Oruka Therapeutics, Inc.

ORKA

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0000907654

SEC filings (opens in a new tab)

In the last 90 days, Oruka Therapeutics, Inc. insiders filed 0 open-market purchases and 15 sales; 255 institutions reported holding it in 13F filings for Q2 2026, worth $7.05B in total; Viking Global Investors is the only superinvestor holding it.

Q1 2026 vs. Q4 2025

How the institutions holding Oruka Therapeutics, Inc. changed between Q4 2025 and Q1 2026.

All holders in Q1 2026 All holders in Q4 2025

13F holders of ORKA: Q4 2025 compared with Q1 2026
Measure	Q4 2025	Of which not filed for Q1 2026	Q1 2026	Change
Holders	143	2	184	+43
Shares	52.9M	2.45M	52.0M	+1.62M (+3.2%)
Value	$1.60B	$74.4M	$2.55B	+$1.02B (+67.0%)

2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so the changes leave them out.

New holders (63)

Institutions that held Oruka Therapeutics, Inc. at the end of Q1 2026 but not at the end of Q4 2025.

Institutions new to ORKA in Q1 2026
Institution	Shares	Value	% of portfolio
Vanguard Capital Management LLC	1,859,631	$91.2M	0.00%
Bellevue Group AG	507,008	$24.9M	0.59%
Vanguard Portfolio Management LLC	350,892	$17.2M	0.00%
Westfield Capital Management Co LP	313,130	$15.4M	0.06%
Vanguard Fiduciary Trust Co	257,071	$12.6M	0.00%
Ikarian Capital, LLC	242,021	$11.9M	1.70%
Atika Capital Management LLC	229,900	$11.3M	1.78%
Adage Capital Partners GP, L.L.C.	190,030	$9.32M	0.01%
Holocene Advisors, LP	185,513	$9.10M	0.02%
Jennison Associates LLC	176,680	$8.67M	0.01%
PFM Health Sciences, LP	174,052	$8.54M	0.90%
Silverarc Capital Management, LLC	150,908	$7.40M	0.87%
Jones Hill Capital LP	140,843	$6.91M	1.48%
Dimensional Fund Advisors LP	113,009	$5.54M	0.00%
ExodusPoint Capital Management, LP	101,354	$4.97M	0.05%
Ensign Peak Advisors, Inc	79,380	$3.89M	0.01%
HighVista Strategies LLC	78,911	$3.87M	1.07%
Boothbay Fund Management, LLC	67,481	$3.31M	0.08%
Superstring Capital Management LP	63,591	$3.12M	2.23%
EAM Investors, LLC	59,946	$2.94M	0.34%
Fred Alger Management, LLC	43,841	$2.15M	0.01%
Martingale Asset Management L P	42,732	$2.10M	0.05%
Y-Intercept (Hong Kong) Ltd	36,912	$1.81M	0.03%
Vanguard Global Advisers, LLC	21,370	$1.05M	0.00%
XTX Topco Ltd	20,180	$989.8K	0.02%
Vanguard Asset Management, Ltd	14,606	$716.4K	0.00%
Optimize Financial Inc	13,442	$659.3K	0.32%
Advisory Services Network, LLC	10,800	$529.7K	0.01%
Abacus Wealth Partners, LLC	7,802	$382.7K	0.03%
State of New Jersey Common Pension Fund D	7,441	$365.0K	0.00%
Brinker Capital Investments, LLC	7,229	$354.6K	0.00%
State Board of Administration of Florida Retirement System	6,687	$328.0K	0.00%
Toroso Investments, LLC	6,546	$321.1K	0.00%
Archer Investment Corp	6,546	$321.1K	0.07%
MML Investors Services, LLC	6,277	$307.9K	0.00%
Stifel Financial Corp	6,156	$302.0K	0.00%
EntryPoint Capital, LLC	6,120	$300.2K	0.09%
Prudential Financial Inc	6,040	$296.3K	0.00%
Arizona State Retirement System	5,980	$293.3K	0.00%
Vanguard Investments Australia, Ltd.	5,839	$286.4K	0.00%
Algert Global LLC	5,200	$255.1K	0.00%
Quantinno Capital Management LP	5,176	$253.9K	0.00%
Arrowpoint Investment Partners (Singapore) Pte. Ltd.	5,147	$252.5K	0.37%
E Fund Management Co., Ltd.	5,090	$249.7K	0.01%
PSP Research LLC	4,968	$243.7K	0.17%
Victory Capital Management Inc	4,678	$229.5K	0.00%
VARCOV Co.	4,673	$229.2K	0.09%
AQR Capital Management LLC	4,207	$206.4K	0.00%
Rock Springs Capital Management LP	4,123	$202.2K	0.01%
Simplex Trading, LLC	2,463	$120.8K	0.00%
Orion Capital Management LLC	953	$46.7K	0.02%
Zurcher Kantonalbank (Zurich Cantonalbank)	496	$24.3K	0.00%
Kemnay Advisory Services Inc.	368	$18.1K	0.00%
Versant Capital Management, Inc	98	$4.81K	0.00%
Jones Financial Companies LLLP	59	$2.62K	0.00%
Fifth Third Bancorp	50	$2.46K	0.00%
Rothschild Investment LLC	26	$1.27K	0.00%
Signaturefd, LLC	23	$1.13K	0.00%
Fortitude Family Office, LLC	12	$589	0.00%
Ameritas Advisory Services, LLC	11	$540	0.00%
Golden State Equity Partners	8	$392	0.00%
MAI Capital Management	1	$50	0.00%
Covestor Ltd	4	$0	0.00%

Sold out (20)

Institutions that held Oruka Therapeutics, Inc. at the end of Q4 2025 and filed for Q1 2026 without it.

Institutions that sold out of ORKA in Q1 2026
Institution	Shares, Q4 2025	Value, Q4 2025
Commodore Capital LP	1,753,054	$53.1M
Avoro Capital Advisors LLC	1,333,340	$40.4M
Blackstone Group Inc.	1,165,408	$35.3M
Point72 Asset Management, L.P.	600,000	$18.2M
Braidwell LP	84,795	$2.57M
D. E. Shaw & Co., Inc.	76,415	$2.32M
Millennium Management LLC	58,723	$1.78M
Verition Fund Management LLC	35,710	$1.08M
Financial Enhancement Group LLC	31,293	$1.08M
Hudson Bay Capital Management LP	20,000	$606.2K
Quest Partners LLC	14,901	$451.6K
Altfest L J & Co Inc	10,857	$329.1K
Brevan Howard Capital Management LP	9,416	$285.4K
SG Americas Securities, LLC	8,275	$251.0K
Seven Fleet Capital Management LP	5,240	$158.8K
Amalgamated Bank	1,212	$37.0K
Balyasny Asset Management LLC	536	$16.2K
DV Trading LLC	492	$14.9K
Daiwa Securities Group Inc.	116	$4.00K
Aster Capital Management (DIFC) Ltd	25	$758

Not filed for Q1 2026 yet (2)

Institutions that held Oruka Therapeutics, Inc. at the end of Q4 2025 and haven't filed a 13F for Q1 2026. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding ORKA in Q4 2025 that haven't filed for Q1 2026
Institution	Shares, Q4 2025	Value, Q4 2025
Vanguard Group Inc	2,453,530	$74.4M
CIBC Private Wealth Group, LLC	1	$30