| Ra Capital Management, L.P. | 7,140,091 | $8,083 萬 | 1.22% | – | – |
| Adage Capital Partners GP, L.L.C. | 6,500,000 | $7,358 萬 | 0.15% | – | – |
| Point72 Asset Management, L.P. | 5,620,291 | $6,362 萬 | 0.32% | – | – |
| State Street Corp | 4,546,824 | $5,147 萬 | 0.00% | – | – |
| Sio Capital Management, LLC | 4,381,668 | $4,960 萬 | 10.37% | – | – |
| OrbiMed Advisors LLC | 4,366,494 | $4,943 萬 | 0.47% | – | – |
| Vanguard Group Inc | 3,702,502 | $4,191 萬 | 0.00% | – | – |
| RTW Investments, LP | 3,619,544 | $4,097 萬 | 0.64% | – | – |
| Octagon Capital Advisors LP | 2,128,400 | $2,409 萬 | 9.08% | – | – |
| Avidity Partners Management LP | 2,053,789 | $2,325 萬 | 0.65% | – | – |
| Emerald Mutual Fund Advisers Trust | 1,895,729 | $2,146 萬 | 0.71% | – | – |
| Invesco Ltd. | 1,813,329 | $2,053 萬 | 0.01% | – | – |
| Artal Group S.A. | 1,804,729 | $2,043 萬 | 0.43% | – | – |
| Emerald Advisers, LLC | 1,795,911 | $2,033 萬 | 0.73% | – | – |
| Nantahala Capital Management, LLC | 1,662,711 | $1,882 萬 | 1.07% | – | – |
| Vivo Capital, LLC | 1,553,500 | $1,759 萬 | 0.62% | – | – |
| BlackRock Inc. | 1,507,381 | $1,706 萬 | 0.00% | – | – |
| Polar Capital Holdings Plc | 1,500,000 | $1,698 萬 | 0.11% | – | – |
| Ikarian Capital, LLC | 1,220,356 | $1,382 萬 | 2.06% | – | – |
| Goldman Sachs Group Inc | 1,099,895 | $1,245 萬 | 0.00% | – | – |
| Farallon Capital Management, L.L.C. | 1,000,000 | $1,132 萬 | 0.06% | – | – |
| Affinity Asset Advisors, LLC | 1,000,000 | $1,132 萬 | 5.55% | – | – |
| HealthCor Management, L.P. | 977,950 | $1,107 萬 | 0.41% | – | – |
| Lord, Abbett & Co. LLC | 952,064 | $1,078 萬 | 0.03% | – | – |
| Sphera Funds Management Ltd. | 885,838 | $1,003 萬 | 0.92% | – | – |
| Susquehanna International Group, LLP | 799,545 | $905.1 萬 | 0.01% | – | – |
| Millennium Management LLC | 791,320 | $895.8 萬 | 0.01% | – | – |
| Altium Capital Management LP | 772,009 | $873.9 萬 | 2.43% | – | – |
| Acuta Capital Partners, LLC | 767,500 | $868.8 萬 | 3.13% | – | – |
| Bain Capital Public Equity Management II, LLC | 687,877 | $778.7 萬 | 0.32% | – | – |
| Geode Capital Management, LLC | 666,356 | $754.3 萬 | 0.00% | – | – |
| Silverarc Capital Management, LLC | 628,793 | $711.8 萬 | 3.99% | – | – |
| Renaissance Technologies LLC | 611,004 | $691.7 萬 | 0.01% | – | – |
| Nicholas Investment Partners, LP | 580,000 | $656.6 萬 | 0.46% | – | – |
| Ghost Tree Capital, LLC | 425,000 | $481.1 萬 | 1.35% | – | – |
| Arnhold LLC | 403,003 | $456.2 萬 | 0.55% | – | – |
| Citigroup Inc | 400,523 | $453.4 萬 | 0.00% | – | – |
| Bleichroeder LP | 311,978 | $353.2 萬 | 0.60% | – | – |
| Citadel Advisors LLC | 307,449 | $348.1 萬 | 0.00% | – | – |
| Rafferty Asset Management, LLC | 305,119 | $345.4 萬 | 0.02% | – | – |
| Marshall Wace North America L.P. | 285,030 | $322.8 萬 | 0.01% | – | – |
| Schonfeld Strategic Advisors LLC | 263,452 | $298.2 萬 | 0.04% | – | – |
| Group One Trading, L.P. | 226,661 | $256.6 萬 | 0.06% | – | – |
| Parkman Healthcare Partners LLC | 195,991 | $221.9 萬 | 0.53% | – | – |
| Truist Financial Corp | 192,075 | $217.4 萬 | 0.00% | – | – |
| ExodusPoint Capital Management, LP | 177,095 | $200.5 萬 | 0.04% | – | – |
| J. Goldman & Co LP | 175,506 | $198.7 萬 | 0.12% | – | – |
| Northern Trust Corp | 150,047 | $169.9 萬 | 0.00% | – | – |
| Jane Street Group, LLC | 130,619 | $147.8 萬 | 0.00% | – | – |
| UBS Group AG | 130,240 | $147.5 萬 | 0.00% | – | – |
| Boothbay Fund Management, LLC | 127,588 | $144.4 萬 | 0.08% | – | – |
| Simplex Trading, LLC | 119,354 | $135.1 萬 | 0.08% | – | – |
| Caption Management, LLC | 111,152 | $125.8 萬 | 0.16% | – | – |
| Deutsche Bank AG | 100,325 | $113.5 萬 | 0.00% | – | – |
| Cubist Systematic Strategies, LLC | 96,795 | $109.6 萬 | 0.01% | – | – |
| California Public Employees Retirement System | 95,818 | $108.5 萬 | 0.00% | – | – |
| EAM Investors, LLC | 93,930 | $106.3 萬 | 0.16% | – | – |
| Ensign Peak Advisors, Inc | 80,833 | $91.5 萬 | 0.00% | – | – |
| Apis Capital Advisors, LLC | 80,000 | $90.6 萬 | 0.82% | – | – |
| Jefferies Group LLC | 79,938 | $90.5 萬 | 0.02% | – | – |
| Bank of New York Mellon Corp | 74,722 | $84.6 萬 | 0.00% | – | – |
| HighVista Strategies LLC | 73,743 | $83.5 萬 | 0.62% | – | – |
| Barclays PLC | 73,308 | $83.0 萬 | 0.00% | – | – |
| Focused Wealth Management, Inc | 70,807 | $80.2 萬 | 0.14% | – | – |
| Jump Financial, LLC | 68,800 | $77.9 萬 | 0.07% | – | – |
| Marshall Wace, LLP | 62,766 | $71.1 萬 | 0.00% | – | – |
| Bridgeway Capital Management, LLC | 60,000 | $67.9 萬 | 0.01% | – | – |
| BNP Paribas Arbitrage, SA | 59,800 | $67.7 萬 | 0.00% | – | – |
| LMR Partners LLP | 55,121 | $62.4 萬 | 0.02% | – | – |
| Silvercrest Asset Management Group LLC | 55,000 | $62.3 萬 | 0.00% | – | – |
| Bank of America Corp | 52,128 | $58.9 萬 | 0.00% | – | – |
| Squarepoint Ops LLC | 43,710 | $49.5 萬 | 0.00% | – | – |
| Kestra Private Wealth Services, LLC | 42,540 | $48.2 萬 | 0.03% | – | – |
| LPL Financial LLC | 39,030 | $44.2 萬 | 0.00% | – | – |
| SG3 Management, LLC | 30,000 | $34.0 萬 | 0.11% | – | – |
| Wolverine Trading, LLC | 29,469 | $33.6 萬 | 0.01% | – | – |
| Raymond James Financial Services Advisors, Inc. | 28,483 | $32.2 萬 | 0.00% | – | – |
| Parametric Portfolio Associates LLC | 27,991 | $31.7 萬 | 0.00% | – | – |
| Charles Schwab Investment Management Inc | 27,613 | $31.3 萬 | 0.00% | – | – |
| Capital Fund Management S.A. | 22,761 | $25.8 萬 | 0.01% | – | – |
| Janney Montgomery Scott LLC | 21,950 | $24.8 萬 | 0.00% | – | – |
| Nomura Holdings Inc | 21,000 | $23.8 萬 | 0.00% | – | – |
| Bank of Montreal | 20,000 | $23.7 萬 | 0.00% | – | – |
| CSS LLC | 20,798 | $23.5 萬 | 0.01% | – | – |
| Franklin Street Advisors Inc | 20,000 | $22.6 萬 | 0.02% | – | – |
| Neuberger Berman Group LLC | 20,000 | $22.6 萬 | 0.00% | – | – |
| Alliance Wealth Management Group | 20,000 | $22.6 萬 | 0.09% | – | – |
| Towercrest Capital Management | 20,000 | $22.6 萬 | 0.05% | – | – |
| Summit Global Investments | 19,100 | $21.6 萬 | 0.01% | – | – |
| Credit Suisse AG | 18,782 | $21.3 萬 | 0.00% | – | – |
| Diametric Capital, LP | 17,812 | $20.2 萬 | 0.15% | – | – |
| Blueshift Asset Management, LLC | 14,580 | $16.5 萬 | 0.02% | – | – |
| Victory Capital Management Inc | 13,975 | $15.8 萬 | 0.00% | – | – |
| Price T Rowe Associates Inc | 13,400 | $15.2 萬 | 0.00% | – | – |
| Quantitative Systematic Strategies LLC | 13,251 | $15.0 萬 | 0.02% | – | – |
| Walleye Trading LLC | 13,185 | $14.9 萬 | 0.01% | – | – |
| Pinz Capital Management, LP | 12,700 | $14.4 萬 | 0.04% | – | – |
| E Fund Management Co., Ltd. | 12,698 | $14.4 萬 | 0.01% | – | – |
| Ergoteles LLC | 11,550 | $13.1 萬 | 0.00% | – | – |
| Morgan Stanley | 11,125 | $12.6 萬 | 0.00% | – | – |
