| Wellington Management Group LLP | 10,488,104 | $4.50 億 | 0.08% | – | – |
| Vanguard Group Inc | 6,104,517 | $2.62 億 | 0.01% | – | – |
| BlackRock Inc. | 5,886,948 | $2.53 億 | 0.01% | – | – |
| HHLR Advisors, Ltd.大師高瓴 HHLR | 4,558,029 | $1.96 億 | 1.93% | – | – |
| Price T Rowe Associates Inc | 3,642,149 | $1.56 億 | 0.02% | – | – |
| Jennison Associates LLC | 2,710,877 | $1.16 億 | 0.09% | – | – |
| State Street Corp | 2,198,573 | $9,434 萬 | 0.01% | – | – |
| Farallon Capital Management, L.L.C. | 2,175,000 | $9,333 萬 | 0.49% | – | – |
| Victory Capital Management Inc | 1,933,780 | $8,298 萬 | 0.09% | – | – |
| Cormorant Asset Management, LP | 1,866,108 | $8,008 萬 | 2.31% | – | – |
| Baker Bros. Advisors LP | 1,674,004 | $7,183 萬 | 0.31% | – | – |
| FMR LLC | 1,621,252 | $6,957 萬 | 0.01% | – | – |
| Goldman Sachs Group Inc | 1,123,741 | $4,822 萬 | 0.01% | – | – |
| AJU IB Investment Co., Ltd. | 1,114,962 | $4,784 萬 | 18.05% | – | – |
| Geode Capital Management, LLC | 1,046,913 | $4,492 萬 | 0.01% | – | – |
| Avoro Capital Advisors LLC | 1,000,000 | $4,291 萬 | 0.74% | – | – |
| Candriam Luxembourg S.C.A. | 555,374 | $3,052 萬 | 0.25% | – | – |
| Two Sigma Advisers, LP | 687,400 | $2,950 萬 | 0.08% | – | – |
| Northern Trust Corp | 664,324 | $2,851 萬 | 0.01% | – | – |
| Fiduciary Trust Co | 565,450 | $2,426 萬 | 0.49% | – | – |
| Octagon Capital Advisors LP | 548,374 | $2,353 萬 | 8.86% | – | – |
| Invesco Ltd. | 540,107 | $2,318 萬 | 0.01% | – | – |
| Norges Bank | 513,050 | $2,202 萬 | 0.01% | – | – |
| venBio Partners LLC | 490,471 | $2,105 萬 | 2.00% | – | – |
| Clough Capital Partners L P | 489,149 | $2,099 萬 | 1.36% | – | – |
| JPMorgan Chase & Co | 436,280 | $1,872 萬 | 0.00% | – | – |
| Deutsche Bank AG | 419,660 | $1,801 萬 | 0.01% | – | – |
| Charles Schwab Investment Management Inc | 404,127 | $1,734 萬 | 0.01% | – | – |
| Compagnie Lombard Odier SCmA | 385,795 | $1,655 萬 | 0.37% | – | – |
| Two Sigma Investments, LP | 384,731 | $1,651 萬 | 0.05% | – | – |
| Lombard Odier Asset Management (Switzerland) SA | 379,395 | $1,628 萬 | 1.09% | – | – |
| Renaissance Technologies LLC | 373,513 | $1,603 萬 | 0.02% | – | – |
| Bank of America Corp | 357,979 | $1,536 萬 | 0.00% | – | – |
| D. E. Shaw & Co., Inc. | 336,643 | $1,445 萬 | 0.02% | – | – |
| Bridger Management, LLC | 324,000 | $1,390 萬 | 1.30% | – | – |
| FIL Ltd | 307,575 | $1,320 萬 | 0.02% | – | – |
| Rhenman & Partners Asset Management AB | 270,000 | $1,159 萬 | 0.81% | – | – |
| Nuveen Asset Management, LLC | 263,961 | $1,133 萬 | 0.00% | – | – |
| Driehaus Capital Management LLC | 263,641 | $1,131 萬 | 0.17% | – | – |
| Jacobs Levy Equity Management, Inc | 261,268 | $1,121 萬 | 0.09% | – | – |
| Point72 Asset Management, L.P. | 250,000 | $1,073 萬 | 0.05% | – | – |
| Ally Bridge Group (NY) LLC | 230,000 | $986.9 萬 | 2.39% | – | – |
| Bank of New York Mellon Corp | 227,134 | $974.6 萬 | 0.00% | – | – |
| Ghost Tree Capital, LLC | 225,000 | $965.5 萬 | 2.71% | – | – |
| Man Group plc | 185,074 | $794.2 萬 | 0.03% | – | – |
| Bank of Montreal | 190,145 | $790.1 萬 | 0.01% | – | – |
| Hennion & Walsh Asset Management, Inc. | 174,056 | $746.9 萬 | 0.45% | – | – |
| Woodline Partners LP | 171,419 | $735.6 萬 | 0.16% | – | – |
| Prudential Financial Inc | 164,960 | $707.8 萬 | 0.01% | – | – |
| Millennium Management LLC | 158,571 | $680.4 萬 | 0.01% | – | – |
| Tekla Capital Management LLC | 152,538 | $654.5 萬 | 0.23% | – | – |
| Morgan Stanley | 152,024 | $652.3 萬 | 0.00% | – | – |
| Alps Advisors Inc | 137,019 | $587.9 萬 | 0.06% | – | – |
| Swiss National Bank | 129,800 | $557.0 萬 | 0.00% | – | – |
| California Public Employees Retirement System | 122,358 | $525.0 萬 | 0.00% | – | – |
| Acuta Capital Partners, LLC | 113,161 | $485.6 萬 | 1.75% | – | – |
| Teachers Retirement System of the State of Kentucky | 113,036 | $485.1 萬 | 0.05% | – | – |
| TD Asset Management Inc | 102,623 | $440.4 萬 | 0.00% | – | – |
| Citigroup Inc | 98,074 | $420.8 萬 | 0.00% | – | – |
| Russell Investments Group, Ltd. | 94,971 | $407.3 萬 | 0.01% | – | – |
| Barclays PLC | 92,034 | $395.0 萬 | 0.00% | – | – |
| California State Teachers Retirement System | 90,557 | $388.6 萬 | 0.01% | – | – |
| Royal Bank of Canada | 87,773 | $376.6 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 80,900 | $347.1 萬 | 0.01% | – | – |
| Burrage Capital Management LLC | 80,727 | $346.4 萬 | 2.81% | – | – |
| Alliancebernstein L.P. | 80,100 | $343.7 萬 | 0.00% | – | – |
| Arrowstreet Capital, Limited Partnership | 73,400 | $315.0 萬 | 0.00% | – | – |
| Rafferty Asset Management, LLC | 71,412 | $306.4 萬 | 0.02% | – | – |
| Private Advisor Group, LLC | 71,127 | $305.2 萬 | 0.03% | – | – |
| Rhumbline Advisers | 64,832 | $278.2 萬 | 0.00% | – | – |
| UBS Asset Management Americas Inc | 56,259 | $241.4 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 55,000 | $236.0 萬 | 0.00% | – | – |
| Aufman Associates Inc | 53,642 | $230.2 萬 | 1.92% | – | – |
| Federated Hermes, Inc. | 52,666 | $226.0 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 52,552 | $225.5 萬 | 0.00% | – | – |
| State of New Jersey Common Pension Fund D | 50,359 | $216.1 萬 | 0.01% | – | – |
| DekaBank Deutsche Girozentrale | 50,700 | $212.1 萬 | 0.01% | – | – |
| Credit Suisse AG | 48,208 | $206.9 萬 | 0.00% | – | – |
| Bellevue Group AG | 48,000 | $206.0 萬 | 0.02% | – | – |
| Legal & General Group Plc | 45,097 | $193.5 萬 | 0.00% | – | – |
| DAFNA Capital Management LLC | 44,926 | $192.8 萬 | 0.46% | – | – |
| AXA S.A. | 44,461 | $190.8 萬 | 0.01% | – | – |
| Ensign Peak Advisors, Inc | 42,701 | $183.2 萬 | 0.00% | – | – |
| Susquehanna Fundamental Investments, LLC | 39,261 | $168.5 萬 | 0.03% | – | – |
| Baird Financial Group, Inc. | 38,277 | $164.2 萬 | 0.00% | – | – |
| American International Group, Inc. | 35,001 | $150.2 萬 | 0.01% | – | – |
| Manufacturers Life Insurance Company, The | 34,216 | $146.8 萬 | 0.00% | – | – |
| Erste Asset Management GmbH | 33,900 | $142.5 萬 | 0.03% | – | – |
| Mackay Shields LLC | 32,400 | $139.1 萬 | 0.01% | – | – |
| Parametric Portfolio Associates LLC | 30,890 | $132.5 萬 | 0.00% | – | – |
| Principal Financial Group Inc | 29,609 | $127.1 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 27,179 | $116.6 萬 | 0.00% | – | – |
| Voya Investment Management LLC | 26,559 | $114.0 萬 | 0.00% | – | – |
| Susquehanna International Group, LLP | 25,923 | $111.2 萬 | 0.00% | – | – |
| Raymond James Financial Services Advisors, Inc. | 25,588 | $109.8 萬 | 0.00% | – | – |
| MetLife Investment Management | 24,199 | $103.8 萬 | 0.01% | – | – |
| State Board of Administration of Florida Retirement System | 23,895 | $102.5 萬 | 0.00% | – | – |
| International Biotechnology Trust PLC | 23,400 | $100.1 萬 | 0.26% | – | – |
| Jane Street Group, LLC | 23,098 | $99.1 萬 | 0.00% | – | – |
| Marshall Wace North America L.P. | 22,762 | $97.7 萬 | 0.00% | – | – |
