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Livermore
ZHEN

Perceptive Advisors LLC

SEC CIK
0001224962
Latest filing
Aug 14, 2026

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed May 4, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
145
+7 vs. Q3 2021
Portfolio value
$6.47B
−$388.8M (−5.7%) vs. Q3 2021
Filed
May 4, 2022
AmendedSEC
Holdings of Perceptive Advisors LLC in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
CareMax, Inc.14171W111*W EXP 06/08/20260,000$84.0K<0.1%00.0%Unchanged–
Surrozen, Inc.86889P117*W EXP 08/01/203166,666$192.0K<0.1%00.0%Unchanged–
EQRx, Inc.26886C115*W EXP 12/17/202250,000$266.0K<0.1%+250,000New–
Butterfly Network, Inc.124155110*W EXP 05/27/202233,333$296.0K<0.1%00.0%Unchanged–
SLGCWSomaLogic, Inc.*W EXP 03/01/202110,000$367.0K<0.1%00.0%UnchangedHistory
PHVSPharvaris N.V.COM27,000$389.0K<0.1%00.0%UnchangedHistory
UTRSMinerva Surgical IncCOM87,768$451.0K<0.1%+87,768NewHistory
Rockley Photonics Holdings LG7614L117*W EXP 08/11/202500,000$605.0K<0.1%00.0%Unchanged–
EIGREiger BioPharmaceuticals, Inc.COM139,890$726.0K<0.1%00.0%UnchangedHistory
MOTSMotus GI Holdings, Inc.COM1,800,542$841.0K<0.1%00.0%UnchangedHistory
ITOSiTeos Therapeutics, Inc.COM20,000$931.0K<0.1%+20,000NewHistory
RACEFerrari N.V.COM6,200$1.60M<0.1%00.0%UnchangedHistory
NVRONevro CorpCOM22,946$1.86M<0.1%−237,026−91.2%ReducedHistory
YARWYarrow Bioscience, Inc.COM2,178,022$2.22M<0.1%−152,449−6.5%ReducedHistory
SRZNSurrozen, Inc.COM413,446$2.66M<0.1%−86,554−17.3%ReducedHistory
TARAProtara Therapeutics, Inc.COM STK421,641$2.85M<0.1%00.0%UnchangedHistory
PMVPPMV Pharmaceuticals, Inc.COM125,000$2.89M<0.1%−176,714−58.6%ReducedHistory
AXSMAxsome Therapeutics, Inc.COM80,420$3.04M<0.1%00.0%UnchangedHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS755,375$3.78M0.1%00.0%Unchanged–
SONXSonendo, Inc.COM668,505$3.85M0.1%+668,505NewHistory
RPIDRapid Micro Biosystems, Inc.CLASS A COM385,693$4.10M0.1%+35,693+10.2%AddedHistory
NEPTFNeptune Wellness Solutions Inc.COM10,055,521$4.12M0.1%00.0%UnchangedHistory
DRIODarioHealth Corp.COM NEW327,869$4.25M0.1%00.0%UnchangedHistory
OBIOOrchestra BioMed Holdings, Inc.ORD SHS450,000$4.54M0.1%00.0%UnchangedHistory
TBIOTelesis Bio Inc.COM425,000$4.59M0.1%00.0%UnchangedHistory
DALSDA32 Life Science Tech Acquisition Corp.CLASS A COM500,000$4.91M0.1%00.0%UnchangedHistory
PRTAProthena Corp Public Ltd CoSHS100,000$4.94M0.1%00.0%UnchangedHistory
FUSNFusion Pharmaceuticals Inc.COM1,227,017$5.12M0.1%−27,590−2.2%ReducedHistory
NVNOenVVeno Medical CorpCOMMON STOCK781,615$5.15M0.1%+781,615NewHistory
FULCFulcrum Therapeutics, Inc.COM294,118$5.20M0.1%00.0%UnchangedHistory
ONCROncorus, Inc.COM999,812$5.27M0.1%−99,998−9.1%ReducedHistory
PRVBProvention Bio, Inc.COM948,481$5.33M0.1%00.0%UnchangedHistory
CLOVClover Health Investments, Corp.COM CL A1,500,000$5.58M0.1%00.0%UnchangedHistory
PEARPear Therapeutics, Inc.CLASS A COM926,232$5.74M0.1%+926,232NewHistory
ZYZymergen Inc.COM883,332$5.91M0.1%00.0%UnchangedHistory
ACCDAccolade, Inc.COM228,774$6.03M0.1%−51,000−18.2%ReducedHistory
AORTArtivion, Inc.COM326,318$6.64M0.1%+326,318NewHistory
PNTPOINT Biopharma Global Inc.COM1,193,995$6.69M0.1%−48,884−3.9%ReducedHistory
CNCEConcert Pharmaceuticals, Inc.COM2,150,641$6.77M0.1%00.0%UnchangedHistory
SGHTSight Sciences, Inc.COM390,000$6.85M0.1%00.0%UnchangedHistory
ATXSAstria Therapeutics, Inc.COM1,281,197$6.91M0.1%−678,455−34.6%ReducedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM86,400$7.32M0.1%+86,400NewHistory
EQRXEQRx, Inc.COM1,250,000$8.53M0.1%+1,250,000NewHistory
NBTXNanobiotix S.A.SPONSORED ADS1,059,800$8.58M0.1%00.0%UnchangedHistory
LEGNLegend Biotech CorpSPONSORED ADS189,100$8.81M0.1%+189,100NewHistory
CLDXCelldex Therapeutics, Inc.COM NEW229,807$8.88M0.1%−163,806−41.6%ReducedHistory
ONEM1Life Healthcare IncCOM532,350$9.35M0.1%00.0%UnchangedHistory
DAWNDay One Biopharmaceuticals, Inc.Stock556,047$9.37M0.1%00.0%UnchangedHistory
TYRATyra Biosciences, Inc.COM673,352$9.47M0.1%−314,148−31.8%ReducedHistory
RACBResearch Alliance Corp. IICOM CL A1,000,000$9.77M0.2%00.0%UnchangedHistory
BCLS Acquisition CorpG0904B105COM CL A1,000,000$9.80M0.2%00.0%Unchanged–
KYMRKymera Therapeutics, Inc.COM155,000$9.84M0.2%−25,000−13.9%ReducedHistory
ADPTAdaptive Biotechnologies CorpCOM352,804$9.90M0.2%00.0%UnchangedHistory
Summit Healthcre Acquistn CoG8566R128UNIT 06/03/20261,000,000$9.95M0.2%00.0%Unchanged–
HRMYHarmony Biosciences Holdings, Inc.COM239,258$10.2M0.2%−252,074−51.3%ReducedHistory
AGRXAgile Therapeutics IncCOM21,294,485$10.4M0.2%+5,374,560+33.8%AddedHistory
LENZLENZ Therapeutics, Inc.COM850,093$10.6M0.2%−25,000−2.9%ReducedHistory
HYPRHyperfine, Inc.COM CL A1,500,000$10.9M0.2%00.0%UnchangedHistory
IMRXImmuneering CorpCLASS A COM681,051$11.0M0.2%00.0%UnchangedHistory
MRUSMerus N.V.COM350,000$11.1M0.2%+350,000NewHistory
WGSGeneDx Holdings Corp.COMMON STOCK2,500,000$11.2M0.2%00.0%UnchangedHistory
ACRSAclaris Therapeutics, Inc.COM781,236$11.4M0.2%00.0%UnchangedHistory
ABSIAbsci CorpCOM1,411,776$11.6M0.2%−65,000−4.4%ReducedHistory
BIIBBiogen Inc.COM48,600$11.7M0.2%00.0%UnchangedHistory
Nanostring Technologies Inc63009RAD1NOTE 2.625% 5/0–$12.0M0.2%–––
IMCRImmunocore Holdings plcADS360,000$12.3M0.2%−40,000−10.0%ReducedHistory
BCABBioAtla, Inc.COM661,200$13.0M0.2%−188,826−22.2%ReducedHistory
VTRSViatris IncStock1,004,419$13.6M0.2%00.0%UnchangedHistory
LYRALyra Therapeutics, Inc.COM3,222,560$14.1M0.2%00.0%UnchangedHistory
NUVLNuvalent, Inc.COM750,000$14.3M0.2%00.0%UnchangedHistory
ADMAAdma Biologics, Inc.COM11,933,387$16.8M0.3%−1,328,988−10.0%ReducedHistory
SLGCSomaLogic, Inc.CLASS A COM1,500,000$17.5M0.3%−550,000−26.8%ReducedHistory
DICEDICE Therapeutics, Inc.COM704,885$17.8M0.3%+704,885NewHistory
HCATHealth Catalyst, Inc.COM454,004$18.0M0.3%−135,000−22.9%ReducedHistory
TMCITreace Medical Concepts, Inc.COM980,186$18.3M0.3%−255,700−20.7%ReducedHistory
ATNXAthenex, Inc.COM13,532,467$18.4M0.3%00.0%UnchangedHistory
SNCEScience 37 Holdings, Inc.COM1,500,000$18.7M0.3%+1,500,000NewHistory
VRNAVerona Pharma plcSPONSORED ADS2,867,510$19.3M0.3%−21,379−0.7%ReducedHistory
UTHRUnited Therapeutics CorpCOM94,064$20.3M0.3%−47,636−33.6%ReducedHistory
HLTHCue Health Inc.COM1,580,607$21.2M0.3%00.0%UnchangedHistory
PYXSPyxis Oncology, Inc.COMMON STOCK1,944,114$21.3M0.3%+1,944,114NewHistory
SLDBSolid Biosciences Inc.COM13,412,552$23.5M0.4%00.0%UnchangedHistory
NVTAInvitae CorpCOM1,584,585$24.2M0.4%−2,339,156−59.6%ReducedHistory
LUNGPulmonx CorpCOM762,304$24.4M0.4%+762,304NewHistory
NUVBNuvation Bio Inc.COM CL A2,920,823$24.8M0.4%−120,181−4.0%ReducedHistory
VERUVeru Inc.COM4,451,342$26.2M0.4%00.0%UnchangedHistory
MGNXMacrogenics IncCOM1,665,243$26.7M0.4%−482,817−22.5%ReducedHistory
CMAXCareMax, Inc.COM CL A3,549,525$27.3M0.4%+164,525+4.9%AddedHistory
COGTCogent Biosciences, Inc.COM3,188,750$27.4M0.4%00.0%UnchangedHistory
ESTAEstablishment Labs Holdings Inc.COM405,541$27.4M0.4%−100,000−19.8%ReducedHistory
CYPHCypherpunk Technologies Inc.COM8,476,496$27.5M0.4%00.0%UnchangedHistory
VRDNViridian Therapeutics, Inc.COM1,423,053$28.1M0.4%+530.0%AddedHistory
TARSTarsus Pharmaceuticals, Inc.COM1,296,416$29.2M0.5%00.0%UnchangedHistory
Rain Oncology Inc.75082Q105COM2,483,619$32.0M0.5%−53,400−2.1%Reduced–
KRONKronos Bio, Inc.COM2,421,142$32.9M0.5%00.0%UnchangedHistory
VRCAVerrica Pharmaceuticals Inc.COM3,610,412$33.1M0.5%00.0%UnchangedHistory
PRCTPROCEPT BioRobotics CorpCOM1,328,285$33.2M0.5%−328,705−19.8%ReducedHistory
IMTXImmatics N.V.SHS2,500,000$33.6M0.5%00.0%UnchangedHistory
ZNTLZentalis Pharmaceuticals, Inc.COM430,544$36.2M0.6%+430,544NewHistory
ACADAcadia Pharmaceuticals IncCOM1,584,052$37.0M0.6%+1,584,052NewHistory

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Perceptive Advisors LLC in Q4 2021
SecurityClassPutsCalls
FLNAFilana Therapeutics, Inc.COM$13.1M–
DCPHDeciphera Pharmaceuticals, Inc.COM–$1.95M

Sold out since Q3 2021 (15)

Positions held at the end of Q3 2021 that are gone from this filing.

Positions of Perceptive Advisors LLC sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
AVIRAtea Pharmaceuticals, Inc.COM2,259,224$79.2M1.2%History
BEAMBeam Therapeutics Inc.COM537,635$46.8M0.7%History
DBVTDBV Technologies S.A.SPONSORED ADR7,695,505$37.7M0.5%History
Avidity Biosciences, Inc.05370A108COM885,818$21.8M0.3%–
NTRANatera, Inc.COM160,000$17.8M0.3%History
CM Life Sciences III Inc125841205UNIT 04/30/20281,250,000$12.8M0.2%–
PODDInsulet CorpStock44,522$12.7M0.2%History
FDMT4D Molecular Therapeutics, Inc.COM375,256$10.1M0.1%History
TSHATaysha Gene Therapies, Inc.COM SHS320,440$5.97M0.1%History
PSTXPoseida Therapeutics, Inc.COM787,745$5.74M0.1%History
ATECAlphatec Holdings, Inc.COM NEW430,900$5.25M0.1%History
RGNXREGENXBIO Inc.COM89,283$3.74M0.1%History
SNCEScience 37 Holdings, Inc.COM300,000$2.94M<0.1%History
IMGOImago BioSciences, Inc.COM125,000$2.50M<0.1%History
KRROKorro Bio, Inc.COM222,222$1.57M<0.1%History