Upstream Bio, Inc.
UPB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.
Q1 2026 vs. Q4 2025
How the institutions holding Upstream Bio, Inc. changed between Q4 2025 and Q1 2026.
All holders in Q1 2026All holders in Q4 2025
| Measure | Q4 2025 | Of which not filed for Q1 2026 | Q1 2026 | Change |
|---|---|---|---|---|
| Holders | 133 | 3 | 140 | +10 |
| Shares | 51.2M | 5.27M | 44.9M | −1.02M (−2.2%) |
| Value | $1.39B | $143.1M | $404.5M | −$841.8M (−67.5%) |
3 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so the changes leave them out.
New holders (47)
Institutions that held Upstream Bio, Inc. at the end of Q1 2026 but not at the end of Q4 2025.
Sold out (37)
Institutions that held Upstream Bio, Inc. at the end of Q4 2025 and filed for Q1 2026 without it.
Not filed for Q1 2026 yet (3)
Institutions that held Upstream Bio, Inc. at the end of Q4 2025 and haven't filed a 13F for Q1 2026. Not filing isn't selling, so they aren't counted as sold out.
| Institution | Shares, Q4 2025 | Value, Q4 2025 |
|---|---|---|
| Norges Bank | 2,882,647 | $78.3M |
| Vanguard Group Inc | 2,388,439 | $64.8M |
| Global Retirement Partners, LLC | 273 | $7.41K |