01% | +4,142+0.1% | Added |
| Citadel Advisors LLC | 1,964,255 | $2.65M | 0.00% | −113,035−5.4% | Reduced |
| D. E. Shaw & Co., Inc. | 1,660,378 | $2.24M | 0.00% | +251,575+17.9% | Added |
| Two Sigma Advisers, LP | 1,483,500 | $2.00M | 0.00% | +22,300+1.5% | Added |
| Two Sigma Investments, LP | 1,471,414 | $1.99M | 0.00% | +108,067+7.9% | Added |
| Opaleye Management Inc. | 1,400,906 | $1.89M | 0.25% | +1,084,356+342.6% | Added |
| Bank of America Corp | 1,367,254 | $1.85M | 0.00% | −181,527−11.7% | Reduced |
| Decheng Capital LLC | 1,323,327 | $1.79M | 0.24% | 00.0% | Unchanged |
| Ishara Investments LP | 1,320,000 | $1.78M | 2.07% | +1,320,000 | New |
| BlackRock, Inc. | 1,249,968 | $1.69M | 0.00% | +4640.0% | Added |
| Gsa Capital Partners LLP | 1,169,573 | $1.58M | 0.14% | +91,917+8.5% | Added |
| Primecap Management Co | 957,420 | $1.29M | 0.00% | −5,200−0.5% | Reduced |
| Pfizer Inc | 953,834 | $1.29M | 0.54% | 00.0% | Unchanged |
| Morgan Stanley | 803,654 | $1.08M | 0.00% | −604,175−42.9% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 787,055 | $1.06M | 0.00% | +406,233+106.7% | Added |
| UBS Group AG | 674,598 | $910.7K | 0.00% | +141,920+26.6% | Added |
| Millennium Management LLC | 673,129 | $908.7K | 0.00% | −229,392−25.4% | Reduced |
| Almitas Capital LLC | 610,073 | $823.6K | 0.18% | +152,751+33.4% | Added |
| Geode Capital Management, LLC | 589,105 | $795.7K | 0.00% | −1170.0% | Reduced |
| XTX Topco Ltd | 576,707 | $778.6K | 0.02% | +28,078+5.1% | Added |
| Barclays PLC | 568,443 | $767.4K | 0.00% | +406,973+252.0% | Added |
| Woodline Partners LP | 530,582 | $716.3K | 0.00% | 00.0% | Unchanged |
| Jane Street Group, LLC | 473,175 | $638.8K | 0.00% | −172,448−26.7% | Reduced |
| Stonepine Capital Management, LLC | 463,700 | $626.0K | 0.50% | +9,900+2.2% | Added |
| Peapod Lane Capital LLC | 448,861 | $606.0K | 0.52% | −116,510−20.6% | Reduced |
| BNP Paribas Arbitrage, SA | 419,367 | $566.1K | 0.00% | +260,432+163.9% | Added |
| State Street Corp | 271,790 | $366.9K | 0.00% | 00.0% | Unchanged |
| Creative Planning | 260,000 | $351.0K | 0.00% | 00.0% | Unchanged |
| Marshall Wace, LLP | 247,788 | $334.5K | 0.00% | +247,788 | New |
| FMR LLC | 243,308 | $328.5K | 0.00% | +40,003+19.7% | Added |
| Anfield Capital Management, LLC | 242,605 | $327.5K | 0.10% | +171,228+239.9% | Added |
| Invesco Ltd. | 188,582 | $254.6K | 0.00% | +14,961+8.6% | Added |
| JPMorgan Chase & Co | 185,007 | $249.8K | 0.00% | −538,068−74.4% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 130,407 | $232.1K | 0.00% | −35,883−21.6% | Reduced |
| SEI Investments Co | 167,100 | $225.6K | 0.00% | 00.0% | Unchanged |
| Quadrature Capital Ltd | 137,568 | $185.7K | 0.00% | +76,917+126.8% | Added |
| Quarry LP | 132,000 | $178.2K | 0.03% | +23,250+21.4% | Added |
| Opal Capital LLC | 72,251 | $173.4K | 0.04% | +72,251 | New |
| Jacobs Levy Equity Management, Inc | 124,525 | $168.1K | 0.00% | −576,051−82.2% | Reduced |
| Goldman Sachs Group Inc | 118,212 | $159.6K | 0.00% | −226,943−65.8% | Reduced |
| Walleye Capital LLC | 110,448 | $149.1K | 0.00% | −10,000−8.3% | Reduced |
| Squarepoint Ops LLC | 107,734 | $145.4K | 0.00% | +86,412+405.3% | Added |
| Point72 Asset Management, L.P. | 100,290 | $135.4K | 0.00% | +100,290 | New |
| Dimensional Fund Advisors LP | 96,263 | $129.9K | 0.00% | −88,769−48.0% | Reduced |
| Northern Trust Corp | 92,871 | $125.4K | 0.00% | −1,248−1.3% | Reduced |
| Graham Capital Management, L.P. | 90,910 | $122.7K | 0.00% | −61,237−40.2% | Reduced |
| Panagora Asset Management Inc | 86,640 | $117.0K | 0.00% | −11,258−11.5% | Reduced |
| RBF Capital, LLC | 80,000 | $108.0K | 0.00% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 80,000 | $108.0K | 0.01% | +30,000+60.0% | Added |
| Bridgeway Capital Management, LLC | 77,300 | $104.4K | 0.00% | 00.0% | Unchanged |
| 49 Wealth Management, LLC | 70,911 | $95.7K | 0.01% | +42,719+151.5% | Added |
| Commonwealth Equity Services, LLC | 61,412 | $82.9K | 0.00% | +425+0.7% | Added |
| Barr E S & Co | 57,500 | $77.6K | 0.00% | +17,500+43.8% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 51,061 | $68.9K | 0.00% | 00.0% | Unchanged |
| Algert Global LLC | 48,496 | $65.5K | 0.00% | 00.0% | Unchanged |
| AQR Capital Management LLC | 45,995 | $62.1K | 0.00% | −60,970−57.0% | Reduced |
| Tudor Investment Corp Et Al | 34,849 | $47.0K | 0.00% | 00.0% | Unchanged |
| Federated Hermes, Inc. | 34,574 | $46.7K | 0.00% | −6,545−15.9% | Reduced |
| Regency Capital Management Inc. | 29,500 | $39.8K | 0.02% | 00.0% | Unchanged |
| Prudential Financial Inc | 24,550 | $33.1K | 0.00% | +2,950+13.7% | Added |
| Carson Advisory Inc. | 23,470 | $31.7K | 0.02% | −8,600−26.8% | Reduced |
| Acorn Wealth Advisors, LLC | 20,000 | $27.0K | 0.01% | 00.0% | Unchanged |
| Sivia Capital Partners, LLC | 20,000 | $27.0K | 0.01% | +20,000 | New |
| Raymond James Financial Inc | 19,895 | $26.9K | 0.00% | −700−3.4% | Reduced |
| Qube Research & Technologies Ltd | 17,471 | $23.6K | 0.00% | −39,168−69.2% | Reduced |
| Birchview Capital, LP | 17,000 | $22.9K | 0.01% | 00.0% | Unchanged |
| Evergreen Capital Management LLC | 16,915 | $22.8K | 0.00% | 00.0% | Unchanged |
| American Century Companies Inc | 12,880 | $17.4K | 0.00% | +12,880 | New |
| Royal Bank of Canada | 12,740 | $17.0K | 0.00% | +12,318+2,919.0% | Added |
| Ieq Capital, LLC | 12,229 | $16.5K | 0.00% | −21,924−64.2% | Reduced |
| Shay Capital LLC | 10,662 | $14.4K | 0.00% | +10,662 | New |
| Susquehanna International Group, LLP | 10,343 | $14.0K | 0.00% | −190,766−94.9% | Reduced |
| CWM, LLC | 8,564 | $12.0K | 0.00% | −4,554−34.7% | Reduced |
| Highline Wealth Partners LLC | 5,000 | $6.75K | 0.00% | −7,000−58.3% | Reduced |
| EverSource Wealth Advisors, LLC | 1,644 | $2.22K | 0.00% | −949−36.6% | Reduced |
| Bryn Mawr Trust Co | 1,000 | $1.35K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 387 | $522 | 0.00% | 00.0% | Unchanged |
| HighMark Wealth Management LLC | 130 | $175 | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 44 | $59 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 27 | $36 | 0.00% | −1−3.6% | Reduced |
| CWM Advisors, LLC | 16 | $22 | 0.00% | +16 | New |
| Caitong International Asset Management Co., Ltd | 1 | $1 | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 51 | $0 | 0.00% | −1−1.9% | Reduced |
| Matrix Capital Management Company, LP | 0 | $0 | 0.00% | −13,959,973−100.0% | Sold out |
| Tang Capital Management LLC | 0 | $0 | 0.00% | −1,550,000−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −1,185,521−100.0% | Sold out |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −52,572−100.0% | Sold out |
| Catalyst Funds Management Pty Ltd | 0 | $0 | 0.00% | −51,400−100.0% | Sold out |
| Charles Schwab Investment Management Inc | 0 | $0 | 0.00% | −41,981−100.0% | Sold out |
| Public Employees Retirement System of Ohio | 0 | $0 | 0.00% | −31,900−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −31,579−100.0% | Sold out |
| Bluefin Capital Management, LLC | 0 | $0 | 0.00% | −31,266−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −30,424−100.0% | Sold out |
| Tower Research Capital LLC (TRC) | 0 | $0 | 0.00% | −29,386−100.0% | Sold out |
| Voleon Capital Management LP | 0 | $0 | 0.00% | −27,161−100.0% | Sold out |
| Harvest Investment Services, LLC | 0 | $0 | 0.00% | −14,206−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −13,619−100.0% | Sold out |