Baker Bros. Advisors LP
- SEC CIK
- 0001263508
- Latest filing
- Aug 14, 2026
Holdings in Q1 2026
Holdings as of Mar 31, 2026, filed May 15, 2026. Long positions only; changes compare share counts with Q4 2025.
- Positions
- 84
- −2 vs. Q4 2025
- Portfolio value
- $17.4B
- +$337.1M (+2.0%) vs. Q4 2025
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| INCYIncyte Corp | COM | 30,744,412 | $2.89B | 16.6% | +4210.0% | Added | History |
| ONCBeOne Medicines Ltd. | ADR | 8,799,053 | $2.61B | 15.0% | 00.0% | Unchanged | History |
| INSMINSMED Inc | COM PAR $.01 | 7,421,111 | $1.21B | 7.0% | +828,365+12.6% | Added | History |
| MDGLMadrigal Pharmaceuticals, Inc. | COM | 2,141,701 | $1.12B | 6.4% | 00.0% | Unchanged | History |
| ACADAcadia Pharmaceuticals Inc | COM | 42,896,690 | $954.9M | 5.5% | 00.0% | Unchanged | History |
| RVMDRevolution Medicines, Inc. | COM | 9,555,357 | $929.3M | 5.3% | +100,000+1.1% | Added | History |
| CELCCelcuity Inc. | COM | 7,915,792 | $903.5M | 5.2% | 00.0% | Unchanged | History |
| KODKodiak Sciences Inc. | COM | 19,919,186 | $759.3M | 4.4% | 00.0% | Unchanged | History |
| KYMRKymera Therapeutics, Inc. | COM | 8,657,242 | $721.1M | 4.1% | 00.0% | Unchanged | History |
| SMMTSummit Therapeutics Inc. | COM | 36,391,063 | $690.0M | 4.0% | 00.0% | Unchanged | History |
| PRAXPraxis Precision Medicines, Inc. | COM NEW | 1,753,198 | $564.9M | 3.2% | +626,710+55.6% | Added | History |
| RYTMRhythm Pharmaceuticals, Inc. | COM | 5,604,483 | $487.4M | 2.8% | 00.0% | Unchanged | History |
| ALKSAlkermes plc. | SHS | 10,012,267 | $354.0M | 2.0% | 00.0% | Unchanged | History |
| GRALGRAIL, Inc. | COM | 4,028,614 | $208.2M | 1.2% | +1,943,281+93.2% | Added | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 6,575,940 | $207.1M | 1.2% | 00.0% | Unchanged | History |
| IONSIonis Pharmaceuticals Inc | COM | 2,047,727 | $153.8M | 0.9% | +255,886+14.3% | Added | History |
| KNSAKiniksa Pharmaceuticals International, plc | ORD SHS CL A | 2,826,246 | $136.1M | 0.8% | 00.0% | Unchanged | History |
| IMVTImmunovant, Inc. | COM | 5,457,881 | $135.6M | 0.8% | 00.0% | Unchanged | History |
| ROIVRoivant Sciences Ltd. | SHS | 4,867,723 | $134.8M | 0.8% | −687,294−12.4% | Reduced | History |
| IDYAIDEAYA Biosciences, Inc. | COM | 3,946,515 | $131.5M | 0.8% | +327,689+9.1% | Added | History |
| ARWRArrowhead Pharmaceuticals, Inc. | COM | 1,992,783 | $124.9M | 0.7% | −182,862−8.4% | Reduced | History |
| STOKStoke Therapeutics, Inc. | COM | 3,336,697 | $108.6M | 0.6% | 00.0% | Unchanged | History |
| IMTXImmatics N.V. | SHS | 10,916,693 | $107.4M | 0.6% | −1,177,401−9.7% | Reduced | History |
| ABCLAbCellera Biologics Inc. | COM | 30,275,938 | $105.7M | 0.6% | +2,750,298+10.0% | Added | History |
| ABVXAbivax S.A. | SPONSORED ADS | 875,796 | $97.5M | 0.6% | 00.0% | Unchanged | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 2,351,465 | $85.4M | 0.5% | +702,596+42.6% | Added | History |
| REPLReplimune Group, Inc. | COM | 11,045,336 | $84.5M | 0.5% | 00.0% | Unchanged | History |
| Celcuity Inc.15102KAA8 | NOTE 2.750% 8/0 | 30,750,000 | $74.9M | 0.4% | – | – | – |
| NRIXNurix Therapeutics, Inc. | COM | 4,658,556 | $72.2M | 0.4% | 00.0% | Unchanged | History |
| DNLIDenali Therapeutics Inc. | COM | 3,731,695 | $71.6M | 0.4% | 00.0% | Unchanged | History |
| DNTHDianthus Therapeutics, Inc. | COM | 852,164 | $71.5M | 0.4% | +62,405+7.9% | Added | History |
| GLUEMonte Rosa Therapeutics, Inc. | COM | 4,345,736 | $71.5M | 0.4% | 00.0% | Unchanged | History |
| GPCRStructure Therapeutics Inc. | SPONSORED ADS | 1,432,529 | $69.0M | 0.4% | 00.0% | Unchanged | History |
| TRDAEntrada Therapeutics, Inc. | COM | 5,072,730 | $64.0M | 0.4% | 00.0% | Unchanged | History |
| BCYCBicycle Therapeutics PLC | SPONSORED ADS | 10,885,357 | $50.5M | 0.3% | 00.0% | Unchanged | History |
| SYRESpyre Therapeutics, Inc. | COM NEW | 1,000,000 | $50.4M | 0.3% | 00.0% | Unchanged | History |
| RAPPRapport Therapeutics, Inc. | COM | 1,547,090 | $48.4M | 0.3% | 00.0% | Unchanged | History |
| ALMSAlumis Inc. | COM | 2,012,500 | $44.3M | 0.3% | +450,000+28.8% | Added | History |
| MIRMMirum Pharmaceuticals, Inc. | COM | 445,975 | $41.2M | 0.2% | +445,975 | New | History |
| VRDNViridian Therapeutics, Inc. | COM | 1,971,678 | $38.6M | 0.2% | 00.0% | Unchanged | History |
| ELVNEnliven Therapeutics, Inc. | COM | 905,191 | $35.5M | 0.2% | +633,785+233.5% | Added | History |
| PRLDPrelude Therapeutics Inc | COM | 10,123,824 | $34.6M | 0.2% | 00.0% | Unchanged | History |
| DBVTDBV Technologies S.A. | SPONSORED ADS | 1,461,425 | $30.5M | 0.2% | 00.0% | Unchanged | History |
| DSGNDesign Therapeutics, Inc. | COM | 2,585,978 | $27.5M | 0.2% | +352,879+15.8% | Added | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 670,751 | $26.6M | 0.2% | 00.0% | Unchanged | History |
| CTMXCytomX Therapeutics, Inc. | COM | 4,975,826 | $23.4M | 0.1% | +725,000+17.1% | Added | History |
| JBIOJade Biosciences, Inc. | COM NEW | 1,641,137 | $23.1M | 0.1% | 00.0% | Unchanged | History |
| IRONDisc Medicine, Inc. | COM | 349,657 | $22.4M | 0.1% | +12,607+3.7% | Added | History |
| IMCRImmunocore Holdings plc | ADS | 734,397 | $22.1M | 0.1% | −1,588,259−68.4% | Reduced | History |
| XENEXenon Pharmaceuticals Inc. | COM | 370,208 | $21.5M | 0.1% | 00.0% | Unchanged | History |
| CLDXCelldex Therapeutics, Inc. | COM NEW | 665,370 | $21.1M | 0.1% | 00.0% | Unchanged | History |
| NGNENeurogene Inc. | COM | 991,691 | $20.0M | 0.1% | 00.0% | Unchanged | History |
| EVMNEvommune, Inc. | COM SHS | 847,390 | $19.5M | 0.1% | +847,390 | New | History |
| TECXTectonic Therapeutic, Inc. | COM | 607,788 | $18.8M | 0.1% | −295,612−32.7% | Reduced | History |
| CTNMContineum Therapeutics, Inc. | CL A | 1,420,838 | $18.6M | 0.1% | 00.0% | Unchanged | History |
| ARGXArgenx SE | SPONSORED ADR | 25,174 | $18.4M | 0.1% | 00.0% | Unchanged | History |
| CERSCerus Corp | COM | 10,008,345 | $18.2M | 0.1% | 00.0% | Unchanged | History |
| TSHATaysha Gene Therapies, Inc. | COM SHS | 4,004,756 | $17.9M | 0.1% | 00.0% | Unchanged | History |
| AKTSAktis Oncology, Inc. | COM | 996,351 | $17.8M | 0.1% | +996,351 | New | History |
| GENBGenerate Biomedicines, Inc. | COM SHS | 1,423,602 | $17.8M | 0.1% | +1,423,602 | New | History |
| SIONSionna Therapeutics, Inc. | COM | 400,000 | $16.0M | 0.1% | 00.0% | Unchanged | History |
| DYNDyne Therapeutics, Inc. | COM | 813,449 | $14.7M | 0.1% | 00.0% | Unchanged | History |
| XNCRXencor Inc | COM | 1,102,106 | $13.3M | 0.1% | 00.0% | Unchanged | History |
| CMPSCOMPASS Pathways plc | SPONSORED ADS | 2,344,720 | $13.0M | 0.1% | +2,344,720 | New | History |
| RLAYRelay Therapeutics, Inc. | COM | 1,160,117 | $11.5M | 0.1% | 00.0% | Unchanged | History |
| SERASera Prognostics, Inc. | CLASS A COM | 5,498,170 | $11.2M | 0.1% | 00.0% | Unchanged | History |
| BNTXBioNTech SE | SPONSORED ADS | 119,743 | $10.6M | 0.1% | −249,180−67.5% | Reduced | History |
| PHVSPharvaris N.V. | COM | 375,000 | $10.6M | 0.1% | 00.0% | Unchanged | History |
| RCUSArcus Biosciences, Inc. | COM | 415,621 | $8.98M | 0.1% | +145,621+53.9% | Added | History |
| MPLTMapLight Therapeutics, Inc. | COM | 364,705 | $7.41M | <0.1% | 00.0% | Unchanged | History |
| ABSIAbsci Corp | COM | 2,134,803 | $6.40M | <0.1% | 00.0% | Unchanged | History |
| WVEWave Life Sciences, Inc. | SHS | 822,638 | $5.96M | <0.1% | +478,575+139.1% | Added | History |
| VTVTvTv Therapeutics Inc. | CL A NEW | 148,314 | $5.88M | <0.1% | 00.0% | Unchanged | History |
| EIKNEikon Therapeutics, Inc. | COM | 555,555 | $5.88M | <0.1% | +555,555 | New | History |
| TARAProtara Therapeutics, Inc. | COM STK | 971,614 | $5.06M | <0.1% | 00.0% | Unchanged | History |
| SGMTSagimet Biosciences Inc. | COM SER A | 952,996 | $4.98M | <0.1% | 00.0% | Unchanged | History |
| LBRXLB Pharmaceuticals Inc | COM SHS | 200,000 | $4.93M | <0.1% | 00.0% | Unchanged | History |
| VSTMVerastem, Inc. | COM NEW | 584,757 | $3.10M | <0.1% | +584,757 | New | History |
| TCRXTScan Therapeutics, Inc. | COM | 2,784,792 | $2.81M | <0.1% | 00.0% | Unchanged | History |
| SKYESkye Bioscience, Inc. | COM NEW | 1,575,243 | $968.1K | <0.1% | +124,605+8.6% | Added | History |
| SANASana Biotechnology, Inc. | COM | 310,483 | $894.2K | <0.1% | 00.0% | Unchanged | History |
| ALGSAligos Therapeutics, Inc. | COM NEW | 83,055 | $617.1K | <0.1% | 00.0% | Unchanged | History |
| TYRATyra Biosciences, Inc. | COM | 10,607 | $406.2K | <0.1% | 00.0% | Unchanged | History |
| Surrozen, Inc.86889P117 | *W EXP 08/01/203 | 833,333 | $13.3K | <0.1% | 00.0% | Unchanged | – |
Sold out since Q4 2025 (9)
Positions held at the end of Q4 2025 that are gone from this filing.
| Security | Class | Shares in Q4 2025 | Value in Q4 2025 | % of portfolio in Q4 2025 | History |
|---|---|---|---|---|---|
| RAREUltragenyx Pharmaceutical Inc. | COM | 2,772,692 | $63.8M | 0.4% | History |
| TERNTerns Pharmaceuticals, Inc. | COM | 950,000 | $38.4M | 0.2% | History |
| BCRXBiocryst Pharmaceuticals Inc | COM | 2,822,727 | $22.0M | 0.1% | History |
| VTYXVentyx Biosciences, Inc. | COM | 2,349,280 | $21.2M | 0.1% | History |
| NUVLNuvalent, Inc. | COM | 143,937 | $14.5M | 0.1% | History |
| FDMT4D Molecular Therapeutics, Inc. | COM | 475,737 | $3.57M | <0.1% | History |
| VIRVir Biotechnology, Inc. | COM | 542,539 | $3.27M | <0.1% | History |
| KALAKALA BIO, Inc. | COMM STK | 1,804,055 | $1.00M | <0.1% | History |
| ACRVAcrivon Therapeutics, Inc. | COMMON STOCK | 22,809 | $55.0K | <0.1% | History |