MBX Biosciences, Inc.
MBX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001776111
In the last 90 days, MBX Biosciences, Inc. insiders filed 0 open-market purchases and 1 sale; 172 institutions reported holding it in 13F filings for Q2 2026, worth $3.06B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in MBX Biosciences, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 138
- +20 vs. Q3 2025
- Shares held
- 48.4M
- +638.7K (+1.3%) vs. Q3 2025
- Total value
- $1.53B
- +$690.9M (+82.6%) vs. Q3 2025
- New holders
- 45
- 53 more added
- Sold out
- 25
- 25 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting MBX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 172 | $3.06B |
| Q1 2026 | 157 | $1.57B |
| Q4 2025 | 138 | $1.53B |
| Q3 2025 | 118 | $836.4M |
| Q2 2025 | 88 | $420.3M |
| Q1 2025 | 79 | $263.2M |
| Q4 2024 | 63 | $606.5M |
| Q3 2024 | 45 | $784.1M |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding MBX Biosciences, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6,652,013 | $209.8M | 5.64% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 3,935,203 | $124.1M | 2.54% | −67,684−1.7% | Reduced |
| NEA Management Company, LLC | 3,614,486 | $114.0M | 5.81% | 00.0% | Unchanged |
| Wellington Management Group LLP | 3,349,961 | $105.7M | 0.02% | −1,473,375−30.5% | Reduced |
| Deep Track Capital, LP | 3,249,790 | $102.5M | 2.34% | +99,790+3.2% | Added |
| BlackRock, Inc. | 2,919,756 | $92.1M | 0.00% | +962,295+49.2% | Added |
| NVP Associates, LLC | 2,136,335 | $67.4M | 26.40% | 00.0% | Unchanged |
| EcoR1 Capital, LLC | 2,123,604 | $67.0M | 3.07% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,817,811 | $57.3M | 0.00% | +140,449+8.4% | Added |
| Driehaus Capital Management LLC | 1,408,159 | $44.4M | 0.30% | −131,480−8.5% | Reduced |
| Cormorant Asset Management, LP | 1,120,000 | $35.3M | 2.00% | −105,000−8.6% | Reduced |
| Braidwell LP | 1,018,600 | $32.1M | 1.03% | +1,018,600 | New |
| Woodline Partners LP | 1,000,063 | $31.5M | 0.12% | −201,087−16.7% | Reduced |
| Kynam Capital Management, LP | 934,799 | $29.5M | 1.92% | −1,065,201−53.3% | Reduced |
| Eventide Asset Management, LLC | 890,000 | $28.1M | 0.44% | +890,000 | New |
| Parkman Healthcare Partners LLC | 885,639 | $27.9M | 2.66% | +112,335+14.5% | Added |
| Price T Rowe Associates Inc | 840,506 | $26.5M | 0.00% | −114,220−12.0% | Reduced |
| Citadel Advisors LLC | 809,857 | $25.5M | 0.02% | −186,226−18.7% | Reduced |
| Point72 Asset Management, L.P. | 680,609 | $21.5M | 0.03% | +52,942+8.4% | Added |
| State Street Corp | 672,740 | $21.2M | 0.00% | +353,466+110.7% | Added |
| D. E. Shaw & Co., Inc. | 671,838 | $21.2M | 0.02% | +671,838 | New |
| TCG Crossover Management, LLC | 650,000 | $20.5M | 0.68% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 649,391 | $20.5M | 0.00% | +175,459+37.0% | Added |
| Millennium Management LLC | 462,049 | $14.6M | 0.01% | −193,367−29.5% | Reduced |
| Soleus Capital Management, L.P. | 408,900 | $12.9M | 0.55% | +133,900+48.7% | Added |
| Goldman Sachs Group Inc | 331,938 | $10.5M | 0.00% | −26,183−7.3% | Reduced |
| Trails Edge Capital Partners, LP | 315,158 | $9.94M | 2.46% | +315,158 | New |
| Rock Springs Capital Management LP | 282,624 | $8.91M | 0.46% | 00.0% | Unchanged |
| UBS Group AG | 281,212 | $8.87M | 0.00% | +220,487+363.1% | Added |
| Opaleye Management Inc. | 260,000 | $8.20M | 1.08% | +7,000+2.8% | Added |
| Affinity Asset Advisors, LLC | 250,000 | $7.88M | 0.57% | +85,000+51.5% | Added |
| Charles Schwab Investment Management Inc | 222,180 | $7.01M | 0.00% | +52,174+30.7% | Added |
| Goelzer Investment Management, Inc. | 221,672 | $6.99M | 0.32% | +221,672 | New |
| Elmind Capital, LP | 211,000 | $6.65M | 1.96% | +211,000 | New |
| Northern Trust Corp | 190,881 | $6.02M | 0.00% | +57,616+43.2% | Added |
| Schonfeld Strategic Advisors LLC | 167,125 | $5.27M | 0.03% | −115,552−40.9% | Reduced |
| DAFNA Capital Management LLC | 165,265 | $5.21M | 1.21% | +80,265+94.4% | Added |
| Polygon Management Ltd. | 143,327 | $4.52M | 0.95% | −34,513−19.4% | Reduced |
| Two Sigma Investments, LP | 138,571 | $4.37M | 0.01% | +124,984+919.9% | Added |
| KVP Capital Advisors, LP | 121,524 | $3.83M | 3.96% | +121,524 | New |
| Balyasny Asset Management LLC | 119,726 | $3.78M | 0.01% | +94,085+366.9% | Added |
| TD Asset Management Inc | 101,450 | $3.20M | 0.00% | −17,342−14.6% | Reduced |
| Burkehill Global Management, LP | 100,000 | $3.15M | 0.21% | 00.0% | Unchanged |
| Jane Street Group, LLC | 86,581 | $2.73M | 0.00% | +86,581 | New |
| PFM Health Sciences, LP | 79,310 | $2.50M | 0.25% | −142,195−64.2% | Reduced |
| StemPoint Capital LP | 78,553 | $2.48M | 0.43% | +3,553+4.7% | Added |
| Advisor Group Holdings, Inc. | 77,601 | $2.45M | 0.00% | +77,601 | New |
| Susquehanna International Group, LLP | 76,528 | $2.41M | 0.00% | +76,528 | New |
| Nuveen, LLC | 75,565 | $2.38M | 0.00% | +53,422+241.3% | Added |
| Bank of New York Mellon Corp | 75,262 | $2.37M | 0.00% | +27,527+57.7% | Added |
| Schroder Investment Management Group | 73,736 | $2.28M | 0.00% | −10,030−12.0% | Reduced |
| Aaron Wealth Advisors | 70,000 | $2.21M | 0.12% | +20,000+40.0% | Added |
| Manufacturers Life Insurance Company, The | 69,551 | $2.15M | 0.00% | +1,175+1.7% | Added |
| Morgan Stanley | 59,026 | $1.86M | 0.00% | +14,158+31.6% | Added |
| Verition Fund Management LLC | 57,575 | $1.82M | 0.01% | +57,575 | New |
| ExodusPoint Capital Management, LP | 57,005 | $1.80M | 0.02% | −42,995−43.0% | Reduced |
| Barclays PLC | 52,691 | $1.66M | 0.00% | +31,065+143.6% | Added |
| Acadian Asset Management LLC | 48,614 | $1.53M | 0.00% | +43,605+870.5% | Added |
| Squarepoint Ops LLC | 46,702 | $1.47M | 0.00% | +46,702 | New |
| Platinum Investment Management Ltd | 43,597 | $1.38M | 0.32% | −25,831−37.2% | Reduced |
| Bank of America Corp | 37,894 | $1.20M | 0.00% | +11,278+42.4% | Added |
| Alps Advisors Inc | 36,872 | $1.16M | 0.01% | +20,032+119.0% | Added |
| Creative Planning | 33,651 | $1.06M | 0.00% | +4,919+17.1% | Added |
| Rhumbline Advisers | 33,420 | $1.05M | 0.00% | +11,599+53.2% | Added |
| Renaissance Technologies LLC | 32,644 | $1.03M | 0.00% | +32,644 | New |
| Wells Fargo & Company | 31,931 | $1.01M | 0.00% | +20,176+171.6% | Added |
| AQR Capital Management LLC | 31,409 | $990.6K | 0.00% | +15,645+99.2% | Added |
| Alliancebernstein L.P. | 27,900 | $880.0K | 0.00% | +17,400+165.7% | Added |
| Brevan Howard Capital Management LP | 25,663 | $809.4K | 0.02% | +25,663 | New |
| Trexquant Investment LP | 24,268 | $765.4K | 0.01% | +24,268 | New |
| Fox Run Management, L.L.C. | 23,820 | $751.3K | 0.12% | +23,820 | New |
| Qube Research & Technologies Ltd | 23,213 | $732.1K | 0.00% | +23,213 | New |
| Cerity Partners LLC | 21,323 | $672.5K | 0.00% | +21,323 | New |
| Invesco Ltd. | 21,203 | $668.7K | 0.00% | +9,415+79.9% | Added |
| XTX Topco Ltd | 20,139 | $635.2K | 0.02% | −18,239−47.5% | Reduced |
| Deutsche Bank AG | 20,027 | $631.7K | 0.00% | +9,104+83.3% | Added |
| Gsa Capital Partners LLP | 19,295 | $609.0K | 0.05% | +19,295 | New |
| Koa Wealth Management, LLC | 18,413 | $580.7K | 0.40% | −8,300−31.1% | Reduced |
| Seven Fleet Capital Management LP | 18,200 | $574.0K | 0.39% | +18,200 | New |
| Citigroup Inc | 16,391 | $517.0K | 0.00% | +16,213+9,108.4% | Added |
| MetLife Investment Management | 16,018 | $505.2K | 0.00% | +5,000+45.4% | Added |
| FMR LLC | 15,746 | $496.6K | 0.00% | −53,230−77.2% | Reduced |
| China Universal Asset Management Co., Ltd. | 15,317 | $483.1K | 0.04% | +10,317+206.3% | Added |
| JPMorgan Chase & Co | 14,645 | $461.9K | 0.00% | +8,470+137.2% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 13,258 | $418.2K | 0.00% | +6,138+86.2% | Added |
| American Century Companies Inc | 12,236 | $385.9K | 0.00% | +12,236 | New |
| Canada Pension Plan Investment Board | 11,600 | $365.9K | 0.00% | +11,600 | New |
| Graham Capital Management, L.P. | 11,254 | $355.0K | 0.01% | +11,254 | New |
| Bridgeway Capital Management, LLC | 10,000 | $315.4K | 0.01% | −4,200−29.6% | Reduced |
| Group One Trading, L.P. | 9,428 | $297.4K | 0.01% | +9,428 | New |
| Profund Advisors LLC | 9,214 | $290.6K | 0.01% | +9,214 | New |
| Simplex Trading, LLC | 8,925 | $281.5K | 0.01% | +8,925 | New |
| Virtus Investment Advisers, Inc. | 8,910 | $281.0K | 0.08% | −1,704−16.1% | Reduced |
| Rafferty Asset Management, LLC | 8,113 | $255.9K | 0.00% | +8,113 | New |
| SEI Investments Co | 7,657 | $241.5K | 0.00% | +7,657 | New |
| Police & Firemen's Retirement System of New Jersey | 7,520 | $237.2K | 0.00% | +3,011+66.8% | Added |
| ProShare Advisors LLC | 7,187 | $226.7K | 0.00% | +7,187 | New |
| Los Angeles Capital Management LLC | 10,360 | $225.7K | 0.00% | +10,360 | New |
| Intech Investment Management LLC | 6,858 | $216.3K | 0.00% | +6,858 | New |
| BNP Paribas Arbitrage, SA | 6,784 | $214.0K | 0.00% | +3,888+134.3% | Added |