Upstream Bio, Inc.
UPB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Upstream Bio, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 140
- +10 vs. Q4 2025
- Shares held
- 44.9M
- −1.02M (−2.2%) vs. Q4 2025
- Total value
- $404.5M
- −$841.8M (−67.5%) vs. Q4 2025
- New holders
- 47
- 47 more added
- Sold out
- 37
- 35 more reduced
3 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting UPB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 148 | $350.1M |
| Q1 2026 | 140 | $404.5M |
| Q4 2025 | 133 | $1.39B |
| Q3 2025 | 95 | $836.3M |
| Q2 2025 | 83 | $530.9M |
| Q1 2025 | 79 | $266.9M |
| Q4 2024 | 70 | $690.1M |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Upstream Bio, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 4 | $0 | 0.00% | +4 | New |
| IFP Advisors, Inc | 1 | $9 | 0.00% | 00.0% | Unchanged |
| Freestone Grove Partners LP | 1 | $9 | 0.00% | +1 | New |
| Parallel Advisors, LLC | 2 | $18 | 0.00% | 00.0% | Unchanged |
| SJS Investment Consulting Inc. | 2 | $18 | 0.00% | +2 | New |
| Root Financial Partners, LLC | 20 | $180 | 0.00% | +20 | New |
| Caitong International Asset Management Co., Ltd | 23 | $207 | 0.00% | +23 | New |
| Ameritas Advisory Services, LLC | 31 | $279 | 0.00% | +31 | New |
| Rothschild Investment LLC | 61 | $549 | 0.00% | +60+6,000.0% | Added |
| Signaturefd, LLC | 66 | $594 | 0.00% | −51−43.6% | Reduced |
| SRS Capital Advisors, Inc. | 77 | $693 | 0.00% | +75+3,750.0% | Added |
| Farther Finance Advisors, LLC | 81 | $754 | 0.00% | +81 | New |
| Wealth Preservation Advisors, LLC | 86 | $774 | 0.00% | +86 | New |
| New York State Common Retirement Fund | 100 | $900 | 0.00% | −11,600−99.1% | Reduced |
| N.E.W. Advisory Services LLC | 120 | $1.08K | 0.00% | +60+100.0% | Added |
| Natixis | 120 | $1.08K | 0.00% | +120 | New |
| Torren Management, LLC | 162 | $1.46K | 0.00% | −937−85.3% | Reduced |
| MAI Capital Management | 171 | $1.54K | 0.00% | +171 | New |
| EverSource Wealth Advisors, LLC | 222 | $2.00K | 0.00% | −60−21.3% | Reduced |
| Allworth Financial LP | 263 | $2.37K | 0.00% | +195+286.8% | Added |
| Advisor Group Holdings, Inc. | 389 | $3.50K | 0.00% | +384+7,680.0% | Added |
| Essential Partners LLC | 402 | $3.62K | 0.00% | +305+314.4% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 477 | $4.29K | 0.00% | +477 | New |
| UBS Asset Management Americas Inc | 588 | $5.29K | 0.00% | +346+143.0% | Added |
| US Bancorp | 590 | $5.31K | 0.00% | +44+8.1% | Added |
| Quantbot Technologies LP | 663 | $5.97K | 0.00% | +663 | New |
| GAMMA Investing LLC | 715 | $6.43K | 0.00% | −185−20.6% | Reduced |
| Rockefeller Capital Management L.P. | 738 | $6.64K | 0.00% | +738 | New |
| Versant Capital Management, Inc | 762 | $6.86K | 0.00% | +204+36.6% | Added |
| Sterling Capital Management LLC | 1,094 | $9.85K | 0.00% | −825−43.0% | Reduced |
| Larson Financial Group LLC | 1,107 | $9.96K | 0.00% | +1,093+7,807.1% | Added |
| GF Fund Management Co. Ltd. | 1,203 | $10.8K | 0.00% | +142+13.4% | Added |
| Tower Research Capital LLC (TRC) | 1,425 | $12.8K | 0.00% | +756+113.0% | Added |
| Ameritas Investment Partners, Inc. | 2,741 | $24.7K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 2,819 | $25.4K | 0.00% | +193+7.3% | Added |
| Wellington Grp LLC | 3,000 | $27.0K | 0.01% | +1,000+50.0% | Added |
| Russell Investments Group, Ltd. | 3,647 | $32.8K | 0.00% | +824+29.2% | Added |
| CWM, LLC | 3,883 | $34.9K | 0.00% | +523+15.6% | Added |
| Vanguard Investments Australia, Ltd. | 4,096 | $36.9K | 0.00% | +4,096 | New |
| Citigroup Inc | 5,055 | $45.5K | 0.00% | −1,894−27.3% | Reduced |
| Persistent Asset Partners Ltd | 5,495 | $49.5K | 0.02% | −3,412−38.3% | Reduced |
| KLP Kapitalforvaltning AS | 5,900 | $53.1K | 0.00% | +3,000+103.4% | Added |
| Vanguard Asset Management, Ltd | 9,250 | $83.3K | 0.00% | +9,250 | New |
| Police & Firemen's Retirement System of New Jersey | 9,456 | $85.1K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 9,590 | $86.3K | 0.01% | +784+8.9% | Added |
| Legal & General Group Plc | 9,609 | $86.5K | 0.00% | −4,100−29.9% | Reduced |
| STRS Ohio | 9,800 | $88.2K | 0.00% | 00.0% | Unchanged |
| Shay Capital LLC | 10,000 | $90.0K | 0.01% | +10,000 | New |
| Virtus Investment Advisers, Inc. | 10,046 | $90.4K | 0.02% | +245+2.5% | Added |
| Creative Planning | 10,850 | $97.7K | 0.00% | −899−7.7% | Reduced |
| CI Private Wealth, LLC | 12,157 | $109.4K | 0.00% | +12,157 | New |
| Vanguard Global Advisers, LLC | 13,059 | $117.5K | 0.00% | +13,059 | New |
| Franklin Resources Inc | 14,589 | $131.3K | 0.00% | +14,589 | New |
| Manufacturers Life Insurance Company, The | 15,338 | $138.0K | 0.00% | +5,191+51.2% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 15,608 | $140.5K | 0.00% | −1,883−10.8% | Reduced |
| Susquehanna International Group, LLP | 15,961 | $143.6K | 0.00% | −39,880−71.4% | Reduced |
| Wells Fargo & Company | 18,402 | $165.6K | 0.00% | −18,392−50.0% | Reduced |
| MetLife Investment Management | 19,380 | $174.4K | 0.00% | −298−1.5% | Reduced |
| Nisa Investment Advisors, LLC | 19,558 | $176.0K | 0.00% | +19,158+4,789.5% | Added |
| Man Group plc | 21,154 | $190.4K | 0.00% | +21,154 | New |
| Diadema Partners LP | 21,609 | $194.5K | 0.08% | +1,109+5.4% | Added |
| Entropy Technologies, LP | 23,336 | $210.0K | 0.01% | +23,336 | New |
| DnB Asset Management AS | 23,515 | $211.6K | 0.00% | +10,722+83.8% | Added |
| Barclays PLC | 24,720 | $222.5K | 0.00% | −499,779−95.3% | Reduced |
| Victory Capital Management Inc | 25,866 | $232.8K | 0.00% | +25,866 | New |
| Martingale Asset Management L P | 26,223 | $236.0K | 0.01% | +26,223 | New |
| Tudor Investment Corp Et Al | 26,412 | $237.7K | 0.00% | +26,412 | New |
| Price T Rowe Associates Inc | 26,434 | $238.0K | 0.00% | +6,798+34.6% | Added |
| Mariner, LLC | 27,314 | $245.8K | 0.00% | +15,484+130.9% | Added |
| Axq Capital, LP | 27,503 | $247.5K | 0.03% | +27,503 | New |
| Bleakley Financial Group, LLC | 28,864 | $259.8K | 0.00% | +28,864 | New |
| Aquatic Capital Management LLC | 31,484 | $283.4K | 0.01% | +31,484 | New |
| Stonepine Capital Management, LLC | 35,000 | $315.0K | 0.28% | +35,000 | New |
| ADAR1 Capital Management, LLC | 35,000 | $315.0K | 0.02% | +35,000 | New |
| Gsa Capital Partners LLP | 39,232 | $353.0K | 0.02% | +39,232 | New |
| California State Teachers Retirement System | 39,661 | $356.9K | 0.00% | +25,009+170.7% | Added |
| Invesco Ltd. | 40,510 | $364.6K | 0.00% | −122,676−75.2% | Reduced |
| Rhumbline Advisers | 41,203 | $370.8K | 0.00% | −320−0.8% | Reduced |
| State of Wisconsin Investment Board | 41,671 | $375.0K | 0.00% | +41,671 | New |
| Alps Advisors Inc | 43,992 | $395.9K | 0.00% | −384−0.9% | Reduced |
| Squarepoint Ops LLC | 44,626 | $401.6K | 0.00% | +44,626 | New |
| Swiss National Bank | 48,100 | $432.9K | 0.00% | +21,500+80.8% | Added |
| Bank of America Corp | 48,460 | $436.1K | 0.00% | −37,924−43.9% | Reduced |
| Quantinno Capital Management LP | 49,389 | $444.5K | 0.00% | +33,974+220.4% | Added |
| Renaissance Technologies LLC | 62,100 | $558.9K | 0.00% | +45,700+278.7% | Added |
| Marshall Wace, LLP | 66,770 | $600.9K | 0.00% | −277,021−80.6% | Reduced |
| AQR Capital Management LLC | 72,171 | $649.5K | 0.00% | +41,668+136.6% | Added |
| EntryPoint Capital, LLC | 73,568 | $662.1K | 0.19% | +73,568 | New |
| Nuveen, LLC | 75,536 | $679.8K | 0.00% | −3,032−3.9% | Reduced |
| Simplify Asset Management Inc. | 77,793 | $700.1K | 0.01% | +77,793 | New |
| Dimensional Fund Advisors LP | 80,002 | $719.5K | 0.00% | +80,002 | New |
| Bank of New York Mellon Corp | 81,383 | $732.4K | 0.00% | −3,470−4.1% | Reduced |
| American Century Companies Inc | 87,624 | $788.6K | 0.00% | −132−0.2% | Reduced |
| ExodusPoint Capital Management, LP | 91,431 | $822.9K | 0.01% | +16,029+21.3% | Added |
| Alliancebernstein L.P. | 31,010 | $841.9K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 126,000 | $1.13M | 0.00% | +121,024+2,432.2% | Added |
| Boxer Capital Management, LLC | 150,000 | $1.35M | 0.18% | 00.0% | Unchanged |
| Schonfeld Strategic Advisors LLC | 161,349 | $1.45M | 0.01% | +45,542+39.3% | Added |
| Trexquant Investment LP | 176,657 | $1.59M | 0.01% | +145,608+469.0% | Added |
| Point72 Asset Management, L.P. | 178,168 | $1.60M | 0.00% | +178,168 | New |