Skip to main content
Livermore
Livermore
ZHEN

Perceptive Advisors LLC

SEC CIK
0001224962
Latest filing
Aug 14, 2026

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed May 4, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
145
+7 vs. Q3 2021
Portfolio value
$6.47B
−$388.8M (−5.7%) vs. Q3 2021
Filed
May 4, 2022
AmendedSEC
Holdings of Perceptive Advisors LLC in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
Retrophin Inc761299AB2NOTE 2.500% 9/1–$484.7M7.5%–––
MRTXMirati Therapeutics, Inc.COM3,283,783$481.7M7.4%−103,962−3.1%ReducedHistory
LIANYLianBioSPONSORED ADS56,319,960$346.9M5.4%+56,319,960NewHistory
FOLDAmicus Therapeutics, Inc.COM26,559,443$306.8M4.7%00.0%UnchangedHistory
SWTXSpringWorks Therapeutics, Inc.COM4,849,912$300.6M4.6%00.0%UnchangedHistory
IOVAIovance Biotherapeutics, Inc.COM10,127,941$193.3M3.0%−1,361,831−11.9%ReducedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS1,738,140$187.3M2.9%−218,800−11.2%ReducedHistory
Collegium Pharmaceutical, Inc19459JAA2NOTE 2.625% 2/1–$169.3M2.6%–––
MGTXMeiraGTx Holdings plcCOM6,948,277$165.0M2.5%00.0%UnchangedHistory
CERECerevel Therapeutics Holdings, Inc.COM5,086,727$164.9M2.5%00.0%UnchangedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM5,163,517$146.7M2.3%+1,200,000+30.3%AddedHistory
RXDXPrometheus Biosciences, Inc.COM3,172,785$125.5M1.9%−141,247−4.3%ReducedHistory
VBIVVBI Vaccines Inc/BCCOM NEW52,335,002$122.5M1.9%−2,707,463−4.9%ReducedHistory
BBIOBridgeBio Pharma, Inc.COM7,128,755$118.9M1.8%−628,173−8.1%ReducedHistory
ISEEIVERIC bio, Inc.COM6,480,000$108.3M1.7%−991,798−13.3%ReducedHistory
RAPTRAPT Therapeutics, Inc.COM2,927,565$107.5M1.7%+20,000+0.7%AddedHistory
BMRNBiomarin Pharmaceutical IncCOM1,180,000$104.3M1.6%+1,180,000NewHistory
Nevro Corp64157FAC7NOTE 2.750% 4/0–$101.5M1.6%–––
GBTGlobal Blood Therapeutics, Inc.COM3,449,915$101.0M1.6%−957,484−21.7%ReducedHistory
CHRSCoherus Oncology, Inc.COM5,407,798$86.3M1.3%+628,411+13.1%AddedHistory
OMOutset Medical, Inc.COM1,863,397$85.9M1.3%−127,236−6.4%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM2,411,447$75.3M1.2%+389,396+19.3%AddedHistory
LABPLandos Biopharma, Inc.COM14,869,915$71.4M1.1%00.0%UnchangedHistory
CCCCC4 Therapeutics, Inc.COM STK2,208,913$71.1M1.1%−49,653−2.2%ReducedHistory
APLSApellis Pharmaceuticals, Inc.COM1,451,700$68.6M1.1%+836,700+136.0%AddedHistory
Bellus Health Inc New07987C204COM NEW7,645,234$61.5M1.0%+7,645,234New–
ZYMEZymeworks Inc.COM3,679,845$60.3M0.9%00.0%UnchangedHistory
RLAYRelay Therapeutics, Inc.COM1,943,097$59.7M0.9%00.0%UnchangedHistory
INBXInhibrx Biosciences, Inc.COM1,343,490$58.7M0.9%+222,000+19.8%AddedHistory
TVTXTravere Therapeutics, Inc.COM1,845,555$57.3M0.9%−120,000−6.1%ReducedHistory
ALBOAlbireo Pharma, Inc.COM2,360,139$55.0M0.8%00.0%UnchangedHistory
ChemoCentryx, Inc.16383L106COM1,415,446$51.5M0.8%+865,446+157.4%Added–
Coherus Biosciences Inc19249HAB9NOTE 1.500% 4/1–$51.5M0.8%–––
NAUTNautilus Biotechnology, Inc.COM9,111,151$47.2M0.7%+200,000+2.2%AddedHistory
ARNAArena Pharmaceuticals IncCOM NEW500,000$46.5M0.7%+500,000NewHistory
LONALeonaBio, Inc.COM3,425,916$44.6M0.7%00.0%UnchangedHistory
KODKodiak Sciences Inc.COM520,152$44.1M0.7%+58,904+12.8%AddedHistory
ICVXIcosavax, Inc.COM1,906,548$43.6M0.7%−16,001−0.8%ReducedHistory
RCKTRocket Pharmaceuticals, Inc.COM1,959,125$42.8M0.7%−351,136−15.2%ReducedHistory
QTNTQuotient LtdSHS16,200,818$42.0M0.6%00.0%UnchangedHistory
NBIXNeurocrine Biosciences IncStock483,007$41.1M0.6%00.0%UnchangedHistory
MORFMorphic Holding, Inc.COM836,521$39.6M0.6%−50,819−5.7%ReducedHistory
ALDXAldeyra Therapeutics, Inc.COM9,903,879$39.6M0.6%00.0%UnchangedHistory
OMICSingular Genomics Systems, Inc.COM3,333,824$38.5M0.6%+260,000+8.5%AddedHistory
ISOIsoPlexis CorpCOM4,095,498$37.6M0.6%+4,095,498NewHistory
ACADAcadia Pharmaceuticals IncCOM1,584,052$37.0M0.6%+1,584,052NewHistory
ZNTLZentalis Pharmaceuticals, Inc.COM430,544$36.2M0.6%+430,544NewHistory
IMTXImmatics N.V.SHS2,500,000$33.6M0.5%00.0%UnchangedHistory
PRCTPROCEPT BioRobotics CorpCOM1,328,285$33.2M0.5%−328,705−19.8%ReducedHistory
VRCAVerrica Pharmaceuticals Inc.COM3,610,412$33.1M0.5%00.0%UnchangedHistory
KRONKronos Bio, Inc.COM2,421,142$32.9M0.5%00.0%UnchangedHistory
Rain Oncology Inc.75082Q105COM2,483,619$32.0M0.5%−53,400−2.1%Reduced–
TARSTarsus Pharmaceuticals, Inc.COM1,296,416$29.2M0.5%00.0%UnchangedHistory
VRDNViridian Therapeutics, Inc.COM1,423,053$28.1M0.4%+530.0%AddedHistory
CYPHCypherpunk Technologies Inc.COM8,476,496$27.5M0.4%00.0%UnchangedHistory
ESTAEstablishment Labs Holdings Inc.COM405,541$27.4M0.4%−100,000−19.8%ReducedHistory
COGTCogent Biosciences, Inc.COM3,188,750$27.4M0.4%00.0%UnchangedHistory
CMAXCareMax, Inc.COM CL A3,549,525$27.3M0.4%+164,525+4.9%AddedHistory
MGNXMacrogenics IncCOM1,665,243$26.7M0.4%−482,817−22.5%ReducedHistory
VERUVeru Inc.COM4,451,342$26.2M0.4%00.0%UnchangedHistory
NUVBNuvation Bio Inc.COM CL A2,920,823$24.8M0.4%−120,181−4.0%ReducedHistory
LUNGPulmonx CorpCOM762,304$24.4M0.4%+762,304NewHistory
NVTAInvitae CorpCOM1,584,585$24.2M0.4%−2,339,156−59.6%ReducedHistory
SLDBSolid Biosciences Inc.COM13,412,552$23.5M0.4%00.0%UnchangedHistory
PYXSPyxis Oncology, Inc.COMMON STOCK1,944,114$21.3M0.3%+1,944,114NewHistory
HLTHCue Health Inc.COM1,580,607$21.2M0.3%00.0%UnchangedHistory
UTHRUnited Therapeutics CorpCOM94,064$20.3M0.3%−47,636−33.6%ReducedHistory
VRNAVerona Pharma plcSPONSORED ADS2,867,510$19.3M0.3%−21,379−0.7%ReducedHistory
SNCEScience 37 Holdings, Inc.COM1,500,000$18.7M0.3%+1,500,000NewHistory
ATNXAthenex, Inc.COM13,532,467$18.4M0.3%00.0%UnchangedHistory
TMCITreace Medical Concepts, Inc.COM980,186$18.3M0.3%−255,700−20.7%ReducedHistory
HCATHealth Catalyst, Inc.COM454,004$18.0M0.3%−135,000−22.9%ReducedHistory
DICEDICE Therapeutics, Inc.COM704,885$17.8M0.3%+704,885NewHistory
SLGCSomaLogic, Inc.CLASS A COM1,500,000$17.5M0.3%−550,000−26.8%ReducedHistory
ADMAAdma Biologics, Inc.COM11,933,387$16.8M0.3%−1,328,988−10.0%ReducedHistory
NUVLNuvalent, Inc.COM750,000$14.3M0.2%00.0%UnchangedHistory
LYRALyra Therapeutics, Inc.COM3,222,560$14.1M0.2%00.0%UnchangedHistory
VTRSViatris IncStock1,004,419$13.6M0.2%00.0%UnchangedHistory
BCABBioAtla, Inc.COM661,200$13.0M0.2%−188,826−22.2%ReducedHistory
IMCRImmunocore Holdings plcADS360,000$12.3M0.2%−40,000−10.0%ReducedHistory
Nanostring Technologies Inc63009RAD1NOTE 2.625% 5/0–$12.0M0.2%–––
BIIBBiogen Inc.COM48,600$11.7M0.2%00.0%UnchangedHistory
ABSIAbsci CorpCOM1,411,776$11.6M0.2%−65,000−4.4%ReducedHistory
ACRSAclaris Therapeutics, Inc.COM781,236$11.4M0.2%00.0%UnchangedHistory
WGSGeneDx Holdings Corp.COMMON STOCK2,500,000$11.2M0.2%00.0%UnchangedHistory
MRUSMerus N.V.COM350,000$11.1M0.2%+350,000NewHistory
IMRXImmuneering CorpCLASS A COM681,051$11.0M0.2%00.0%UnchangedHistory
HYPRHyperfine, Inc.COM CL A1,500,000$10.9M0.2%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM850,093$10.6M0.2%−25,000−2.9%ReducedHistory
AGRXAgile Therapeutics IncCOM21,294,485$10.4M0.2%+5,374,560+33.8%AddedHistory
HRMYHarmony Biosciences Holdings, Inc.COM239,258$10.2M0.2%−252,074−51.3%ReducedHistory
Summit Healthcre Acquistn CoG8566R128UNIT 06/03/20261,000,000$9.95M0.2%00.0%Unchanged–
ADPTAdaptive Biotechnologies CorpCOM352,804$9.90M0.2%00.0%UnchangedHistory
KYMRKymera Therapeutics, Inc.COM155,000$9.84M0.2%−25,000−13.9%ReducedHistory
BCLS Acquisition CorpG0904B105COM CL A1,000,000$9.80M0.2%00.0%Unchanged–
RACBResearch Alliance Corp. IICOM CL A1,000,000$9.77M0.2%00.0%UnchangedHistory
TYRATyra Biosciences, Inc.COM673,352$9.47M0.1%−314,148−31.8%ReducedHistory
DAWNDay One Biopharmaceuticals, Inc.Stock556,047$9.37M0.1%00.0%UnchangedHistory
ONEM1Life Healthcare IncCOM532,350$9.35M0.1%00.0%UnchangedHistory
CLDXCelldex Therapeutics, Inc.COM NEW229,807$8.88M0.1%−163,806−41.6%ReducedHistory

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Perceptive Advisors LLC in Q4 2021
SecurityClassPutsCalls
FLNAFilana Therapeutics, Inc.COM$13.1M–
DCPHDeciphera Pharmaceuticals, Inc.COM–$1.95M

Sold out since Q3 2021 (15)

Positions held at the end of Q3 2021 that are gone from this filing.

Positions of Perceptive Advisors LLC sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
AVIRAtea Pharmaceuticals, Inc.COM2,259,224$79.2M1.2%History
BEAMBeam Therapeutics Inc.COM537,635$46.8M0.7%History
DBVTDBV Technologies S.A.SPONSORED ADR7,695,505$37.7M0.5%History
Avidity Biosciences, Inc.05370A108COM885,818$21.8M0.3%–
NTRANatera, Inc.COM160,000$17.8M0.3%History
CM Life Sciences III Inc125841205UNIT 04/30/20281,250,000$12.8M0.2%–
PODDInsulet CorpStock44,522$12.7M0.2%History
FDMT4D Molecular Therapeutics, Inc.COM375,256$10.1M0.1%History
TSHATaysha Gene Therapies, Inc.COM SHS320,440$5.97M0.1%History
PSTXPoseida Therapeutics, Inc.COM787,745$5.74M0.1%History
ATECAlphatec Holdings, Inc.COM NEW430,900$5.25M0.1%History
RGNXREGENXBIO Inc.COM89,283$3.74M0.1%History
SNCEScience 37 Holdings, Inc.COM300,000$2.94M<0.1%History
IMGOImago BioSciences, Inc.COM125,000$2.50M<0.1%History
KRROKorro Bio, Inc.COM222,222$1.57M<0.1%History