Upstream Bio, Inc.
UPB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Upstream Bio, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 133
- +38 vs. Q3 2025
- Shares held
- 51.2M
- +6.71M (+15.1%) vs. Q3 2025
- Total value
- $1.39B
- +$553.1M (+66.1%) vs. Q3 2025
- New holders
- 46
- 42 more added
- Sold out
- 8
- 33 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting UPB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 148 | $350.1M |
| Q1 2026 | 140 | $404.5M |
| Q4 2025 | 133 | $1.39B |
| Q3 2025 | 95 | $836.3M |
| Q2 2025 | 83 | $530.9M |
| Q1 2025 | 79 | $266.9M |
| Q4 2024 | 70 | $690.1M |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Upstream Bio, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Mirae Asset Global Investments Co., Ltd. | 2,626 | $71.3K | 0.00% | +2,626 | New |
| Wellington Grp LLC | 2,000 | $54.3K | 0.02% | +2,000 | New |
| Sterling Capital Management LLC | 1,919 | $52.1K | 0.00% | −345−15.2% | Reduced |
| Torren Management, LLC | 1,099 | $29.8K | 0.02% | +1,099 | New |
| GF Fund Management Co. Ltd. | 1,061 | $28.8K | 0.00% | +1,061 | New |
| Amalgamated Bank | 1,031 | $28.0K | 0.00% | +437+73.6% | Added |
| Royal Bank of Canada | 969 | $26.0K | 0.00% | +137+16.5% | Added |
| GAMMA Investing LLC | 900 | $24.4K | 0.00% | +10+1.1% | Added |
| Tower Research Capital LLC (TRC) | 669 | $18.2K | 0.00% | −1,199−64.2% | Reduced |
| Versant Capital Management, Inc | 558 | $15.2K | 0.00% | +10+1.8% | Added |
| US Bancorp | 546 | $14.8K | 0.00% | +15+2.8% | Added |
| Federated Hermes, Inc. | 482 | $13.1K | 0.00% | +482 | New |
| Simplex Trading, LLC | 466 | $12.7K | 0.00% | +466 | New |
| Nisa Investment Advisors, LLC | 400 | $10.9K | 0.00% | +304+316.7% | Added |
| EverSource Wealth Advisors, LLC | 282 | $7.66K | 0.00% | −28−9.0% | Reduced |
| Global Retirement Partners, LLC | 273 | $7.41K | 0.00% | −59−17.8% | Reduced |
| Aster Capital Management (DIFC) Ltd | 271 | $7.36K | 0.00% | −870−76.2% | Reduced |
| UBS Asset Management Americas Inc | 242 | $6.57K | 0.00% | +242 | New |
| Daiwa Securities Group Inc. | 180 | $5.00K | 0.00% | +180 | New |
| J.Safra Asset Management Corp | 128 | $3.48K | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 117 | $3.18K | 0.00% | +66+129.4% | Added |
| The PNC Financial Services Group, Inc. | 106 | $2.88K | 0.00% | −24−18.5% | Reduced |
| Essential Partners LLC | 97 | $2.63K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 68 | $1.85K | 0.00% | +1+1.5% | Added |
| N.E.W. Advisory Services LLC | 60 | $1.63K | 0.00% | 00.0% | Unchanged |
| SageView Advisory Group, LLC | 30 | $815 | 0.00% | +30 | New |
| Sunbelt Securities, Inc. | 19 | $516 | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 14 | $380 | 0.00% | +14 | New |
| Advisor Group Holdings, Inc. | 5 | $136 | 0.00% | +5 | New |
| SRS Capital Advisors, Inc. | 2 | $54 | 0.00% | −147−98.7% | Reduced |
| Parallel Advisors, LLC | 2 | $54 | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 1 | $27 | 0.00% | −1−50.0% | Reduced |
| Rothschild Investment LLC | 1 | $27 | 0.00% | +1 | New |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −161,113−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −73,131−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −61,299−100.0% | Sold out |
| Nomura Holdings Inc | 0 | $0 | 0.00% | −28,290−100.0% | Sold out |
| Caption Management, LLC | 0 | $0 | 0.00% | −18,196−100.0% | Sold out |
| Commonwealth Equity Services, LLC | 0 | $0 | 0.00% | −15,503−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −1,305−100.0% | Sold out |
| Clearstead Advisors, LLC | 0 | $0 | 0.00% | −163−100.0% | Sold out |