Skip to main content

Artal Group S.A.

SEC CIK
0001053906
Latest filing
Aug 13, 2026

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed Feb 11, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
144
+4 vs. Q3 2021
Portfolio value
$3.40B
−$663.6M (−16.3%) vs. Q3 2021
Filed
Feb 11, 2022
SEC
Holdings of Artal Group S.A. in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
LXRXLexicon Pharmaceuticals, Inc.COM NEW71,178,364$280.4M8.2%00.0%UnchangedHistory
WWWW International, Inc.COM14,818,300$239.0M7.0%00.0%UnchangedHistory
MRTXMirati Therapeutics, Inc.COM1,400,000$205.4M6.0%+200,000+16.7%AddedHistory
ONCBeOne Medicines Ltd.ADR675,000$182.9M5.4%+25,000+3.8%AddedHistory
ARGXArgenx SESPONSORED ADR500,000$175.1M5.1%−77,308−13.4%ReducedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM650,000$110.2M3.2%−50,000−7.1%ReducedHistory
SEERSeer, Inc.COM CL A4,750,000$108.3M3.2%00.0%UnchangedHistory
FATEFate Therapeutics IncCOM1,800,000$105.3M3.1%+350,000+24.1%AddedHistory
SGENSeagen Inc.COM500,000$77.3M2.3%+125,000+33.3%AddedHistory
MORFMorphic Holding, Inc.COM1,585,049$75.1M2.2%00.0%UnchangedHistory
FOLDAmicus Therapeutics, Inc.COM6,000,000$69.3M2.0%−696,955−10.4%ReducedHistory
Bellus Health Inc New07987C204COM NEW8,500,000$68.4M2.0%+3,250,000+61.9%Added–
KYMRKymera Therapeutics, Inc.COM1,000,000$63.5M1.9%+600,000+150.0%AddedHistory
SRRKScholar Rock Holding CorpCOM2,450,000$60.9M1.8%+500,000+25.6%AddedHistory
SWTXSpringWorks Therapeutics, Inc.COM850,000$52.7M1.5%+250,000+41.7%AddedHistory
ERASErasca, Inc.COM3,172,221$49.4M1.5%00.0%UnchangedHistory
KRYSKrystal Biotech, Inc.COM700,000$49.0M1.4%+200,000+40.0%AddedHistory
CERECerevel Therapeutics Holdings, Inc.COM1,500,000$48.6M1.4%−300,000−16.7%ReducedHistory
CYTKCytokinetics IncCOM NEW1,000,000$45.6M1.3%−300,000−23.1%ReducedHistory
IGMSIGM Biosciences, Inc.COM1,500,000$44.0M1.3%+150,000+11.1%AddedHistory
PTGXProtagonist Therapeutics, IncCOM1,250,000$42.8M1.3%−250,000−16.7%ReducedHistory
SAGESage Therapeutics, Inc.COM1,000,000$42.5M1.3%00.0%UnchangedHistory
NBPNovaBridge BiosciencesSPONSORED ADS850,000$40.3M1.2%+25,000+3.0%AddedHistory
FHTXFoghorn Therapeutics Inc.COM1,720,720$39.4M1.2%00.0%UnchangedHistory
RUBYRubius Therapeutics, Inc.COM3,701,580$35.8M1.1%−454,045−10.9%ReducedHistory
NTLAIntellia Therapeutics, Inc.COM275,000$32.5M1.0%00.0%UnchangedHistory
TRMLTourmaline Bio, Inc.COM2,064,262$31.6M0.9%00.0%UnchangedHistory
KLRSKalaris Therapeutics, Inc.COM2,323,371$30.1M0.9%00.0%UnchangedHistory
EVOEvotec SESPONSORED ADS1,149,425$27.3M0.8%+1,149,425NewHistory
EQRXEQRx, Inc.COM4,000,000$27.3M0.8%+4,000,000NewHistory
DNLIDenali Therapeutics Inc.COM600,000$26.8M0.8%+100,000+20.0%AddedHistory
GOSSGossamer Bio, Inc.COM2,358,968$26.7M0.8%00.0%UnchangedHistory
OMGAOmega Therapeutics, Inc.COMMON STOCK2,273,530$25.8M0.8%00.0%UnchangedHistory
ITOSiTeos Therapeutics, Inc.COM544,047$25.3M0.7%−450,000−45.3%ReducedHistory
REPLReplimune Group, Inc.COM900,000$24.4M0.7%00.0%UnchangedHistory
SDGRSchrodinger, Inc.COM700,000$24.4M0.7%00.0%UnchangedHistory
ATRAAtara Biotherapeutics, Inc.COM1,500,000$23.6M0.7%00.0%UnchangedHistory
PRAXPraxis Precision Medicines, Inc.COM1,200,000$23.6M0.7%00.0%UnchangedHistory
RLAYRelay Therapeutics, Inc.COM750,000$23.0M0.7%+350,000+87.5%AddedHistory
AUPHAurinia Pharmaceuticals Inc.COM1,000,000$22.9M0.7%00.0%UnchangedHistory
KRONKronos Bio, Inc.COM1,542,954$21.0M0.6%+225,000+17.1%AddedHistory
AGENAgenus IncCOM NEW6,500,000$20.9M0.6%+1,000,000+18.2%AddedHistory
GBIOGeneration Bio Co.COM2,814,191$19.9M0.6%00.0%UnchangedHistory
AMAMAmbrx Biopharma Cayman, Inc.SPONSORED ADS2,152,291$19.4M0.6%+1,302,291+153.2%AddedHistory
IMAImageneBio, Inc.COM1,549,513$19.4M0.6%00.0%UnchangedHistory
NGNovagold Resources IncCOM NEW2,600,000$17.8M0.5%00.0%UnchangedHistory
APTXAptinyx Inc.COM6,116,493$16.3M0.5%00.0%UnchangedHistory
TGTXTG Therapeutics, Inc.COM800,000$15.2M0.4%00.0%UnchangedHistory
RPTXRepare Therapeutics Inc.COM700,000$14.8M0.4%+150,000+27.3%AddedHistory
VERVVerve Therapeutics, Inc.COM400,000$14.7M0.4%00.0%UnchangedHistory
KURAKura Oncology, Inc.COM1,050,000$14.7M0.4%00.0%UnchangedHistory
SQZSQZ Biotechnologies CoCOM1,606,309$14.3M0.4%00.0%UnchangedHistory
FMTXForma Therapeutics Holdings, Inc.SHS1,000,000$14.2M0.4%00.0%UnchangedHistory
ALBOAlbireo Pharma, Inc.COM600,000$14.0M0.4%00.0%UnchangedHistory
RNACCartesian Therapeutics, Inc.COM4,000,000$13.0M0.4%00.0%UnchangedHistory
CYPHCypherpunk Technologies Inc.COM4,000,000$13.0M0.4%00.0%UnchangedHistory
TSHATaysha Gene Therapies, Inc.COM SHS1,040,882$12.1M0.4%00.0%UnchangedHistory
OTLYOatly Group ABSPONSORED ADS1,500,000$11.9M0.4%00.0%UnchangedHistory
TPTXTurning Point Therapeutics, Inc.COM250,000$11.9M0.4%−100,000−28.6%ReducedHistory
MRNSMarinus Pharmaceuticals, Inc.COM NEW1,000,000$11.9M0.3%00.0%UnchangedHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS2,255,375$11.3M0.3%00.0%Unchanged–
Exscientia PLC30223G102ADS550,000$10.9M0.3%+550,000New–
ALXOAlx Oncology Holdings IncCOM500,000$10.7M0.3%00.0%UnchangedHistory
SYRSSyros Pharmaceuticals, Inc.COM3,000,000$9.78M0.3%+1,000,000+50.0%AddedHistory
GRTSGritstone bio, Inc.COM750,000$9.64M0.3%+750,000NewHistory
BDTXBlack Diamond Therapeutics, Inc.COM1,646,517$8.78M0.3%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM700,000$8.70M0.3%00.0%UnchangedHistory
DSGNDesign Therapeutics, Inc.COM400,000$8.56M0.3%00.0%UnchangedHistory
ALPNAlpine Immune Sciences, Inc.COM593,030$8.21M0.2%00.0%UnchangedHistory
NBTXNanobiotix S.A.SPONSORED ADS1,000,000$8.10M0.2%00.0%UnchangedHistory
ADAGAdagene Inc.ADS1,000,000$8.07M0.2%00.0%UnchangedHistory
OVIDOvid Therapeutics Inc.COM2,500,000$8.03M0.2%00.0%UnchangedHistory
SPROSpero Therapeutics, Inc.COM500,000$8.01M0.2%00.0%UnchangedHistory
TILInstil Bio, Inc.COM450,000$7.70M0.2%00.0%UnchangedHistory
HARPHarpoon Therapeutics, Inc.COM1,000,000$7.55M0.2%00.0%UnchangedHistory
MRSNMersana Therapeutics, Inc.COM1,200,000$7.46M0.2%00.0%UnchangedHistory
ZYMEZymeworks Inc.COM450,000$7.38M0.2%00.0%UnchangedHistory
Omega Alpha SpacG6749V107CL A750,000$7.33M0.2%00.0%Unchanged–
XLOXilio Therapeutics, Inc.COM450,000$7.20M0.2%+450,000NewHistory
IMCRImmunocore Holdings plcADS200,000$6.85M0.2%00.0%UnchangedHistory
IMUXImmunic, Inc.COM700,000$6.70M0.2%00.0%UnchangedHistory
YMABY-mAbs Therapeutics, Inc.COM400,000$6.48M0.2%00.0%UnchangedHistory
VORVor Biopharma Inc.COM550,000$6.39M0.2%00.0%UnchangedHistory
DYNDyne Therapeutics, Inc.COM525,000$6.24M0.2%00.0%UnchangedHistory
SANASana Biotechnology, Inc.COM400,000$6.19M0.2%00.0%UnchangedHistory
CRISCuris IncCOM NEW1,300,000$6.19M0.2%00.0%UnchangedHistory
CRBUCaribou Biosciences, Inc.COM405,347$6.12M0.2%00.0%UnchangedHistory
EVLOEvelo Biosciences, Inc.COM1,000,000$6.07M0.2%00.0%UnchangedHistory
STOKStoke Therapeutics, Inc.COM250,000$6.00M0.2%00.0%UnchangedHistory
Avidity Biosciences, Inc.05370A108COM250,000$5.94M0.2%+107,500+75.4%Added–
ORICOric Pharmaceuticals, Inc.COM400,000$5.88M0.2%00.0%UnchangedHistory
NEXINexImmune, Inc.COM1,200,000$5.53M0.2%00.0%UnchangedHistory
LYELLyell Immunopharma, Inc.COM700,000$5.42M0.2%00.0%UnchangedHistory
ADVMAdverum Biotechnologies, Inc.COM3,000,000$5.28M0.2%00.0%UnchangedHistory
SLDBSolid Biosciences Inc.COM3,000,000$5.25M0.2%00.0%UnchangedHistory
MIRMirion Technologies, Inc.COM CL A500,000$5.24M0.2%+500,000NewHistory
SYRESpyre Therapeutics, Inc.COM1,045,000$4.96M0.1%00.0%UnchangedHistory
ACIUAC Immune SASHS1,000,000$4.95M0.1%00.0%UnchangedHistory
Dynamics Special Purpose Cor268010105CLASS A COM500,000$4.93M0.1%00.0%Unchanged–
KRSAKorsana Biosciences, Inc.COM2,779,122$4.78M0.1%00.0%UnchangedHistory

Options (6)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Artal Group S.A. in Q4 2021
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF–$112.0M
BMYBristol Myers Squibb CoStock–$62.4M
CCitigroup IncStock–$60.4M
VRTXVertex Pharmaceuticals IncStock–$22.0M
INTCIntel CorpStock–$15.4M
SAGESage Therapeutics, Inc.COM–$10.6M

Sold out since Q3 2021 (8)

Positions held at the end of Q3 2021 that are gone from this filing.

Positions of Artal Group S.A. sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
XLRNAcceleron Pharma IncCOM1,000,000$172.1M4.2%History
BABAAlibaba Group Holding LtdADR100,000$14.8M0.4%History
DRNADicerna Pharmaceuticals IncCOM700,000$14.1M0.3%History
BPMCBlueprint Medicines CorpCOM100,000$10.3M0.3%History
OLPXOlaplex Holdings, Inc.COM225,000$5.51M0.1%History
AVTRAvantor, Inc.COM50,000$2.04M0.1%History
OPTUOptimum Communications, Inc.CL A27,000$559.0K<0.1%History
EQTEQT CorpStock9,678$198.0K<0.1%History