Upstream Bio, Inc.
UPB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Upstream Bio, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 133
- +38 vs. Q3 2025
- Shares held
- 51.2M
- +6.71M (+15.1%) vs. Q3 2025
- Total value
- $1.39B
- +$553.1M (+66.1%) vs. Q3 2025
- New holders
- 46
- 42 more added
- Sold out
- 8
- 33 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting UPB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 148 | $350.1M |
| Q1 2026 | 140 | $404.5M |
| Q4 2025 | 133 | $1.39B |
| Q3 2025 | 95 | $836.3M |
| Q2 2025 | 83 | $530.9M |
| Q1 2025 | 79 | $266.9M |
| Q4 2024 | 70 | $690.1M |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Upstream Bio, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| IFP Advisors, Inc | 1 | $27 | 0.00% | −1−50.0% | Reduced |
| Rothschild Investment LLC | 1 | $27 | 0.00% | +1 | New |
| SRS Capital Advisors, Inc. | 2 | $54 | 0.00% | −147−98.7% | Reduced |
| Parallel Advisors, LLC | 2 | $54 | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 5 | $136 | 0.00% | +5 | New |
| Larson Financial Group LLC | 14 | $380 | 0.00% | +14 | New |
| Sunbelt Securities, Inc. | 19 | $516 | 0.00% | 00.0% | Unchanged |
| SageView Advisory Group, LLC | 30 | $815 | 0.00% | +30 | New |
| N.E.W. Advisory Services LLC | 60 | $1.63K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 68 | $1.85K | 0.00% | +1+1.5% | Added |
| Essential Partners LLC | 97 | $2.63K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 106 | $2.88K | 0.00% | −24−18.5% | Reduced |
| Signaturefd, LLC | 117 | $3.18K | 0.00% | +66+129.4% | Added |
| J.Safra Asset Management Corp | 128 | $3.48K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 180 | $5.00K | 0.00% | +180 | New |
| UBS Asset Management Americas Inc | 242 | $6.57K | 0.00% | +242 | New |
| Aster Capital Management (DIFC) Ltd | 271 | $7.36K | 0.00% | −870−76.2% | Reduced |
| Global Retirement Partners, LLC | 273 | $7.41K | 0.00% | −59−17.8% | Reduced |
| EverSource Wealth Advisors, LLC | 282 | $7.66K | 0.00% | −28−9.0% | Reduced |
| Nisa Investment Advisors, LLC | 400 | $10.9K | 0.00% | +304+316.7% | Added |
| Simplex Trading, LLC | 466 | $12.7K | 0.00% | +466 | New |
| Federated Hermes, Inc. | 482 | $13.1K | 0.00% | +482 | New |
| US Bancorp | 546 | $14.8K | 0.00% | +15+2.8% | Added |
| Versant Capital Management, Inc | 558 | $15.2K | 0.00% | +10+1.8% | Added |
| Tower Research Capital LLC (TRC) | 669 | $18.2K | 0.00% | −1,199−64.2% | Reduced |
| GAMMA Investing LLC | 900 | $24.4K | 0.00% | +10+1.1% | Added |
| Royal Bank of Canada | 969 | $26.0K | 0.00% | +137+16.5% | Added |
| Amalgamated Bank | 1,031 | $28.0K | 0.00% | +437+73.6% | Added |
| GF Fund Management Co. Ltd. | 1,061 | $28.8K | 0.00% | +1,061 | New |
| Torren Management, LLC | 1,099 | $29.8K | 0.02% | +1,099 | New |
| Sterling Capital Management LLC | 1,919 | $52.1K | 0.00% | −345−15.2% | Reduced |
| Wellington Grp LLC | 2,000 | $54.3K | 0.02% | +2,000 | New |
| Mirae Asset Global Investments Co., Ltd. | 2,626 | $71.3K | 0.00% | +2,626 | New |
| Ameritas Investment Partners, Inc. | 2,741 | $74.4K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 2,823 | $76.6K | 0.00% | −211−7.0% | Reduced |
| KLP Kapitalforvaltning AS | 2,900 | $78.7K | 0.00% | +2,900 | New |
| CWM, LLC | 3,360 | $91.0K | 0.00% | +19+0.6% | Added |
| BNP Paribas Arbitrage, SA | 4,976 | $135.1K | 0.00% | −1,551−23.8% | Reduced |
| SG Americas Securities, LLC | 5,518 | $150.0K | 0.00% | +5,518 | New |
| Citigroup Inc | 6,949 | $188.7K | 0.00% | −35,088−83.5% | Reduced |
| SEI Investments Co | 8,087 | $219.6K | 0.00% | +8,087 | New |
| ProShare Advisors LLC | 8,354 | $226.8K | 0.00% | +8,354 | New |
| China Universal Asset Management Co., Ltd. | 8,806 | $239.1K | 0.02% | +8,806 | New |
| Persistent Asset Partners Ltd | 8,907 | $241.8K | 0.12% | +8,907 | New |
| Police & Firemen's Retirement System of New Jersey | 9,456 | $256.7K | 0.00% | +9+0.1% | Added |
| VARCOV Co. | 9,619 | $261.2K | 0.10% | +9,619 | New |
| STRS Ohio | 9,800 | $266.1K | 0.00% | +9,800 | New |
| Virtus Investment Advisers, Inc. | 9,801 | $266.1K | 0.07% | −42−0.4% | Reduced |
| Manufacturers Life Insurance Company, The | 10,147 | $275.5K | 0.00% | −1,945−16.1% | Reduced |
| Intech Investment Management LLC | 10,396 | $282.3K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 10,500 | $285.1K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 11,700 | $317.7K | 0.00% | +5,400+85.7% | Added |
| Creative Planning | 11,749 | $319.0K | 0.00% | −2,517−17.6% | Reduced |
| Mariner, LLC | 11,830 | $321.2K | 0.00% | +897+8.2% | Added |
| Verition Fund Management LLC | 12,020 | $326.3K | 0.00% | −34,981−74.4% | Reduced |
| Virtu Financial LLC | 12,246 | $332.0K | 0.01% | +12,246 | New |
| DnB Asset Management AS | 12,793 | $347.3K | 0.00% | +12,793 | New |
| Citadel Advisors LLC | 13,420 | $364.4K | 0.00% | +13,420 | New |
| Legal & General Group Plc | 13,709 | $372.2K | 0.00% | +10,785+368.8% | Added |
| Graham Capital Management, L.P. | 13,712 | $372.3K | 0.01% | +13,712 | New |
| Profund Advisors LLC | 14,582 | $395.9K | 0.01% | +14,582 | New |
| California State Teachers Retirement System | 14,652 | $397.8K | 0.00% | +12,476+573.3% | Added |
| XTX Topco Ltd | 15,091 | $409.7K | 0.01% | +15,091 | New |
| Quantinno Capital Management LP | 15,415 | $418.5K | 0.00% | +526+3.5% | Added |
| Renaissance Technologies LLC | 16,400 | $445.3K | 0.00% | +16,400 | New |
| Prelude Capital Management, LLC | 16,560 | $449.6K | 0.03% | +825+5.2% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 17,491 | $475.3K | 0.00% | +628+3.7% | Added |
| PSP Research LLC | 17,634 | $478.8K | 0.42% | +17,634 | New |
| Price T Rowe Associates Inc | 19,636 | $534.0K | 0.00% | +1,135+6.1% | Added |
| MetLife Investment Management | 19,678 | $534.3K | 0.00% | −2,013−9.3% | Reduced |
| Diadema Partners LP | 20,500 | $556.6K | 0.33% | +20,500 | New |
| Swiss National Bank | 26,600 | $722.2K | 0.00% | +26,600 | New |
| D. E. Shaw & Co., Inc. | 27,091 | $735.5K | 0.00% | +27,091 | New |
| AQR Capital Management LLC | 30,503 | $828.2K | 0.00% | +549+1.8% | Added |
| Alliancebernstein L.P. | 31,010 | $841.9K | 0.00% | +11,160+56.2% | Added |
| Trexquant Investment LP | 31,049 | $843.0K | 0.01% | +31,049 | New |
| Wells Fargo & Company | 36,794 | $999.0K | 0.00% | +11,634+46.2% | Added |
| Rafferty Asset Management, LLC | 38,683 | $1.05M | 0.00% | +4,162+12.1% | Added |
| Rhumbline Advisers | 41,523 | $1.13M | 0.00% | −7,883−16.0% | Reduced |
| Alps Advisors Inc | 44,376 | $1.20M | 0.01% | +18,414+70.9% | Added |
| Y-Intercept (Hong Kong) Ltd | 46,559 | $1.26M | 0.03% | +46,559 | New |
| Seven Grand Managers, LLC | 50,000 | $1.36M | 0.10% | +50,000 | New |
| Susquehanna International Group, LLP | 55,841 | $1.52M | 0.00% | +55,841 | New |
| Ameriprise Financial Inc | 56,557 | $1.54M | 0.00% | +56,557 | New |
| Exome Asset Management LLC | 64,845 | $1.76M | 0.87% | +12,885+24.8% | Added |
| Artia Global Partners LP | 68,653 | $1.86M | 0.30% | +68,653 | New |
| ExodusPoint Capital Management, LP | 75,402 | $2.05M | 0.02% | +75,402 | New |
| Nuveen, LLC | 78,568 | $2.13M | 0.00% | +8,686+12.4% | Added |
| Bank of New York Mellon Corp | 84,853 | $2.30M | 0.00% | −6,668−7.3% | Reduced |
| Bank of America Corp | 86,384 | $2.35M | 0.00% | +30,911+55.7% | Added |
| American Century Companies Inc | 87,756 | $2.38M | 0.00% | +16,216+22.7% | Added |
| JPMorgan Chase & Co | 110,280 | $2.99M | 0.00% | +80,333+268.3% | Added |
| Schonfeld Strategic Advisors LLC | 115,807 | $3.14M | 0.02% | −74,437−39.1% | Reduced |
| SummitTX Capital, L.P. | 116,724 | $3.17M | 0.10% | +4,320+3.8% | Added |
| Morgan Stanley | 122,068 | $3.31M | 0.00% | +34,533+39.5% | Added |
| Deutsche Bank AG | 127,815 | $3.47M | 0.00% | +101,078+378.0% | Added |
| Boxer Capital Management, LLC | 150,000 | $4.07M | 0.89% | +150,000 | New |
| Invesco Ltd. | 163,186 | $4.43M | 0.00% | +145,996+849.3% | Added |
| Squadron Capital Management LLC | 230,650 | $6.26M | 2.79% | +230,650 | New |
| Northern Trust Corp | 236,799 | $6.43M | 0.00% | −17,920−7.0% | Reduced |