MBX Biosciences, Inc.
MBX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001776111
In the last 90 days, MBX Biosciences, Inc. insiders filed 0 open-market purchases and 1 sale; 172 institutions reported holding it in 13F filings for Q2 2026, worth $3.06B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in MBX Biosciences, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 138
- +20 vs. Q3 2025
- Shares held
- 48.4M
- +638.7K (+1.3%) vs. Q3 2025
- Total value
- $1.53B
- +$690.9M (+82.6%) vs. Q3 2025
- New holders
- 45
- 53 more added
- Sold out
- 25
- 25 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting MBX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 172 | $3.06B |
| Q1 2026 | 157 | $1.57B |
| Q4 2025 | 138 | $1.53B |
| Q3 2025 | 118 | $836.4M |
| Q2 2025 | 88 | $420.3M |
| Q1 2025 | 79 | $263.2M |
| Q4 2024 | 63 | $606.5M |
| Q3 2024 | 45 | $784.1M |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding MBX Biosciences, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Polygon Management Ltd. | 143,327 | $4.52M | 0.95% | −34,513−19.4% | Reduced |
| DAFNA Capital Management LLC | 165,265 | $5.21M | 1.21% | +80,265+94.4% | Added |
| Schonfeld Strategic Advisors LLC | 167,125 | $5.27M | 0.03% | −115,552−40.9% | Reduced |
| Northern Trust Corp | 190,881 | $6.02M | 0.00% | +57,616+43.2% | Added |
| Elmind Capital, LP | 211,000 | $6.65M | 1.96% | +211,000 | New |
| Goelzer Investment Management, Inc. | 221,672 | $6.99M | 0.32% | +221,672 | New |
| Charles Schwab Investment Management Inc | 222,180 | $7.01M | 0.00% | +52,174+30.7% | Added |
| Affinity Asset Advisors, LLC | 250,000 | $7.88M | 0.57% | +85,000+51.5% | Added |
| Opaleye Management Inc. | 260,000 | $8.20M | 1.08% | +7,000+2.8% | Added |
| UBS Group AG | 281,212 | $8.87M | 0.00% | +220,487+363.1% | Added |
| Rock Springs Capital Management LP | 282,624 | $8.91M | 0.46% | 00.0% | Unchanged |
| Trails Edge Capital Partners, LP | 315,158 | $9.94M | 2.46% | +315,158 | New |
| Goldman Sachs Group Inc | 331,938 | $10.5M | 0.00% | −26,183−7.3% | Reduced |
| Soleus Capital Management, L.P. | 408,900 | $12.9M | 0.55% | +133,900+48.7% | Added |
| Millennium Management LLC | 462,049 | $14.6M | 0.01% | −193,367−29.5% | Reduced |
| Geode Capital Management, LLC | 649,391 | $20.5M | 0.00% | +175,459+37.0% | Added |
| TCG Crossover Management, LLC | 650,000 | $20.5M | 0.68% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 671,838 | $21.2M | 0.02% | +671,838 | New |
| State Street Corp | 672,740 | $21.2M | 0.00% | +353,466+110.7% | Added |
| Point72 Asset Management, L.P. | 680,609 | $21.5M | 0.03% | +52,942+8.4% | Added |
| Citadel Advisors LLC | 809,857 | $25.5M | 0.02% | −186,226−18.7% | Reduced |
| Price T Rowe Associates Inc | 840,506 | $26.5M | 0.00% | −114,220−12.0% | Reduced |
| Parkman Healthcare Partners LLC | 885,639 | $27.9M | 2.66% | +112,335+14.5% | Added |
| Eventide Asset Management, LLC | 890,000 | $28.1M | 0.44% | +890,000 | New |
| Kynam Capital Management, LP | 934,799 | $29.5M | 1.92% | −1,065,201−53.3% | Reduced |
| Woodline Partners LP | 1,000,063 | $31.5M | 0.12% | −201,087−16.7% | Reduced |
| Braidwell LP | 1,018,600 | $32.1M | 1.03% | +1,018,600 | New |
| Cormorant Asset Management, LP | 1,120,000 | $35.3M | 2.00% | −105,000−8.6% | Reduced |
| Driehaus Capital Management LLC | 1,408,159 | $44.4M | 0.30% | −131,480−8.5% | Reduced |
| Vanguard Group Inc | 1,817,811 | $57.3M | 0.00% | +140,449+8.4% | Added |
| EcoR1 Capital, LLC | 2,123,604 | $67.0M | 3.07% | 00.0% | Unchanged |
| NVP Associates, LLC | 2,136,335 | $67.4M | 26.40% | 00.0% | Unchanged |
| BlackRock, Inc. | 2,919,756 | $92.1M | 0.00% | +962,295+49.2% | Added |
| Deep Track Capital, LP | 3,249,790 | $102.5M | 2.34% | +99,790+3.2% | Added |
| Wellington Management Group LLP | 3,349,961 | $105.7M | 0.02% | −1,473,375−30.5% | Reduced |
| NEA Management Company, LLC | 3,614,486 | $114.0M | 5.81% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 3,935,203 | $124.1M | 2.54% | −67,684−1.7% | Reduced |
| Frazier Life Sciences Management, L.P. | 6,652,013 | $209.8M | 5.64% | 00.0% | Unchanged |
| Franklin Resources Inc | 0 | $0 | 0.00% | −1,307,288−100.0% | Sold out |
| Baker Bros. Advisors LP | 0 | $0 | 0.00% | −277,777−100.0% | Sold out |
| Longaeva Partners L.P. | 0 | $0 | 0.00% | −224,433−100.0% | Sold out |
| Sectoral Asset Management Inc | 0 | $0 | 0.00% | −194,898−100.0% | Sold out |
| Hudson Bay Capital Management LP | 0 | $0 | 0.00% | −85,000−100.0% | Sold out |
| Murchinson Ltd. | 0 | $0 | 0.00% | −80,000−100.0% | Sold out |
| Exome Asset Management LLC | 0 | $0 | 0.00% | −52,402−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −48,071−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −39,498−100.0% | Sold out |
| Readystate Asset Management LP | 0 | $0 | 0.00% | −38,500−100.0% | Sold out |
| Ghisallo Capital Management LLC | 0 | $0 | 0.00% | −38,250−100.0% | Sold out |
| Weiss Asset Management LP | 0 | $0 | 0.00% | −30,823−100.0% | Sold out |
| SummitTX Capital, L.P. | 0 | $0 | 0.00% | −29,310−100.0% | Sold out |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | $0 | 0.00% | −28,461−100.0% | Sold out |
| Caption Management, LLC | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −15,176−100.0% | Sold out |
| Silverarc Capital Management, LLC | 0 | $0 | 0.00% | −15,000−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −10,225−100.0% | Sold out |
| Symmetry Investments LP | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Quarry LP | 0 | $0 | 0.00% | −6,499−100.0% | Sold out |
| FNY Investment Advisers, LLC | 0 | $0 | 0.00% | −1,575−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −398−100.0% | Sold out |
| Washington Trust Advisors, Inc. | 0 | $0 | 0.00% | −83−100.0% | Sold out |
| Comerica Bank | 0 | $0 | 0.00% | −76−100.0% | Sold out |
| Rise Advisors, LLC | 0 | $0 | 0.00% | −68−100.0% | Sold out |