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Livermore
ZHEN

Perceptive Advisors LLC

SEC CIK
0001224962
Latest filing
Aug 14, 2026

Holdings in Q3 2021

Holdings as of Sep 30, 2021, filed Dec 3, 2021. Long positions only; changes compare share counts with Q2 2021.

Institution overview
Positions
138
−10 vs. Q2 2021
Portfolio value
$6.86B
−$827.2M (−10.8%) vs. Q2 2021
Filed
Dec 3, 2021
AmendedSEC
Holdings of Perceptive Advisors LLC in Q3 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
MRTXMirati Therapeutics, Inc.COM3,387,745$599.3M8.7%+201,847+6.3%AddedHistory
Retrophin Inc761299AB2NOTE 2.500% 9/1–$454.8M6.6%–––
BBIOBridgeBio Pharma, Inc.COM7,756,928$363.6M5.3%00.0%UnchangedHistory
SWTXSpringWorks Therapeutics, Inc.COM4,849,912$307.7M4.5%00.0%UnchangedHistory
IOVAIovance Biotherapeutics, Inc.COM11,489,772$283.3M4.1%+530,000+4.8%AddedHistory
FOLDAmicus Therapeutics, Inc.COM26,559,443$253.6M3.7%+3,438,114+14.9%AddedHistory
LABPLandos Biopharma, Inc.COM14,869,915$217.1M3.2%00.0%UnchangedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS1,956,940$214.4M3.1%−28,062−1.4%ReducedHistory
Collegium Pharmaceutical, Inc19459JAA2NOTE 2.625% 2/1–$180.3M2.6%–––
VBIVVBI Vaccines Inc/BCCOM NEW55,042,465$171.2M2.5%00.0%UnchangedHistory
CERECerevel Therapeutics Holdings, Inc.COM5,086,727$150.1M2.2%+443,632+9.6%AddedHistory
Nevro Corp64157FAC7NOTE 2.750% 4/0–$126.2M1.8%–––
ISEEIVERIC bio, Inc.COM7,471,798$121.3M1.8%+2,886,286+62.9%AddedHistory
GBTGlobal Blood Therapeutics, Inc.COM4,407,399$112.3M1.6%+254,710+6.1%AddedHistory
NVTAInvitae CorpCOM3,923,741$111.6M1.6%−895,060−18.6%ReducedHistory
ZYMEZymeworks Inc.COM3,679,845$106.9M1.6%−625,755−14.5%ReducedHistory
CCCCC4 Therapeutics, Inc.COM STK2,258,566$100.9M1.5%00.0%UnchangedHistory
OMOutset Medical, Inc.COM1,990,633$98.4M1.4%−396,902−16.6%ReducedHistory
MGTXMeiraGTx Holdings plcCOM6,948,277$91.6M1.3%00.0%UnchangedHistory
RAPTRAPT Therapeutics, Inc.COM2,907,565$90.3M1.3%+431,905+17.4%AddedHistory
ALDXAldeyra Therapeutics, Inc.COM9,903,879$87.0M1.3%00.0%UnchangedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM3,963,517$83.4M1.2%00.0%UnchangedHistory
AVIRAtea Pharmaceuticals, Inc.COM2,259,224$79.2M1.2%00.0%UnchangedHistory
RXDXPrometheus Biosciences, Inc.COM3,314,032$78.6M1.1%00.0%UnchangedHistory
CHRSCoherus Oncology, Inc.COM4,779,387$76.8M1.1%+81,775+1.7%AddedHistory
ALBOAlbireo Pharma, Inc.COM2,360,139$73.6M1.1%00.0%UnchangedHistory
RCKTRocket Pharmaceuticals, Inc.COM2,310,261$69.1M1.0%−441,342−16.0%ReducedHistory
PRCTPROCEPT BioRobotics CorpCOM1,656,990$63.2M0.9%+1,656,990NewHistory
RLAYRelay Therapeutics, Inc.COM1,943,097$61.3M0.9%−75,000−3.7%ReducedHistory
ICVXIcosavax, Inc.COM1,922,549$56.9M0.8%+1,922,549NewHistory
NAUTNautilus Biotechnology, Inc.COM8,911,151$54.7M0.8%00.0%UnchangedHistory
KRONKronos Bio, Inc.COM2,421,142$50.7M0.7%−106,910−4.2%ReducedHistory
MORFMorphic Holding, Inc.COM887,340$50.3M0.7%−50,800−5.4%ReducedHistory
Coherus Biosciences Inc19249HAB9NOTE 1.500% 4/1–$49.4M0.7%–––
TVTXTravere Therapeutics, Inc.COM1,965,555$47.7M0.7%+120,000+6.5%AddedHistory
BEAMBeam Therapeutics Inc.COM537,635$46.8M0.7%00.0%UnchangedHistory
NBIXNeurocrine Biosciences IncStock483,007$46.3M0.7%−328,825−40.5%ReducedHistory
VRCAVerrica Pharmaceuticals Inc.COM3,610,412$45.1M0.7%00.0%UnchangedHistory
MGNXMacrogenics IncCOM2,148,060$45.0M0.7%00.0%UnchangedHistory
KODKodiak Sciences Inc.COM461,248$44.3M0.6%+175,207+61.3%AddedHistory
ATNXAthenex, Inc.COM13,532,467$40.7M0.6%00.0%UnchangedHistory
VERUVeru Inc.COM4,451,342$38.0M0.6%00.0%UnchangedHistory
Rain Oncology Inc.75082Q105COM2,537,019$38.0M0.6%00.0%Unchanged–
QTNTQuotient LtdSHS16,200,818$37.9M0.6%00.0%UnchangedHistory
DBVTDBV Technologies S.A.SPONSORED ADR7,695,505$37.7M0.5%00.0%UnchangedHistory
INBXInhibrx Biosciences, Inc.COM1,121,490$37.4M0.5%+214,400+23.6%AddedHistory
ESTAEstablishment Labs Holdings Inc.COM505,541$36.2M0.5%−194,867−27.8%ReducedHistory
OMICSingular Genomics Systems, Inc.COM3,073,824$34.4M0.5%−9,046−0.3%ReducedHistory
CYPHCypherpunk Technologies Inc.COM8,476,496$34.0M0.5%00.0%UnchangedHistory
TMCITreace Medical Concepts, Inc.COM1,235,886$33.2M0.5%00.0%UnchangedHistory
CMAXCareMax, Inc.COM CL A3,385,000$32.7M0.5%+65,000+2.0%AddedHistory
IMTXImmatics N.V.SHS2,500,000$32.5M0.5%00.0%UnchangedHistory
LONALeonaBio, Inc.COM3,425,916$32.1M0.5%00.0%UnchangedHistory
SLDBSolid Biosciences Inc.COM13,412,552$32.1M0.5%00.0%UnchangedHistory
XENEXenon Pharmaceuticals Inc.COM2,022,051$30.9M0.5%+343,078+20.4%AddedHistory
NVRONevro CorpCOM259,972$30.3M0.4%−558,788−68.2%ReducedHistory
NUVBNuvation Bio Inc.COM CL A3,041,004$30.2M0.4%00.0%UnchangedHistory
HCATHealth Catalyst, Inc.COM589,004$29.5M0.4%+22,920+4.0%AddedHistory
LYRALyra Therapeutics, Inc.COM3,222,560$29.4M0.4%00.0%UnchangedHistory
TARSTarsus Pharmaceuticals, Inc.COM1,296,416$27.9M0.4%00.0%UnchangedHistory
COGTCogent Biosciences, Inc.COM3,188,750$26.8M0.4%00.0%UnchangedHistory
UTHRUnited Therapeutics CorpCOM141,700$26.2M0.4%−475,102−77.0%ReducedHistory
SLGCSomaLogic, Inc.CLASS A COM2,050,000$25.4M0.4%+2,050,000NewHistory
BCABBioAtla, Inc.COM850,026$25.0M0.4%+164,507+24.0%AddedHistory
VRDNViridian Therapeutics, Inc.COM1,423,000$23.4M0.3%+628,494+79.1%AddedHistory
Avidity Biosciences, Inc.05370A108COM885,818$21.8M0.3%−193,210−17.9%Reduced–
CLDXCelldex Therapeutics, Inc.COM NEW393,613$21.3M0.3%−349,086−47.0%ReducedHistory
APLSApellis Pharmaceuticals, Inc.COM615,000$20.3M0.3%−46,162−7.0%ReducedHistory
WGSGeneDx Holdings Corp.COMMON STOCK2,500,000$19.0M0.3%+2,500,000NewHistory
HRMYHarmony Biosciences Holdings, Inc.COM491,332$18.8M0.3%00.0%UnchangedHistory
HLTHCue Health Inc.COM1,580,607$18.7M0.3%+1,580,607NewHistory
IMRXImmuneering CorpCLASS A COM681,051$18.1M0.3%+681,051NewHistory
NTRANatera, Inc.COM160,000$17.8M0.3%+160,000NewHistory
TYRATyra Biosciences, Inc.COM987,500$17.4M0.3%+987,500NewHistory
ATXSAstria Therapeutics, Inc.COM1,959,652$17.3M0.3%+1,959,652NewHistory
ABSIAbsci CorpCOM1,476,776$17.2M0.3%+1,476,776NewHistory
NUVLNuvalent, Inc.COM750,000$16.9M0.2%+750,000NewHistory
VRNAVerona Pharma plcSPONSORED ADS2,888,889$15.8M0.2%00.0%UnchangedHistory
AGRXAgile Therapeutics IncCOM15,919,925$15.3M0.2%00.0%UnchangedHistory
ADMAAdma Biologics, Inc.COM13,262,375$15.0M0.2%−3,322,427−20.0%ReducedHistory
HYPRHyperfine, Inc.CL A SHS1,500,000$14.8M0.2%00.0%UnchangedHistory
IMCRImmunocore Holdings plcADS400,000$14.8M0.2%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM875,093$14.3M0.2%00.0%UnchangedHistory
ACRSAclaris Therapeutics, Inc.COM781,236$14.1M0.2%−68,764−8.1%ReducedHistory
BIIBBiogen Inc.COM48,600$13.8M0.2%+48,600NewHistory
VTRSViatris IncStock1,004,419$13.6M0.2%00.0%UnchangedHistory
DAWNDay One Biopharmaceuticals, Inc.Stock556,047$13.2M0.2%−200,000−26.5%ReducedHistory
CM Life Sciences III Inc125841205UNIT 04/30/20281,250,000$12.8M0.2%00.0%Unchanged–
Nanostring Technologies Inc63009RAD1NOTE 2.625% 5/0–$12.8M0.2%–––
PODDInsulet CorpStock44,522$12.7M0.2%+44,522NewHistory
NBTXNanobiotix S.A.SPONSORED ADS1,059,800$12.0M0.2%00.0%UnchangedHistory
ADPTAdaptive Biotechnologies CorpCOM352,804$12.0M0.2%00.0%UnchangedHistory
ACCDAccolade, Inc.COM279,774$11.8M0.2%+34,033+13.8%AddedHistory
ZYZymergen Inc.COM883,332$11.6M0.2%−750,000−45.9%ReducedHistory
CLOVClover Health Investments, Corp.COM CL A1,500,000$11.1M0.2%00.0%UnchangedHistory
ONEM1Life Healthcare IncCOM532,350$10.8M0.2%+16,306+3.2%AddedHistory
KYMRKymera Therapeutics, Inc.COM180,000$10.6M0.2%+180,000NewHistory
ONCROncorus, Inc.COM1,099,810$10.3M0.1%−363,789−24.9%ReducedHistory
FDMT4D Molecular Therapeutics, Inc.COM375,256$10.1M0.1%00.0%UnchangedHistory
Summit Healthcre Acquistn CoG8566R128UNIT 06/03/20261,000,000$10.1M0.1%00.0%Unchanged–

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Perceptive Advisors LLC in Q3 2021
SecurityClassPutsCalls
ChemoCentryx, Inc.16383L106COM–$15.8M
FLNAFilana Therapeutics, Inc.COM$6.21M–

Sold out since Q2 2021 (34)

Positions held at the end of Q2 2021 that are gone from this filing.

Positions of Perceptive Advisors LLC sold out since Q2 2021
SecurityClassShares in Q2 2021Value in Q2 2021% of portfolio in Q2 2021History
KDMNKadmon Holdings, Inc.COM15,711,334$60.8M0.8%History
MDTMedtronic plcStock450,000$55.9M0.7%History
DRNADicerna Pharmaceuticals IncCOM800,000$29.9M0.4%History
EXASExact Sciences CorpCOM233,523$29.0M0.4%History
NARIInari Medical, Inc.Stock310,437$29.0M0.4%History
XLRNAcceleron Pharma IncCOM226,760$28.5M0.4%History
RGENRepligen CorpCOM132,500$26.4M0.3%History
ARWRArrowhead Pharmaceuticals, Inc.COM315,141$26.1M0.3%History
COLLCollegium Pharmaceutical, IncCOM978,277$23.1M0.3%History
FBRXForte Biosciences, Inc.COM685,000$23.0M0.3%History
STOKStoke Therapeutics, Inc.COM671,978$22.6M0.3%History
CM Life Sciences II Inc125842203UNIT 02/25/20281,250,000$16.8M0.2%–
Catabasis Pharmaceuticals IN14875P206COM NEW7,687,185$16.2M0.2%–
Therapeutics Acquisition Cor88339T103COM CL A1,500,000$15.4M0.2%–
CVRXCVRx, Inc.COM440,000$12.3M0.2%History
CTMXCytomX Therapeutics, Inc.COM1,640,957$10.4M0.1%History
SILKSilk Road Medical IncCOM147,133$7.04M0.1%History
PRVAPrivia Health Group, Inc.COM135,000$5.99M0.1%History
AKYAAkoya Biosciences, Inc.COM300,000$5.80M0.1%History
BCTG Acquisition Corp05492W103COM500,000$5.69M0.1%–
MREOMereo BioPharma Group plcSPON ADS1,696,068$5.38M0.1%History
Consonance HFW Acquisition CG2445M129UNIT 99/99/9999500,000$5.20M0.1%–
Longview Acquisition Corp. II54319Q204UNIT 99/99/9999500,000$5.04M0.1%–
MRUSMerus N.V.COM175,000$3.69M<0.1%History
AMWLAmerican Well CorpCL A290,000$3.65M<0.1%History
CM Life Sciences Inc18978W109COM CL A227,000$3.18M<0.1%–
GRTXGalera Therapeutics, Inc.COM254,664$2.50M<0.1%History
Cerevel Therapeutics HLDNG I15678U102*W EXP 06/09/202133,066$1.91M<0.1%–
SGTXSigilon Therapeutics, Inc.COM125,000$1.34M<0.1%History
SRRASierra Oncology, Inc.COM NEW66,655$1.30M<0.1%History
SC Health CorpG78516401*W EXP 99/99/999500,000$1.05M<0.1%–
PLXPPLx Pharma Winddown Corp.COM57,459$793.0K<0.1%History
TKNOAlpha Teknova, Inc.COM30,000$712.0K<0.1%History
TCRRTCR2 Therapeutics Inc.COM30,753$505.0K<0.1%History