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Livermore
Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q1 2026

Holdings as of Mar 31, 2026, filed May 15, 2026. Long positions only; changes compare share counts with Q4 2025.

Institution overview
Positions
107
+2 vs. Q4 2025
Portfolio value
$4.40B
−$485.6M (−9.9%) vs. Q4 2025
Filed
May 15, 2026
SEC
Holdings of OrbiMed Advisors LLC in Q1 2026
SecurityClassSharesValue% of portfolioShare changeActionHistory
TRAWTraws Pharma, Inc.COM NEW605,531$1.11M<0.1%00.0%UnchangedHistory
Cogent Biosciences, Inc.19240QAA0NOTE 1.625%11/1–$1.22M<0.1%–––
ATAIAtaiBeckley Inc.COM SHS347,000$1.23M<0.1%+347,000NewHistory
VTGNVistagen Therapeutics, Inc.COM3,060,000$1.75M<0.1%00.0%UnchangedHistory
IMAImageneBio, Inc.COM378,556$1.89M<0.1%00.0%UnchangedHistory
KALVKalVista Pharmaceuticals, Inc.COM94,400$1.90M<0.1%−288,000−75.3%ReducedHistory
CCCCC4 Therapeutics, Inc.COM STK856,353$2.25M0.1%−548,549−39.0%ReducedHistory
JBIOJade Biosciences, Inc.COM NEW185,011$2.60M0.1%−346,152−65.2%ReducedHistory
DRUGBright Minds Biosciences Inc.COM NEW40,000$2.92M0.1%+40,000NewHistory
LFSTLifeStance Health Group, Inc.COM500,000$3.19M0.1%+500,000NewHistory
PTCTPTC Therapeutics, Inc.COM49,100$3.35M0.1%+25,900+111.6%AddedHistory
CGEMCullinan Therapeutics, Inc.COM243,006$3.45M0.1%−27,000−10.0%ReducedHistory
SVRASavara IncCOM635,000$3.47M0.1%+635,000NewHistory
ANROAlto Neuroscience, Inc.COM SHS167,500$3.77M0.1%+42,500+34.0%AddedHistory
PALIPalisade Bio, Inc.COM2,333,000$4.08M0.1%+461,580+24.7%AddedHistory
PTGXProtagonist Therapeutics, IncCOM42,100$4.44M0.1%+20,400+94.0%AddedHistory
ADCTADC Therapeutics SASHS1,318,026$4.94M0.1%−4,504,828−77.4%ReducedHistory
RVMDRevolution Medicines, Inc.COM52,000$5.06M0.1%+26,100+100.8%AddedHistory
NSPRInspireMD, Inc.COM3,133,405$5.11M0.1%00.0%UnchangedHistory
AORTArtivion, Inc.COM151,000$5.53M0.1%+151,000NewHistory
ALXOAlx Oncology Holdings IncCOM2,866,256$5.75M0.1%+2,866,256NewHistory
PHVSPharvaris N.V.COM205,400$5.80M0.1%00.0%UnchangedHistory
CMPSCOMPASS Pathways plcSPONSORED ADS1,150,646$6.36M0.1%+1,150,646NewHistory
ACETAdicet Bio, Inc.COM NEW1,027,944$7.00M0.2%00.0%UnchangedHistory
TECXTectonic Therapeutic, Inc.COM226,600$7.00M0.2%−348,000−60.6%ReducedHistory
AVTXAvalo Therapeutics, Inc.COM NEW475,165$7.09M0.2%−712,135−60.0%ReducedHistory
HRTXHeron Therapeutics, Inc.COM9,816,940$7.85M0.2%+9,816,940NewHistory
GILDGilead Sciences, Inc.Stock59,600$8.31M0.2%+59,600NewHistory
KROSKeros Therapeutics, Inc.COM759,155$8.38M0.2%−45,057−5.6%ReducedHistory
KNSAKiniksa Pharmaceuticals International, plcORD SHS CL A180,599$8.70M0.2%−6,600−3.5%ReducedHistory
BIIBBiogen Inc.COM61,600$11.3M0.3%+61,600NewHistory
CARLCarlsmed, Inc.COM1,252,600$11.3M0.3%00.0%UnchangedHistory
REGNRegeneron Pharmaceuticals, Inc.COM14,700$11.4M0.3%+14,700NewHistory
ALMSAlumis Inc.COM548,163$12.1M0.3%−554,567−50.3%ReducedHistory
COGTCogent Biosciences, Inc.COM322,100$12.4M0.3%−48,900−13.2%ReducedHistory
BIOABioAge Labs, Inc.COM711,811$12.4M0.3%−79,090−10.0%ReducedHistory
BCAXBicara Therapeutics Inc.COM667,300$13.3M0.3%+458,200+219.1%AddedHistory
BCRXBiocryst Pharmaceuticals IncCOM1,425,200$13.6M0.3%−316,600−18.2%ReducedHistory
JANXJanux Therapeutics, Inc.COM983,600$13.7M0.3%−970,826−49.7%ReducedHistory
EYPTEyePoint, Inc.COM NEW1,069,147$13.8M0.3%−1,399,167−56.7%ReducedHistory
ALHCAlignment Healthcare, Inc.COM791,000$13.9M0.3%+791,000NewHistory
AMGNAmgen IncStock39,900$14.0M0.3%+39,900NewHistory
WHWKWhitehawk Therapeutics, Inc.COM4,166,000$14.4M0.3%00.0%UnchangedHistory
QTTBQ32 Bio Inc.COM2,252,987$14.5M0.3%00.0%UnchangedHistory
VERAVera Therapeutics, Inc.CL A369,596$14.9M0.3%+16,096+4.6%AddedHistory
DFTXDefinium Therapeutics, Inc.COM SHS804,000$15.2M0.3%−422,700−34.5%ReducedHistory
URGNUroGen Pharma Ltd.COM875,487$15.7M0.4%00.0%UnchangedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW1,737,287$16.3M0.4%+140,000+8.8%AddedHistory
PVLAPalvella Therapeutics, Inc.COM134,600$16.8M0.4%+134,600NewHistory
KRYSKrystal Biotech, Inc.COM69,100$17.8M0.4%−50,700−42.3%ReducedHistory
HELPHelus Pharma Inc.COM NEW3,832,843$18.4M0.4%−7,657−0.2%ReducedHistory
NKTRNektar TherapeuticsCOM NEW275,000$19.8M0.4%+275,000NewHistory
STROSutro Biopharma, Inc.COM SHS801,144$20.0M0.5%+801,144NewHistory
LXEOLexeo Therapeutics, Inc.COM3,602,450$20.7M0.5%+1,477,450+69.5%AddedHistory
BTSGBrightSpring Health Services, Inc.COM497,800$21.2M0.5%+9,300+1.9%AddedHistory
0000000000Stock6,210,899$22.1M0.5%00.0%Unchanged–
SNDXSyndax Pharmaceuticals IncCOM962,300$22.5M0.5%+962,300NewHistory
TMOThermo Fisher Scientific Inc.Stock46,500$22.9M0.5%00.0%UnchangedHistory
RYTMRhythm Pharmaceuticals, Inc.COM314,100$27.3M0.6%+74,300+31.0%AddedHistory
NPCENeuroPace IncCOM2,096,527$27.6M0.6%−309,808−12.9%ReducedHistory
ESPREsperion Therapeutics, Inc.COM10,570,300$29.0M0.7%+4,604,802+77.2%AddedHistory
TRVITrevi Therapeutics, Inc.COM2,454,400$29.3M0.7%−736,300−23.1%ReducedHistory
FBRXForte Biosciences, Inc.COM NEW1,196,955$31.0M0.7%00.0%UnchangedHistory
RLMDRelmada Therapeutics, Inc.COM4,715,864$32.8M0.7%+2,105,264+80.6%AddedHistory
ELVElevance Health, Inc.Stock114,700$33.6M0.8%+15,600+15.7%AddedHistory
ORICOric Pharmaceuticals, Inc.COM2,693,929$34.1M0.8%−947,827−26.0%ReducedHistory
QUREuniQure N.V.SHS2,136,149$34.9M0.8%+1,398,749+189.7%AddedHistory
AXSMAxsome Therapeutics, Inc.COM213,921$36.2M0.8%−39,200−15.5%ReducedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM999,000$36.3M0.8%00.0%UnchangedHistory
PRLDPrelude Therapeutics IncCOM10,909,256$37.3M0.8%00.0%UnchangedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM119,000$39.4M0.9%−169,800−58.8%ReducedHistory
GHGuardant Health, Inc.COM435,200$40.2M0.9%+435,200NewHistory
STTKShattuck Labs, Inc.COM6,306,127$40.5M0.9%00.0%UnchangedHistory
ASNDAscendis Pharma A/SSPONSORED ADR181,977$41.6M0.9%+10,000+5.8%AddedHistory
RCELAVITA Medical, Inc.COM544,895$42.5M1.0%+544,895NewHistory
CAICaris Life Sciences, Inc.COM2,806,811$50.2M1.1%−309,200−9.9%ReducedHistory
DHRDanaher CorpStock265,800$50.4M1.1%−34,000−11.3%ReducedHistory
UPBUpstream Bio, Inc.COM5,693,589$51.2M1.2%00.0%UnchangedHistory
ABVXAbivax S.A.SPONSORED ADS465,700$51.9M1.2%+97,800+26.6%AddedHistory
NTRANatera, Inc.COM262,000$52.4M1.2%−103,800−28.4%ReducedHistory
DYNDyne Therapeutics, Inc.COM2,917,884$52.9M1.2%+715,700+32.5%AddedHistory
PFEPfizer IncStock1,946,500$54.7M1.2%+293,600+17.8%AddedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW172,500$55.6M1.3%+78,000+82.5%AddedHistory
MLYSMineralys Therapeutics, Inc.COM2,052,900$55.6M1.3%+1,072,500+109.4%AddedHistory
BMYBristol Myers Squibb CoStock925,000$56.1M1.3%+150,000+19.4%AddedHistory
SYKStryker CorpStock182,500$60.0M1.4%−142,500−43.8%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM1,059,971$61.6M1.4%+612,771+137.0%AddedHistory
CGONCG Oncology, Inc.COM948,267$64.2M1.5%−568,283−37.5%ReducedHistory
SPRYARS Pharmaceuticals, Inc.COM8,288,510$66.6M1.5%00.0%UnchangedHistory
IRONDisc Medicine, Inc.COM1,067,550$68.3M1.6%00.0%UnchangedHistory
AVBPArriVent BioPharma, Inc.COM3,027,328$69.8M1.6%00.0%UnchangedHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS1,475,403$71.1M1.6%+313,600+27.0%AddedHistory
MRKMerck & Co., Inc.Stock663,400$79.8M1.8%+663,400NewHistory
CMPXCompass Therapeutics, Inc.COM15,219,994$80.5M1.8%00.0%UnchangedHistory
ISRGIntuitive Surgical IncCOM NEW208,700$96.2M2.2%−54,700−20.8%ReducedHistory
EWEdwards Lifesciences CorpStock1,230,600$98.5M2.2%−612,300−33.2%ReducedHistory
ARGXArgenx SESPONSORED ADR136,900$100.0M2.3%−9,100−6.2%ReducedHistory
CRVSCorvus Pharmaceuticals, Inc.COM7,165,006$104.8M2.4%00.0%UnchangedHistory
MBXMBX Biosciences, Inc.COM3,637,887$108.6M2.5%−297,316−7.6%ReducedHistory
MYGNMyriad Genetics IncCOM–$122.9M2.8%–NewHistory

Options (5)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q1 2026
SecurityClassPutsCalls
MDXHMDxHealth SASHS NEW–$285.9M
RCELAVITA Medical, Inc.COM–$154.4M
QGENQiagen N.V.ORD SHARES–$10.0M
PVLAPalvella Therapeutics, Inc.COM–$6.23M
SLNOSoleno Therapeutics IncCOM–$3.35M

Sold out since Q4 2025 (20)

Positions held at the end of Q4 2025 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q4 2025
SecurityClassShares in Q4 2025Value in Q4 2025% of portfolio in Q4 2025History
TERNTerns Pharmaceuticals, Inc.COM2,153,300$87.0M1.8%History
APLSApellis Pharmaceuticals, Inc.COM2,429,868$61.0M1.2%History
CICigna GroupStock205,000$56.4M1.2%History
RAPTRAPT Therapeutics, Inc.COM NEW1,642,891$55.6M1.1%History
UTHRUnited Therapeutics CorpCOM105,200$51.3M1.0%History
ROIVRoivant Sciences Ltd.SHS2,190,907$47.5M1.0%History
Avidity Biosciences, Inc.05370A108COM619,530$44.7M0.9%–
NBIXNeurocrine Biosciences IncStock314,240$44.6M0.9%History
EXASExact Sciences CorpCOM351,716$35.7M0.7%History
BRKRBruker CorpCOM555,789$26.2M0.5%History
CTMXCytomX Therapeutics, Inc.COM3,525,650$15.0M0.3%History
VIRVir Biotechnology, Inc.COM2,380,715$14.4M0.3%History
TARSTarsus Pharmaceuticals, Inc.COM154,400$12.6M0.3%History
FOLDAmicus Therapeutics, Inc.COM729,900$10.4M0.2%History
RPTXRepare Therapeutics Inc.COM3,322,488$8.64M0.2%History
CELCCelcuity Inc.COM85,664$8.54M0.2%History
PMVPPMV Pharmaceuticals, Inc.COM4,975,291$6.22M0.1%History
INSMINSMED IncCOM PAR $.0125,400$4.42M0.1%History
OCULOcular Therapeutix, IncCOM157,300$1.91M<0.1%History
MPLTMapLight Therapeutics, Inc.COM56,000$952.0K<0.1%History